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Article

Upregulation of microRNA‑337 promotes the proliferation of endometrial carcinoma cells via targeting PTEN

  • Authors:
    • Yangyang Cai
    • Tao He
    • Lidan Liang
    • Xin Zhang
    • Hongying Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Gynaecology and Obstetrics, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan 471000, P.R. China, Department of Pathogenic Biology, Henan University of Science and Technology, Luoyang, Henan 471000, P.R. China
  • Pages: 4827-4834
    |
    Published online on: April 15, 2016
       https://doi.org/10.3892/mmr.2016.5134
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Abstract

Endometrial carcinoma (EC) is a common malignancy in females. MicroRNAs (miRs) are a class of non‑coding RNA that regulate a wide variety of cellular processes, and are important in the development of multiple types of malignancy. In the present study, cancerous and adjacent non‑cancerous normal tissue samples were collected from 24 patients diagnosed with EC. Reverse transcription quantitative polymerase chain reaction was performed on the tissue samples to determine the expression levels of six candidate miRs. These miRs have been previously reported to be differentially expressed in EC; however, the present study observed that only miR‑337 was differentially expressed. In addition, the current study identified phosphatase and tensin homolog (PTEN) as a target of miR‑337 using computational analysis and a luciferase assay. EC cells transfected with miR‑337 mimics and anti‑PTEN small interfering RNA demonstrated significantly decreased expression of PTEN, markedly increased proliferation and inhibition of cell apoptosis. The results indicate that miR‑337 is oncogenic in EC cells, as it suppresses PTEN expression. This may facilitate the development of miR‑based prevention or treatment strategies for EC.
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Copy and paste a formatted citation
Spandidos Publications style
Cai Y, He T, Liang L, Zhang X and Yuan H: Upregulation of microRNA‑337 promotes the proliferation of endometrial carcinoma cells via targeting PTEN. Mol Med Rep 13: 4827-4834, 2016.
APA
Cai, Y., He, T., Liang, L., Zhang, X., & Yuan, H. (2016). Upregulation of microRNA‑337 promotes the proliferation of endometrial carcinoma cells via targeting PTEN. Molecular Medicine Reports, 13, 4827-4834. https://doi.org/10.3892/mmr.2016.5134
MLA
Cai, Y., He, T., Liang, L., Zhang, X., Yuan, H."Upregulation of microRNA‑337 promotes the proliferation of endometrial carcinoma cells via targeting PTEN". Molecular Medicine Reports 13.6 (2016): 4827-4834.
Chicago
Cai, Y., He, T., Liang, L., Zhang, X., Yuan, H."Upregulation of microRNA‑337 promotes the proliferation of endometrial carcinoma cells via targeting PTEN". Molecular Medicine Reports 13, no. 6 (2016): 4827-4834. https://doi.org/10.3892/mmr.2016.5134
Copy and paste a formatted citation
x
Spandidos Publications style
Cai Y, He T, Liang L, Zhang X and Yuan H: Upregulation of microRNA‑337 promotes the proliferation of endometrial carcinoma cells via targeting PTEN. Mol Med Rep 13: 4827-4834, 2016.
APA
Cai, Y., He, T., Liang, L., Zhang, X., & Yuan, H. (2016). Upregulation of microRNA‑337 promotes the proliferation of endometrial carcinoma cells via targeting PTEN. Molecular Medicine Reports, 13, 4827-4834. https://doi.org/10.3892/mmr.2016.5134
MLA
Cai, Y., He, T., Liang, L., Zhang, X., Yuan, H."Upregulation of microRNA‑337 promotes the proliferation of endometrial carcinoma cells via targeting PTEN". Molecular Medicine Reports 13.6 (2016): 4827-4834.
Chicago
Cai, Y., He, T., Liang, L., Zhang, X., Yuan, H."Upregulation of microRNA‑337 promotes the proliferation of endometrial carcinoma cells via targeting PTEN". Molecular Medicine Reports 13, no. 6 (2016): 4827-4834. https://doi.org/10.3892/mmr.2016.5134
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