Open Access

Extracts of Bauhinia championii (Benth.) Benth. attenuate the inflammatory response in a rat model of collagen-induced arthritis

  • Authors:
    • Wei Xu
    • Mingqing Huang
    • Yuqin Zhang
    • Huang Li
    • Haiyin Zheng
    • Lishuang Yu
    • Kedan Chu
    • Yu Lin
    • Lidian Chen
  • View Affiliations

  • Published online on: March 30, 2016     https://doi.org/10.3892/mmr.2016.5070
  • Pages: 4167-4174
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Rheumatoid arthritis is considered a serious public health problem, which is commonly treated with traditional Chinese or herbal medicine. The present study evaluated the effects of Bauhinia championii (Benth.) Benth. extraction (BCBE) on a type II collagen-induced arthritis (CIA) rat model. Wistar rats with CIA received either 125 or 500 mg/kg BCBE, after which, paw swelling was markedly suppressed compared with in the model group. In addition, BCBE significantly ameliorated pathological joint alterations, including synovial hyperplasia, and cartilage and bone destruction. The protein and mRNA expression levels of interleukin (IL)‑6, IL‑8, tumor necrosis factor‑α and nuclear factor‑κB in synovial tissue were determined by immunohistochemical staining, western blot analysis and reverse transcription‑polymerase chain reaction. The results demonstrated that the expression levels of these factors were significantly downregulated in the BCBE‑treated group compared with in the model group. These results indicated that BCBE may exert an inhibitory effect on the CIA rat model, and its therapeutic potential is associated with its anti-inflammatory action.
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May-2016
Volume 13 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Xu W, Huang M, Zhang Y, Li H, Zheng H, Yu L, Chu K, Lin Y and Chen L: Extracts of Bauhinia championii (Benth.) Benth. attenuate the inflammatory response in a rat model of collagen-induced arthritis. Mol Med Rep 13: 4167-4174, 2016
APA
Xu, W., Huang, M., Zhang, Y., Li, H., Zheng, H., Yu, L. ... Chen, L. (2016). Extracts of Bauhinia championii (Benth.) Benth. attenuate the inflammatory response in a rat model of collagen-induced arthritis. Molecular Medicine Reports, 13, 4167-4174. https://doi.org/10.3892/mmr.2016.5070
MLA
Xu, W., Huang, M., Zhang, Y., Li, H., Zheng, H., Yu, L., Chu, K., Lin, Y., Chen, L."Extracts of Bauhinia championii (Benth.) Benth. attenuate the inflammatory response in a rat model of collagen-induced arthritis". Molecular Medicine Reports 13.5 (2016): 4167-4174.
Chicago
Xu, W., Huang, M., Zhang, Y., Li, H., Zheng, H., Yu, L., Chu, K., Lin, Y., Chen, L."Extracts of Bauhinia championii (Benth.) Benth. attenuate the inflammatory response in a rat model of collagen-induced arthritis". Molecular Medicine Reports 13, no. 5 (2016): 4167-4174. https://doi.org/10.3892/mmr.2016.5070