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Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model

  • Authors:
    • Huimin Wang
    • Huiling Wang
    • Huixin Cheng
    • Zhenyong Che
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  • Published online on: March 28, 2016     https://doi.org/10.3892/mmr.2016.5052
  • Pages: 4215-4220
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Alzheimer's disease (AD) is one of the most prevalent neurodegenerative disorder. It is characterized by the formation of amyloid plaques and neurofibrillary tangles in the brain, the degeneration of cholinergic neurons and neuronal cell death. The present study aimed to investigate the effect of luteolin, a flavonoid compound, on memory impairment in a streptozotocin (STZ)‑induced Alzheimer's rat model. Morris water maze and probe tests were performed to examine the effect of luteolin treatment on cognition and memory. The effect of luteolin on CA1 pyramidal layer thickness was also examined. The results demonstrated that luteolin significantly ameliorated the spatial learning and memory impairment induced by STZ treatment. STZ significantly reduced the thickness of CA1 pyramidal layer and treatment of luteolin completely abolished the inhibitory effect of STZ. Our results suggest that luteolin has a potentially protective effect on learning defects and hippocampal structures in AD.
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May-2016
Volume 13 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang H, Wang H, Cheng H and Che Z: Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model. Mol Med Rep 13: 4215-4220, 2016
APA
Wang, H., Wang, H., Cheng, H., & Che, Z. (2016). Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model. Molecular Medicine Reports, 13, 4215-4220. https://doi.org/10.3892/mmr.2016.5052
MLA
Wang, H., Wang, H., Cheng, H., Che, Z."Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model". Molecular Medicine Reports 13.5 (2016): 4215-4220.
Chicago
Wang, H., Wang, H., Cheng, H., Che, Z."Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model". Molecular Medicine Reports 13, no. 5 (2016): 4215-4220. https://doi.org/10.3892/mmr.2016.5052