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Article Open Access

Production of interleukin‑4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growth

Retraction in: /10.3892/mmr.2016.5732
  • Authors:
    • Chun‑Tao Liu
    • Ying Xin
    • Chun‑Yan Tong
    • Bing Li
    • Hong‑Li Bao
    • Cai‑Yun Zhang
    • Xue‑Hui Wang
  • View Affiliations / Copyright

    Affiliations: Department of Gynecology, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning 116001, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 5068-5076
    |
    Published online on: April 27, 2016
       https://doi.org/10.3892/mmr.2016.5195
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Abstract

The cancer stem cell (CSC) theory suggests that cancer growth and invasion is dictated by the small population of CSCs within the heterogenous tumor. The aim of the present study was to elucidate the cause for chemotherapy failure and the resistance of CSCs to apoptosis. A total of ~2.3% cluster of differentiation (CD)133+ cancer stem‑like side population (SP) cells were identified in cases of uterine cervical cancer. These CD133+ SP cells were found to potently initiate tumor growth and invasion, as they exhibit transcriptional upregulation of stemness genes, including octamer‑binding transcription factor‑4, B‑cell‑specific Moloney murine leukemia virus insertion site‑1, epithelial cell adhesion molecule, (sex determining region Y)‑box 2, Nestin and anti‑apoptotic B cell lymphoma‑2. In addition, the CD133+ SP cells showed resistance to multi‑drug treatment and apoptosis. The present study further showed that the secretion of interleukin‑4 (IL‑4) in CD133+ cervical cancer SP cells promoted cell proliferation and prevented the SP cells from apoptosis. Following the neutralization of IL‑4 with anti‑IL‑4 antibody, the CD133+ SP cells were more sensitive to drug treatment and apoptosis. Therefore, the data obtained in the present study suggested that the autocrine secretion of IL‑4 promotes increased survival and resistance to cell death in CSCs.
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Copy and paste a formatted citation
Spandidos Publications style
Liu CT, Xin Y, Tong CY, Li B, Bao HL, Zhang CY and Wang XH: Production of interleukin‑4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growth Retraction in /10.3892/mmr.2016.5732. Mol Med Rep 13: 5068-5076, 2016.
APA
Liu, C., Xin, Y., Tong, C., Li, B., Bao, H., Zhang, C., & Wang, X. (2016). Production of interleukin‑4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growth Retraction in /10.3892/mmr.2016.5732. Molecular Medicine Reports, 13, 5068-5076. https://doi.org/10.3892/mmr.2016.5195
MLA
Liu, C., Xin, Y., Tong, C., Li, B., Bao, H., Zhang, C., Wang, X."Production of interleukin‑4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growth Retraction in /10.3892/mmr.2016.5732". Molecular Medicine Reports 13.6 (2016): 5068-5076.
Chicago
Liu, C., Xin, Y., Tong, C., Li, B., Bao, H., Zhang, C., Wang, X."Production of interleukin‑4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growth Retraction in /10.3892/mmr.2016.5732". Molecular Medicine Reports 13, no. 6 (2016): 5068-5076. https://doi.org/10.3892/mmr.2016.5195
Copy and paste a formatted citation
x
Spandidos Publications style
Liu CT, Xin Y, Tong CY, Li B, Bao HL, Zhang CY and Wang XH: Production of interleukin‑4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growth Retraction in /10.3892/mmr.2016.5732. Mol Med Rep 13: 5068-5076, 2016.
APA
Liu, C., Xin, Y., Tong, C., Li, B., Bao, H., Zhang, C., & Wang, X. (2016). Production of interleukin‑4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growth Retraction in /10.3892/mmr.2016.5732. Molecular Medicine Reports, 13, 5068-5076. https://doi.org/10.3892/mmr.2016.5195
MLA
Liu, C., Xin, Y., Tong, C., Li, B., Bao, H., Zhang, C., Wang, X."Production of interleukin‑4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growth Retraction in /10.3892/mmr.2016.5732". Molecular Medicine Reports 13.6 (2016): 5068-5076.
Chicago
Liu, C., Xin, Y., Tong, C., Li, B., Bao, H., Zhang, C., Wang, X."Production of interleukin‑4 in CD133+ cervical cancer stem cells promotes resistance to apoptosis and initiates tumor growth Retraction in /10.3892/mmr.2016.5732". Molecular Medicine Reports 13, no. 6 (2016): 5068-5076. https://doi.org/10.3892/mmr.2016.5195
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