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Article

MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1

Corrigendum in: /10.3892/mmr.2022.12799
  • Authors:
    • Deyao Wu
    • Xiaobing Niu
    • Huixing Pan
    • Yunfeng Zhou
    • Ping Qu
    • Jian Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng, Jiangsu 224001, P.R. China, Department of Urology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China
  • Pages: 4379-4385
    |
    Published online on: March 28, 2016
       https://doi.org/10.3892/mmr.2016.5055
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Abstract

The expression of microRNA‑335 (miR‑335) has been demonstrated to be downregulated in numerous types of cancer. Thus far, no previous studies have investigated the miR‑335 expression in bladder cancer. In the present study, the expression and effects of miR‑335 were assessed in bladder cancer. The results of the present study provided, to the best of our knowledge, the first evidence that miR‑335 is downregulated in the tumor tissue of patients with bladder cancer. Following transfection of miR‑335, MTT, cell migration and invasion, luciferase and western blot assays were conducted in bladder cancer cell lines. The results demonstrated that miR‑335 inhibited cell proliferation, migration and invasion in T24 and EJ cells. In addition, the results suggested that miR‑335 directly targets Rho‑associated protein kinase 1 (ROCK1) in bladder cancer. The present study provided a novel therapeutic target, the miR‑335/ROCK1 axis in bladder cancer. The suggested approach will be beneficial in developing an effective treatment against bladder cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Wu D, Niu X, Pan H, Zhou Y, Qu P and Zhou J: MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1 Corrigendum in /10.3892/mmr.2022.12799. Mol Med Rep 13: 4379-4385, 2016.
APA
Wu, D., Niu, X., Pan, H., Zhou, Y., Qu, P., & Zhou, J. (2016). MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1 Corrigendum in /10.3892/mmr.2022.12799. Molecular Medicine Reports, 13, 4379-4385. https://doi.org/10.3892/mmr.2016.5055
MLA
Wu, D., Niu, X., Pan, H., Zhou, Y., Qu, P., Zhou, J."MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1 Corrigendum in /10.3892/mmr.2022.12799". Molecular Medicine Reports 13.5 (2016): 4379-4385.
Chicago
Wu, D., Niu, X., Pan, H., Zhou, Y., Qu, P., Zhou, J."MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1 Corrigendum in /10.3892/mmr.2022.12799". Molecular Medicine Reports 13, no. 5 (2016): 4379-4385. https://doi.org/10.3892/mmr.2016.5055
Copy and paste a formatted citation
x
Spandidos Publications style
Wu D, Niu X, Pan H, Zhou Y, Qu P and Zhou J: MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1 Corrigendum in /10.3892/mmr.2022.12799. Mol Med Rep 13: 4379-4385, 2016.
APA
Wu, D., Niu, X., Pan, H., Zhou, Y., Qu, P., & Zhou, J. (2016). MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1 Corrigendum in /10.3892/mmr.2022.12799. Molecular Medicine Reports, 13, 4379-4385. https://doi.org/10.3892/mmr.2016.5055
MLA
Wu, D., Niu, X., Pan, H., Zhou, Y., Qu, P., Zhou, J."MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1 Corrigendum in /10.3892/mmr.2022.12799". Molecular Medicine Reports 13.5 (2016): 4379-4385.
Chicago
Wu, D., Niu, X., Pan, H., Zhou, Y., Qu, P., Zhou, J."MicroRNA-335 is downregulated in bladder cancer and inhibits cell growth, migration and invasion via targeting ROCK1 Corrigendum in /10.3892/mmr.2022.12799". Molecular Medicine Reports 13, no. 5 (2016): 4379-4385. https://doi.org/10.3892/mmr.2016.5055
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