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Article

Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords

  • Authors:
    • Lin‑Lin Wang
    • Dong‑Ling Shi
    • Hui‑Yao Gu
    • Ming‑Zhi Zheng
    • Jue Hu
    • Xing‑Hui Song
    • Yue‑Liang Shen
    • Ying‑Ying Chen
  • View Affiliations / Copyright

    Affiliations: Department of Physiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China, Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China, Department of Pharmacology, Zhejiang Medical College, Hangzhou, Zhejiang 310053, P.R. China, Core Facilities, Department of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310058, P.R. China
  • Pages: 4051-4057
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    Published online on: March 21, 2016
       https://doi.org/10.3892/mmr.2016.5027
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Abstract

The present study aimed to investigate the effect of resveratrol on inflammatory pain. Mice were injected intraperitoneally with lipopolysaccharide (LPS) for 5 consecutive days to induce subacute systemic inflammation. Acetic acid‑induced writhing tests and tail‑flick tests were performed following the final LPS injection. Glial fibrillary acidic protein (GFAP; an astrocyte‑specific activation marker), ionized calcium binding adapter molecule 1 (Iba‑1; a microglia‑specific activation marker) and sirtuin 1 (SIRT1) protein expression levels were detected using immunohistochemistry analysis or western blotting. Following administration of LPS for 5 days, the number of writhes increased and the tail‑flick latency decreased. Resveratrol (10 or 20 mg/kg) partly inhibited LPS‑induced hyperalgesia and prevented the increase in tumor necrosis factor‑α and interleukin 6 levels induced by LPS. LPS injection reduced the SIRT1 protein expression and increased the number of GFAP‑positive and Iba‑1‑positive cells in the spinal cord. Resveratrol increased the SIRT1 protein expression levels and decreased the number of GFAP‑positive and Iba‑1‑positive cells in LPS‑treated mice. The protective effect of resveratrol was partly blocked by a selective SIRT1 inhibitor, EX‑257. Results from the present study suggest that subacute treatment with LPS induced the activation of glial cells and hyperalgesia. Resveratrol was demonstrated to inhibit the activation of glial cells and attenuate inflammatory hyperalgesia in a SIRT1‑dependent manner.
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View References

1 

Watkins LR and Maier SF: Immune regulation of central nervous system functions: From sickness responses to pathological pain. J Intern Med. 257:139–155. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Schinkel C, Gaertner A, Zaspel J, Zedler S, Faist E and Schuermann M: Inflammatory mediators are altered in the acute phase of posttraumatic complex regional pain syndrome. Clin J Pain. 22:235–239. 2006. View Article : Google Scholar : PubMed/NCBI

3 

Koch A, Zacharowski K, Boehm O, Stevens M, Lipfert P, von Giesen HJ, Wolf A and Freynhagen R: Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients. Inflamm Res. 56:32–37. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Jiang YH, Peng CH, Liu HT and Kuo HC: Increased pro-inflammatory cytokines, C-reactive protein and nerve growth factor expressions in serum of patients with interstitial cystitis/bladder pain syndrome. PLoS One. 8:e767792013. View Article : Google Scholar : PubMed/NCBI

5 

Sandhir R, Gregory E, He YY and Berman NE: Upregulation of inflammatory mediators in a model of chronic pain after spinal cord injury. Neurochem Res. 36:856–862. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Laird BJ, McMillan DC, Fayers P, Fearon K, Kaasa S, Fallon MT and Klepstad P: The systemic inflammatory response and its relationship to pain and other symptoms in advanced cancer. Oncologist. 18:1050–1055. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Sun AY, Wang Q, Simonyi A and Sun GY: Resveratrol as a therapeutic agent for neurodegenerative diseases. Mol Neurobiol. 41:375–383. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Pangeni R, Sahni JK, Ali J, Sharma S and Baboota S: Resveratrol: Review on therapeutic potential and recent advances in drug delivery. Expert Opin Drug Deliv. 11:1285–1298. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Cheng W, Zhao Y, Liu H, Fan Q, Lu FF, Li J, Yin Q and Yan CD: Resveratrol attenuates bone cancer pain through the inhibition of spinal glial activation and CX3CR1 upregulation. Fundam Clin Pharmacol. 28:661–670. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Sharma S, Kulkarni SK and Chopra K: Effect of resveratrol, a polyphenolic phytoalexin, on thermal hyperalgesia in a mouse model of diabetic neuropathic pain. Fundam Clin Pharmacol. 21:89–94. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Falchi M, Bertelli A, Galazzo R, Viganò P and Dib B: Central antalgic activity of resveratrol. Arch Ital Biol. 148:389–396. 2010.

12 

Švajger U and Jeras M: Anti-inflammatory effects of resveratrol and its potential use in therapy of immune-mediated diseases. Int Rev Immunol. 31:202–222. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Institute of Laboratory Animal Resources (US); Committee on Care Use of Laboratory Animals National Institutes of Health (US); Division of Research Resources: Guide for the care and use of laboratory animals. 8th edition. National Academies Press; Washington, DC: 2011

14 

Zhao H, Luo F, Li H, Zhang L, Yi Y and Wan J: Antinociceptive effect of tetrandrine on LPS-induced hyperalgesia via the inhibition of IKKβ phosphorylation and the COX-2/PGE2 pathway in mice. PLoS One. 9:e945862014. View Article : Google Scholar

15 

Sora I, Takahashi N, Funada M, Ujike H, Revay RS, Donovan DM, Miner LL and Uhl GR: Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci USA. 94:1544–1549. 1997. View Article : Google Scholar : PubMed/NCBI

16 

Clark MR: Targeting systemic inflammation in patients with obesity-related pain: How best to prevent acute pain from becoming chronic? J Fam Pract. 62(9 Suppl CHPP): S3–S9. 2013.PubMed/NCBI

17 

Ribeiro RA, Vale ML, Thomazzi SM, Paschoalato AB, Poole S, Ferreira SH and Cunha FQ: Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur J Pharmacol. 387:111–118. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Jha MK, Seo M, Kim JH, Kim BG, Cho JY and Suk K: The secretome signature of reactive glial cells and its pathological implications. Biochim Biophys Acta. 1834:2418–2428. 2013. View Article : Google Scholar

19 

Gwak YS, Kang J, Unabia GC and Hulsebosch CE: Spatial and temporal activation of spinal glial cells: Role of gliopathy in central neuropathic pain following spinal cord injury in rats. Exp Neurol. 234:362–372. 2012. View Article : Google Scholar :

20 

Parpura V, Heneka MT, Montana V, Oliet SH, Schousboe A, Haydon PG, Stout RF Jr, Spray DC, Reichenbach A, Pannicke T, et al: Glial cells in (patho)physiology. J Neurochem. 121:4–27. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Watkins LR and Maier SF: Beyond neurons: Evidence that immune and glial cells contribute to pathological pain states. Physiol Rev. 82:981–1011. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Barragán-Iglesias P, Pineda-Farias JB, Cervantes-Durán C, Bravo-Hernández M, Rocha-González HI, Murbartián J and Granados-Soto V: Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: Possible involvement of glial cells. Mol Pain. 10:292014. View Article : Google Scholar : PubMed/NCBI

23 

Ji XT, Qian NS, Zhang T, Li JM, Li XK, Wang P, Zhao DS, Huang G, Zhang L, Fei Z, et al: Spinal astrocytic activation contributes to mechanical allodynia in a rat chemotherapy-induced neuropathic pain model. PLoS One. 8:e607332013. View Article : Google Scholar : PubMed/NCBI

24 

Chen FL, Dong YL, Zhang ZJ, Cao DL, Xu J, Hui J, Zhu L and Gao YJ: Activation of astrocytes in the anterior cingulate cortex contributes to the affective component of pain in an inflammatory pain model. Brain Res Bull. 87:60–66. 2012. View Article : Google Scholar

25 

Feng QX, Wang W, Feng XY, Mei XP, Zhu C, Liu ZC, Li YQ, Dou KF and Zhao QC: Astrocytic activation in thoracic spinal cord contributes to persistent pain in rat model of chronic pancreatitis. Neuroscience. 167:501–509. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Cui J, He W, Yi B, Zhao H, Lu K, Ruan H and Ma D: mTOR pathway is involved in ADP-evoked astrocyte activation and ATP release in the spinal dorsal horn in a rat neuropathic pain model. Neuroscience. 275:395–403. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Shen W, Hu XM, Liu YN, Han Y, Chen LP, Wang CC and Song C: CXCL12 in astrocytes contributes to bone cancer pain through CXCR4-mediated neuronal sensitization and glial activation in rat spinal cord. J Neuroinflammation. 11:752014. View Article : Google Scholar : PubMed/NCBI

28 

Vega-Avelaira D, Ballesteros JJ and López-García JA: Inflammation-induced hyperalgesia and spinal microglia reactivity in neonatal rats. Eur J Pain. 17:1180–1188. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Xu ZZ, Berta T and Ji RR: Resolvin E1 inhibits neuropathic pain and spinal cord microglial activation following peripheral nerve injury. J Neuroimmune Pharmacol. 8:37–41. 2013. View Article : Google Scholar :

30 

Moss A, Beggs S, Vega-Avelaira D, Costigan M, Hathway GJ, Salter MW and Fitzgerald M: Spinal microglia and neuropathic pain in young rats. Pain. 128:215–224. 2007. View Article : Google Scholar

31 

Guo J, Jia D, Jin B, Xu F, Yuan X and Shen H: Effects of glial cell line-derived neurotrophic factor intrathecal injection on spinal dorsal horn glial fibrillary acidic protein expression in a rat model of neuropathic pain. Int J Neurosci. 122:388–394. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Blum E, Procacci P, Conte V and Hanani M: Systemic inflammation alters satellite glial cell function and structure. A possible contribution to pain. Neuroscience. 274:209–217. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Cao FL, Xu M, Wang Y, Gong KR and Zhang JT: Tanshinone IIA attenuates neuropathic pain via inhibiting glial activation and immune response. Pharmacol Biochem Behav. 128:1–7. 2015. View Article : Google Scholar

34 

Silva GD, Lopes PS, Fonoff ET and Pagano RL: The spinal anti-inflammatory mechanism of motor cortex stimulation: Cause of success and refractoriness in neuropathic pain? J Neuroinflammation. 12:102015. View Article : Google Scholar : PubMed/NCBI

35 

Zhu MD, Zhao LX, Wang XT, Gao YJ and Zhang ZJ: Ligustilide inhibits microglia-mediated proinflammatory cytokines production and inflammatory pain. Brain Res Bull. 109:54–60. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Clark AK, Staniland AA, Marchand F, Kaan TK, McMahon SB and Malcangio M: P2X7-dependent release of interleukin-1beta and nociception in the spinal cord following lipopolysaccharide. J Neurosci. 30:573–582. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Luo XY, Qu SL, Tang ZH, Zhang Y, Liu MH, Peng J, Tang H, Yu KL, Zhang C, Ren Z and Zhang ZS: SIRT1 in cardiovascular aging. Clin Chim Acta. 437:106–114. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Herskovits AZ and Guarente L: SIRT1 in neurodevelopment and brain senescence. Neuron. 81:471–483. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Leibiger IB and Berggren PO: Sirt1: A metabolic master switch that modulates lifespan. Nat Med. 12:34–36. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Kalle AM, Mallika A, Badiger J, Alinakhi, Talukdar P and Sachchidanand: Inhibition of SIRT1 by a small molecule induces apoptosis in breast cancer cells. Biochem Biophys Res Commun. 401:13–19. 2010. View Article : Google Scholar : PubMed/NCBI

41 

He X, Ou P, Wu K, Huang C, Wang Y, Yu Z and Guo Q: Resveratrol attenuates morphine antinociceptive tolerance via SIRT1 regulation in the rat spinal cord. Neurosci Lett. 566:55–60. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Yin Q, Lu FF, Zhao Y, Cheng MY, Fan Q, Cui J, Liu L, Cheng W and Yan CD: Resveratrol facilitates pain attenuation in a rat model of neuropathic pain through the activation of spinal Sirt1. Reg Anesth Pain Med. 38:93–99. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Shao H, Xue Q, Zhang F, Luo Y, Zhu H, Zhang X, Zhang H, Ding W and Yu B: Spinal SIRT1 activation attenuates neuropathic pain in mice. PLoS One. 9:e1009382014. View Article : Google Scholar : PubMed/NCBI

44 

Winnik S, Stein S and Matter CM: SIRT1-an anti-inflammatory pathway at the crossroads between metabolic disease and atherosclerosis. Curr Vasc Pharmacol. 10:693–696. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Xie J, Zhang X and Zhang L: Negative regulation of inflammation by SIRT1. Pharmacol Res. 67:60–67. 2013. View Article : Google Scholar

46 

Joe IS, Jeong SG and Cho GW: Resveratrol-induced SIRT1 activation promotes neuronal differentiation of human bone marrow mesenchymal stem cells. Neurosci Lett. 584:97–102. 2015. View Article : Google Scholar

47 

Li L, Sun Q, Li Y, Yang Y, Yang Y, Chang T, Man M and Zheng L: Overexpression of SIRT1 Induced by resveratrol and inhibitor of miR-204 suppresses activation and proliferation of microglia. J Mol Neurosci. 56:858–867. 2015. View Article : Google Scholar : PubMed/NCBI

48 

Sin TK, Tam BT, Yung BY, Yip SP, Chan LW, Wong CS, Ying M, Rudd JA and Siu PM: Resveratrol protects against doxorubicin-induced cardiotoxicity in aged hearts through the SIRT1-USP7 axis. J Physiol. 593:1887–1899. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Han Y, Jiang C, Tang J, Wang C, Wu P, Zhang G, Liu W, Jamangulova N, Wu X and Song X: Resveratrol reduces morphine tolerance by inhibiting microglial activation via AMPK signalling. Eur J Pain. 18:1458–1470. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Zong Y, Sun L, Liu B, Deng YS, Zhan D, Chen YL, He Y, Liu J, Zhang ZJ, Sun J and Lu D: Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells. PLoS One. 7:e441072012. View Article : Google Scholar : PubMed/NCBI

51 

Centeno-Baez C, Dallaire P and Marette A: Resveratrol inhibition of inducible nitric oxide synthase in skeletal muscle involves AMPK but not SIRT1. Am J Physiol Endocrinol Metab. 301:E922–E930. 2011. View Article : Google Scholar : PubMed/NCBI

52 

Yang H, Zhang W, Pan H, Feldser HG, Lainez E, Miller C, Leung S, Zhong Z, Zhao H, Sweitzer S, et al: SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-kappaB activity. PLoS One. 7:e463642012. View Article : Google Scholar

53 

Park GJ, Kim YS, Kang KL, Bae SJ, Baek HS, Auh QS, Chun YH, Park BH and Kim EC: Effects of sirtuin 1 activation on nicotine and lipopolysaccharide-induced cytotoxicity and inflammatory cytokine production in human gingival fibroblasts. J Periodontal Res. 48:483–492. 2013. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Wang LL, Shi DL, Gu HY, Zheng MZ, Hu J, Song XH, Shen YL and Chen YY: Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords. Mol Med Rep 13: 4051-4057, 2016.
APA
Wang, L., Shi, D., Gu, H., Zheng, M., Hu, J., Song, X. ... Chen, Y. (2016). Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords. Molecular Medicine Reports, 13, 4051-4057. https://doi.org/10.3892/mmr.2016.5027
MLA
Wang, L., Shi, D., Gu, H., Zheng, M., Hu, J., Song, X., Shen, Y., Chen, Y."Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords". Molecular Medicine Reports 13.5 (2016): 4051-4057.
Chicago
Wang, L., Shi, D., Gu, H., Zheng, M., Hu, J., Song, X., Shen, Y., Chen, Y."Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords". Molecular Medicine Reports 13, no. 5 (2016): 4051-4057. https://doi.org/10.3892/mmr.2016.5027
Copy and paste a formatted citation
x
Spandidos Publications style
Wang LL, Shi DL, Gu HY, Zheng MZ, Hu J, Song XH, Shen YL and Chen YY: Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords. Mol Med Rep 13: 4051-4057, 2016.
APA
Wang, L., Shi, D., Gu, H., Zheng, M., Hu, J., Song, X. ... Chen, Y. (2016). Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords. Molecular Medicine Reports, 13, 4051-4057. https://doi.org/10.3892/mmr.2016.5027
MLA
Wang, L., Shi, D., Gu, H., Zheng, M., Hu, J., Song, X., Shen, Y., Chen, Y."Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords". Molecular Medicine Reports 13.5 (2016): 4051-4057.
Chicago
Wang, L., Shi, D., Gu, H., Zheng, M., Hu, J., Song, X., Shen, Y., Chen, Y."Resveratrol attenuates inflammatory hyperalgesia by inhibiting glial activation in mice spinal cords". Molecular Medicine Reports 13, no. 5 (2016): 4051-4057. https://doi.org/10.3892/mmr.2016.5027
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