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Article

Role of estrogen receptor in breast cancer cell gene expression

  • Authors:
    • Yabing Zheng
    • Xiying Shao
    • Yuan Huang
    • Lei Shi
    • Bo Chen
    • Xiaojia Wang
    • Hongjian Yang
    • Zhanhong Chen
    • Xiping Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology (Breast), Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Pathology, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China, Department of Breast Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang 310022, P.R. China
  • Pages: 4046-4050
    |
    Published online on: March 21, 2016
       https://doi.org/10.3892/mmr.2016.5018
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Abstract

The aim of the present study was to establish the underlying regulatory mechanism of estrogen receptor (ER) in breast cancer cell gene expression. A gene expression profile (accession no. GSE11324) was downloaded from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) from an estrogen treatment group and a control group were identified. Chromatin immunoprecipitation with high‑throughput sequencing data (series GSE25710) was obtained from the GEO for the ER binding sites, and binding and expression target analysis was performed. A total of 3,122 DEGs were obtained and ER was demonstrated to exhibit inhibition and activation roles during the regulation of its target gene expression. Motif analysis revealed that the upregulated target genes that demonstrated interactions with ER were meis homeobox 1 (MEIS1) and forkhead box P3 (FOXP3). The downregulated target genes, which demonstrated interactions with ER, were thyroid hormone receptor, β (THRB) and grainyhead‑like 1 (GRHL1). Thus, it was observed that ER stimulated gene expression by interacting with MEIS1 and FOXP3, and ER inhibited gene expression by interacting with THRB and GRHL1. However, additional experiments are required to provide further confirmation of these findings.
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1 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Dworkin AM, Huang TH and Toland AE: Epigenetic alterations in the breast: Implications for breast cancer detection, prognosis and treatment. Semin Cancer Biol. 19:165–171. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Jovanovic J, Rønneberg JA, Tost J and Kristensen V: The epigenetics of breast cancer. Mol Oncol. 4:242–254. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Polyak K: Breast cancer: Origins and evolution. J Clin Invest. 117:3155–3163. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Jemal A, Bray F, Center MM, Ferlay J, Ward E and Forman D: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, Rosso S, Coebergh JW, Comber H, Forman D and Bray F: Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012. Eur J Cancer. 49:1374–1403. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Ding LH, Ye QN, Lu QJ, Zhu JH, Yan JH, Wang ZH and Huang CF: Expression of XBP-1 in breast cancer cell lines and its role in ERalpha signaling. Yi Chuan Xue Bao. 31:380–384. 2004.In Chinese. PubMed/NCBI

8 

Katzenellenbogen BS: Estrogen receptors: Bioactivities and interactions with cell signaling pathways. Biol Reprod. 54:287–293. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Katzenellenbogen BS, Montano MM, Ekena K, Herman ME, McInerney EM and William L: McGuire Memorial Lecture. Antiestrogens: Mechanisms of action and resistance in breast cancer. Breast Cancer Res Treat. 44:23–38. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Horwitz KB and McGuire WL: Estrogen control of progesterone receptor in human breast cancer: Correlation with nuclear processing of estrogen receptor. J Biol Chem. 253:2223–2228. 1978.PubMed/NCBI

11 

Shang Y, Hu X, DiRenzo J, Lazar MA and Brown M: Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell. 103:843–852. 2000. View Article : Google Scholar

12 

Shang Y and Brown M: Molecular determinants for the tissue specificity of SERMs. Science. 295:2465–2468. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Carroll JS, Meyer CA, Song J, Li W, Geistlinger TR, Eeckhoute J, Brodsky AS, Keeton EK, Fertuck KC, Hall GF, et al: Genome-wide analysis of estrogen receptor binding sites. Nat Genet. 38:1289–1297. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Lippman M, Bolan G and Huff K: The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res. 36:4595–4601. 1976.PubMed/NCBI

15 

Irizarry R, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U and Speed TP: Exploration, normalization and summaries of high density oligonucleotide array probe level data. Biostatistics. 4:249–264. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Smyth GK: limma: Linear models for microarray data. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. Gentleman R, Carey VJ, Huber W, Irizarry RA and Dudoit S: 1st edition. Springer; New York, NY, USA: pp. 397–420. 2005, View Article : Google Scholar

17 

Langfelder P and Horvath S: Fast R functions for robust correlations and hierarchical clustering. J Stat Softw. 46:pii: i11. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Langmead B, Trapnell C, Pop M and Salzberg SL: Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10:R252009. View Article : Google Scholar : PubMed/NCBI

19 

Feng J, Liu T and Zhang Y: Using MACS to identify peaks from ChIP-Seq data. Curr Protoc Bioinformatics Chapter 2: Unit 2. 14:2011. View Article : Google Scholar

20 

Zhang Y, Liu T, Meyer CA, Eeckhoute J, Johnson DS, Bernstein BE, Nusbaum C, Myers RM, Brown M, Li W and Liu XS: Model-based analysis of ChIP-Seq (MACS). Genome Biol. 9:R1372008. View Article : Google Scholar : PubMed/NCBI

21 

Shin H, Liu T, Manrai AK and Liu XS: CEAS: Cis-regulatory element annotation system. Bioinformatics. 25:2605–2606. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Grober OM, Mutarelli M, Giurato G, Ravo M, Cicatiello L, De Filippo MR, Ferraro L, Nassa G, Papa MF, Paris O, et al: Global analysis of estrogen receptor beta binding to breast cancer cell genome reveals an extensive interplay with estrogen receptor alpha for target gene regulation. BMC Genomics. 12:362011. View Article : Google Scholar : PubMed/NCBI

23 

Wang S, Sun H, Ma J, Zang C, Wang C, Wang J, Tang Q, Meyer CA, Zhang Y and Liu XS: Target analysis by integration of transcriptome and ChIP-seq data with BETA. Nat Protoc. 8:2502–2515. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Moskow JJ, Bullrich F, Huebner K, Daar IO and Buchberg AM: Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol Cell Biol. 15:5434–5443. 1995. View Article : Google Scholar : PubMed/NCBI

25 

Mahmoud AI, Kocabas F, Muralidhar SA, Kimura W, Koura AS, Thet S, Porrello ER and Sadek HA: Meis1 regulates postnatal cardiomyocyte cell cycle arrest. Nature. 497:249–253. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Doolan P, Clynes M, Kennedy S, Mehta JP, Germano S, Ehrhardt C, Crown J and O'Driscoll L: TMEM25, REPS2 and Meis 1: Favourable prognostic and predictive biomarkers for breast cancer. Tumour Biol. 30:200–209. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y and Pietenpol JA: Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest. 121:2750–2767. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Merlo A, Casalini P, Carcangiu ML, Malventano C, Triulzi T, Mènard S, Tagliabue E and Balsari A: FOXP3 expression and overall survival in breast cancer. J Clin Oncol. 27:1746–1752. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Polanczyk MJ, Hopke C, Huan J, Vandenbark AA and Offner H: Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice. J Neuroimmunol. 170:85–92. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Fox SB, Brown P, Han C, Ashe S, Leek RD, Harris AL and Banham AH: Expression of the forkhead transcription factor FOXP1 is associated with estrogen receptor alpha and improved survival in primary human breast carcinomas. Clin Cancer Res. 10:3521–3527. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Ling Y, Xu X, Hao J, Ling X, Du X, Liu X and Zhao X: Aberrant methylation of the THRB gene in tissue and plasma of breast cancer patients. Cancer Genet Cytogenet. 196:140–145. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Baniahmad A, Ha I, Reinberg D, Tsai S, Tsai MJ and O'Malley BW: Interaction of human thyroid hormone receptor beta with transcription factor TFIIB may mediate target gene derepression and activation by thyroid hormone. Proc Natl Acad Sci USA. 90:8832–8836. 1993. View Article : Google Scholar : PubMed/NCBI

33 

Fabian J, Lodrini M, Schier M, Thole T, Kopp-Schneider A, Capper D, von Deimling A, Oehme I, Wiegand I, Milde T, et al: GRHL1 inhibits tumorigenicity and is a prognostic marker in neuroblastoma. Klin Padiatr. 225:A292013. View Article : Google Scholar

34 

Fabian J, Lodrini M, Oehme I, Schier MC, Thole TM, Hielscher T, Kopp-Schneider A, Opitz L, Capper D, von Deimling A, et al: GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3. Cancer Res. 74:2604–2616. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Tao J, Kuliyev E, Wang X, Li X, Wilanowski T, Jane SM, Mead PE and Cunningham JM: BMP4-dependent expression of Xenopus Grainyhead-like 1 is essential for epidermal differentiation. Development. 132:1021–1034. 2005. View Article : Google Scholar : PubMed/NCBI

36 

de la Garza G, Schleiffarth JR, Dunnwald M, Mankad A, Weirather JL, Bonde G, Butcher S, Mansour TA, Kousa YA, Fukazawa CF, et al: Interferon regulatory factor 6 promotes differentiation of the periderm by activating expression of grainyhead-like 3. J Invest Dermatol. 133:68–77. 2013. View Article : Google Scholar :

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Copy and paste a formatted citation
Spandidos Publications style
Zheng Y, Shao X, Huang Y, Shi L, Chen B, Wang X, Yang H, Chen Z and Zhang X: Role of estrogen receptor in breast cancer cell gene expression. Mol Med Rep 13: 4046-4050, 2016.
APA
Zheng, Y., Shao, X., Huang, Y., Shi, L., Chen, B., Wang, X. ... Zhang, X. (2016). Role of estrogen receptor in breast cancer cell gene expression. Molecular Medicine Reports, 13, 4046-4050. https://doi.org/10.3892/mmr.2016.5018
MLA
Zheng, Y., Shao, X., Huang, Y., Shi, L., Chen, B., Wang, X., Yang, H., Chen, Z., Zhang, X."Role of estrogen receptor in breast cancer cell gene expression". Molecular Medicine Reports 13.5 (2016): 4046-4050.
Chicago
Zheng, Y., Shao, X., Huang, Y., Shi, L., Chen, B., Wang, X., Yang, H., Chen, Z., Zhang, X."Role of estrogen receptor in breast cancer cell gene expression". Molecular Medicine Reports 13, no. 5 (2016): 4046-4050. https://doi.org/10.3892/mmr.2016.5018
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng Y, Shao X, Huang Y, Shi L, Chen B, Wang X, Yang H, Chen Z and Zhang X: Role of estrogen receptor in breast cancer cell gene expression. Mol Med Rep 13: 4046-4050, 2016.
APA
Zheng, Y., Shao, X., Huang, Y., Shi, L., Chen, B., Wang, X. ... Zhang, X. (2016). Role of estrogen receptor in breast cancer cell gene expression. Molecular Medicine Reports, 13, 4046-4050. https://doi.org/10.3892/mmr.2016.5018
MLA
Zheng, Y., Shao, X., Huang, Y., Shi, L., Chen, B., Wang, X., Yang, H., Chen, Z., Zhang, X."Role of estrogen receptor in breast cancer cell gene expression". Molecular Medicine Reports 13.5 (2016): 4046-4050.
Chicago
Zheng, Y., Shao, X., Huang, Y., Shi, L., Chen, B., Wang, X., Yang, H., Chen, Z., Zhang, X."Role of estrogen receptor in breast cancer cell gene expression". Molecular Medicine Reports 13, no. 5 (2016): 4046-4050. https://doi.org/10.3892/mmr.2016.5018
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