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Article

Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages

  • Authors:
    • Soo‑Jin Jeong
    • Ohn‑Soon Kim
    • Sae‑Rom Yoo
    • Chang‑Seob Seo
    • Yeji Kim
    • Hyeun‑Kyoo Shin
  • View Affiliations / Copyright

    Affiliations: KM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic of Korea, K‑herb Research Center, Korea Institute of Oriental Medicine, Daejeon, Chungcheong 34054, Republic of Korea
  • Pages: 4365-4371
    |
    Published online on: April 4, 2016
       https://doi.org/10.3892/mmr.2016.5084
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Abstract

Gwakhyangjeonggi‑san (GHJGS) is a mixture of herbal plants, including Agastache rugosa, Perilla frutescens, Angelica dahurica, Areca catechu, Poria cocos, Magnolia officinalis, Atractylodes macrocephala, Citrus reticulata, Pinellia ternata, Platycodon grandiflorum, Glycyrrhiza uralensis, Ziziphus jujuba and Zingiber officinale. GHJGS has been used for treating diarrhea‑predominant irritable bowel syndrome in traditional Korean medicine. In the present study, the anti‑inflammatory and antioxidant effects of GHJGS were investigated using the RAW 264.7 murine macrophage cell line. GHJGS significantly reduced production of the proinflammatory cytokines, tumor necrosis factor‑α, interleukin‑6 and prostaglandin E2 in lipopolysaccharide (LPS)‑stimulated macrophages. GHJGS markedly suppressed LPS‑induced phosphorylation of mitogen‑activated protein kinases, whereas it had no effect on nuclear factor‑κB activation. Furthermore, GHJGS enhanced expression of heme oxygenase‑1 and prevented the generation of reactive oxygen species in RAW 264.7 cells. These results indicate that GHJGS is a viable therapeutic agent against inflammation and oxidative stress‑associated disorders.
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1 

Yun HS, Ryu BH, Park DW and Ryu KW: Experimental comparative studies on the effects of Kwakhyangjeonggisan and Souminkwakhyang-jeonggisan. K H Univ O Med J. 21:197–211. 1998.In Korean.

2 

Chuan-xing Y and Ling Z: Experimental researches on inhibitory effect of Huoxiang Zhengqi liquid on histamine release. Chin J Integr Med. 9:276–280. 2003.In Chinese. View Article : Google Scholar

3 

Xie C, Wang XF, Qi XJ, Lu LL and Chan HC: Effect of Huoxiang-zhengqi liquid on HCO3- secretion by intact porcine distal airway epithelium. Sheng Li Xue Bao. 60:90–96. 2008.In Chinese. PubMed/NCBI

4 

Koo CM, Sun JK, Kim HH and Nam CG: Effects of GwakHyangJungGiSan on the arterial contraction in rabbit. Kor Orient Int Med. 24:260–268. 2003.In Korean.

5 

Zhang HK, Huang Y, Li K and Wu SH: Antibacterial material basis and quality control of Huoxiang Zhengqi tincture. Chin Tradit Herbal Drugs. 43:1349–1354. 2012.In Chinese.

6 

Ferrero-Miliani L, Nielsen OH, Andersen PS and Girardin SE: Chronic inflammation: Importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol. 147:227–235. 2007.PubMed/NCBI

7 

Huerre MR and Gounon P: Inflammation: Patterns and new concepts. Res Immunol. 47:417–434. 1996. View Article : Google Scholar

8 

Kalinski P: Regulation of immune responses by prostaglandin E2. J Immunol. 188:21–28. 2012. View Article : Google Scholar :

9 

Saklatvala J, Dean J and Clark A: Control of the expression of inflammatory response genes. Biochem Soc Symp. 95–106. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Motterlini R, Foresti R, Bassi R and Green CJ: Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Radic Biol Med. 28:1303–1312. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Liu H and Talalay P: Relevance of anti-inflammatory and antioxidant activities of exemestane and synergism with sulforaphane for disease prevention. Proc Natl Acad Sci USA. 110:19065–19070. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Lee MY, Lee JA, Seo CS, Ha H, Lee H, Son J-K and Shin H-K: Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1. Food Chem Toxic. 49:1047–1055. 2011. View Article : Google Scholar

13 

Gurney SM, Scott KS, Kacinko SL, Presley BC and Logan BK: Pharmacology, toxicology, and adverse effects of synthetic cannabinoid drugs. Forensic Sci Rev. 26:53–78. 2014.PubMed/NCBI

14 

He M and Guo QL: Drug-induced fatal adverse effects in the United States from 1999 to 2004. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 33:1060–1065. 2008.In Chinese. PubMed/NCBI

15 

Szychowski J, Truchon JF and Bennani YL: Natural products in medicine. Transformational outcome of synthetic chemistry. 57:9292–9308. 2014.

16 

Koeberle A and Werz O: Multi-target approach for natural products in inflammation. 19:1871–1882. 2014.

17 

Kim HK, Kim YA, Chun JM and Ko BS: Pattern analysis of Agastachis Herba and Pogostemonis Herba. Korean J Pharmacogn. 34:274–277. 2003.In Korean.

18 

Kim BY, Jeong JS, Kwon HJ, Lee JH and Hong SP: Determination of rosmarinic acid and caffeic acid from Perilla frutescens var. japonica and var. acuta by reversed-phase HPLC. Kor J Herbology. 23:67–72. 2008.In Korean.

19 

Jeon IH, Kim HS, Kang HJ, Lee HS, Jeong SI, Kim SJ and Jang SI: Anti-inflammatory and antipruritic effects of luteolin from Perilla (P. frutescens L.) leaves. Molecules. 19:6941–6951. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Li B, Zhang X, Wang J, Zhang L, Gao B, Shi S, Wang X, Li J and Tu P: Simultaneous characterisation of fifty coumarins from the roots of Angelica dahurica by off-line two-dimensional high-performance liquid chromatography coupled with electrospray ionisation tandem mass spectrometry. Phytochem Anal. 25:229–240. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Wu Q, Yang Y and Simon JE: Qualitative and quantitative HPLC/MS determination of proanthocyanidins in areca nut (Areca catechu). Chem Biodivers. 4:2817–2826. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Li G, Xu ML, Lee CS, Woo MH, Chang HW and Son JK: Cytotoxicity and DNA topoisomerases inhibitory activity of constituents from the sclerotium of Poria cocos. Arch Pharm Res. 27:829–833. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Jiang Y, Vaysse J, Gilard V, Balayssac S, Déjean S, Malet-Martino M, David B, Fiorini C and Barbin Y: Quality assessment of commercial Magnoliae officinalis Cortex by 1H-NMR-based metabolomics and HPLC methods. Phytochem Anal. 23:387–395. 2012. View Article : Google Scholar

24 

Tsai CJ, Liang JW and Lin HR: Sesquiterpenoids from Atractylodes macrocephala act as farnesoid X receptor and progesterone receptor modulators. Bioorg Med Chem Lett. 22:2326–2329. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Liu EH, Zhao P, Duan L, Zheng GD, Guo L, Yang H and Li P: Simultaneous determination of six bioactive flavonoids in Citri Reticulatae Pericarpium by rapid resolution liquid chromatography coupled with triple quadrupole electrospray tandem mass spectrometry. Food Chem. 141:3977–3983. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Han JH, Jo SG, Lee MJ, Baek SH and Park SH: Contents of homogentisic acid and 3,4-dihydroxybenzaldehyde in the Pinellia ternate by various processing method and its safety estimate. J Orient Physiol Pathol. 18:846–853. 2004.In Korean.

27 

Ha YW and Kim YS: Preparative isolation of six major saponins from Platycodi Radix by high-speed counter-current chromatography. Phytochem Anal. 20:207–213. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Zhang Q and Ye M: Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice). J Chromatogr A. 1216:1954–1969. 2009. View Article : Google Scholar

29 

Niu C and Zhang J: Quantitative analysis and chromatographic fingerprinting of the semen zizyphi spinosae by ultra-high-performance liquid chromatography coupled with diode-array detector. J Sep Sci. 34:2989–2996. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Lee HR, Lee JH, Park CS, Ra KR, Ha JS, Cha MH, Kim SN, Choi Y, Hwang J and Nam JS: Physicochemical properties and antioxidant capacities of different parts of Ginger (Zingiber officinale Roscoe). J Korean Soc Food Sci Nutr. 43:1369–1379. 2014.In Korean. View Article : Google Scholar

31 

Ahmed JS and Mehlhorn H: Review: The cellular basis of the immunity to and immunopathogenesis of tropical theileriosis. Parasitol Res. 85:539–549. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Fujiwara N and Kobayashi K: Macrophages in inflammation. Curr Drug Targets Inflamm Allergy. 4:281–286. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Bottomley MJ, Webb NJ, Watson CJ, Holt PJ, Freemont AJ and Brenchley PE: Peripheral blood mononuclear cells from patients with rheumatoid arthritis spontaneously secrete vascular endothelial growth factor (VEGF): Specific up-regulation by tumour necrosis factor-alpha (TNF-alpha) in synovial fluid. Clin Exp Immunol. 117:171–176. 1999. View Article : Google Scholar : PubMed/NCBI

34 

Crofford LJ, Wilder RL, Ristimäki AP, Sano H, Remmers EF, Epps HR and Hla T: Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J Clin Invest. 93:1095–1101. 1994. View Article : Google Scholar : PubMed/NCBI

35 

Kim KS, Cui X, Lee DS, Sohn JH, Yim JH, Kim YC and Oh H: Anti-inflammatory effect of neoechinulin a from the marine fungus Eurotium sp. SF-5989 through the suppression of nf-κb and p38 MAPK Pathways in lipopolysaccharide-stimulated RAW2647 macrophages. Molecules. 18:13245–13259. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Kwon DJ, Bae YS, Ju SM, Youn GS, Choi SY and Park J: Salicortin suppresses lipopolysaccharide-stimulated inflammatory responses via blockade of NF-κB and JNK activation in RAW 264.7 macrophages. BMB Rep. 47:318–323. 2014. View Article : Google Scholar :

37 

Shao J, Li Y, Wang Z, Xiao M, Yin P, Lu Y, Qian X, Xu Y and Liu J: 7b, a novel naphthalimide derivative, exhibited anti-inflammatory effects via targeted-inhibiting TAK1 following down-regulation of ERK1/2- and p38 MAPK-mediated activation of NF-κB in LPS-stimulated RAW264.7 macrophages. Int Immunopharmacol. 17:216–228. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Winyard PG, Ryan B, Eggleton P, Nissim A, Taylor E, Lo Faro ML, Burkholz T, Szabó-Taylor KE, Fox B, Viner N, et al: Measurement and meaning of markers of reactive species of oxygen, nitrogen and sulfur in healthy human subjects and patients with inflammatory joint disease. Biochem Soc Trans. 39:1226–1232. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Singh KB, Maurya BK and Trigun SK: Activation of oxidative stress and inflammatory factors could account for histopathological progression of aflatoxin-B1 induced hepatocarcinogenesis in rat. Mol Cell Biochem. 401:185–196. 2015. View Article : Google Scholar

40 

Ryter SW, Alam J and Choi AM: Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications. Physiol Rev. 86:583–650. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Southan GJ and Szabó C: Selective pharmacological inhibition of distinct nitric oxide synthase isoforms. Biochem Pharmacol. 51:383–394. 1996. View Article : Google Scholar : PubMed/NCBI

42 

Zabalgoitia M, Colston JT, Reddy SV, Holt JW, Regan RF, Stec DE, Rimoldi JM, Valente AJ and Chandrasekar B: Carbon monoxide donors or heme oxygenase-1 (HO-1) overexpression blocks interleukin-18-mediated NF-kappaB-PTEN-dependent human cardiac endothelial cell death. Free Radic Biol Med. 44:284–298. 2008. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jeong SJ, Kim OS, Yoo SR, Seo CS, Kim Y and Shin HK: Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages. Mol Med Rep 13: 4365-4371, 2016.
APA
Jeong, S., Kim, O., Yoo, S., Seo, C., Kim, Y., & Shin, H. (2016). Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages. Molecular Medicine Reports, 13, 4365-4371. https://doi.org/10.3892/mmr.2016.5084
MLA
Jeong, S., Kim, O., Yoo, S., Seo, C., Kim, Y., Shin, H."Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages". Molecular Medicine Reports 13.5 (2016): 4365-4371.
Chicago
Jeong, S., Kim, O., Yoo, S., Seo, C., Kim, Y., Shin, H."Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages". Molecular Medicine Reports 13, no. 5 (2016): 4365-4371. https://doi.org/10.3892/mmr.2016.5084
Copy and paste a formatted citation
x
Spandidos Publications style
Jeong SJ, Kim OS, Yoo SR, Seo CS, Kim Y and Shin HK: Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages. Mol Med Rep 13: 4365-4371, 2016.
APA
Jeong, S., Kim, O., Yoo, S., Seo, C., Kim, Y., & Shin, H. (2016). Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages. Molecular Medicine Reports, 13, 4365-4371. https://doi.org/10.3892/mmr.2016.5084
MLA
Jeong, S., Kim, O., Yoo, S., Seo, C., Kim, Y., Shin, H."Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages". Molecular Medicine Reports 13.5 (2016): 4365-4371.
Chicago
Jeong, S., Kim, O., Yoo, S., Seo, C., Kim, Y., Shin, H."Anti‑inflammatory and antioxidant activity of the traditional herbal formula Gwakhyangjeonggi‑san via enhancement of heme oxygenase‑1 expression in RAW264.7 macrophages". Molecular Medicine Reports 13, no. 5 (2016): 4365-4371. https://doi.org/10.3892/mmr.2016.5084
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