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Review

The role of ultraviolet radiation in the pathogenesis of pterygia (Review)

  • Authors:
    • Wei‑Ping Zhou
    • Yuan‑Fang Zhu
    • Bei Zhang
    • Wen‑Ya Qiu
    • Yu‑Feng Yao
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China
  • Pages: 3-15
    |
    Published online on: May 9, 2016
       https://doi.org/10.3892/mmr.2016.5223
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Abstract

Pterygium is a common ophthalmic disease affecting humans only. Extensive epidemiological data have demonstrated a causative effect of chronic ultraviolet (UV) radiation on pterygia. Progress has been made in determining the origin of pterygia, their nasal predilection and wing‑shaped appearance, and the roles of UV radiation in the initiation and the development of pterygia. In the present review, the current understanding of the involvement of UV radiation in the pathogenesis of pterygia is summarized. This involvement includes the alteration of limbal stem cells and fibroblasts that contribute to the initiation of pterygia and the induction of various pro‑inflammatory cytokines, growth factors and matrix metalloproteinases that promote the progression of pterygia. Further elucidation of the roles of UV radiation in the pathogenesis of pterygia may help to encourage individuals at risk of developing pterygia to take preventive measures and aid researchers in the development of novel targeted therapeutic agents to treat pterygia.
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1 

Chui J, Di Girolamo N, Wakefield D and Coroneo MT: The pathogenesis of pterygium: Current concepts and their therapeutic implications. Ocul Surf. 6:24–43. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Mackenzie FD, Hirst LW, Battistutta D and Green A: Risk analysis in the development of pterygia. Ophthalmology. 99:1056–1061. 1992. View Article : Google Scholar : PubMed/NCBI

3 

Moran DJ and Hollows FC: Pterygium and ultraviolet radiation: A positive correlation. Br J Ophthalmol. 68:343–346. 1984. View Article : Google Scholar : PubMed/NCBI

4 

Cameron ME: Pterygium throughout the world. Charles C Thomas; Springfield IL: 1965

5 

Taylor HR, West SK, Rosenthal FS, Munoz B, Newland HS and Emmett EA: Corneal changes associated with chronic UV irradiation. Arch Ophthalmol. 107:1481–1484. 1989. View Article : Google Scholar : PubMed/NCBI

6 

Detorakis ET, Sourvinos G and Spandidos DA: Detection of herpes simplex virus and human papilloma virus in ophthalmic pterygium. Cornea. 20:164–167. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Gallagher MJ, Giannoudis A, Herrington CS and Hiscott P: Human papillomavirus in pterygium. Br J Ophthalmol. 85:782–784. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Chalkia AK, Spandidos DA and Detorakis ET: Viral involvement in the pathogenesis and clinical features of ophthalmic pterygium (Review). Int J Mol Med. 32:539–543. 2013.PubMed/NCBI

9 

Anguria P, Kitinya J, Ntuli S and Carmichael T: The role of heredity in pterygium development. Int J Ophthalmol. 7:563–573. 2014.PubMed/NCBI

10 

Tsai YY, Bau DT, Chiang CC, Cheng YW, Tseng SH and Tsai FJ: Pterygium and genetic polymorphism of DNA double strand break repair gene Ku70. Mol Vis. 13:1436–1440. 2007.PubMed/NCBI

11 

Kau HC, Tsai CC, Hsu WM, Liu JH and Wei YH: Genetic polymorphism of hOGG1 and risk of pterygium in Chinese. Eye (Lond). 18:635–639. 2004. View Article : Google Scholar

12 

Pinkerton OD, Hokama Y and Shigemura LA: Immunologic basis for the pathogenesis of pterygium. Am J Ophthalmol. 98:225–228. 1984. View Article : Google Scholar : PubMed/NCBI

13 

Hill JC and Maske R: Pathogenesis of pterygium. Eye (Lond). 3:218–226. 1989. View Article : Google Scholar

14 

Coroneo MT: Pterygium as an early indicator of ultraviolet insolation: A hypothesis. Br J Ophthalmol. 77:734–739. 1993. View Article : Google Scholar : PubMed/NCBI

15 

Nubile M, Curcio C, Lanzini M, Calienno R, Iezzi M, Mastropasqua A, Di Nicola M and Mastropasqua L: Expression of CREB in primary pterygium and correlation with cyclin D1, ki-67, MMP7, p53, p63, Survivin and Vimentin. Ophthalmic Res. 50:99–107. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Peng ML, Tsai YY, Chiang CC, Huang YC, Chou MC, Yeh KT, Lee H and Cheng YW: CYP1A1 protein activity is associated with allelic variation in pterygium tissues and cells. Mol Vis. 18:1937–1943. 2012.PubMed/NCBI

17 

Tong L, Li J, Chew J, Tan D and Beuerman R: Phospholipase D in the human ocular surface and in pterygium. Cornea. 27:693–698. 2008.PubMed/NCBI

18 

Ortak H, Cayli S, Ocakli S and Demir S: Increased expression of aquaporin-1 and aquaporin-3 in pterygium. Cornea. 32:1375–1379. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Tan CS, Lim TH, Koh WP, Liew GC, Hoh ST, Tan CC and Au Eong KG: Epidemiology of pterygium on a tropical island in the Riau Archipelago. Eye (Lond). 20:908–912. 2006. View Article : Google Scholar

20 

McCarty CA, Fu CL and Taylor HR: Epidemiology of pterygium in Victoria, Australia. Br J Ophthalmol. 84:289–292. 2000. View Article : Google Scholar : PubMed/NCBI

21 

Threlfall TJ and English DR: Sun exposure and pterygium of the eye: A dose-response curve. Am J Ophthalmol. 128:280–287. 1999. View Article : Google Scholar : PubMed/NCBI

22 

Hilgers JH: Pterygium: Its incidence, heredity and etiology. Am J Ophthalmol. 50:635–644. 1960. View Article : Google Scholar : PubMed/NCBI

23 

Di Girolamo N, Chui J, Coroneo MT and Wakefield D: Pathogenesis of pterygia: Role of cytokines, growth factors and matrix metalloproteinases. Prog Retin Eye Res. 23:195–228. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Kwok LS and Coroneo MT: A model for pterygium formation. Cornea. 13:219–224. 1994. View Article : Google Scholar : PubMed/NCBI

25 

Coroneo MT: Albedo concentration in the anterior eye: A phenomenon that locates some solar diseases. Ophthalmic Surg. 21:60–66. 1990.PubMed/NCBI

26 

Coroneo MT, Di Girolamo N and Wakefield D: The pathogenesis of pterygia. Curr Opin Ophthalmol. 10:282–288. 1999. View Article : Google Scholar

27 

Anguria P, Carmichael T, Ntuli S and Kitinya J: Chronic inflammatory cells and damaged limbal cells in pterygium. Afr Health Sci. 13:725–730. 2013.PubMed/NCBI

28 

Cooper SJ and Bowden GT: Ultraviolet B regulation of transcription factor families: Roles of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) in UVB-induced skin carcinogenesis. Curr Cancer Drug Targets. 7:325–334. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Yajima H, Lee KJ, Zhang S, Kobayashi J and Chen BP: DNA double-strand break formation upon UV-induced replication stress activates ATM and DNA-PKcs kinases. J Mol Biol. 385:800–810. 2009. View Article : Google Scholar

30 

Heck DE, Vetrano AM, Mariano TM and Laskin JD: UVB light stimulates production of reactive oxygen species: Unexpected role for catalase. J Biol Chem. 278:22432–22436. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Fisher GJ and Voorhees JJ: Molecular mechanisms of photoaging and its prevention by retinoic acid: Ultraviolet irradiation induces MAP kinase signal transduction cascades that induce Ap-1-regulated matrix metalloproteinases that degrade human skin in vivo. J Investig Dermatol Symp Proc. 3:61–68. 1998.PubMed/NCBI

32 

Dy LC, Pei Y and Travers JB: Augmentation of ultraviolet B radiation-induced tumor necrosis factor production by the epidermal platelet-activating factor receptor. J Biol Chem. 274:26917–26921. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Coffer PJ, Burgering BM, Peppelenbosch MP, Bos JL and Kruijer W: UV activation of receptor tyrosine kinase activity. Oncogene. 11:561–569. 1995.PubMed/NCBI

34 

Rosette C and Karin M: Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors. Science. 274:1194–1197. 1996. View Article : Google Scholar : PubMed/NCBI

35 

Cimpean AM, Sava MP and Raica M: DNA damage in human pterygium: One-shot multiple targets. Mol Vis. 19:348–356. 2013.PubMed/NCBI

36 

Lee DH, Cho HJ, Kim JT, Choi JS and Joo CK: Expression of vascular endothelial growth factor and inducible nitric oxide synthase in pterygia. Cornea. 20:738–742. 2001. View Article : Google Scholar : PubMed/NCBI

37 

Kau HC, Tsai CC, Lee CF, Kao SC, Hsu WM, Liu JH and Wei YH: Increased oxidative DNA damage, 8-hydroxydeoxy-guanosine, in human pterygium. Eye (Lond). 20:826–831. 2006. View Article : Google Scholar

38 

Tsai YY, Cheng YW, Lee H, Tsai FJ, Tseng SH, Lin CL and Chang KC: Oxidative DNA damage in pterygium. Mol Vis. 11:71–75. 2005.PubMed/NCBI

39 

Perra MT, Maxia C, Corbu A, Minerba L, Demurtas P, Colombari R, Murtas D, Bravo S, Piras F and Sirigu P: Oxidative stress in pterygium: Relationship between p53 and 8-hydroxy-deoxyguanosine. Mol Vis. 12:1136–1142. 2006.PubMed/NCBI

40 

Klebe S, Callahan T and Power JH: Peroxiredoxin I and II in human eyes: Cellular distribution and association with pterygium and DNA damage. J Histochem Cytochem. 62:85–96. 2014. View Article : Google Scholar :

41 

Di Girolamo N, Coroneo M and Wakefield D: Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiation. Am J Pathol. 167:489–503. 2005. View Article : Google Scholar : PubMed/NCBI

42 

Di Girolamo N, Wakefield D and Coroneo MT: UVB-mediated induction of cytokines and growth factors in pterygium epithelial cells involves cell surface receptors and intracellular signaling. Invest Ophthalmol Vis Sci. 47:2430–2437. 2006. View Article : Google Scholar : PubMed/NCBI

43 

Dushku N and Reid TW: Immunohistochemical evidence that human pterygia originate from an invasion of vimentin-expressing altered limbal epithelial basal cells. Curr Eye Res. 13:473–481. 1994. View Article : Google Scholar : PubMed/NCBI

44 

Davanger M and Evensen A: Role of the pericorneal papillary structure in renewal of corneal epithelium. Nature. 229:560–561. 1971. View Article : Google Scholar : PubMed/NCBI

45 

Tseng SCG CJ, Huang AJW, Kruse FE, Maskin SL and Tsai RJF: Classification of conjunctival surgeries for corneal diseases based on stem cell concept. Ophthalmol Clin North Am. 3:595–610. 1990.

46 

Reid TW and Dushku N: What a study of pterygia teaches us about the cornea? Molecular mechanisms of formation. Eye Contact Lens. 36:290–295. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Dushku N, John MK, Schultz GS and Reid TW: Pterygia pathogenesis: Corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells. Arch Ophthalmol. 119:695–706. 2001. View Article : Google Scholar : PubMed/NCBI

48 

Reid TW and Dushku N: Pterygia and limbal epithelial cells: Relationship and molecular mechanisms. Prog Retin Eye Res. 15(2): 297–329. 1996. View Article : Google Scholar

49 

Jaworski CJ, Aryankalayil-John M, Campos MM, Fariss RN, Rowsey J, Agarwalla N, Reid TW, Dushku N, Cox CA, Carper D and Wistow G: Expression analysis of human pterygium shows a predominance of conjunctival and limbal markers and genes associated with cell migration. Mol Vis. 15:2421–2434. 2009.PubMed/NCBI

50 

Chui J, Coroneo MT, Tat LT, Crouch R, Wakefield D and Di Girolamo N: Ophthalmic pterygium: A stem cell disorder with premalignant features. Am J Pathol. 178:817–827. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Fuchs E: Ueber das Pterygium [Concerning the pterygium]. Graefes Arch Ophthalmol. 38:1–89. 1892.In German. View Article : Google Scholar

52 

Hoover HL: Solar ultraviolet irradiation of human cornea, lens and retina: Equations of ocular irradiation. Appl Opt. 25:359–368. 1986. View Article : Google Scholar : PubMed/NCBI

53 

Brash DE, Rudolph JA, Simon JA, Lin A, McKenna GJ, Baden HP, Halperin AJ and Pontén J: A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci USA. 88:10124–10128. 1991. View Article : Google Scholar : PubMed/NCBI

54 

Kress S, Sutter C, Strickland PT, Mukhtar H, Schweizer J and Schwarz M: Carcinogen-specific mutational pattern in the p53 gene in ultraviolet B radiation-induced squamous cell carcinomas of mouse skin. Cancer Res. 52:6400–6403. 1992.PubMed/NCBI

55 

Ziegler A, Leffell DJ, Kunala S, Sharma HW, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro PE, Bale AE, et al: Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc Natl Acad Sci USA. 90:4216–4220. 1993. View Article : Google Scholar : PubMed/NCBI

56 

Finlay CA, Hinds PW, Tan TH, Eliyahu D, Oren M and Levine AJ: Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life. Mol Cell Biol. 8:531–539. 1988. View Article : Google Scholar : PubMed/NCBI

57 

Dushku N and Reid TW: P53 expression in altered limbal basal cells of pingueculae, pterygia and limbal tumors. Curr Eye Res. 16:1179–1192. 1997. View Article : Google Scholar

58 

Tan DT, Lim AS, Goh HS and Smith DR: Abnormal expression of the p53 tumor suppressor gene in the conjunctiva of patients with pterygium. Am J Ophthalmol. 123:404–405. 1997. View Article : Google Scholar : PubMed/NCBI

59 

Weinstein O, Rosenthal G, Zirkin H, Monos T, Lifshitz T and Argov S: Overexpression of p53 tumor suppressor gene in pterygia. Eye (Lond). 16:619–621. 2002. View Article : Google Scholar

60 

Ueda Y, Kanazawa S, Kitaoka T, Dake Y, Ohira A, Ouertani AM and Amemiya T: Immunohistochemical study of p53, p21 and PCNA in pterygium. Acta Histochem. 103:159–165. 2001. View Article : Google Scholar : PubMed/NCBI

61 

Tsai YY, Cheng YW, Lee H, Tsai FJ, Tseng SH and Chang KC: P53 gene mutation spectrum and the relationship between gene mutation and protein levels in pterygium. Mol Vis. 11:50–55. 2005.PubMed/NCBI

62 

Reisman D, McFadden JW and Lu G: Loss of heterozygosity and p53 expression in Pterygium. Cancer Lett. 206:77–83. 2004. View Article : Google Scholar : PubMed/NCBI

63 

Shimmura S, Ishioka M, Hanada K, Shimazaki J and Tsubota K: Telomerase activity and p53 expression in pterygia. Invest Ophthalmol Vis Sci. 41:1364–1369. 2000.PubMed/NCBI

64 

Chen JK, Tsai RJ and Lin SS: Fibroblasts isolated from human pterygia exhibit transformed cell characteristics. In Vitro Cell Dev Biol Anim. 30A:243–248. 1994. View Article : Google Scholar : PubMed/NCBI

65 

Cameron ME: Histology of pterygium: An electron microscopic study. Br J Ophthalmol. 67:604–608. 1983. View Article : Google Scholar : PubMed/NCBI

66 

Lemercier G, Cornand G and Burckhart MF: Pinguecula and pterygium: Histologic and electron microscopic study (author's transl). Virchows Arch A Pathol Anat Histol. 379:321–333. 1978.In French. View Article : Google Scholar : PubMed/NCBI

67 

Ye J, Song YS, Kang SH, Yao K and Kim JC: Involvement of bone marrow-derived stem and progenitor cells in the pathogenesis of pterygium. Eye (Lond). 18:839–843. 2004. View Article : Google Scholar

68 

Touhami A, Di Pascuale MA, Kawatika T, Del Valle M, Rosa RH Jr, Dubovy S and Tseng SC: Characterisation of myofibroblasts in fibrovascular tissues of primary and recurrent pterygia. Br J Ophthalmol. 89:269–274. 2005. View Article : Google Scholar : PubMed/NCBI

69 

Kato N, Shimmura S, Kawakita T, Miyashita H, Ogawa Y, Yoshida S, Higa K, Okano H and Tsubota K: Beta-catenin activation and epithelial-mesenchymal transition in the pathogenesis of pterygium. Invest Ophthalmol Vis Sci. 48:1511–1517. 2007. View Article : Google Scholar : PubMed/NCBI

70 

Maloof AJ, Ho A and Coroneo MT: Influence of corneal shape on limbal light focusing. Invest Ophthalmol Vis Sci. 35:2592–2598. 1994.PubMed/NCBI

71 

Butrus SI, Ashraf MF, Laby DM, Rabinowitz AI, Tabbara SO and Hidayat AA: Increased numbers of mast cells in pterygia. Am J Ophthalmol. 119:236–237. 1995. View Article : Google Scholar : PubMed/NCBI

72 

Ratnakar KS, Goswamy V and Agarwal LP: Mast cells and pterygium. Acta Ophthalmol (Copenh). 54:363–368. 1976. View Article : Google Scholar

73 

Golu T, Mogoantă L, Streba CT, Pirici DN, Mălăescu D, Mateescu GO and Mutiu G: Pterygium: Histological and immunohistochemical aspects. Rom J Morphol Embryol. 52:153–158. 2011.PubMed/NCBI

74 

Wen Z and Liu Z: The abnormal expression of interleukine-1 family in pterygium. Yan Ke Xue Bao. 19:133–136. 2003.PubMed/NCBI

75 

Di Girolamo N, Kumar RK, Coroneo MT and Wakefield D: UVB-mediated induction of interleukin-6 and -8 in pterygia and cultured human pterygium epithelial cells. Invest Ophthalmol Vis Sci. 43:3430–3437. 2002.PubMed/NCBI

76 

Kria L, Ohira A and Amemiya T: Immunohistochemical localization of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor-beta and tumor necrosis factor-alpha in the pterygium. Acta Histochem. 98:195–201. 1996. View Article : Google Scholar : PubMed/NCBI

77 

Kennedy M, Kim KH, Harten B, Brown J, Planck S, Meshul C, Edelhauser H, Rosenbaum JT, Armstrong CA and Ansel JC: Ultraviolet irradiation induces the production of multiple cytokines by human corneal cells. Invest Ophthalmol Vis Sci. 38:2483–2491. 1997.PubMed/NCBI

78 

Krämer M, Sachsenmaier C, Herrlich P and Rahmsdorf HJ: UV irradiation-induced interleukin-1 and basic fibroblast growth factor synthesis and release mediate part of the UV response. J Biol Chem. 268:6734–6741. 1993.PubMed/NCBI

79 

Bazzoni F, Kruys V, Shakhov A, Jongeneel CV and Beutler B: Analysis of tumor necrosis factor promoter responses to ultraviolet light. J Clin Invest. 93:56–62. 1994. View Article : Google Scholar : PubMed/NCBI

80 

Devary Y, Rosette C, DiDonato JA and Karin M: NF-kappa B activation by ultraviolet light not dependent on a nuclear signal. Science. 261:1442–1445. 1993. View Article : Google Scholar : PubMed/NCBI

81 

Siak JJ, Ng SL, Seet LF, Beuerman RW and Tong L: The nuclear-factor kappaB pathway is activated in pterygium. Invest Ophthalmol Vis Sci. 52:230–236. 2011. View Article : Google Scholar

82 

Cubitt CL, Tang Q, Monteiro CA, Lausch RN and Oakes JE: IL-8 gene expression in cultures of human corneal epithelial cells and keratocytes. Invest Ophthalmol Vis Sci. 34:3199–3206. 1993.PubMed/NCBI

83 

Cubitt CL, Lausch RN and Oakes JE: Differences in interleukin-6 gene expression between cultured human corneal epithelial cells and keratocytes. Invest Ophthalmol Vis Sci. 36:330–336. 1995.PubMed/NCBI

84 

Hong JW, Liu JJ, Lee JS, Mohan RR, Mohan RR, Woods DJ, He YG and Wilson SE: Proinflammatory chemokine induction in keratocytes and inflammatory cell infiltration into the cornea. Invest Ophthalmol Vis Sci. 42:2795–2803. 2001.PubMed/NCBI

85 

Di Girolamo N, McCluskey P, Lloyd A, Coroneo MT and Wakefield D: Expression of MMPs and TIMPs in human pterygia and cultured pterygium epithelial cells. Invest Ophthalmol Vis Sci. 41:671–679. 2000.PubMed/NCBI

86 

Fenton RR, Molesworth-Kenyon S, Oakes JE and Lausch RN: Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation. Invest Ophthalmol Vis Sci. 43:737–743. 2002.PubMed/NCBI

87 

Cohen T, Nahari D, Cerem LW, Neufeld G and Levi BZ: Interleukin 6 induces the expression of vascular endothelial growth factor. J Biol Chem. 271:736–741. 1996. View Article : Google Scholar : PubMed/NCBI

88 

Bacon KB and Camp RD: Interleukin (IL) -8-induced in vitro human lymphocyte migration is inhibited by cholera and pertussis toxins and inhibitors of protein kinase C. Biochem Biophys Res Commun. 169:1099–1104. 1990. View Article : Google Scholar : PubMed/NCBI

89 

Roebuck KA: Regulation of interleukin-8 gene expression. J Interferon Cytokine Res. 19:429–438. 1999. View Article : Google Scholar : PubMed/NCBI

90 

Strieter RM, Kunkel SL, Elner VM, Martonyi CL, Koch AE, Polverini PJ and Elner SG: Interleukin-8. A corneal factor that induces neovascularization. Am J Pathol. 141:1279–1284. 1992.PubMed/NCBI

91 

Starcher B: Role for tumour necrosis factor-alpha receptors in ultraviolet-induced skin tumours. Br J Dermatol. 142:1140–1147. 2000. View Article : Google Scholar : PubMed/NCBI

92 

Yoshida S, Ono M, Shono T, Izumi H, Ishibashi T, Suzuki H and Kuwano M: Involvement of interleukin-8, vascular endothelial growth factor, and basic fibroblast growth factor in tumor necrosis factor alpha-dependent angiogenesis. Mol Cell Biol. 17:4015–4023. 1997. View Article : Google Scholar : PubMed/NCBI

93 

Menzel EJ, Egerer I, Kulnig W and Smolen JS: Electron-microscopic and biochemical characteristics of pterygia (author's transl). Klin Monbl Augenheilkd. 179:438–441. 1981.In German. View Article : Google Scholar : PubMed/NCBI

94 

Dake Y, Mukae R, Soda Y, Kaneko M and Amemiya T: Immunohistochemical localization of collagen types I, II, III and IV in pterygium tissues. Acta Histochem. 87:71–74. 1989. View Article : Google Scholar

95 

Nolan TM, Di Girolamo N, Sachdev NH, Hampartzoumian T, Coroneo MT and Wakefield D: The role of ultraviolet irradiation and heparin-binding epidermal growth factor-like growth factor in the pathogenesis of pterygium. Am J Pathol. 162:567–574. 2003. View Article : Google Scholar : PubMed/NCBI

96 

Bianchi E, Scarinci F, Grande C, Plateroti R, Plateroti P, Plateroti AM, Fumagalli L, Capozzi P, Feher J and Artico M: Immunohistochemical profile of VEGF, TGF-β and PGE2 in human pterygium and normal conjunctiva: Experimental study and review of the literature. Int J Immunopathol Pharmacol. 25:607–615. 2012.PubMed/NCBI

97 

Liu Z, Xie Y and Zhang M: Overexpression of type I growth factor receptors in pterygium. Chin Med J (Engl). 115:418–421. 2002.

98 

Detorakis ET and Spandidos DA: Pathogenetic mechanisms and treatment options for ophthalmic pterygium: Trends and perspectives (Review). Int J Mol Med. 23:439–447. 2009. View Article : Google Scholar : PubMed/NCBI

99 

Krial L, Ohira A and Amemiya T: Growth factors in cultured pterygium fibroblasts: Immunohistochemical and ELISA analysis. Graefes Arch Clin Exp Ophthalmol. 236:702–708. 1998. View Article : Google Scholar

100 

Li Y, Bi Z, Yan B and Wan Y: UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway. Int J Mol Med. 18:713–719. 2006.PubMed/NCBI

101 

Kim H, Kang JS and Lee WJ: The production IL-21 and VEGF in UVB-irradiated human keratinocyte cell line, HaCaT. Immune Netw. 10:75–80. 2010. View Article : Google Scholar : PubMed/NCBI

102 

Brauchle M, Funk JO, Kind P and Werner S: Ultraviolet B and H2O2 are potent inducers of vascular endothelial growth factor expression in cultured keratinocytes. J Biol Chem. 271:21793–21797. 1996. View Article : Google Scholar : PubMed/NCBI

103 

Ley RD, Miska KB and Kusewitt DF: Photoreactivation of ultraviolet radiation-induced basic fibroblast growth factor (bFGF) and the role of bFGF in corneal lesion formation in Monodelphis domestica. Environ Mol Mutagen. 38:175–179. 2001. View Article : Google Scholar : PubMed/NCBI

104 

Brenner M, Degitz K, Besch R and Berking C: Differential expression of melanoma-associated growth factors in keratinocytes and fibroblasts by ultraviolet A and ultraviolet B radiation. Br J Dermatol. 153:733–739. 2005. View Article : Google Scholar : PubMed/NCBI

105 

Quan T, He T, Kang S, Voorhees JJ and Fisher GJ: Ultraviolet irradiation alters transforming growth factor beta/smad pathway in human skin in vivo. J Invest Dermatol. 119:499–506. 2002. View Article : Google Scholar : PubMed/NCBI

106 

Xu D, Yuan R, Gu H, Liu T, Tu Y, Yang Z and He L: The effect of ultraviolet radiation on the transforming growth factor beta 1/Smads pathway and p53 in actinic keratosis and normal skin. Arch Dermatol Res. 305:777–786. 2013. View Article : Google Scholar : PubMed/NCBI

107 

Abramovitch R, Neeman M, Reich R, Stein I, Keshet E, Abraham J, Solomon A and Marikovsky M: Intercellular communication between vascular smooth muscle and endothelial cells mediated by heparin-binding epidermal growth factor-like growth factor and vascular endothelial growth factor. FEBS Lett. 425:441–447. 1998. View Article : Google Scholar : PubMed/NCBI

108 

Harding PA, Davis-Fleischer KM, Crissman-Combs MA, Miller MT, Brigstock DR and Besner GE: Induction of anchorage independent growth by heparin-binding EGF-like growth factor (HB-EGF). Growth Factors. 17:49–61. 1999. View Article : Google Scholar : PubMed/NCBI

109 

Nolan TM, Di Girolamo N, Coroneo MT and Wakefield D: Proliferative effects of heparin-binding epidermal growth factor-like growth factor on pterygium epithelial cells and fibroblasts. Invest Ophthalmol Vis Sci. 45:110–113. 2004. View Article : Google Scholar

110 

Witmer AN, Vrensen GF, Van Noorden CJ and Schlingemann RO: Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res. 22:1–29. 2003. View Article : Google Scholar : PubMed/NCBI

111 

Andresen JL and Ehlers N: Chemotaxis of human keratocytes is increased by platelet-derived growth factor-BB, epidermal growth factor, transforming growth factor-alpha, acidic fibroblast growth factor, insulin-like growth factor-I, and transforming growth factor-beta. Curr Eye Res. 17:79–87. 1998. View Article : Google Scholar : PubMed/NCBI

112 

Fredj-Reygrobellet D, Plouet J, Delayre T, Baudouin C, Bourret F and Lapalus P: Effects of aFGF and bFGF on wound healing in rabbit corneas. Curr Eye Res. 6:1205–1209. 1987. View Article : Google Scholar : PubMed/NCBI

113 

Nugent MA and Iozzo RV: Fibroblast growth factor-2. Int J Biochem Cell Biol. 32:115–120. 2000. View Article : Google Scholar : PubMed/NCBI

114 

Govinden R and Bhoola KD: Genealogy, expression, and cellular function of transforming growth factor-beta. Pharmacol Ther. 98:257–265. 2003. View Article : Google Scholar : PubMed/NCBI

115 

Roberts AB, Sporn MB, Assoian RK, Smith JM, Roche NS, Wakefield LM, Heine UI, Liotta LA, Falanga V, Kehrl JH, et al: Transforming growth factor type beta: Rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA. 83:4167–4171. 1986. View Article : Google Scholar : PubMed/NCBI

116 

Verrecchia F and Mauviel A: Transforming growth factor-beta and fibrosis. World J Gastroenterol. 13:3056–3062. 2007.PubMed/NCBI

117 

Dushku N and Reid TW: Immunohistochemical evidence that pterygia originate from Rb and TGF-beta expressing, p53 transformed, limbal basal stem cells. Invest Ophthalmol Vis Sci. 36:S10271995.

118 

Oikawa T, Onozawa C, Sakaguchi M, Morita I and Murota S: Three isoforms of platelet-derived growth factors all have the capability to induce angiogenesis in vivo. Biol Pharm Bull. 17:1686–1688. 1994. View Article : Google Scholar : PubMed/NCBI

119 

Kamiyama K, Iguchi I, Wang X and Imanishi J: Effects of PDGF on the migration of rabbit corneal fibroblasts and epithelial cells. Cornea. 17:315–325. 1998. View Article : Google Scholar : PubMed/NCBI

120 

Aspiotis M, Tsanou E, Gorezis S, Ioachim E, Skyrlas A, Stefaniotou M and Malamou-Mitsi V: Angiogenesis in pterygium: Study of microvessel density, vascular endothelial growth factor, and thrombospondin-1. Eye (Lond). 21:1095–1101. 2007. View Article : Google Scholar

121 

Chui J, Di Girolamo N, Coroneo MT and Wakefield D: The role of substance P in the pathogenesis of pterygia. Invest Ophthalmol Vis Sci. 48:4482–4489. 2007. View Article : Google Scholar : PubMed/NCBI

122 

Naib-Majani W, Breipohl W, Shazli EE, Theuerkauf I, Pleyer U, Hahne JC and Wernert N: The Ets-1 transcription factor is involved in pterygial angiogenesis. Anat Histol Embryol. 36:107–110. 2007. View Article : Google Scholar : PubMed/NCBI

123 

Lee JK, Song YS, Ha HS, Park JH, Kim MK, Park AJ and Kim JC: Endothelial progenitor cells in pterygium pathogenesis. Eye (Lond). 21:1186–1193. 2007. View Article : Google Scholar

124 

Tran MT, Lausch RN and Oakes JE: Substance P differentially stimulates IL-8 synthesis in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 41:3871–3877. 2000.PubMed/NCBI

125 

Jin J, Guan M, Sima J, Gao G, Zhang M, Liu Z, Fant J and Ma JX: Decreased pigment epithelium-derived factor and increased vascular endothelial growth factor levels in pterygia. Cornea. 22:473–477. 2003. View Article : Google Scholar : PubMed/NCBI

126 

Legat FJ, Griesbacher T, Schicho R, Althuber P, Schuligoi R, Kerl H and Wolf P: Repeated subinflammatory ultraviolet B irradiation increases substance P and calcitonin gene-related peptide content and augments mustard oil-induced neurogenic inflammation in the skin of rats. Neurosci Lett. 329:309–313. 2002. View Article : Google Scholar : PubMed/NCBI

127 

Tsai YY, Chiang CC, Yeh KT, Lee H and Cheng YW: Effect of TIMP-1 and MMP in pterygium invasion. Invest Ophthalmol Vis Sci. 51:3462–3467. 2010. View Article : Google Scholar : PubMed/NCBI

128 

Zeng J, Jiang D, Liu X and Tang L: Expression of matrix metal-loproteinase in human pterygia. Yan Ke Xue Bao. 20:242–245. 2004.In Chinese.

129 

Ansari MW, Rahi AH and Shukla BR: Pseudoelastic nature of pterygium. Br J Ophthalmol. 54:473–476. 1970. View Article : Google Scholar : PubMed/NCBI

130 

Hogan MJ and Alvarado J: Pterygium and pinguecula: Electron microscopic study. Arch Ophthalmol. 78:174–186. 1967. View Article : Google Scholar : PubMed/NCBI

131 

Austin P, Jakobiec FA and Iwamoto T: Elastodysplasia and elastodystrophy as the pathologic bases of ocular pterygia and pinguecula. Ophthalmology. 90:96–109. 1983. View Article : Google Scholar : PubMed/NCBI

132 

Bernstein EF, Chen YQ, Tamai K, Shepley KJ, Resnik KS, Zhang H, Tuan R, Mauviel A and Uitto J: Enhanced elastin and fibrillin gene expression in chronically photodamaged skin. J Invest Dermatol. 103:182–186. 1994. View Article : Google Scholar : PubMed/NCBI

133 

Bernstein EF, Brown DB, Urbach F, Forbes D, Del Monaco M, Wu M, Katchman SD and Uitto J: Ultraviolet radiation activates the human elastin promoter in transgenic mice: A novel in vivo and in vitro model of cutaneous photoaging. J Invest Dermatol. 105:269–273. 1995. View Article : Google Scholar : PubMed/NCBI

134 

Schwartz E, Feinberg E, Lebwohl M, Mariani TJ and Boyd CD: Ultraviolet radiation increases tropoelastin accumulation by a post-transcriptional mechanism in dermal fibroblasts. J Invest Dermatol. 105:65–69. 1995. View Article : Google Scholar : PubMed/NCBI

135 

Wang IJ, Hu FR, Chen PJ and Lin CT: Mechanism of abnormal elastin gene expression in the pinguecular part of pterygia. Am J Pathol. 157:1269–1276. 2000. View Article : Google Scholar : PubMed/NCBI

136 

Di Girolamo N, Wakefield D and Coroneo MT: Differential expression of matrix metalloproteinases and their tissue inhibitors at the advancing pterygium head. Invest Ophthalmol Vis Sci. 41:4142–4149. 2000.PubMed/NCBI

137 

Naib-Majani W, Eltohami I, Wernert N, Watts W, Tschesche H, Pleyer U and Breipohl W: Distribution of extracellular matrix proteins in pterygia: An immunohistochemical study. Graefes Arch Clin Exp Ophthalmol. 242:332–338. 2004. View Article : Google Scholar : PubMed/NCBI

138 

Sekhon BS: Matrix metalloproteinases - an overview. Res Rep Biol. 1:1–20. 2010.

139 

Li DQ, Lee SB, Gunja-Smith Z, Liu Y, Solomon A, Meller D and Tseng SC: Overexpression of collagenase (MMP-1) and stromelysin (MMP-3) by pterygium head fibroblasts. Arch Ophthalmol. 119:71–80. 2001.PubMed/NCBI

140 

Di Girolamo N, Coroneo MT and Wakefield D: Active matrilysin (MMP-7) in human pterygia: Potential role in angiogenesis. Invest Ophthalmol Vis Sci. 42:1963–1968. 2001.PubMed/NCBI

141 

Yang SF, Lin CY, Yang PY, Chao SC, Ye YZ and Hu DN: Increased expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts with disease progression and activation of protein kinase C. Invest Ophthalmol Vis Sci. 50:4588–4596. 2009. View Article : Google Scholar : PubMed/NCBI

142 

Koźák I, Klisenbauer D and Juhás T: UV-B induced production of MMP-2 and MMP-9 in human corneal cells. Physiol Res. 52:229–234. 2003.

143 

Ramos MC, Steinbrenner H, Stuhlmann D, Sies H and Brenneisen P: Induction of MMP-10 and MMP-1 in a squamous cell carcinoma cell line by ultraviolet radiation. Biol Chem. 385:75–86. 2004. View Article : Google Scholar : PubMed/NCBI

144 

Brenneisen P, Sies H and Scharffetter-Kochanek K: Ultraviolet-B irradiation and matrix metalloproteinases: From induction via signaling to initial events. Ann N Y Acad Sci. 973:31–43. 2002. View Article : Google Scholar : PubMed/NCBI

145 

Stein B, Rahmsdorf HJ, Steffen A, Litfin M and Herrlich P: UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol Cell Biol. 9:5169–5181. 1989. View Article : Google Scholar : PubMed/NCBI

146 

Rittié L and Fisher GJ: UV-light-induced signal cascades and skin aging. Ageing Res Rev. 1:705–720. 2002. View Article : Google Scholar : PubMed/NCBI

147 

Di Girolamo N, Coroneo MT and Wakefield D: UVB-elicited induction of MMP-1 expression in human ocular surface epithelial cells is mediated through the ERK1/2 MAPK-dependent pathway. Invest Ophthalmol Vis Sci. 44:4705–4714. 2003. View Article : Google Scholar : PubMed/NCBI

148 

Bachelor MA and Bowden GT: UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. Semin Cancer Biol. 14:131–138. 2004. View Article : Google Scholar : PubMed/NCBI

149 

Chao SC, Hu DN, Yang PY, Lin CY, Nien CW, Yang SF and Robert JE: Ultraviolet-A irradiation upregulated urokinase-type plasminogen activator in pterygium fibroblasts through ERK and JNK pathways. Invest Ophthalmol Vis Sci. 54:999–1007. 2013. View Article : Google Scholar : PubMed/NCBI

150 

Ooi JL, Sharma NS, Papalkar D, Sharma S, Oakey M, Dawes P and Coroneo MT: Ultraviolet fluorescence photography to detect early sun damage in the eyes of school-aged children. Am J Ophthalmol. 141:294–298. 2006. View Article : Google Scholar : PubMed/NCBI

151 

Tan DT, Tang WY, Liu YP, Goh HS and Smith DR: Apoptosis and apoptosis related gene expression in normal conjunctiva and pterygium. Br J Ophthalmol. 84:212–226. 2000. View Article : Google Scholar : PubMed/NCBI

152 

Kwok LS, Kuznetsov VA, Ho A and Coroneo MT: Prevention of the adverse photic effects of peripheral light-focusing using UV-blocking contact lenses. Invest Ophthalmol Vis Sci. 44:1501–1507. 2003. View Article : Google Scholar : PubMed/NCBI

153 

Coroneo M: Ultraviolet radiation and the anterior eye. Eye Contact Lens. 37:214–224. 2011. View Article : Google Scholar : PubMed/NCBI

154 

Said DG, Faraj LA, Elalfy MS, Yeung A, Miri A, Fares U, Otri AM, Rahman I, Maharajan S and Dua HS: Intra-lesional 5 fluorouracil for the management of recurrent pterygium. Eye (Lond). 27:1123–1129. 2013. View Article : Google Scholar

155 

Cuevas P, Outeiriño LA, Angulo J and Giménez-Gallego G: Topical dobesilate eye drops for ophthalmic primary pterygium. BMJ Case Rep. 2012. View Article : Google Scholar

156 

Lee K, Young Lee S, Park SY and Yang H: Antifibrotic effect of pirfenidone on human pterygium fibroblasts. Curr Eye Res. 39:680–685. 2014. View Article : Google Scholar : PubMed/NCBI

157 

Sarac O, Demirel S and Oltulu R: Efficacy of intralesional bevacizumab administration in primary pterygium: A quantitative analysis. Eye Contact Lens. 40:46–50. 2014. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Zhou WP, Zhu YF, Zhang B, Qiu WY and Yao YF: The role of ultraviolet radiation in the pathogenesis of pterygia (Review). Mol Med Rep 14: 3-15, 2016.
APA
Zhou, W., Zhu, Y., Zhang, B., Qiu, W., & Yao, Y. (2016). The role of ultraviolet radiation in the pathogenesis of pterygia (Review). Molecular Medicine Reports, 14, 3-15. https://doi.org/10.3892/mmr.2016.5223
MLA
Zhou, W., Zhu, Y., Zhang, B., Qiu, W., Yao, Y."The role of ultraviolet radiation in the pathogenesis of pterygia (Review)". Molecular Medicine Reports 14.1 (2016): 3-15.
Chicago
Zhou, W., Zhu, Y., Zhang, B., Qiu, W., Yao, Y."The role of ultraviolet radiation in the pathogenesis of pterygia (Review)". Molecular Medicine Reports 14, no. 1 (2016): 3-15. https://doi.org/10.3892/mmr.2016.5223
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou WP, Zhu YF, Zhang B, Qiu WY and Yao YF: The role of ultraviolet radiation in the pathogenesis of pterygia (Review). Mol Med Rep 14: 3-15, 2016.
APA
Zhou, W., Zhu, Y., Zhang, B., Qiu, W., & Yao, Y. (2016). The role of ultraviolet radiation in the pathogenesis of pterygia (Review). Molecular Medicine Reports, 14, 3-15. https://doi.org/10.3892/mmr.2016.5223
MLA
Zhou, W., Zhu, Y., Zhang, B., Qiu, W., Yao, Y."The role of ultraviolet radiation in the pathogenesis of pterygia (Review)". Molecular Medicine Reports 14.1 (2016): 3-15.
Chicago
Zhou, W., Zhu, Y., Zhang, B., Qiu, W., Yao, Y."The role of ultraviolet radiation in the pathogenesis of pterygia (Review)". Molecular Medicine Reports 14, no. 1 (2016): 3-15. https://doi.org/10.3892/mmr.2016.5223
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