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Article

Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells

  • Authors:
    • Jingru Jiang
    • Xiaohong Wang
    • Kai Cheng
    • Wanzhong Zhao
    • Yitong Hua
    • Chengfeng Xu
    • Zhenlin Yang
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid and Breast Surgery, The Affiliated Hospital of Binzhou University of Medicine, Binzhou, Shandong 256603, P.R. China
  • Pages: 4745-4750
    |
    Published online on: April 8, 2016
       https://doi.org/10.3892/mmr.2016.5098
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Abstract

The resistance of cancer to chemotherapeutic agents is a major obstacle during chemotherapy. Clinical multidrug resistance (MDR) is commonly mediated by membrane drug efflux pumps, including ATP‑binding cassette subfamily B member 1, also termed P-glycoprotein (P-gp). P-gp is a membrane transporter encoded by the MDR1 gene. The current study aimed to investigate the impact of psoralen on the expression and function of P‑gp. The 10% inhibitory concentration (IC10) of psoralen, and its capacity to reduce MDR in adriamycin (ADR)‑resistant MCF‑7/ADR cells were determined using MTT assay. The ability of psoralen to modulate the transport activity of P‑gp in MCF‑7/ADR cells was evaluated by measuring the accumulation and efflux of rhodamine 123 (Rh 123) and adriamycin with flow cytometry. The present study evaluated the mRNA level of MDR1 in MCF‑7 and MCF‑7/ADR cells treated with psoralen using reverse transcription-quantitative polymerase chain reaction. The protein expression level of P‑gp was examined by western blot analysis. The current study demonstrated that the IC10 of psoralen in MCF‑7/ADR cells was 8 µg/ml. At 8 µg/ml, psoralen reduced MDR and the sensitivity of the MCF‑7/ADR cells to ADR compared with untreated cells. Additionally, psoralen significantly increased the intracellular accumulation of ADR and Rh 123. However, the IC10 of psoralen did not affect the protein expression levels of P‑gp or mRNA levels of MDR1 (P>0.05). Psoralen reduces MDR by inhibiting the efflux function of P‑gp, which may be important for increasing the efficiency of chemotherapy and improving the clinical protocols aiming to reverse P-gp-mediated MDR.
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1 

Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J and Jemal A: Global cancer statistics, 2012. CA Cancer J Clin. 65:87–108. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Li X, Xu H, Dai X, Zhu Z, Liu B and Lu X: Enhanced in vitro and in vivo therapeutic efficacy of codrug-loaded nanoparticles against liver cancer. Int J Nanomedicine. 7:5183–5190. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Cao X, Luo J, Gong T, Zhang ZR, Sun X and Fu Y: Coencapsulated doxorubicin and bromotetrandrine lipid nanoemulsions in reversing multidrug resistance in breast cancer in vitro and in vivo. Mol Pharm. 12:274–286. 2015. View Article : Google Scholar

4 

Shuhendler AJ, Cheung RY, Manias J, Connor A, Rauth AM and Wu XY: A novel doxorubicin-mitomycin C co-encapsulated nanoparticle formulation exhibits anti-cancer synergy in multidrug resistant human breast cancer cells. Breast Cancer Res Treat. 119:255–69. 2010. View Article : Google Scholar

5 

Duan Z, Zhang J, Ye S, Shen J, Choy E, Cote G, Harmon D, Mankin H, Hua Y, Zhang Y, et al: A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells. BMC Cancer. 14:6812014. View Article : Google Scholar : PubMed/NCBI

6 

Susa M, Iyer AK, Ryu K, Choy E, Hornicek FJ, Mankin H, Milane L, Amiji MM and Duan Z: Inhibition of ABCB1 (MDR1) expression by an siRNA nanoparticulate delivery system to overcome drug resistance in osteosarcoma. PLoS One. 5:e107642010. View Article : Google Scholar : PubMed/NCBI

7 

Kobayashi E, Iyer AK, Hornicek FJ, Amiji MM and Duan Z: Lipid-functionalized dextran nanosystems to overcome multidrug resistance in cancer: A pilot study. Clin Orthop Relat Res. 471:915–925. 2013. View Article : Google Scholar :

8 

Brambilla D, Zamboni S, Federici C, Lugini L, Lozupone F, De Milito A, Cecchetti S, Cianfriglia M and Fais S: P-glycoprotein binds to ezrin at amino acid residues 149–242 in the FERM domain and plays a key role in the multidrug resistance of human osteosarcoma. Int J Cancer. 130:2824–2834. 2012. View Article : Google Scholar

9 

Pakos EE and Ioannidis JP: The association of P-glycoprotein with response to chemotherapy and clinical outcome in patients with osteosarcoma. A meta-analysis. Cancer. 98:581–589. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Schneiderman RS, Shmueli E, Kirson ED and Palti Y: TTFields alone and in combination with chemotherapeutic agents effectively reduce the viability of MDR cell sub-lines that over-express ABC transporters. BMC Cancer. 10:2292010. View Article : Google Scholar : PubMed/NCBI

11 

Barthomeuf C, Grassi J, Demeule M, Fournier C, Boivin D and Béliveau R: Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin. Cancer Chemother Pharmacol. 56:173–181. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Leonard GD, Fojo T and Bates SE: The role of ABC transporters in clinical practice. Oncologist. 8:411–424. 2003. View Article : Google Scholar : PubMed/NCBI

13 

Wang B, Feng D, Han L, Fan J, Zhang X, Wang X, Ye L, Shi X and Feng M: Combination of apolipoprotein A1-modi liposome-doxorubicin with autophagy inhibitors overcame drug resistance in vitro. J Pharm Sci. 103:3994–4004. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Kim JH, Choi AR, Kim YK and Yoon S: Co-treatment with the anti-malarial drugs mefloquine and primaquine highly sensitizes drug-resistant cancer cells by increasing P-gp inhibition. Biochem Biophys Res Commun. 441:655–60. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Georgantzopoulou A, Skoczynska E, Van den Berg JH, Brand W, Legay S, Klein SG, Rietjens IM and Murk AJ: P-gp efflux pump inhibition potential of common environmental contaminants determined in vitro. Environ Toxicol Chem. 33:804–813. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Jin J, Wang FP, Wei H and Liu G: Reversal of multidrug resistance of cancer through inhibition of P-glycoprotein by 5-bromotetrandrine. Cancer Chemother Pharmacol. 55:179–188. 2005. View Article : Google Scholar

17 

Jodoin J, Demeule M and Beliveau R: Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols. Biochim Biophys Acta. 1542:149–159. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Wang EJ, Casciano CN, Clement RP and Johnson WW: Inhibition of P-glycoprotein transport function by grapefruit juice psoralen. Pharm Res. 18:432–8. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Di Pietro A, Conseil G, Pérez-Victoria JM, Dayan G, Baubichon-Cortay H, Trompier D, Steinfels E, Jault JM, de Wet H, Maitrejean M, et al: Modulation by flavonoids of cell multidrug resistance mediated by P-glycoprotein and related ABC transporters. Cell Mol Life Sci. 59:307–322. 2002. View Article : Google Scholar : PubMed/NCBI

20 

Chai S, To KK and Lin G: Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines. Chin Med. 5:262010. View Article : Google Scholar : PubMed/NCBI

21 

Edelson R, Berger C, Gasparro F, Jegasothy B, Heald P, Wintroub B, Vonderheid E, Knobler R, Wolff K, Plewig G, et al: Treatment of cutaneous T-cell lymphoma by extracorporeal photochemotherapy. Preliminary results. N Engl J Med. 316:297–303. 1987. View Article : Google Scholar : PubMed/NCBI

22 

McGinnis KS, Shapiro M, Vittorio CC, Rook AH and Junkins-Hopkins JM: Psoralen plus long-wave UV-A (PUVA) and bexarotene therapy: An effective and synergistic combined adjunct to therapy for patients with advanced cutaneous T-cell lymphoma. Arch Dermatol. 139:771–775. 2013.

23 

Querfeld C, Rosen ST, Kuzel TM, Kirby KA, Roenigk HH Jr, Prinz BM and Guitart J: Long-term follow-up of patients with early-stage cutaneous T-cell lymphoma who achieved complete remission with psoralen plus UV-A monotherapy. Arch Dermatol. 141:305–311. 2005. View Article : Google Scholar : PubMed/NCBI

24 

Wu JZ, Situ ZQ, Chen JY, Liu B and Wang W: Chemosensitivity of salivary gland and oral cancer cell lines. Chin Med J (Engl). 105:1026–1028. 1992.

25 

Latha PG, Evans DA, Panikkar KR and Jayavardhanan KK: Immunomodulatory and antitumour proper ties of Psoralea corylifolia seeds. Fitoterapia. 71:223–231. 2000. View Article : Google Scholar : PubMed/NCBI

26 

Xiang QF, Zhang DM, Wang JN, Zhang HW, Zheng ZY, Yu DC, Li YJ, Xu J, Chen YJ and Shang CZ: Cabozantinib reverses multidrug resistance of human hepatoma HepG2/adr cells by modulating the function of P-glycoprotein. Liver Int. 35:1010–1023. 2015. View Article : Google Scholar

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

28 

Minderman H, O'Loughlin KL, Pendyala L and Baer MR: VX-710 (biricodar) increases drug retention and enhances chemosensitivity in resistant cells overexpressing P-glycoprotein, multidrug resistance protein, and breast cancer resistance protein. Clin Cancer Res. 10:18261834. View Article : Google Scholar

29 

Eicher C, Dewerth A, Kirchner B, Warmann SW, Fuchs J and Armeanu-Ebinger S: Development of a drug resistance model for hepatoblastoma. Int J Oncol. 38:447–454. 2011.

30 

Oliveira Rodrigues F, Dos Santos RE, de Oliveira AL, de Lima Rozenowicz R, de Melo MB and Scheffer DK: Prognostic assessment of polymorphisms of the MDR-1 and GSTP1 genes in patients with stage II and III breast cancer submitted to neoadjuvant chemotherapy. Breast J. 18:185–187. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Tiwari AK, Sodani K, Dai CL, Ashby CRJ and Chen ZS: Revisiting the ABCs of multidrug resistance in cancer chemotherapy. Curr Pharm Biotechnol. 12:570–594. 2011. View Article : Google Scholar

32 

Ernst R, Kueppers P, Stindt J, Kuchler K and Schmitt L: Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps - first come, first served? FEBS J. 277:540–549. 2010. View Article : Google Scholar

33 

Liscovitch M and Lavie Y: Cancer multidrug resistance: A review of recent drug discovery research. IDrugs. 5:349–355. 2002.

34 

Lavie Y, Cao H, Volner A, Lucci A, Han TY, Geffen V, Giuliano AE and Cabot MC: Agents that reverse multidrug resistance, tamoxifen, verapamil, and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells. J Biol Chem. 272:1682–1687. 1997. View Article : Google Scholar : PubMed/NCBI

35 

Ward AB, Szewczyk P, Grimard V, Lee CW, Martinez L, Doshi R, Caya A, Villaluz M, Pardon E, Cregger C, et al: Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain. Proc Natl Acad Sci USA. 110:13386–13391. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Chen WT, Yang TS, Chen HC, Chen HH, Chiang HC, Lin TC, Yeh CH, Ke TW, Chen JS, Hsiao KH and Kuo ML: Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer. Nutr Res. 34:585–594. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Montazeri AS, Raei M, Ghanbari A, Dadgari A, Montazeri AS and Hamidzadeh A: Effect of herbal therapy to intensity chemotherapy-induced nausea and vomiting in cancer patients. Iran Red Crescent Med J. 15:101–106. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Hsieh MJ, Chen MK, Yu YY, Sheu GT and Chiou HL: Psoralen reverses docetaxel-induced multidrug resistance in A549/D16 human lung cancer cells lines. Phytomedicine. 21:970–977. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jiang J, Wang X, Cheng K, Zhao W, Hua Y, Xu C and Yang Z: Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells. Mol Med Rep 13: 4745-4750, 2016.
APA
Jiang, J., Wang, X., Cheng, K., Zhao, W., Hua, Y., Xu, C., & Yang, Z. (2016). Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells. Molecular Medicine Reports, 13, 4745-4750. https://doi.org/10.3892/mmr.2016.5098
MLA
Jiang, J., Wang, X., Cheng, K., Zhao, W., Hua, Y., Xu, C., Yang, Z."Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells". Molecular Medicine Reports 13.6 (2016): 4745-4750.
Chicago
Jiang, J., Wang, X., Cheng, K., Zhao, W., Hua, Y., Xu, C., Yang, Z."Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells". Molecular Medicine Reports 13, no. 6 (2016): 4745-4750. https://doi.org/10.3892/mmr.2016.5098
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang J, Wang X, Cheng K, Zhao W, Hua Y, Xu C and Yang Z: Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells. Mol Med Rep 13: 4745-4750, 2016.
APA
Jiang, J., Wang, X., Cheng, K., Zhao, W., Hua, Y., Xu, C., & Yang, Z. (2016). Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells. Molecular Medicine Reports, 13, 4745-4750. https://doi.org/10.3892/mmr.2016.5098
MLA
Jiang, J., Wang, X., Cheng, K., Zhao, W., Hua, Y., Xu, C., Yang, Z."Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells". Molecular Medicine Reports 13.6 (2016): 4745-4750.
Chicago
Jiang, J., Wang, X., Cheng, K., Zhao, W., Hua, Y., Xu, C., Yang, Z."Psoralen reverses the P-glycoprotein-mediated multidrug resistance in human breast cancer MCF-7/ADR cells". Molecular Medicine Reports 13, no. 6 (2016): 4745-4750. https://doi.org/10.3892/mmr.2016.5098
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