Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
June-2016 Volume 13 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
June-2016 Volume 13 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

LIF and LIF‑R expression in the endometrium of fertile and infertile women: A prospective observational case‑control study

  • Authors:
    • Chrysoula Margioula‑Siarkou
    • Yannis Prapas
    • Stamatios Petousis
    • Stefanos Milias
    • Konstantinos Ravanos
    • Ioannis Kalogiannidis
    • George Mavromatidis
    • Constantinos Haitoglou
    • Nikolaos Prapas
    • David Rousso
  • View Affiliations / Copyright

    Affiliations: 3rd Department of Obstetrics and Gynaecology, Aristotle University of Thessaloniki, 56242 Thessaloniki, Greece, Department of Pathology, 424 General Army Hospital, 57001 Thessaloniki, Greece, IAKENTRO, Infertility Treatment Center, 54250 Thessaloniki, Greece, Laboratory of Biochemistry, Aristotle University of Thessaloniki, 56242 Thessaloniki, Greece
  • Pages: 4721-4728
    |
    Published online on: April 15, 2016
       https://doi.org/10.3892/mmr.2016.5142
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to determine the expression of leukemia inhibitory factor (LIF) and LIF receptor (LIF‑R) in the endometrium of fertile and infertile women during the implantation window. A prospective study was conducted between March 2013 and March 2015 at Iakentro, Infertility Treatment Center (Thessaloniki, Greece) and the 3rd Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki (Thessaloniki, Greece). The patient group consisted of women diagnosed with infertility, whereas the control group consisted of women who had delivered at least one live newborn (fertile women). An endometrial biopsy was obtained using a Pipelle on day 7 or 8 post‑ovulation, and the expression of LIF and LIF‑R was assessed by immunohistochemistry in epithelial and stromal cells. Primary outcomes included positive cellular percentage, staining intensity and H‑score. P<0.05 was considered to indicate a statistically significant difference. Overall, 45 women were included in the present analysis (15 fertile women and 30 infertile women). Mean age was 32.8±6.0 years for the fertile group, and 37.6±3.7 for the infertile group. LIF and LIF‑R expression was significantly reduced in the epithelial cells of infertile women (P=0.05 and P=0.006, respectively). However, no significant differences were detected with regards to the expression of LIF in stromal cells (P=0.95). In addition, LIF‑R expression was relatively higher in the stromal cells of the fertile group; however, the difference did not reach statistical significance (P=0.10). In conclusion, endometrial expression of LIF and LIF‑R is significantly reduced in the epithelial cells of infertile women. Expression patterns of LIF‑R in stromal cells require further research in order to achieve definitive results.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Dimitriadis E, Menkhorst E, Salamonsen LA and Paiva P: Review: LIF and IL11 in trophoblast endometrial interactions during the establishment of pregnancy. Placenta. 31(Suppl): S99–S104. 2010. View Article : Google Scholar

2 

Koot YE and Macklon NS: Embryo implantation: Biology, evaluation, and enhancement. Curr Opin Obstet Gynecol. 25:274–279. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Tabibzadeh S and Babaknia A: The signals and molecular pathways involved in implantation, a symbiotic interaction between blastocyst and endometrium involving adhesion and tissue invasion. Hum Reprod. 10:1579–1602. 1995. View Article : Google Scholar : PubMed/NCBI

4 

Paiva P, Menkhorst E, Salamonsen L and Dimitriadis E: Leukemia inhibitory factor and interleukin 11: Critical regulators in the establishment of pregnancy. Cytokine Growth Factor Rev. 20:319–328. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Gearing DP, Gough NM, King JA, Hilton DJ, Nicola NA, Simpson RJ, Nice EC, Kelso A and Metcalf D: Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF). EMBO J. 6:3995–4002. 1987.PubMed/NCBI

6 

Stewart CL, Kaspar P, Brunet LJ, Bhatt H, Gadi I, Köntgen F and Abbondanzo SJ: Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor. Nature. 359:76–79. 1992. View Article : Google Scholar : PubMed/NCBI

7 

Stewart CL: The role of leukemia inhibitory factor (LIF) and other cytokines in regulating implantation in mammals. Ann NY Acad Sci. 734:157–165. 1994. View Article : Google Scholar : PubMed/NCBI

8 

Aghajanova L: Leukemia inhibitory factor and embryo human implantation. Ann NY Acad Sci. 1034:176–183. 2004. View Article : Google Scholar

9 

Singh M, Chaudry P and Asselin E: Bridging endometrial receptivity and implantation: Network of hormones, cytokines, and growth factors. J Endocrinol. 210:5–14. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Sánchez Cuenca J, Martín JC, Pellicer A and Simón C: Cytokine pleiotropy and redundancy gp130 cytokines in human implantation. Immunol Today. 20:57–59. 1999. View Article : Google Scholar

11 

Classen Linke I, Müller Newen G, Heinrich PC, Beier HM and von Rango U: The cytokine receptor gp130 and its soluble form are under hormonal control in human endometrium and decidua. Mol Hum Reprod. 10:495–504. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Gearing DP, Thut CJ, VandeBos T, Gimpel SD, Delaney PB, King J, Price V, Cosman D and Beckmann MP: Leukemia inhibitory factor receptor is structurally related to the IL 6 signal transducer, gp130. EMBO J. 10:2839–2848. 1991.PubMed/NCBI

13 

Gearing DP, Comeau MR, Friend DJ, Gimpel SD, Thut CJ, McGourty J, Brasher KK, King JA, Gillis S, Mosley B, et al: The IL 6 signal transducer, gp130: An oncostatin M receptor and affinity converter for the LIF receptor. Science. 255:1434–1437. 1992. View Article : Google Scholar : PubMed/NCBI

14 

Auernhammer CJ and Melmed S: Leukemia inhibitory factor neuroimmune modulator of endocrine function. Endocr Rev. 21:313–345. 2000.PubMed/NCBI

15 

Heinrich PC, Behrmann I, Müller Newen G, Schaper F and Graeve L: Interleukin 6 type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J. 334:297–314. 1998. View Article : Google Scholar

16 

Duval D, Reinhardt B, Kedinger C and Boeuf H: Role of suppressors of cytokine signaling (Socs) in leukemia inhibitory factor (LIF) dependent embryonic stem cell survival. FASEB J. 14:1577–1584. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Cheng JG, Chen JR, Hernandez L, Alvord WG and Stewart CL: Dual control of LIF expression and LIF receptor function regulate Stat3 activation at the onset of uterine receptivity and embryo implantation. Proc Natl Acad Sci USA. 98:8680–8685. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Cullinan EB, Abbondanzo SJ, Anderson PS, Pollard JW, Lessey BA and Stewart CL: Leukemia inhibitory factor (LIF) and LIF receptor expression in human endometrium suggests a potential autocrine/paracrine function in regulating embryo implantation. Proc Natl Acad Sci USA. 93:3115–3120. 1996. View Article : Google Scholar : PubMed/NCBI

19 

Vogiagis D, Marsh MM, Fry RC and Salamonsen LA: Leukaemia inhibitory factor in human endometrium throughout the menstrual cycle. J Endocrinol. 148:95–102. 1996. View Article : Google Scholar : PubMed/NCBI

20 

Tawfeek MA, Eid MA, Hasan AM, Mostafa M and El Serogy HA: Assessment of leukemia inhibitory factor and glycoprotein 130 expression in endometrium and uterine flushing: A possible diagnostic tool for impaired fertility. BMC Womens Health. 12:102012. View Article : Google Scholar : PubMed/NCBI

21 

Sharkey AM, King A, Clark DE, Burrows TD, Jokhi PP, Charnock Jones DS, Loke YW and Smith SK: Localization of leukemia inhibitory factor and its receptor in human placenta throughout pregnancy. Biol Reprod. 60:355–364. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Laird SM, Tuckerman EM, Dalton CF, Dunphy BC, Li TC and Zhang X: The production of leukaemia inhibitory factor by human endometrium: Presence in uterine flushings and production by cells in culture. Hum Reprod. 12:569–574. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Aghajanova L, Stavreus Evers A, Nikas Y, Hovatta O and Landgren BM: Coexpression of pinopodes and leukemia inhibitory factor, as well as its receptor, in human endometrium. Fertil Steril. 79(Suppl 1): S808–S814. 2003. View Article : Google Scholar

24 

Lass A, Weiser W, Munafo A and Loumaye E: Leukemia inhibitory factor in human reproduction. Fertil Steril. 76:1091–1096. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Lei T, Yang ZQ, Xia T, Gan L, Chen XD, Yuan JH and Zhu Y: Stage-specific expression of leukaemia inhibitory factor and its receptor in rabbit pre implantation embryo and uterine epithelium during early pregnancy. Reprod Domest Anim. 39:13–18. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Noyes RW, Hertig AI and Rock J: Dating the endometrial biopsy. Am J Obstet Gynecol. 122:262–263. 1975.PubMed/NCBI

27 

Ellis YO, Pider SE and Lee A: Tumors of the breast. 2nd Edition. Diagnostic Histopathology of Tumors. Fletcher C: Churchill Livingstone; Elsevier, London, UK: pp. 1057–1070. 2007

28 

Mariee N, Li TC and Laird SM: Expression of leukaemia inhibitory factor and interleukin 15 in endometrium of women with recurrent implantation failure after IVF; correlation with the number of endometrial natural killer cells. Hum Reprod. 27:1946–1954. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Wu M, Yin Y, Zhao M, Hu L and Chen Q: The low expression of leukemia inhibitory factor in endometrium: Possible relevant to unexplained infertility with multiple implantation failures. Cytokine. 62:334–339. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Dimitriadis E, Stoikos C, Stafford Bell M, Clark I, Paiva P, Kovacs G and Salamonsen LA: Interleukin 11 receptoralpha and leukemia inhibitory factor are dysregulated in endometrium of infertile women with endometriosis during the implantation window. J Reprod Immunol. 69:53–64. 2006. View Article : Google Scholar

31 

Alizadeh Z, Shokrzadeh N, Saidijam M and Sanoee MF: Semi quantitative analysis of HOXA11, leukemia inhibitory factor and basic transcriptional element binding protein 1 mRNA expression in the mid secretory endometrium of patients with endometriosis. Iran Biomed J. 15:66–72. 2011.

32 

Hambartsoumian E: Endometrial leukemia inhibitory factor (LIF) as a possible cause of unexplained infertility and multiple failures of implantation. Am J Reprod Immunol. 39:137–143. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Xu B, Sun X, Li L, Wu L, Zhang A and Feng Y: Pinopodes, leukemia inhibitory factor, integrin β3 and mucin 1 expression in the peri implantation endometrium of women with unex plained recurrent pregnancy loss. Fertil Steril. 98:389–395. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Mikolajczyk M, Wirstlein P and Skrzypczak J: Leukaemia inhibitory factor and interleukin 11 levels in uterine flushings of infertile patients with endometriosis. Hum Reprod. 21:3054–3058. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Aghajanova L, Altmäe S, Bjuresten K, Hovatta O, Landgren BM and Stavreus Evers A: Disturbances in the LIF pathway in the endometrium among women with unexplained infertility. Fertil Steril. 91:2602–2610. 2009. View Article : Google Scholar

36 

Aghajanova L: Update on the role of leukemia inhibitory factor in assisted reproduction. Curr Opin Obstet Gynecol. 22:213–219. 2010. View Article : Google Scholar : PubMed/NCBI

37 

Ding T, Song H, Wang X, Khatua A and Paria BC: Leukemia inhibitory factor ligand receptor signaling is important for uterine receptivity and implantation in golden hamsters (Mesocricetus auratus). Reproduction. 135:41–53. 2008. View Article : Google Scholar

38 

Subramani E, Madogwe E, Ray CD, Dutta SK, Chakravarty B, Bordignon V, Duggavathi R and Chaudhury K: Dysregulated leukemia inhibitory factor and its receptor regulated signal transducers and activators of transcription 3 pathway:A possible cause for repeated implantation failure in women with dormant genital tuberculosis? Fertil Steril. pii: S0015-0282 02184-6. 2016.Epub ahead of print. View Article : Google Scholar

39 

Moberg C, Bourlev V, Ilyasova N and Olovsson M: Endometrial expression of LIF and its receptor and peritoneal fluid levels of IL 1α and IL 6 in women with endometriosis are associated with the probability of pregnancy. Arch Gynecol Obstet. 292:429–437. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Margioula‑Siarkou C, Prapas Y, Petousis S, Milias S, Ravanos K, Kalogiannidis I, Mavromatidis G, Haitoglou C, Prapas N, Rousso D, Rousso D, et al: LIF and LIF‑R expression in the endometrium of fertile and infertile women: A prospective observational case‑control study. Mol Med Rep 13: 4721-4728, 2016.
APA
Margioula‑Siarkou, C., Prapas, Y., Petousis, S., Milias, S., Ravanos, K., Kalogiannidis, I. ... Rousso, D. (2016). LIF and LIF‑R expression in the endometrium of fertile and infertile women: A prospective observational case‑control study. Molecular Medicine Reports, 13, 4721-4728. https://doi.org/10.3892/mmr.2016.5142
MLA
Margioula‑Siarkou, C., Prapas, Y., Petousis, S., Milias, S., Ravanos, K., Kalogiannidis, I., Mavromatidis, G., Haitoglou, C., Prapas, N., Rousso, D."LIF and LIF‑R expression in the endometrium of fertile and infertile women: A prospective observational case‑control study". Molecular Medicine Reports 13.6 (2016): 4721-4728.
Chicago
Margioula‑Siarkou, C., Prapas, Y., Petousis, S., Milias, S., Ravanos, K., Kalogiannidis, I., Mavromatidis, G., Haitoglou, C., Prapas, N., Rousso, D."LIF and LIF‑R expression in the endometrium of fertile and infertile women: A prospective observational case‑control study". Molecular Medicine Reports 13, no. 6 (2016): 4721-4728. https://doi.org/10.3892/mmr.2016.5142
Copy and paste a formatted citation
x
Spandidos Publications style
Margioula‑Siarkou C, Prapas Y, Petousis S, Milias S, Ravanos K, Kalogiannidis I, Mavromatidis G, Haitoglou C, Prapas N, Rousso D, Rousso D, et al: LIF and LIF‑R expression in the endometrium of fertile and infertile women: A prospective observational case‑control study. Mol Med Rep 13: 4721-4728, 2016.
APA
Margioula‑Siarkou, C., Prapas, Y., Petousis, S., Milias, S., Ravanos, K., Kalogiannidis, I. ... Rousso, D. (2016). LIF and LIF‑R expression in the endometrium of fertile and infertile women: A prospective observational case‑control study. Molecular Medicine Reports, 13, 4721-4728. https://doi.org/10.3892/mmr.2016.5142
MLA
Margioula‑Siarkou, C., Prapas, Y., Petousis, S., Milias, S., Ravanos, K., Kalogiannidis, I., Mavromatidis, G., Haitoglou, C., Prapas, N., Rousso, D."LIF and LIF‑R expression in the endometrium of fertile and infertile women: A prospective observational case‑control study". Molecular Medicine Reports 13.6 (2016): 4721-4728.
Chicago
Margioula‑Siarkou, C., Prapas, Y., Petousis, S., Milias, S., Ravanos, K., Kalogiannidis, I., Mavromatidis, G., Haitoglou, C., Prapas, N., Rousso, D."LIF and LIF‑R expression in the endometrium of fertile and infertile women: A prospective observational case‑control study". Molecular Medicine Reports 13, no. 6 (2016): 4721-4728. https://doi.org/10.3892/mmr.2016.5142
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team