Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2016 Volume 13 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2016 Volume 13 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae

  • Authors:
    • Swathi Raju M
    • Jahnavi V
    • Ratnakar S. Kamaraju
    • Venkataraman Sritharan
    • Karthik Rajkumar
    • Sumathi Natarajan
    • Anil D. Kumar
    • Sandeepta Burgula
  • View Affiliations / Copyright

    Affiliations: Department of Microbiology, Osmania University, Hyderabad, Telangana 500007, India, Molecular Diagnostics and Biomarkers Department of Laboratory Medicine Global Hospitals, Hyderabad, Telangana 500004, India, Department of Biochemistry, Osmania University, Hyderabad, Telangana 500007, India
  • Pages: 4835-4844
    |
    Published online on: April 12, 2016
       https://doi.org/10.3892/mmr.2016.5112
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Serum protein profiles of patients with bacterial sepsis from the day of diagnosis until recovery/mortality were compared from early to late stages in response to severe sepsis using two dimensional electrophoresis. The proteins exhibiting changes during the course of sepsis (20‑28 day mortality) were selected and identified by matrix‑assisted laser desorption ionization‑time of flight‑tandem mass spectrometry. Among the proteins identified, haptoglobin (Hp), transthyretin (TTR), orosomucoid 1/α1 acid glycoprotein (ORM1), α1 antitrypsin (A1AT), serum amyloid A (SAA) and S100A9 exhibited differential expression patterns between survivors (S; n=6) and non‑survivors (NS; n=6), particularly during the early stages of sepsis. Expression factors (EFs), taken as the ratio between the NS and S during early stages, showed ratios of Hp, 0.39 (P≤0.012); TTR, 3.96 (P≤0.03); ORM1, 0.69 (P≤0.79); A1AT, 0.92 (P≤0.87) and SAA, 0.69 (P≤0.01). S100A9, an acute phase protein, exhibited an EF ratio of 1.68 (P≤0.004) during the end stages of sepsis. A delayed rise in levels was observed in Hp, A1AT, ORM1, S100A9 and SAA, whereas TTR levels increased during the early stages of sepsis in NS. Analysis of inflammatory responses in the early stages of sepsis revealed increased mRNA expression in leukocytes of interleukin (IL)‑6 (EF, 2.50), IL‑10 (EF, 1.70) and prepronociceptin (EF, 1.6), which is a precursor for nociceptin in NS compared with S, and higher Toll‑like receptor‑4 (EF, 0.30) levels in S compared with NS. Therefore, a weaker acute phase response in the early stages of sepsis in NS, combined with an inefficient inflammatory response, may contribute to sepsis mortality.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Todi S: Sepsis: New horizons. Ind J Crit Care Med. 14:1–2. 2010. View Article : Google Scholar

2 

Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J and Pinsky MR: Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome and associated costs of care. Crit Care Med. 29:1303–1310. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Martin GS, Mannino DM, Eaton S and Moss M: The epidemiology of sepsis in the United States from 1979 through 2000. New Eng J Med. 348:1546–1554. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Carvalho PR and Trotta Ede A: Advances in sepsis diagnosis and treatment. J Pediatr (Rio J). 79(Suppl 2): S195–S204. 2003. View Article : Google Scholar

5 

Marra MN, Thornton MB, Snable JL, Wilde CG and Scott RW: Endotoxin-binding and -neutralizing properties of recombinant bactericidal/permeability-increasing protein and monoclonal antibodies HA-1A and E5. Crit Care Med. 22:559–565. 1994. View Article : Google Scholar : PubMed/NCBI

6 

Cohen J: Adjunctive therapy in sepsis: A critical analysis of the clinical trial programme. Brit Med Bull. 55:212–225. 1999. View Article : Google Scholar

7 

Riedemann NC, Guo RF and Ward PA: The enigma of sepsis. J Clin Invest. 112:460–467. 2003. View Article : Google Scholar : PubMed/NCBI

8 

Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA and Balk RA: Sepsis syndrome: A valid clinical entity. Methylprednisolone severe sepsis study group. Crit Care Med. 17:389–393. 1989. View Article : Google Scholar : PubMed/NCBI

9 

Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, Suppes R, Feinstein D, Zanotti S, Taiberg L, et al: Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 34:1589–1596. 2006. View Article : Google Scholar : PubMed/NCBI

10 

Zambon M, Ceola M, Almeida-de-Castro R, Gullo A and Vincent JL: Implementation of the surviving sepsis campaign guidelines for severe sepsis and septic shock: We could go faster. J Crit Care. 23:455–460. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Schröder J, Kahlke V, Staubach KH, Zabel P and Stüber F: Gender differences in human sepsis. Arch Surg. 133:1200–1205. 1998. View Article : Google Scholar : PubMed/NCBI

12 

Pietropaoli AP, Glance LG, Oakes D and Fisher SG: Gender differences in mortality in patients with severe sepsis and septic shock. Gender Med. 7:422–437. 2010. View Article : Google Scholar

13 

Angstwurm MW, Gaertner R and Schopohl J: Outcome in elderly patients with severe infection is influenced by sex hormones but not gender. Crit Care Med. 33:2786–2793. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Schröder J, Kahlke V, Book M and Stüber F: Gender differences in sepsis: Genetically determined? Shock. 14:307–310; discussion 310–313. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Baghel K, Srivastava RN, Chandra A, Raj S, Goel SK, Pant AB and Agrawal J: Tumor necrosis factor-β Nco1 polymorphism and susceptibility to sepsis following major elective surgery. Surg Infect (Larchmt). 15:213–20. 2014. View Article : Google Scholar

16 

Kalenka A, Feldmann RE Jr, Otero K, Maurer MH, Waschke KF and Fiedler F: Changes in the serum proteome of patients with sepsis and septic shock. Anesth Analg. 103:1522–1526. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Su L, Cao L, Zhou R, Jiang Z, Xiao K, Kong W, Wang H, Deng J, Wen B, Tan F, et al: Identification of novel biomarkers for sepsis prognosis via urinary proteomic analysis using iTRAQ labeling and 2D-LC-MS/MS. PloS One. 8:e542372013. View Article : Google Scholar : PubMed/NCBI

18 

Knaus WA, Draper EA, Wagner DP and Zimmerman JE: APACHE II: A severity of disease classification system. Crit Care Med. 13:818–829. 1985. View Article : Google Scholar : PubMed/NCBI

19 

Markgraf R, Deutschinoff G, Pientka L and Scholten T: Comparison of acute physiology and chronic health evaluations II and III and simplified acute physiology score II: A prospective cohort study evaluating these methods to predict outcome in a German interdisciplinary intensive care unit. Crit Care Med. 28:26–33. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Wiersinga WJ, Leopold SJ, Cranendonk DR and van der Poll T: Host innate immune responses to sepsis. Virulence. 5:36–44. 2014. View Article : Google Scholar :

21 

Becker KL, Snider R and Nylen ES: Procalcitonin assay in systemic inflammation, infection and sepsis: Clinical utility and limitations. Crit Care Med. 36:941–452. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Sakr Y, Sponholz C, Tuche F, Brunkhorst F and Reinhart K: The role of procalcitonin in febrile neutropenic patients: Review of the literature. Infection. 36:396–407. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Kim KE and Han JY: Evaluation of the clinical performance of an automated procalcitonin assay for the quantitative detection of bloodstream infection. Korean J Lab Med. 30:153–159. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Pettilü V, Hynninen M, Takkunen O, Kuusela P and Valtonen M: Predictive value of procalcitonin and interleukin 6 in critically ill patients with suspected sepsis. Intensive Care Med. 28:1220–1225. 2002. View Article : Google Scholar

25 

Ruiz-Alvarez MJ, Garcia-Valdecasas S, De Pablo R, Sanchez Garcia M, Coca C, Groeneveld TW, Roos A, Daha MR and Arribas I: Diagnostic efficacy and prognostic value of serum procalcitonin concentration in patients with suspected sepsis. J Intens Care Med. 24:63–71. 2009. View Article : Google Scholar

26 

Fischer CL, Gill C, Forrester MG and Nakamura R: Quantitation of 'acute-phase proteins' postoperatively. Value in detection and monitoring of complications. Am J Clin Pathol. 66:840–846. 1976. View Article : Google Scholar : PubMed/NCBI

27 

Gruys E, Toussaint MJ, Niewold TA and Koopmans SJ: Acute phase reaction and acute phase proteins. J Zhejiang Univ Sci B. 6:1045–1556. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Hari-Dass R, Shah C, Meyer DJ and Raynes JG: Serum amyloid A protein binds to outer membrane protein A of gram-negative bacteria. J Biol Chem. 280:18562–18567. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Larson MA, Weber A, Weber AT and McDonald TL: Differential expression and secretion of bovine serum amyloid A3 (SAA3) by mammary epithelial cells stimulated with prolactin or lipopolysaccharide. Vet Immunol Immunop. 107:255–264. 2005. View Article : Google Scholar

30 

Cicarelli LM, Perroni AG, Zugaib M, de Albuquerque PB and Campa A: Maternal and cord blood levels of serum amyloid A, C-reactive protein, tumor necrosis factor-alpha, interleukin-1beta and interleukin-8 during and after delivery. Mediat Inflamm. 2005:96–100. 2005. View Article : Google Scholar

31 

Gabay C and Kushner I: Acute-phase proteins and other systemic responses to inflammation. N Eng J Med. 340:448–454. 1999. View Article : Google Scholar

32 

Weimer HE and Winzler RJ: Comparative study of orosomucoid preparations from sera of six species of mammals. Proc Soc Exp Biol Med. 90:458–60. 1955. View Article : Google Scholar : PubMed/NCBI

33 

Whicher JT: BCR/IFCC reference material for plasma proteins (CRM 470). Community bureau of reference. International Federation of Clinical Chemistry. Clin Biochem. 31:459–465. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Dinarello CA: Cytokines as mediators in the pathogenesis of septic shock. Curr Top Microbiol Immunol. 216:133–165. 1996.PubMed/NCBI

35 

Henry OF, Blacher J, Verdavaine J, Duviquet M and Safar ME: Alpha 1-acid glycoprotein is an independent predictor of in-hospital death in the elderly. Age Ageing. 32:37–42. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Barroso-Sousa R, Lobo RR, Mendonça PR, Memória RR, Spiller F, Cunha FQ and Pazin-Filho A: Decreased levels of alpha-1-acid glycoprotein are related to the mortality of septic patients in the emergency department. Clinics (Sao Paulo). 68:1134–1139. 2013. View Article : Google Scholar

37 

Langlois MR and Delanghe JR: Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem. 42:1589–600. 1996.PubMed/NCBI

38 

Cynober L, Prugnaud O, Lioret N, Duchemin C, Saizy R and Giboudeau J: Serum transthyretin levels in patients with burn injury. Surgery. 109:640–644. 1991.PubMed/NCBI

39 

Payen D, Lukaszewicz AC, Belikova I, Faivre V, Gelin C, Russwurm S, Launay JM and Sevenet N: Gene profiling in human blood leucocytes during recovery from septic shock. Intens Care Med. 34:1371–1376. 2008. View Article : Google Scholar

40 

Szallasi Z: Genetic network analysis in light of massively parallel biological data acquisition. Pac Symp Biocomput. 5–16. 1999.PubMed/NCBI

41 

Cho RJ, Campbell MJ, Winzeler EA, Steinmetz L, Conway A, Wodicka L, Wolfsberg TG, Gabrielian AE, Landsman D, Lockhart DJ and Davis RW: A genome-wide transcriptional analysis of the mitotic cell cycle. Mol Cell. 2:65–73. 1998. View Article : Google Scholar : PubMed/NCBI

42 

Lichtinghagen R, Musholt PB, Lein M, Römer A, Rudolph B, Kristiansen G, Hauptmann S, Schnorr D, Loening SA and Jung K: Different mRNA and protein expression of matrix metalloproteinases 2 and 9 and tissue inhibitor of metalloproteinases 1 in benign and malignant prostate tissue. Eur Urol. 42:398–406. 2002. View Article : Google Scholar : PubMed/NCBI

43 

Chen G, Gharib TG, Huang CC, Taylor JM, Misek DE, Kardia SL, Giordano TJ, Iannettoni MD, Orringer MB, Hanash SM and Beer DG: Discordant protein and mRNA expression in lung adenocarcinomas. Mol Cell Proteomics. 1:304–313. 2002. View Article : Google Scholar : PubMed/NCBI

44 

Glickman MH and Ciechanover A: The ubiquitin-proteasome proteolytic pathway: Destruction for the sake of construction. Physiol Rev. 82:373–428. 2002. View Article : Google Scholar : PubMed/NCBI

45 

Pratt JM, Petty J, Riba-Garcia I, Robertson DH, Gaskell SJ, Oliver SG and Beynon RJ: Dynamics of protein turnover, a missing dimension in proteomics. Mol Cell Proteomics. 1:579–591. 2002. View Article : Google Scholar : PubMed/NCBI

46 

Langlois MR and Delanghe JR: Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem. 42:1589–1600. 1996.PubMed/NCBI

47 

Gogos CA, Drosou E, Bassaris HP and Skoutelis A: Pro-versus anti-inflammatory cytokine profile in patients with severe Sepsis: A marker for prognosis and future therapeutic options. J Infect Dis. 181:176–180. 2000. View Article : Google Scholar

48 

Wang CH, Gee MJ, Yang C and Su YC: A new model for outcome prediction in intra-abdominal sepsis by the linear discriminant function analysis of IL-6 and IL-10 at different heart rates. J Surg Res. 132:46–51. 2006. View Article : Google Scholar

49 

Acosta C and Davies A: Bacterial lipopolysaccharide regulates nociceptin expression in sensory neurons. J Neurosci Res. 86:1077–1086. 2008. View Article : Google Scholar

50 

Andoh T, Itoh M and Kuraishi Y: Nociceptin gene expression in rat dorsal root ganglia induced by peripheral inflammation. Neuroreport. 8:2793–2796. 1997. View Article : Google Scholar : PubMed/NCBI

51 

Itoh M, Takasaki I, Andoh T, Nojima H, Tominaga M and Kuraishi Y: Induction by carrageenan inflammation of prepronociceptin mRNA in VR1-immunoreactive neurons in rat dorsal root ganglia. Neurosci Res. 40:227–233. 2001. View Article : Google Scholar : PubMed/NCBI

52 

Williams JP, Thompson JP, Young SP, Gold SJ, McDonald J, Rowbotham DJ and Lambert DG: Nociceptin and urotensin-II concentrations in critically ill patients with sepsis. Bri J Anaesth. 100:810–814. 2008. View Article : Google Scholar

53 

Dellinger RP, Levy M, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al: Surviving sepsis campaign: International guidelines for management of severe sepsis and septic shock, 2012. Intens Care Med. 39:165–228. 2012, 2013. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Raju M S, V J, Kamaraju RS, Sritharan V, Rajkumar K, Natarajan S, Kumar AD and Burgula S: Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae. Mol Med Rep 13: 4835-4844, 2016.
APA
Raju M, S., V, J., Kamaraju, R.S., Sritharan, V., Rajkumar, K., Natarajan, S. ... Burgula, S. (2016). Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae. Molecular Medicine Reports, 13, 4835-4844. https://doi.org/10.3892/mmr.2016.5112
MLA
Raju M, S., V, J., Kamaraju, R. S., Sritharan, V., Rajkumar, K., Natarajan, S., Kumar, A. D., Burgula, S."Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae". Molecular Medicine Reports 13.6 (2016): 4835-4844.
Chicago
Raju M, S., V, J., Kamaraju, R. S., Sritharan, V., Rajkumar, K., Natarajan, S., Kumar, A. D., Burgula, S."Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae". Molecular Medicine Reports 13, no. 6 (2016): 4835-4844. https://doi.org/10.3892/mmr.2016.5112
Copy and paste a formatted citation
x
Spandidos Publications style
Raju M S, V J, Kamaraju RS, Sritharan V, Rajkumar K, Natarajan S, Kumar AD and Burgula S: Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae. Mol Med Rep 13: 4835-4844, 2016.
APA
Raju M, S., V, J., Kamaraju, R.S., Sritharan, V., Rajkumar, K., Natarajan, S. ... Burgula, S. (2016). Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae. Molecular Medicine Reports, 13, 4835-4844. https://doi.org/10.3892/mmr.2016.5112
MLA
Raju M, S., V, J., Kamaraju, R. S., Sritharan, V., Rajkumar, K., Natarajan, S., Kumar, A. D., Burgula, S."Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae". Molecular Medicine Reports 13.6 (2016): 4835-4844.
Chicago
Raju M, S., V, J., Kamaraju, R. S., Sritharan, V., Rajkumar, K., Natarajan, S., Kumar, A. D., Burgula, S."Continuous evaluation of changes in the serum proteome from early to late stages of sepsis caused by Klebsiella pneumoniae". Molecular Medicine Reports 13, no. 6 (2016): 4835-4844. https://doi.org/10.3892/mmr.2016.5112
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team