Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model
- Huimin Wang
- Huiling Wang
- Huixin Cheng
- Zhenyong Che
Affiliations: Department of Neurology, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China, Department of Pediatrics, Xinxiang Hospital of Municipal Offices, Xinxiang, Henan 453000, P.R. China, Department of Pathology, Xinxiang Central Hospital, Xinxiang, Henan 453000, P.R. China
- Published online on: March 28, 2016 https://doi.org/10.3892/mmr.2016.5052
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et al. This is an open access article distributed under the
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Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorder. It is characterized by the formation of amyloid plaques and neurofibrillary tangles in the brain, the degeneration of cholinergic neurons and neuronal cell death. The present study aimed to investigate the effect of luteolin, a flavonoid compound, on memory impairment in a streptozotocin (STZ)‑induced Alzheimer's rat model. Morris water maze and probe tests were performed to examine the effect of luteolin treatment on cognition and memory. The effect of luteolin on CA1 pyramidal layer thickness was also examined. The results demonstrated that luteolin significantly ameliorated the spatial learning and memory impairment induced by STZ treatment. STZ significantly reduced the thickness of CA1 pyramidal layer and treatment of luteolin completely abolished the inhibitory effect of STZ. Our results suggest that luteolin has a potentially protective effect on learning defects and hippocampal structures in AD.