Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2016 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2016 Volume 13 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia

  • Authors:
    • Ming‑Yi Zhao
    • Yan Yu
    • Min Xie
    • Ming‑Hua Yang
    • Shan Zhu
    • Liang‑Chun Yang
    • Rui Kang
    • Dao‑Lin Tang
    • Ling‑Ling Zhao
    • Li‑Zhi Cao
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China, Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410006, P.R. China
  • Pages: 4321-4328
    |
    Published online on: April 5, 2016
       https://doi.org/10.3892/mmr.2016.5089
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Acute lymphoblastic leukemia (ALL) is the most commonly diagnosed malignancy in children. It is a heterogeneous disease, and is determined by multiple gene alterations and chromosomal rearrangements. To improve current understanding of the underlying molecular mechanisms of ALL, the present study profiled genome‑wide digital gene expression (DGE) in a population of children with ALL in China. Using second‑generation sequencing technology, the profiling revealed that 2,825 genes were upregulated and 1,952 were downregulated in the ALL group. Based on the DGE profiling data, the present study further investigated seven genes (WT1, RPS26, MSX1, CD70, HOXC4, HOXA5 and HOXC6) using reverse transcription‑quantitative polymerase chain reaction analysis. Gene Ontology analysis suggested that the differentially expressed genes were predominantly involved in immune cell differentiation, metabolic processes and programmed cell death. The results of the present study provided novel insights into the gene expression patterns in children with ALL.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Biswas S, Chakrabarti S, Chakraborty J, Paul PC, Konar A and Das S: Childhood acute leukemia in West Bengal, India with an emphasis on uncommon clinical features. Asian Pac J Cancer Prev. 10:903–906. 2009.

2 

Burke PW and Douer D: Acute lymphoblastic leukemia in adolescents and young adults. Acta Haematol. 132:264–273. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Awan T, Iqbal Z, Aleem A, Sabir N, Absar M, Rasool M, Tahir AH, Basit S, Khalid AM, Sabar MF, et al: Five most common prognos-tically important fusion oncogenes are detected in the majority of Pakistani pediatric acute lymphoblastic leukemia patients and are strongly associated with disease biology and treatment outcome. Asian Pac J Cancer Prev. 13:5469–5475. 2012. View Article : Google Scholar

4 

Shaikh MS, Adil SN, Shaikh MU and Khurshid M: Frequency of chromosomal abnormalities in Pakistani adults with acute lymphoblastic leukemia. Asian Pac J Cancer Prev. 15:9495–9498. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Zhao M, Yang M, Yang L, Yu Y, Xie M, Zhu S, Kang R, Tang D, Jiang Z, Yuan W, et al: HMGB1 regulates autophagy through increasing transcriptional activities of JNK and ERK in human myeloid leukemia cells. BMB Rep. 44:601–606. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Yeoh AE, Tan D, Li CK, Hori H, Tse E and Pui CH; Asian Oncology Summit 2013: Management of adult and paediatric acute lymphoblastic leukaemia in Asia: Resource-stratified guidelines from the Asian Oncology Summit 2013. Lancet Oncol. 14:e508–e523. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Gaynon PS: Childhood acute lymphoblastic leukaemia and relapse. Br J Haematol. 131:579–587. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Kulkarni KP and Marwaha RK: Outcomes of children with relapsed acute lymphoblastic leukemia in India. Asian Pac J Cancer Prev. 12:1101–1102. 2011.PubMed/NCBI

9 

Tharnprisan P, Khiewyoo J, Sripraya P and Wiangnon S: Relapse-free rate with childhood acute lymphoblastic leukemia treated under the thai national protocol. Asian Pac J Cancer Prev. 14:1127–1130. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Soheila K, Hamid A, Farid Z, Mostafa RT, Nasrin DN, Syyed-Mohammad T and Vahide T: Comparison of univariate and multivariate gene set analysis in acute lymphoblastic leukemia. Asian Pac J Cancer Prev. 14:1629–1633. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Ross ME, Mahfouz R, Onciu M, Liu HC, Zhou X, Song G, Shurtleff SA, Pounds S, Cheng C, Ma J, et al: Gene expression profiling of pediatric acute myelogenous leukemia. Blood. 104:3679–3687. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Unfried C, Burbach G, Korf HW and Von Gall C: Melatonin receptor 1-dependent gene expression in the mouse pars tuberalis as revealed by cDNA microarray analysis and in situ hybridization. J Pineal Res. 48:148–156. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Wang Y, Zhang H, Li H and Miao X: Second-generation sequencing supply an effective way to screen RNAi targets in large scale for potential application in pest insect control. PLoS One. 6:e186442011. View Article : Google Scholar : PubMed/NCBI

14 

Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR and Sultan C: Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group. Ann Intern Med. 103:620–625. 1985. View Article : Google Scholar : PubMed/NCBI

15 

Cheson BD, Cassileth PA, Head DR, Schiffer CA, Bennett JM, Bloomfield CD, Brunning R, Gale RP, Grever MR and Keating MJ: Report of the National Cancer Institute-sponsored workshop on definitions of diagnosis and response in acute myeloid leukemia. J Clin Oncol. 8:813–819. 1990.PubMed/NCBI

16 

't Hoen PA, Ariyurek Y, Thygesen HH, Vreugdenhil E, Vossen RH, de Menezes RX, Boer JM, van Ommen GJ and den Dunnen JT: Deep sequencing-based expression analysis shows major advances in robustness, resolution and inter-lab portability over five microarray platforms. Nucleic Acids Res. 36:e1412008. View Article : Google Scholar : PubMed/NCBI

17 

Morrissy AS, Morin RD, Delaney A, Zeng T, McDonald H, Jones S, Zhao Y, Hirst M and Marra MA: Next-generation tag sequencing for cancer gene expression profiling. Genome Res. 19:1825–1835. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Li H, Ruan J and Durbin R: Mapping short DNA sequencing reads and calling variants using mapping quality scores. Genome Res. 18:1851–1858. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Mullighan CG: Genomic profiling of B-progenitor acute lymphoblastic leukemia. Best Pract Res Clin Haematol. 24:489–503. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Nordlund J, Kiialainen A, Karlberg O, Berglund EC, Göransson-Kultima H, Sønderkær M, Nielsen KL, Gustafsson MG, Behrendtz M, Forestier E, et al: Digital gene expression profiling of primary acute lymphoblastic leukemia cells. Leukemia. 26:1218–1227. 2012. View Article : Google Scholar :

21 

Figueroa ME, Chen SC, Andersson AK, Phillips LA, Li Y, Sotzen J, Kundu M, Downing JR, Melnick A and Mullighan CG: Integrated genetic and epigenetic analysis of childhood acute lymphoblastic leukemia. J Clin Invest. 123:3099–3111. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Mullighan CG: Genome sequencing of lymphoid malignancies. Blood. 122:3899–3907. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Iranparast S, Assarehzadegan MA, Heike Y, Hossienzadeh M and Khodadadi A: Wilms' tumor gene (WT1) expression correlates with vascular epithelial growth factor (VEGF) in newly acute leukemia patients undergoing chemotherapy. Asian Pac J Cancer Prev. 15:9217–9223. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Yang L, Han Y, Suarez Saiz F and Minden MD: A tumor suppressor and oncogene: The WT1 story. Leukemia. 21:868–876. 2007.PubMed/NCBI

25 

Bergmann L, Miething C, Maurer U, Brieger J, Karakas T, Weidmann E and Hoelzer D: High levels of Wilms' tumor gene (wt1) mRNA in acute myeloid leukemias are associated with a worse long-term outcome. Blood. 90:1217–1225. 1997.PubMed/NCBI

26 

Netinatsunthorn W, Hanprasertpong J, Dechsukhum C, Leetanaporn R and Geater A: WT1 gene expression as a prognostic marker in advanced serous epithelial ovarian carcinoma: An immunohistochemical study. BMC Cancer. 6:902006. View Article : Google Scholar : PubMed/NCBI

27 

Arteaga CL and Engelman JA: ERBB receptors: From oncogene discovery to basic science to mechanism-based cancer therapeutics. Cancer Cell. 25:282–303. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Hwang JA, Lee BB, Kim Y, Park SE, Heo K, Hong SH, Kim YH, Han J, Shim YM, Lee YS and Kim DH: HOXA11 hypermethylation is associated with progression of non-small cell lung cancer. Oncotarget. 4:2317–2325. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Koch J, Steinle A, Watzl C and Mandelboim O: Activating natural cytotoxicity receptors of natural killer cells in cancer and infection. Trends Immunol. 34:182–191. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Luo LP, Han B, Yu XP, Chen XY, Zhou J, Chen W, Zhu YF, Peng XL, Zou Q and Li SY: Anti-metastasis activity of black rice anthocyanins against breast cancer: Analyses using an ErbB2 positive breast cancer cell line and tumoral xenograft model. Asian Pac J Cancer Prev. 15:6219–6225. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Song Y and Zuo Y: Occurrence of HHIP gene CpG island methylation in gastric cancer. Oncol Lett. 8:2340–2344. 2014.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhao MY, Yu Y, Xie M, Yang MH, Zhu S, Yang LC, Kang R, Tang DL, Zhao LL, Cao LZ, Cao LZ, et al: Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia. Mol Med Rep 13: 4321-4328, 2016.
APA
Zhao, M., Yu, Y., Xie, M., Yang, M., Zhu, S., Yang, L. ... Cao, L. (2016). Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia. Molecular Medicine Reports, 13, 4321-4328. https://doi.org/10.3892/mmr.2016.5089
MLA
Zhao, M., Yu, Y., Xie, M., Yang, M., Zhu, S., Yang, L., Kang, R., Tang, D., Zhao, L., Cao, L."Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia". Molecular Medicine Reports 13.5 (2016): 4321-4328.
Chicago
Zhao, M., Yu, Y., Xie, M., Yang, M., Zhu, S., Yang, L., Kang, R., Tang, D., Zhao, L., Cao, L."Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia". Molecular Medicine Reports 13, no. 5 (2016): 4321-4328. https://doi.org/10.3892/mmr.2016.5089
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao MY, Yu Y, Xie M, Yang MH, Zhu S, Yang LC, Kang R, Tang DL, Zhao LL, Cao LZ, Cao LZ, et al: Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia. Mol Med Rep 13: 4321-4328, 2016.
APA
Zhao, M., Yu, Y., Xie, M., Yang, M., Zhu, S., Yang, L. ... Cao, L. (2016). Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia. Molecular Medicine Reports, 13, 4321-4328. https://doi.org/10.3892/mmr.2016.5089
MLA
Zhao, M., Yu, Y., Xie, M., Yang, M., Zhu, S., Yang, L., Kang, R., Tang, D., Zhao, L., Cao, L."Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia". Molecular Medicine Reports 13.5 (2016): 4321-4328.
Chicago
Zhao, M., Yu, Y., Xie, M., Yang, M., Zhu, S., Yang, L., Kang, R., Tang, D., Zhao, L., Cao, L."Digital gene expression profiling analysis of childhood acute lymphoblastic leukemia". Molecular Medicine Reports 13, no. 5 (2016): 4321-4328. https://doi.org/10.3892/mmr.2016.5089
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team