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Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells

  • Authors:
    • Ri Zhou
    • Zhi Yuan
    • Jierong Liu
    • Jian Liu
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 4689-4696
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    Published online on: April 13, 2016
       https://doi.org/10.3892/mmr.2016.5117
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Abstract

Calcitonin gene-related peptide (CGRP) is known to induce osteoblastic differentiation and alkaline phosphatase activity in bone marrow stromal stem cells (BMSCs). However, it has remained elusive whether this effect is mediated by CGRP receptors directly or whether other signaling pathways are involved. The present study assessed the possible involvement of the Wnt/β‑catenin signaling pathway in the activation of CGRP signaling during the differentiation of BMSCs. First, the differentiation of BMSCs was induced in vitro and the expression of CGRP receptors was examined by western blot analysis. The effects of exogenous CGRP and LiCl, a stimulator of the Wnt/β‑catenin signaling pathway, on the osteoblastic differentiation of BMSCs were assessed; furthermore, the expression of mRNA and proteins involved in the Wnt/β‑catenin signaling pathway was assessed using quantitative PCR and western blot analyses. The results revealed that CGRP receptors were expressed throughout the differentiation of BMSCs, at days 7 and 14. Incubation with CGRP and LiCl led to the upregulation of the expression of osteoblastic genes associated with the Wnt/β‑catenin pathway, including the mRNA of c‑myc, cyclin D1, Lef1, Tcf7 and β‑catenin as well as β‑catenin protein. However, the upregulation of these genes and β‑catenin protein was inhibited by CGRP receptor antagonist or secreted frizzled‑related protein, an antagonist of the Wnt/β‑catenin pathway. The results of the present study therefore suggested that the Wnt/β-catenin signaling pathway may be involved in CGRP‑ and LiCl-promoted osteoblastic differentiation of BMSCs.
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1 

Bjurholm A, Kreicbergs A, Brodin E and Schultzberg M: Substance P- and CGRP-immunoreactive nerves in bone. Peptides. 9:165–171. 1988. View Article : Google Scholar : PubMed/NCBI

2 

Imai S and Matsusue Y: Neuronal regulation of bone metabolism and anabolism: Calcitonin gene-related peptide-, substance P- and tyrosine hydroxylase-containing nerves and the bone. Microsc Res Tech. 58:61–69. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Kawase T, Okuda K and Burns DM: Immature human osteoblastic MG63 cells predominantly express a subtype 1-like CGRP receptor that inactivates extracellular signal response kinase by a cAMP-dependent mechanism. Eur J Pharmacol. 470:125–137. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Schinke T, Liese S, Priemel M, Haberland M, Schilling AF, Catala-Lehnen P, Blicharski D, Rueger JM, Gagel RF, Emeson RB and Amling M: Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide. J Bone Miner Res. 19:2049–2056. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Togari A, Arai M, Mizutani S, Mizutani S, Koshihara Y and Nagatsu T: Expression of mRNAs for neuropeptide receptors and beta-adrenergic receptors in human osteoblasts and human osteogenic sarcoma cells. Neurosci Lett. 233:125–128. 1997. View Article : Google Scholar : PubMed/NCBI

6 

Tuo Y, Guo X, Zhang X, Wang Z, Zhou J, Xia L, Zhang Y, Wen J and Jin D: The biological effects and mechanisms of calcitonin gene-related peptide on human endothelial cell. J Recept Signal Transduct Res. 33:114–123. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Uzan B, de Vernejoul MC and Cressent M: RAMPs and CRLR expressions in osteoblastic cells after dexamethasone treatment. Biochem Biophys Res Commun. 321:802–808. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Villa I, Mrak E, Rubinacci A, Ravasi F and Guidobono F: CGRP inhibits osteoprotegerin production in human osteoblast-like cells via cAMP/PKA-dependent pathway. Am J Physiol Cell Physiol. 291:C529–C537. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Wimalawansa SJ: Calcitonin gene-related peptide and its receptors: Molecular genetics, physiology, pathophysiology and therapeutic potentials. Endocr Rev. 17:533–585. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Wimalawansa SJ: Amylin, calcitonin gene-related peptide, calcitonin and adrenomedullin: A peptide superfamily. Crit Rev Neurobiol. 11:167–239. 1997. View Article : Google Scholar

11 

Fang Z, Yang Q, Xiong W, Li GH, Liao H, Xiao J and Li F: Effect of CGRP-adenoviral vector transduction on the osteoblastic differentiation of rat adipose-derived stem cells. PLoS One. 8:e727382013. View Article : Google Scholar : PubMed/NCBI

12 

Wang YS, Wang YH, Zhao GQ and Li YB: Osteogenic potential of human calcitonin gene-related peptide alpha gene-modified bone marrow mesenchymal stem cells. Chin Med J (Engl). 124:3976–3981. 2011.

13 

Xu J, Kauther MD, Hartl J and Wedemeyer C; Study was performed at the University of Duisburg-Essen, Germany: Effects of alpha-calcitonin gene-related peptide on osteoprotegerin and receptor activator of nuclear factor-κB ligand expression in MG-63 osteoblast-like cells exposed to polyethylene particles. J Orthop Surg Res. 5:832010. View Article : Google Scholar

14 

Yoo YM, Kwag JH, Kim KH and Kim CH: Effects of neuropeptides and mechanical loading on bone cell resorption in vitro. Int J Mol Sci. 15:5874–5883. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Ballica R, Valentijn K, Khachatryan A, Guerder S, Kapadia S, Gundberg C, Gilligan J, Flavell RA and Vignery A: Targeted expression of calcitonin gene-related peptide to osteoblasts increases bone density in mice. J Bone Miner Res. 14:1067–1074. 1999. View Article : Google Scholar : PubMed/NCBI

16 

Huebner AK, Schinke T, Priemel M, Schilling S, Schilling AF, Emeson RB, Rueger JM and Amling M: Calcitonin deficiency in mice progressively results in high bone turnover. J Bone Miner Res. 21:1924–1934. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Kim SY, Kim S, Yun-Choi HS and Jho EH: Wnt5a potentiates U46619-induced platelet aggregation via the PI3K/Akt pathway. Mol Cells. 32:333–336. 2011. View Article : Google Scholar : PubMed/NCBI

18 

Zheng Q, Chen P, Xu Z, Li F and Yi XP: Expression and redistribution of β-catenin in the cardiac myocytes of left ventricle of spontaneously hypertensive rat. J Mol Histol. 44:565–573. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Lee JH, Kim BG, Ahn JM, Park HJ, Park SK, Yoo JS, Yates JR III and Cho JY: Role of PI3K on the regulation of BMP2-induced beta-Catenin activation in human bone marrow stem cells. Bone. 46:1522–1532. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Li J, Li J and Chen B: Oct4 was a novel target of Wnt signaling pathway. Mol Cell Biochem. 362:233–240. 2012. View Article : Google Scholar

21 

Liu Y, Liu Y, Zhang R, Wang X, Huang F, Yan Z, Nie M, Huang J, Wang Y, Wang Y, et al: All-trans retinoic acid modulates bone morphogenic protein 9-induced osteogenesis and adipogenesis of preadipocytes through BMP/Smad and Wnt/β-catenin signaling pathways. Int J Biochem Cell Biol. 47:47–56. 2014. View Article : Google Scholar

22 

MacDonald BT, Tamai K and He X: Wnt/beta-catenin signaling: Components, mechanisms and diseases. Dev Cell. 17:9–26. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Peterson-Nedry W, Erdeniz N, Kremer S, Yu J, Baig-Lewis S and Wehrli M: Unexpectedly robust assembly of the Axin destruction complex regulates Wnt/Wg signaling in Drosophila as revealed by analysis in vivo. Dev Biol. 320:226–241. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Salins P, Shawesh S, He Y, Dibrov A, Kashour T, Arthur G and Amara F: Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci Lett. 412:211–216. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Sun YC: Examination of effects of GSK3beta phosphorylation, beta-catenin phosphorylation and beta-catenin degradation on kinetics of Wnt signaling pathway using computational method. Theor Biol Med Model. 6:132009. View Article : Google Scholar

26 

Weng X, Lin P, Liu F, Chen J, Li H, Huang L, Zhen C, Xu H, Liu X, Ye H and Li X: Achyranthes bidentata polysaccharides activate the Wnt/β-catenin signaling pathway to promote chondrocyte proliferation. Int J Mol Med. 34:1045–1050. 2014.PubMed/NCBI

27 

Wen X, Cawthorn WP, MacDougald OA, Stupp SI, Snead ML and Zhou Y: The influence of Leucine-rich amelogenin peptide on MSC fate by inducing Wnt10b expression. Biomaterials. 32:6478–6486. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Georgiou KR, King TJ, Scherer MA, Zhou H, Foster BK and Xian CJ: Attenuated Wnt/β-catenin signalling mediates methotrexate chemotherapy-induced bone loss and marrow adiposity in rats. Bone. 50:1223–1233. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Guo J, Liu M, Yang D, Bouxsein ML, Saito H, Galvin RJ, Kuhstoss SA, Thomas CC, Schipani E, Baron R, et al: Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation. Cell Metab. 11:161–171. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Tamura M, Sato MM and Nashimoto M: Regulation of CXCL12 expression by canonical Wnt signaling in bone marrow stromal cells. Int J Biochem Cell Biol. 43:760–767. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Hu HM, Yang L, Wang Z, Liu YW, Fan JZ, Fan J, Liu J and Luo ZJ: Overexpression of integrin a2 promotes osteogenic differentiation of hBMSCs from senile osteoporosis through the ERK pathway. Int J Clin Exp Pathol. 6:841–852. 2013.PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

33 

Sharma AR, Choi BS, Park JM, Lee DH, Lee JE, Kim HS, Yoon JK, Song DK, Nam JS and Lee SS: Rspo 1 promotes osteoblast differentiation via Wnt signaling pathway. Indian J Biochem Biophys. 50:19–25. 2013.PubMed/NCBI

34 

Bloom AP, Jimenez-Andrade JM, Taylor RN, Castañeda-Corral G, Kaczmarska MJ, Freeman KT, Coughlin KA, Ghilardi JR, Kuskowski MA and Mantyh PW: Breast cancer-induced bone remodeling, skeletal pain and sprouting of sensory nerve fibers. J Pain. 12:698–711. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Eberhardt M, Dux M, Namer B, Miljkovic J, Cordasic N, Will C, Kichko TI, de la Roche J, Fischer M, Suárez SA, et al: H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway. Nat Commun. 5:43812014. View Article : Google Scholar : PubMed/NCBI

36 

Sample SJ, Hao Z, Wilson AP and Muir P: Role of calcitonin gene-related peptide in bone repair after cyclic fatigue loading. PLoS One. 6:e203862011. View Article : Google Scholar : PubMed/NCBI

37 

Shui C, Spelsberg TC, Riggs BL and Khosla S: Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells. J Bone Miner Res. 18:213–221. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Hoppler S and Kavanagh CL: Wnt signalling: Variety at the core. J Cell Sci. 120:385–393. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Lee JE, Wu SF, Goering LM and Dorsky RI: Canonical Wnt signaling through Lef1 is required for hypothalamic neurogenesis. Development. 133:4451–4461. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Shimizu N, Kawakami K and Ishitani T: Visualization and exploration of Tcf/Lef function using a highly responsive Wnt/β-catenin signaling-reporter transgenic zebrafish. Dev Biol. 370:71–85. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhou R, Yuan Z, Liu J and Liu J: Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells. Mol Med Rep 13: 4689-4696, 2016.
APA
Zhou, R., Yuan, Z., Liu, J., & Liu, J. (2016). Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells. Molecular Medicine Reports, 13, 4689-4696. https://doi.org/10.3892/mmr.2016.5117
MLA
Zhou, R., Yuan, Z., Liu, J., Liu, J."Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells". Molecular Medicine Reports 13.6 (2016): 4689-4696.
Chicago
Zhou, R., Yuan, Z., Liu, J., Liu, J."Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells". Molecular Medicine Reports 13, no. 6 (2016): 4689-4696. https://doi.org/10.3892/mmr.2016.5117
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou R, Yuan Z, Liu J and Liu J: Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells. Mol Med Rep 13: 4689-4696, 2016.
APA
Zhou, R., Yuan, Z., Liu, J., & Liu, J. (2016). Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells. Molecular Medicine Reports, 13, 4689-4696. https://doi.org/10.3892/mmr.2016.5117
MLA
Zhou, R., Yuan, Z., Liu, J., Liu, J."Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells". Molecular Medicine Reports 13.6 (2016): 4689-4696.
Chicago
Zhou, R., Yuan, Z., Liu, J., Liu, J."Calcitonin gene-related peptide promotes the expression of osteoblastic genes and activates the WNT signal transduction pathway in bone marrow stromal stem cells". Molecular Medicine Reports 13, no. 6 (2016): 4689-4696. https://doi.org/10.3892/mmr.2016.5117
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