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Molecular Medicine Reports
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Print ISSN: 1791-2997 Online ISSN: 1791-3004
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2016 Volume 14 Issue 1

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Journal Metrics

Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

Review

The role of ultraviolet radiation in the pathogenesis of pterygia (Review)

Wei‑Ping Zhou, Yuan‑Fang Zhu, Bei Zhang, Wen‑Ya Qiu, Yu‑Feng Yao
Pages: 3-15
Published online on: 09 May 2016

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Review Open Access

Telomerase activity in pregnancy complications (Review)

Persefoni Fragkiadaki, Dimitrios Tsoukalas, Irini Fragkiadoulaki, Christos Psycharakis, Dragana Nikitovic, Demetrios A. Spandidos, Aristides M. Tsatsakis
Pages: 16-21
Published online on: 09 May 2016

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Article Open Access

Placental microRNA expression in pregnancies complicated by superimposed pre‑eclampsia on chronic hypertension

Elena S. Vashukova, Andrey S. Glotov, Pavel V. Fedotov, Olga A. Efimova, Vladimir S. Pakin, Elena V. Mozgovaya, Anna A. Pendina, Andrei V. Tikhonov, Alla S. Koltsova, Vladislav S. Baranov
Pages: 22-32
Published online on: 13 May 2016

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Article Open Access

Recessive optic atrophy, sensorimotor neuropathy and cataract associated with novel compound heterozygous mutations in OPA1

Jinho Lee, Sung‑Chul Jung, Young Bin Hong, Jeong Hyun Yoo, Heasoo Koo, Ja Hyun Lee, Hyun Dae Hong, Sang‑Beom Kim, Ki Wha Chung, Byung‑Ok Choi
Pages: 33-40
Published online on: 04 May 2016

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Article Open Access

Phenotypic transformation of smooth muscle cells from porcine coronary arteries is associated with connexin 43

Xumin Zhang, Xiaodong Wang, Xiaohui Zhou, Xiaoye Ma, Yian Yao, Xuebo Liu
Pages: 41-48
Published online on: 13 May 2016

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Article Open Access

CLI-095 decreases atherosclerosis by modulating foam cell formation in apolipoprotein E-deficient mice

Xiao‑Qing Wang, Hui‑Qing Wan, Xian‑Jing Wei, Ying Zhang, Peng Qu
Pages: 49-56
Published online on: 10 May 2016

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Article Open Access

Melittin inhibits tumor angiogenesis modulated by endothelial progenitor cells associated with the SDF-1α/CXCR4 signaling pathway in a UMR-106 osteosarcoma xenograft mouse model

Gang Qin, Yongqiang Chen, Haidong Li, Suyang Xu, Yumei Li, Jian Sun, Wu Rao, Chaowei Chen, Mindong Du, Kaiyi He, Yong Ye
Pages: 57-68
Published online on: 06 May 2016

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Article Open Access

Effects of tacrolimus on morphology, proliferation and differentiation of mesenchymal stem cells derived from gingiva tissue

Dong‑Ho Ha, Chul Soon Yong, Jong Oh Kim, Jee‑Heon Jeong, Jun‑Beom Park
Pages: 69-76
Published online on: 06 May 2016

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Article Open Access

Identification of cardioprotective agents from traditional Chinese medicine against oxidative damage

Jian‑Ming Zhou, Zhi‑Liang Xu, Na Li, Yi‑Wu Zhao, Zhen‑Zhong Wang, Wei Xiao
Pages: 77-88
Published online on: 11 May 2016

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Article Open Access

Feature genes predicting the FLT3/ITD mutation in acute myeloid leukemia

Chenglong Li, Biao Zhu, Jiao Chen, Xiaobing Huang
Pages: 89-94
Published online on: 12 May 2016

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Article Open Access

Isolation, characterization and multi-lineage differentiation of stem cells from human exfoliated deciduous teeth

Nan Zhang, Baoxing Chen, Wei Wang, Chao Chen, Jie Kang, Samuel Qinnan Deng, Bin Zhang, Shuwei Liu, Fabin Han
Pages: 95-102
Published online on: 05 May 2016

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Article Open Access

A semi‑automated FISH‑based micronucleus‑centromere assay for biomonitoring of hospital workers exposed to low doses of ionizing radiation

Anne Vral, Veerle Decorte, Julie Depuydt, André Wambersie, Hubert Thierens
Pages: 103-110
Published online on: 13 May 2016

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Article Open Access

Suppression of calcium‑sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy

Lei Liu, Chao Wang, Yan Lin, Yuhui Xi, Hong Li, Sa Shi, Hongzhu Li, Weihua Zhang, Yajun Zhao, Ye Tian, Changqing Xu, Lina Wang
Pages: 111-120
Published online on: 13 May 2016

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Article Open Access

Chymase inhibition protects diabetic rats from renal lesions

Mei Zhang, Wen Huang, Jing Bai, Xiaodong Nie, Wen Wang
Pages: 121-128
Published online on: 10 May 2016

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Article Open Access

MicroRNA-128 inhibition attenuates myocardial ischemia/reperfusion injury-induced cardiomyocyte apoptosis by the targeted activation of peroxisome proliferator-activated receptor gamma

Xiao Cong Zeng, Lang Li, Hong Wen, Qi Bi
Pages: 129-136
Published online on: 04 May 2016

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Article Open Access

Single nucleotide polymorphism-based microarray analysis for the diagnosis of hydatidiform moles

Yingjun Xie, Xiaojuan Pei, Yu Dong, Huiqun Wu, Jianzhu Wu, Huijuan Shi, Xuying Zhuang, Xiaofang Sun, Jialing He
Pages: 137-144
Published online on: 05 May 2016

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Article Open Access

LYTAK1, a TAK1 inhibitor, suppresses proliferation and epithelial‑mesenchymal transition in retinal pigment epithelium cells

Zhen Chen, Yan Mei, Huo Lei, Run Tian, Ninghua Ni, Fang Han, Shengwei Gan, Shanquan Sun
Pages: 145-150
Published online on: 13 May 2016

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Article Open Access

Next-generation sequencing identifies novel mutations in the FBN1 gene for two Chinese families with Marfan syndrome

Mingjia Ma, Zongzhe Li, Dao Wen Wang, Xiang Wei
Pages: 151-158
Published online on: 09 May 2016

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Article Open Access

Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells

Bin Liu, Yufeng Shi, Wending Peng, Qingyu Zhang, Jie Liu, Nianping Chen, Runzhi Zhu
Pages: 159-164
Published online on: 12 May 2016

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Article Open Access

Proteomic and bioinformatic analyses of spinal cord injury‑induced skeletal muscle atrophy in rats

Zhi‑Jian Wei, Xian‑Hu Zhou, Bao‑You Fan, Wei Lin, Yi‑Ming Ren, Shi‑Qing Feng
Pages: 165-174
Published online on: 13 May 2016

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Article Open Access

Gene expression profiling of NB4 cells following knockdown of nucleostemin using DNA microarrays

Xiaoli Sun, Yu Jia, Yuanyu Wei, Shuai Liu, Baohong Yue
Pages: 175-183
Published online on: 05 May 2016

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Article Open Access

Diagnostic value of miR-30d-5p and miR-125b-5p in acute myocardial infarction

Kegang Jia, Ping Shi, Xuejing Han, Tienan Chen, Hongxia Tang, Jing Wang
Pages: 184-194
Published online on: 11 May 2016

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Article Open Access

Adipose‑derived mesenchymal stem cell‑facilitated TRAIL expression in melanoma treatment in vitro

Hai Xia Jing, De Jian Duan, Hui Zhou, Qing Mei Hu, Tie Chi Lei
Pages: 195-201
Published online on: 13 May 2016

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Article Open Access

Prevention of ultraviolet radiation‑induced immunosuppression by sunscreen in Candida albicans‑induced delayed‑type hypersensitivity

Quan Chen, Runxiang Li, Xiaoxia Zhao, Bihua Liang, Shaoyin Ma, Zhenjie Li, Huilan Zhu
Pages: 202-208
Published online on: 13 May 2016

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Article Open Access

Tumor necrosis factor antagonists in the treatment of multicentric reticulohistiocytosis: Current clinical evidence

Hongjun Zhao, Chunmei Wu, Mengyun Wu, Yaou Zhou, Honglin Zhu, Yisha Li, Yunhui You, Hui Luo, Lijing Wang, Xiaoxia Zuo
Pages: 209-217
Published online on: 12 May 2016

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Article Open Access

Cyclic stretch promotes osteogenesis-related gene expression in osteoblast-like cells through a cofilin-associated mechanism

Jie Gao, Shanmin Fu, Zhaobin Zeng, Feifei Li, Qiannan Niu, Da Jing, Xue Feng
Pages: 218-224
Published online on: 10 May 2016

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Article Open Access

Electroacupuncture ameliorates post-stroke learning and memory through minimizing ultrastructural brain damage and inhibiting the expression of MMP-2 and MMP-9 in cerebral ischemia-reperfusion injured rats

Ruhui Lin, Kunqiang Yu, Xiaojie Li, Jing Tao, Yukun Lin, Congkuai Zhao, Chunyan Li, Li‑Dian Chen
Pages: 225-233
Published online on: 09 May 2016

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Article Open Access

The transplantation of Akt-overexpressing amniotic fluid-derived mesenchymal stem cells protects the heart against ischemia-reperfusion injury in rabbits

Yan Wang, Yigang Li, Lei Song, Yanyan Li, Shan Jiang, Song Zhang
Pages: 234-242
Published online on: 05 May 2016

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Article Open Access

Role of mechanical strain-activated PI3K/Akt signaling pathway in pelvic organ prolapse

Bing‑Shu Li, Wen‑Jun Guo, Li Hong, Yao‑Dan Liu, Cheng Liu, Sha‑Sha Hong, De‑Bin Wu, Jie Min
Pages: 243-253
Published online on: 13 May 2016

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Article Open Access

The prognostic role and reduced expression of FOXJ2 in human hepatocellular carcinoma

Zhongbao Zhang, Guangju Meng, Liang Wang, Yingying Ma, Zhongzheng Guan
Pages: 254-262
Published online on: 12 May 2016

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Article

β-arrestin2 regulates TRAIL-induced HepG2 cell apoptosis via the Src-extracellular signal-regulated signaling pathway

Zhilin Qi, Shimei Qi, Lin Gui, Lei Shen
Pages: 263-270
Published online on: 06 May 2016

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Article

HOXA13 exerts a beneficial effect in albumin-induced epithelial-mesenchymal transition via the glucocorticoid receptor signaling pathway in human renal tubular epithelial cells

Li Peng, Qingnan He, Xiaoyan Li, Lanjun Shuai, Haixia Chen, Yongzhen Li, Zhuwen Yi
Pages: 271-276
Published online on: 11 May 2016

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Article

Matrix metalloproteinase‑2 regulates MDA‑MB‑231 breast cancer cell invasion induced by active mammalian diaphanous-related formin 1

Daehwan Kim, Sangmyung Rhee
Pages: 277-282
Published online on: 13 May 2016

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Article

Aberrant methylation of microRNA-193b in human Barrett's esophagus and esophageal adenocarcinoma

Lin Lü, Tianyu Liu, Jian Gao, Hanqing Zeng, Jia Chen, Xiling Gu, Zhechuan Mei
Pages: 283-288
Published online on: 09 May 2016

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Article

Ratio of S-adenosylmethionine to S-adenosylhomocysteine as a sensitive indicator of atherosclerosis

Huiping Zhang, Zhihong Liu, Shengchao Ma, Hui Zhang, Fanqi Kong, Yangyang He, Xiaoling Yang, Yanhua Wang, Hua Xu, Anning Yang, Jue Tian, Minghao Zhang, Jun Cao, Yideng Jiang, Xiong Guo
Pages: 289-300
Published online on: 09 May 2016

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Article

Lentivirus-mediated inhibition of USP39 suppresses the growth of gastric cancer cells via PARP activation

Xinbao Wang, Qiming Yu, Ling Huang, Pengfei Yu
Pages: 301-306
Published online on: 12 May 2016

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Article

Embelin induces apoptosis of human gastric carcinoma through inhibition of p38 MAPK and NF-κB signaling pathways

Chang‑Long Xu, Bo Zheng, Ji‑Hua Pei, Su‑Jian Shen, Jian‑Zhang Wang
Pages: 307-312
Published online on: 09 May 2016

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Article

Upregulation of Id3 inhibits cell proliferation and induces apoptosis in A549/DDP human lung cancer cells in vitro

Fangfang Chen, Qinfei Zhao, Shuxia Wang, Haiyong Wang, Xiaojun Li
Pages: 313-318
Published online on: 09 May 2016

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Article

Genotypes and phenotypes of a family with a deaf child carrying combined heterozygous mutations in SLC26A4 and GJB3 genes

Yunlong Li, Baosheng Zhu
Pages: 319-324
Published online on: 13 May 2016

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Article

Recombinant human neuregulin-1β is protective against radiation-induced myocardial cell injury

Qiang Zhou, Wenbing Hu, Xinxiong Fei, Xuqun Huang, Xi Chen, Deqing Zhao, Jun Huang, Lan Jiang, Gangsheng Wang
Pages: 325-330
Published online on: 04 May 2016

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Article

Effect of bisphenol A on SOCS-3 and insulin signaling transduction in 3T3-L1 adipocytes

Yue‑E Dai, Wei Chen, Humin Qi, Qian‑Qi Liu
Pages: 331-336
Published online on: 09 May 2016

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Article

Sox9 is a β-catenin-regulated transcription factor that enhances the colony-forming activity of squamous cell carcinoma cells

Xue Mei Li, Yong Jun Piao, Kyung‑Cheol Sohn, Jeong-Min Ha, Myung Im, Young‑Joon Seo, Kyu Uang Whang, Jeung‑Hoon Lee, Young Lee, Chang Deok Kim
Pages: 337-342
Published online on: 04 May 2016

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Article

Resolution acute respiratory distress syndrome through reversing the imbalance of Treg/Th17 by targeting the cAMP signaling pathway

Qian Li, Xiuping Hu, Renhua Sun, Yuexing Tu, Fangxiao Gong, Yin Ni
Pages: 343-348
Published online on: 09 May 2016

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Article

Emulsified isoflurane treatment inhibits the cell cycle and respiration of human bronchial epithelial 16HBE cells in a p53-independent manner

Hui Yang, Jia Deng, Yingying Jiang, Jiao Chen, Xianzheng Zeng, Zhiyang He, Xiaojuan Jiang, Zhuoning Li, Chunling Jiang
Pages: 349-354
Published online on: 12 May 2016

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Article

Beclin 1 promotes apoptosis and decreases invasion by upregulating the expression of ECRG4 in A549 human lung adenocarcinoma cells

Wenyu Wang, Hongkun Fan, Xiaoyan Li, Gang Wu, Weida Zhao, Guihong Zhang, Guoqiang Zhao, Linwei Li
Pages: 355-360
Published online on: 06 May 2016

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Article

Syzygium aromaticum water extract attenuates ethanol‑induced gastric injury through antioxidant effects in rats

Seong Eun Jin, Mee‑Young Lee, In‑Sik Shin, Woo‑Young Jeon, Hyekyung Ha
Pages: 361-366
Published online on: 13 May 2016

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Article

CTF18 interacts with replication protein A in response to replication stress

Yuta Kaneko, Hiroaki Daitoku, Chihiro Komeno, Akiyoshi Fukamizu
Pages: 367-372
Published online on: 13 May 2016

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Article

Investigation of cadmium-induced apoptosis and the protective effect of N-acetylcysteine in BRL 3A cells

Xuezhong Liu, Yiran Zhang, Yi Wang, Yuan Yan, Jiajing Wang, Jianhong Gu, Bianjian Chun, Zongping Liu
Pages: 373-379
Published online on: 06 May 2016

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Article

Saponin 6 derived from Anemone taipaiensis induces U87 human malignant glioblastoma cell apoptosis via regulation of Fas and Bcl‑2 family proteins

Chen‑Chen Ji, Hai‑Feng Tang, Yi‑Yang Hu, Yun Zhang, Min‑Hua Zheng, Hong‑Yan Qin, San‑Zhong Li, Xiao‑Yang Wang, Zhou Fei, Guang Cheng
Pages: 380-386
Published online on: 13 May 2016

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Article

Regulation of cytochrome P450 3A4 by small vault RNAb derived from the non-coding vault RNA1 of multidrug resistance-linked vault particle

Chunjie Meng, Zhiyun Wei, Yiting Zhang, Liang Yan, Hang He, Lirong Zhang, Qinghe Xing
Pages: 387-393
Published online on: 09 May 2016

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Article

Alisertib induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells

Yunfeng Fu, Yanan Zhang, Meng Gao, Lingli Quan, Rong Gui, Jing Liu
Pages: 394-398
Published online on: 11 May 2016

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Article

Protective effects of hyperoside against H2O2-induced apoptosis in human umbilical vein endothelial cells

Xu‑Liang Hao, Ya Kang, Jian‑Kuan Li, Qing‑Shan Li, En‑Li Liu, Xiao‑Xia Liu
Pages: 399-405
Published online on: 10 May 2016

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Article

Rg1 protects rat bone marrow stem cells against hydrogen peroxide-induced cell apoptosis through the PI3K/Akt pathway

Junzheng Hu, Yanqing Gu, Weimin Fan
Pages: 406-412
Published online on: 10 May 2016

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Article

Evodiamine sensitizes BGC-823 gastric cancer cells to radiotherapy in vitro and in vivo

Chengqi Hu, Xuexiang Gao, Yuanyuan Han, Qi Guo, Kailiang Zhang, Miaomiao Liu, Yugang Wang, Jing Wang
Pages: 413-419
Published online on: 10 May 2016

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Article

Protective function of pyridoxamine on retinal photoreceptor cells via activation of the p‑Erk1/2/Nrf2/Trx/ASK1 signalling pathway in diabetic mice

Xiang Ren, Hong Sun, Chenghong Zhang, Chen Li, Jinlei Wang, Jie Shen, Dong Yu, Li Kong
Pages: 420-424
Published online on: 13 May 2016

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Article

Treatment with estrogen protects against ovariectomy-induced hepatic steatosis by increasing AQP7 expression

Xiaohua Fu, Lili Xing, Weihai Xu, Jing Shu
Pages: 425-431
Published online on: 10 May 2016

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Article

MicroRNA-34a inhibits cell proliferation and induces cell apoptosis of glioma cells via targeting of Bcl-2

Junwei Duan, Kejun Zhou, Xiaoping Tang, Jie Duan, Long Zhao
Pages: 432-438
Published online on: 12 May 2016

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Article

Expression and function of microRNA-497 in human osteosarcoma

Qi Liu, Huan Wang, Ankit Singh, Fenyong Shou
Pages: 439-445
Published online on: 12 May 2016

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Article

Molecular evaluation of herbal compounds as potent inhibitors of acetylcholinesterase for the treatment of Alzheimer's disease

Yan‑Xiu Chen, Guan‑Zeng Li, Bin Zhang, Zhang‑Yong Xia, Mei Zhang
Pages: 446-452
Published online on: 11 May 2016

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Article

MicroRNA‑126 is downregulated in thyroid cancer cells, and regulates proliferation, migration and invasion by targeting CXCR4

Yan Qian, Xiaoli Wang, Zhanlu Lv, Chen Guo, Yongjian Yang, Jinliang Zhang, Xianliang Wang
Pages: 453-459
Published online on: 13 May 2016

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Article

Methylsulfonylmethane enhances BMP‑2‑induced osteoblast differentiation in mesenchymal stem cells

Don Nam Kim, Youn Hee Joung, Pramod Darvin, Dong Young Kang, Nipin Sp, Hyo Joo Byun, Kwang Hyun Cho, Kyung Do Park, Hak Kyo Lee, Young Mok Yang
Pages: 460-466
Published online on: 13 May 2016

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Article

miR‑410 regulates apoptosis by targeting Bak1 in human colorectal cancer cells

Chunyuan Liu, Aihong Zhang, Lei Cheng, Yang Gao
Pages: 467-473
Published online on: 13 May 2016

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Article

In vivo response of heme-oxygenase-1 to metal ions released from metal-on-metal hip prostheses

Alina Beraudi, Eva Bianconi, Simona Catalani, Silvia Canaider, Dalila De Pasquale, Pietro Apostoli, Barbara Bordini, Susanna Stea, Aldo Toni, Federica Facchin
Pages: 474-480
Published online on: 11 May 2016

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Molecular study of patients with auditory neuropathy

Guilherme Machado De Carvalho, Priscila Zonzini Ramos, Arthur Menino Castilho, Alexandre Caixeta Guimarães, Edi Lúcia Sartorato
Pages: 481-490
Published online on: 09 May 2016

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Article

Palmatine from Mahonia bealei attenuates gut tumorigenesis in ApcMin/+ mice via inhibition of inflammatory cytokines

Wei‑Kun Ma, Hui Li, Cui‑Lan Dong, Xin He, Chang‑Run Guo, Chun‑Feng Zhang, Chun‑Hao Yu, Chong‑Zhi Wang, Chun‑Su Yuan
Pages: 491-498
Published online on: 13 May 2016

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Article

Enhanced anti-inflammatory effects of DHA and quercetin in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-κB and MAPK activation

Tian‑Lei Si, Qi Liu, Yu‑Fei Ren, Hui Li, Xiao‑Yun Xu, Er‑Hu Li, Si‑Yi Pan, Jiu‑Liang Zhang, Ke‑Xing Wang
Pages: 499-508
Published online on: 12 May 2016

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Article

Expression of NLRC4 in children with septicaemia and mechanisms of NLRC4 in in vitro cytokine secretion

Guoji Zhu, Jing Chen, Jianmei Tian, Lingqing Ge, Aixia Xing, Guangming Tang
Pages: 509-514
Published online on: 12 May 2016

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Article

Livin enhances tumorigenesis by regulating the mitogen-activated protein kinase signaling pathway in human hypopharyngeal squamous cell carcinoma

Sun‑Ae Kim, Tae Mi Yoon, Dong Hoon Lee, Joon Kyoo Lee, Young‑Lan Park, Ik‑Joo Chung, Young‑Eun Joo, Sang Chul Lim
Pages: 515-520
Published online on: 11 May 2016

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Article

PRMT1 regulates tumor growth and metastasis of human melanoma via targeting ALCAM

Lei Li, Zhengwen Zhang, Tengxiao Ma, Ran Huo
Pages: 521-528
Published online on: 13 May 2016

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Article

Differential effects of Rhodiola rosea on regulatory T cell differentiation and interferon‑γ production in vitro and in vivo

Xi Xu, Pingping Li, Peng Zhang, Ming Chu, Hongju Liu, Xiaoping Chen, Qing Ge
Pages: 529-536
Published online on: 13 May 2016

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Article

MicroRNA-23b regulates nasopharyngeal carcinoma cell proliferation and metastasis by targeting E-cadherin

Jun‑Ying Wang, Xiao‑Feng Li, Pei‑Zhong Li, Xin Zhang, Yu Xu, Xin Jin
Pages: 537-543
Published online on: 28 April 2016

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Article

5-Aminolevulinic acid photodynamic therapy in human cervical cancer via the activation of microRNA-143 and suppression of the Bcl-2/Bax signaling pathway

Qingzhi Guo, Baihua Dong, Fangfang Nan, Dongdong Guan, Youzhong Zhang
Pages: 544-550
Published online on: 11 May 2016

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Article

Oxymatrine protects against sepsis-induced myocardial injury via inhibition of the TNF-α/p38-MAPK/caspase-3 signaling pathway

Minghao Zhang, Xiuyu Wang, Bin Bai, Rui Zhang, Yunhong Li, Yin Wang
Pages: 551-559
Published online on: 11 May 2016

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Article

Tumor suppressive miR-196a is associated with cellular migration, proliferation and apoptosis in renal cell carcinoma

Yifan Li, Lu Jin, Duqun Chen, Jiaju Liu, Zhengming Su, Shangqi Yang, Yaoting Gui, Xiangming Mao, Guohui Nie, Yongqing Lai
Pages: 560-566
Published online on: 12 May 2016

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Article

Decreased DAB2IP gene expression, which could be induced by fractionated irradiation, is associated with resistance to γ‑rays and α‑particles in prostate cancer cells

Chen Yang, Hui He, Tingting Zhang, Ying Chen, Zhaolu Kong
Pages: 567-573
Published online on: 13 May 2016

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Article

Action of methotrexate and tofacitinib on directly stimulated and bystander-activated lymphocytes

Elisa Piscianz, Vanessa Candilera, Erica Valencic, Claudia Loganes, Greta Paron, Sara De Iudicibus, Giuliana Decorti, Alberto Tommasini
Pages: 574-582
Published online on: 13 May 2016

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Article

Cytotoxic activity of allogeneic natural killer cells on U251 glioma cells in vitro

Meng Guo, Tingting Wu, Lixin Wan
Pages: 583-589
Published online on: 06 May 2016

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Article

Differentially expressed microRNA identification and target gene function analysis in starvation-induced autophagy of AR42J pancreatic acinar cells

Bo Gao, Duanping Wang, Wang Sun, Xianzhi Meng, Weihui Zhang, Dongbo Xue
Pages: 590-598
Published online on: 10 May 2016

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Article

(‑)‑Epigallocatechin‑3‑gallate induces apoptosis in human pancreatic cancer cells via PTEN

Shi Liu, Zhong‑Ling Xu, Li Sun, Ying Liu, Cheng‑Chong Li, Hong‑Mei Li, Wei Zhang, Cheng‑Jun Li, Wei Qin
Pages: 599-605
Published online on: 13 May 2016

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Article

High salt medium activates RhoA/ROCK and downregulates eNOS expression via the upregulation of ADMA

Yu Cao, Yuan Fang, Jianjun Mu, Xiaohong Liu
Pages: 606-612
Published online on: 11 May 2016

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Retraction Open Access

[Retracted] Clinical, pathological and genetic characteristics of autosomal dominant inherited dynamin 2 centronuclear myopathy

Xinhong Liu, Huamin Wu, Jian Gong, Tao Wang, Chuanzhu Yan
Pages: 613-613
Published online on: 13 May 2016

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Correction Open Access

[Corrigendum] Transient transfection of macrophage migration inhibitory factor small interfering RNA disrupts the biological behavior of oral squamous carcinoma cells

Jie Zeng, Jingjing Quan, Xuefeng Xia
Pages: 614-614
Published online on: 13 May 2016

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MicroRNAs regulate signaling pathways in osteogenic differentiation of mesenchymal stem cells (Review)

Shuping Peng, Dan Gao, Chengde Gao, Pingpin Wei, Man Niu, Cijun Shuai
Pages: 623-629
Published online on: 24 May 2016

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Article Open Access

Population-based analysis of the frequency of HFE gene polymorphisms: Correlation with the susceptibility to develop hereditary hemochromatosis

Martha‑Spyridoula Katsarou, Rosana Latsi, Maria Papasavva, Nikolaos Demertzis, Thodoris Kalogridis, Aristides M. Tsatsakis, Demetrios A. Spandidos, Nikolaos Drakoulis
Pages: 630-636
Published online on: 20 May 2016

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Shox2 influences mesenchymal stem cell fate in a co-culture model in vitro

Yuanyuan Feng, Pan Yang, Shouming Luo, Zhihui Zhang, Huakang Li, Ping Zhu, Zhiyuan Song
Pages: 637-642
Published online on: 18 May 2016

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TNF-α enhances vascular cell adhesion molecule-1 expression in human bone marrow mesenchymal stem cells via the NF-κB, ERK and JNK signaling pathways

Zi‑Yuan Lu, Wan‑Cheng Chen, Yong‑Hua Li, Li Li, Hang Zhang, Yan Pang, Zhi‑Fang Xiao, Hao‑Wen Xiao, Yang Xiao
Pages: 643-648
Published online on: 19 May 2016

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Novel 6-bp deletion in MEF2A linked to premature coronary artery disease in a large Chinese family

Dong‑Ling Xu, Hong‑Liang Tian, Wei‑Li Cai, Jie Zheng, Min Gao, Ming‑Xiang Zhang, Zhao-Tong Zheng, Qing‑Hua Lu
Pages: 649-654
Published online on: 18 May 2016

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Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm Corrigendum in /10.3892/mmr.2017.7593

Takanori Tatsuno, Yuka Nakamura, Shaofu Ma, Naohisa Tomosugi, Yasuhito Ishigaki
Pages: 655-660
Published online on: 24 May 2016

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Deciphering the genetic and modular connections between coronary heart disease, idiopathic pulmonary arterial hypertension and pulmonary heart disease

Ye Yuan, Yingying Zhang, Xiaoxu Zhang, Yanan Yu, Bing Li, Pengqian Wang, Haixia Li, Yijun Zhao, Chunti Shen, Zhong Wang
Pages: 661-670
Published online on: 18 May 2016

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Influence of different types of contact hypersensitivity on imiquimod-induced psoriasis-like inflammation in mice

Shuang Bai, Zhenying Zhang, Suchun Hou, Xiaoming Liu
Pages: 671-680
Published online on: 18 May 2016

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Screening and identification of the differentially expressed proteins in neonatal rat kidney after partial unilateral ureteral obstruction

Qi Zhao, Yansheng Xue, Yi Yang, Zhibin Niu, Changlin Wang, Ying Hou, Hui Chen
Pages: 681-688
Published online on: 24 May 2016

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Notch signaling represses hypoxia-inducible factor-1α-induced activation of Wnt/β-catenin signaling in osteoblasts under cobalt-mimicked hypoxia

Chen‑Tian Li, Jian‑Xiu Liu, Bo Yu, Rui Liu, Chao Dong, Song‑Jian Li
Pages: 689-696
Published online on: 23 May 2016

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Capture of dengue viruses using antibody-integrated graphite-encapsulated magnetic beads produced using gas plasma technology

Akikazu Sakudo, Anchu Viswan, Han Chou, Tadahiro Sasaki, Kazuyoshi Ikuta, Masaaki Nagatsu
Pages: 697-704
Published online on: 24 May 2016

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Dehydroepiandrosterone inhibits cell proliferation and improves viability by regulating S phase and mitochondrial permeability in primary rat Leydig cells

Lin Liu, Dian Wang, Longlong Li, Xiao Ding, Haitian Ma
Pages: 705-714
Published online on: 24 May 2016

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Iptakalim influences the proliferation and apoptosis of human pulmonary artery smooth muscle cells

Qinglin Li, Xiaopei Yan, Hui Kong, Weiping Xie, Hong Wang
Pages: 715-720
Published online on: 24 May 2016

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Subclinical concentrations of sevoflurane reduce oxidative stress but do not prevent hippocampal apoptosis

Zhi‑Bin Zhou, Xiao‑Yu Yang, Ying Tang, Xue Zhou, Li‑Hua Zhou, Xia Feng
Pages: 721-727
Published online on: 24 May 2016

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Receptor-interacting protein kinase 3-mediated programmed cell necrosis in rats subjected to focal cerebral ischemia-reperfusion injury

Yanru Dong, Cuifen Bao, Jingwei Yu, Xia Liu
Pages: 728-736
Published online on: 19 May 2016

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Co‑delivery and controlled release of stromal cell‑derived factor‑1α chemically conjugated on collagen scaffolds enhances bone morphogenetic protein‑2‑driven osteogenesis in rats

Haipeng Sun, Jinming Wang, Feilong Deng, Yun Liu, Xiumei Zhuang, Jiayun Xu, Long Li
Pages: 737-745
Published online on: 24 May 2016

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Adiponectin ameliorates the apoptotic effects of paraquat on alveolar type Ⅱ cells via improvements in mitochondrial function

Yarong He, Liqun Zou, Yaxiong Zhou, Hai Hu, Rong Yao, Yaowen Jiang, Wayne Bond Lau, Tun Yuan, Wen Huang, Zhi Zeng, Yu Cao
Pages: 746-752
Published online on: 23 May 2016

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Potential effect of smoking on semen quality through DNA damage and the downregulation of Chk1 in sperm

Xiangrong Cui, Xuan Jing, Xueqing Wu, Zhenqiang Wang, Qiang Li
Pages: 753-761
Published online on: 20 May 2016

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Analysis of the complementarity determining regions β-chain genomic rearrangement using high-throughput sequencing in periphery cytotoxic T lymphocytes of patients with chronic hepatitis B

Yinuo Huang, Hong Ma, Shutang Wei, Gang Luo, Ruimin Sun, Zhibo Fan, Liping Wu, Wenyi Yang, Lin Fu, Junhui Wang, Dazheng Han, Jun Lu
Pages: 762-768
Published online on: 23 May 2016

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Dexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal rats

Yujie Wang, Changyi Wu, Bin Han, Fei Xu, Mingfeng Mao, Xiangyang Guo, Jun Wang
Pages: 769-775
Published online on: 23 May 2016

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Periostin expression induced by oxidative stress contributes to myocardial fibrosis in a rat model of high salt-induced hypertension

Han Wu, Liang Chen, Jun Xie, Ran Li, Guan‑Nan Li, Qin‑Hua Chen, Xin‑Lin Zhang, Li‑Na Kang, Biao Xu
Pages: 776-782
Published online on: 19 May 2016

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SDF‑1/CXCR4 axis induces apoptosis of human degenerative nucleus pulposus cells via the NF‑κB pathway

Zongchao Liu, Chuan Ma, Jieliang Shen, Dawu Wang, Jie Hao, Zhenming Hu
Pages: 783-789
Published online on: 24 May 2016

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Differential changes in Neuregulin-1 signaling in major brain regions in a lipopolysaccharide-induced neuroinflammation mouse model

Zhai Yang, Qiong Jiang, Shuang‑Xi Chen, Cheng‑Liang Hu, Hui‑Fan Shen, Pei‑Zhi Huang, Jun‑Ping Xu, Jin‑Ping Mei, Ben‑Ping Zhang, Wei‑Jiang Zhao
Pages: 790-796
Published online on: 23 May 2016

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Effects of dexmedetomidine postconditioning on myocardial ischemia and the role of the PI3K/Akt-dependent signaling pathway in reperfusion injury

Xiang Yang Cheng, Xiao Yu Gu, Qin Gao, Qiao Feng Zong, Xiao Hong Li, Ye Zhang
Pages: 797-803
Published online on: 24 May 2016

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Article

Construction and functional analysis of an anti-human cervical carcinoma/anti-human CD3 single-chain bispecific antibody

Hong Wu, Li Yao, Lin Chou, Jin‑Hua Yang, Yun‑Xiu Zhang, Xiao‑Li Li, Bo‑Er Shan
Pages: 804-810
Published online on: 18 May 2016

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Article

Lipopolysaccharide-induced podocyte injury is mediated by suppression of autophagy

Xiaofan Tan, Yuanhan Chen, Xinling Liang, Chunping Yu, Yuxiong Lai, Li Zhang, Xingchen Zhao, Hong Zhang, Ting Lin, Ruizhao Li, Wei Shi
Pages: 811-818
Published online on: 18 May 2016

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Effects of the eukaryotic initiation factor 6 gene on expression levels of inflammatory mediators in M2 macrophages during scar repair Retraction in /10.3892/mmr.2017.7190

Yong‑Qiang Bai, Jian‑Ke Feng, Qing‑Fu Zhang, Hong‑Zhi Wu, Ya‑Ru Du, Wei Wei
Pages: 819-824
Published online on: 18 May 2016

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Article

Enterotoxigenic Escherichia coli infection alters intestinal immunity in mice

Xiangwu Yang, Zhiming Xiao, Fen Liu, Shuai Chen, Wuliang Tang, Decai Zhang, Shaojun Liu
Pages: 825-830
Published online on: 18 May 2016

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Article

Cloning and functional analysis of human acyl coenzyme A: Cholesterol acyltransferase1 gene P1 promoter

Jing Ge, Bei Cheng, Benling Qi, Wen Peng, Hui Wen, Lijuan Bai, Yun Liu, Wei Zhai
Pages: 831-838
Published online on: 18 May 2016

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Article

1,25(OH)2D3 inhibits high glucose-induced apoptosis and ROS production in human peritoneal mesothelial cells via the MAPK/P38 pathway

Lina Yang, Lan Wu, Shuyan Du, Ye Hu, Yi Fan, Jianfei Ma
Pages: 839-844
Published online on: 23 May 2016

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Article

Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cells

Seon Min Woo, Woo Keun Lee, Kyoung‑Jin Min, Dong Eun Kim, Soon Hyung Park, Sung Il Nam, Taeg Kyu Kwon
Pages: 845-850
Published online on: 20 May 2016

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Comparison of catalase immunoreactivity in the hippocampus between young, adult and aged mice and rats

Ji Hyeon Ahn, Bai Hui Chen, Bich‑Na Shin, Tae‑Kyeong Lee, Jeong Hwi Cho, In Hye Kim, Joon Ha Park, Jae‑Chul Lee, Hyun‑Jin Tae, Choong‑Hyun Lee, Moo‑Ho Won, Yun Lyul Lee, Soo Young Choi, Seongkweon Hong
Pages: 851-856
Published online on: 18 May 2016

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Article

MicroRNA‑423‑5p mediates H2O2‑induced apoptosis in cardiomyocytes through O‑GlcNAc transferase

Peng Luo, Wei Zhang
Pages: 857-864
Published online on: 24 May 2016

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Article

Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model

Fang Li, Jian Luo, Zhixiong Wu, Ting Xiao, Ou Zeng, Lin Li, Yan Li, Jun Yang
Pages: 865-873
Published online on: 17 May 2016

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Article

11-O-acetylcyathatriol inhibits MAPK/p38-mediated inflammation in LPS-activated RAW 264.7 macrophages and has a protective effect on ethanol-induced gastric injury

Xin Jin, Junjie Han, Shuxian Yang, Yuan Hu, Hongwei Liu, Feng Zhao
Pages: 874-880
Published online on: 18 May 2016

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Article

SerpinE2 promotes multiple cell proliferation and drug resistance in osteosarcoma

Minzhi Mao, Wanchun Wang
Pages: 881-887
Published online on: 19 May 2016

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Article

Yifuning postpones ovarian aging through antioxidant mechanisms and suppression of the Rb/p53 signal transduction pathway

Lei Liang, Xu‑Hui Zhang, Bo Ji, Hui Yao, Xiao‑Mei Ling, Zhi‑Jian Guo, Hong‑Zhu Deng, Xin‑Rong Wu
Pages: 888-896
Published online on: 23 May 2016

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Article

Effects of platelet-derived growth factor on chondrocyte proliferation, migration and apoptosis via regulation of GIT1 expression

Guang‑Zong Zhao, Long‑Qiang Zhang, Yao Liu, Jun Fang, Hua‑Zhuang Li, Ke‑Hai Gao, Yun‑Zhen Chen
Pages: 897-903
Published online on: 18 May 2016

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Article

Astragalus polysaccharide protects human cardiac microvascular endothelial cells from hypoxia/reoxygenation injury: The role of PI3K/AKT, Bax/Bcl-2 and caspase-3

Liandi Xie, Yang Wu, Zongjing Fan, Yang Liu, Jixiang Zeng
Pages: 904-910
Published online on: 18 May 2016

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Article

Licochalcone A induces T24 bladder cancer cell apoptosis by increasing intracellular calcium levels

Xinhui Yang, Jiangtao Jiang, Xinyan Yang, Jichun Han, Qiusheng Zheng
Pages: 911-919
Published online on: 24 May 2016

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Article

Melatonin protects podocytes from angiotensin II-induced injury in an in vitro diabetic nephropathy model

Zhen‑Zhong Ji, Yan‑Cheng Xu
Pages: 920-926
Published online on: 19 May 2016

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Article

FTY720 enhances osteogenic differentiation of bone marrow mesenchymal stem cells in ovariectomized rats

Chuang Huang, Rui Ling, Fei‑Jiang Li, Er‑Cui Li, Qi‑Ke Huang, Bao‑Gang Liu, Yin Ding, Si‑Wei You
Pages: 927-935
Published online on: 24 May 2016

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Article

Exogenous H2O2 induces growth inhibition and cell death of human pulmonary artery smooth muscle cells via glutathione depletion

Woo Hyun Park
Pages: 936-942
Published online on: 19 May 2016

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Article

Preparation and application of a novel monoclonal antibody specific for human B7-H3

Jian Shi, Dong‑Lei Zhang, Zhi‑Chu Cui, Hui‑Min Wang
Pages: 943-948
Published online on: 17 May 2016

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Article

MicroRNA-27b reverses docetaxel resistance of non-small cell lung carcinoma cells via targeting epithelial growth factor receptor

Shi Chen, Qian Wang, Xian‑Mei Zhou, Ji‑Ping Zhu, Tian Li, Mao Huang
Pages: 949-954
Published online on: 24 May 2016

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Article

Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways

Yan‑Feng Liu, Yun‑Qing Bai, Ming Qi
Pages: 955-962
Published online on: 18 May 2016

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Article

High glucose-induced fibronectin upregulation in cultured mesangial cells involves caveolin-1-dependent RhoA-GTP activation via Src kinase

Yongfu Lu, Lihong Tang, Yiqiao Li, Qiang He
Pages: 963-968
Published online on: 19 May 2016

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Article

FABP4-mediated homocysteine-induced cholesterol accumulation in THP-1 monocyte-derived macrophages and the potential epigenetic mechanism

Yideng Jiang, Shengchao Ma, Huiping Zhang, Xiaoling Yang, Guan Jun Lu, Hui Zhang, Yangyang He, Fanqi Kong, Anning Yang, Hua Xu, Minghao Zhang, Yun Jiao, Guizhong Li, Jun Cao, Yuexia Jia, Shaoju Jin, Jun Wei, Yingkang Shi
Pages: 969-976
Published online on: 19 May 2016

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Article

Hsa-miR-495 acts as a tumor suppressor gene in glioma via the negative regulation of MYB

Benping Zhang, Fei Yuan, Jie Liu, Yang Li, Fucheng Zhou, Xuanxi Liu, Zhen Hao, Qingsong Li, Yongri Zheng, Weizhi Wang
Pages: 977-982
Published online on: 23 May 2016

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Article

Withaferin A inhibits inflammatory responses induced by Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans in macrophages

Eui‑Jeong Noh, Ming‑Jung Kang, Yu‑Jin Jeong, Jun‑Young Lee, Jung‑Hwan Park, Hye‑Jin Choi, Sang‑Muk Oh, Kyung‑Bok Lee, Dong‑Jae Kim, Ji‑Ae Shin, Sung‑Dae Cho, Jong‑Hwan Park
Pages: 983-988
Published online on: 23 May 2016

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Article

Activation of AMP-activated protein kinase reduces collagen production via p38 MAPK in cardiac fibroblasts induced by coxsackievirus B3

Shengyang Jiang, Donglin Jiang, Peng Zhao, Xinlong He, Shunli Tian, Xueming Wu, Yijia Tao
Pages: 989-994
Published online on: 20 May 2016

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Article

Overcoming cetuximab resistance in Ewing's sarcoma by inhibiting lactate dehydrogenase-A

Jiaxin Fu, Han Jiang, Chenxuan Wu, Yi Jiang, Lianping Xiao, Yonggang Tian
Pages: 995-1001
Published online on: 17 May 2016

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Article

Tm7sf2 may participate in the healing of burn wounds

Na Lei, Peng Wang, Qiang Meng
Pages: 1002-1006
Published online on: 19 May 2016

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Article

Heat stress pretreatment decreases lipopolysaccharide-induced apoptosis via the p38 signaling pathway in human umbilical vein endothelial cells

Zhifeng Liu, Tianyu Zhong, Dong Zheng, Inga Cepinskas, Tianqing Peng, Lei Su
Pages: 1007-1013
Published online on: 18 May 2016

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Article

Zeranol stimulates proliferation and aromatase activation in human breast preadipocytes

Saiyi Zhong, Shouchun Liu, Suhua Chen, Huajuan Lin, Weimin Wang, Xiaoming Qin
Pages: 1014-1018
Published online on: 18 May 2016

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Article

Downregulation of lncRNA CASC2 by microRNA-21 increases the proliferation and migration of renal cell carcinoma cells

Yunjie Cao, Renfang Xu, Xianlin Xu, Yaojun Zhou, Li Cui, Xiaozhou He
Pages: 1019-1025
Published online on: 24 May 2016

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Article

HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells

Zhiwei Wang, Xiaoyan Wang, Jiantian Li, Cheng Yang, Zhiyuan Xing, Ruiyun Chen, Fei Xu
Pages: 1026-1032
Published online on: 24 May 2016

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Article

miR-153 regulates apoptosis and autophagy of cardiomyocytes by targeting Mcl-1

Yuhai Zou, Wenting Liu, Jinxia Zhang, Dingcheng Xiang
Pages: 1033-1039
Published online on: 19 May 2016

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NEDD4 regulates VEGF signaling and mTOR to promote angiogenesis and the cell cycle in steroid‑induced osteonecrosis of the femoral head

Jian Li, Dong Zhen, Yuhuan Qin, Caifen Guo
Article Number: 49
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Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathway

Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheu
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Research progress on molecular therapy for glaucoma (Review)

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Natural compounds for the treatment of rheumatoid arthritis based on the ‘gut‑joint axis’ (Review)

Wenjie Hu, Rui Li, Zhongming Zhang
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TGM1 as a novel signature gene in psoriasis identified by integrative bioinformatics and experimental validation

Pan Guo, Mengke Sun, Jingyu Zhang, Qianshu Yuan, Hong Cui, Junkai Huang, Jing Luo, Qianyu Zhu, Bingxin Zhang, Lizhi Hu
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CDK1‑induced regulation of p53 phosphorylation at Ser315 mediates cell cycle arrest and apoptosis of macrophages infected with clinical isolates of Mycobacterium tuberculosis

Banghao Sun, Zhenyu Zhao, Qingyu Meng, Luya Pu, Xingyu Jiang, Shuai Li, Fadi Cao, Fan Li
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High‑intensity exercise training inhibits excessive autophagy in the hyperlipidemic myocardium of ApoE‑/‑ mice via the NAD+‑mediated SIRT1/MFN2 pathway

Shan Gao, Wei Yao, Jin Yang, Yujie Liu, Zuowei Pei
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[Corrigendum] Protective effects of metformin against myocardial ischemia‑reperfusion injury via AMPK‑dependent suppression of NOX4

Yan Shi, Shu-Ai Hou
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Apelin promotes RANKL‑mediated osteoclastogenesis by activating MAPK and NF‑κB pathways

Yu-Han Wang, Yu-Ying Wu, Chun-Hao Tsai, Yi-Chin Fong, Chih-Yuan Ko, Hsien-Te Chen, Yat-Yin Law, Chih-Hsin Tang
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Identification of multimorbidity hub genes for knee osteoarthritis-atherosclerosis and potential clinical applications

Qingyuan Kang, Ping Yuan, Peisen Xie, Wentao Xiao, Liguang Dong, Zhenpeng Guan, Keshi Zhang
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CTSB mediates oxidative stress and intestinal epithelial barrier disruption in intestinal ischemia‑reperfusion injury

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Astragaloside IV promotes the apoptosis of pancreatic cancer cells by activating endoplasmic reticulum stress through the PERK/ATF4/CHOP signaling pathway

Yijun Wang, Mengyang Zhao, Shanshan Liu, Rui Zheng, Tianhui Gao
Article Number: 38
Published online on: 11 November 2025

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[Retracted] Baicalin inhibits influenza virus A replication via activation of type I IFN signaling by reducing miR‑146a

Rui Li, Lianxin Wang
Article Number: 37
Published online on: 10 November 2025

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Migrasomes: Emerging players in intercellular communication and disease pathogenesis (Review)

Yuanliang Cao, Quan Wan, Boqi Zhou, Haixin Zeng, Xiaojie Lu
Article Number: 36
Published online on: 10 November 2025

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Diabetic keratopathy and nuclear proteins (Review)

Haiying Xu, Zhi-Liang Jiang, Yuehong Wang, Xiaoli Hou, Weixia Dong, Yanfang Chen, Qiuying Zhang, Xinying Ji, Shaoping Ji, Yalong Dang
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Published online on: 10 November 2025

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Homocystinuria: Advances in metabolic and molecular therapies targeting homocysteine pathways (Review)

Ayman A. Althubity
Article Number: 34
Published online on: 10 November 2025

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Synovial chondromatosis: Novel advances in understanding the pathogenesis and in diagnostic strategies (Review)

Xingzheng Deng, Shizhang Liu, Huitong Liu
Article Number: 33
Published online on: 10 November 2025

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Protective effects of Notoginsenoside R1 on the ferroptosis of a human non‑small cell lung cancer cell line

Yuejiao Zhang, Zhongshun Mao, Yong Diao
Article Number: 32
Published online on: 06 November 2025

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Unraveling the synergy of inflammation and apoptosis in sepsis-induced acute lung injury: Insights and therapeutic perspectives (Review)

Liwen Zhang, Haoxuan Li, Dongxu Li, Qingqing Dai
Article Number: 31
Published online on: 03 November 2025

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Dihydroalterperylenol from endophytic fungus Alternaria semiverrucosa and its antitumour activity uncovered by transcriptome analysis, molecular docking and molecular dynamics simulations

Mingfei Yang, Yongzhong Lu, Long Han, Zhangjiang He, Jichuan Kang
Article Number: 30
Published online on: 03 November 2025

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[Retracted] Phosphoinositide 3‑kinase/Akt pathway is involved in pingyangmycin‑induced growth inhibition, apoptosis and reduction of invasive potential in EOMA mouse hemangioendothelioma cells

Li-Xia Peng, Ping Zhao, Hong-Sheng Zhao, Er Pan, Bin-Bin Yang, Qin Li
Article Number: 29
Published online on: 03 November 2025

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Tight junction dysfunction and cytoskeletal remodeling in Hirschsprung‑associated enterocolitis: A decade of mechanistic insights and therapeutic prospects (Review)

Shuai Li, Chen Wang, Ling Zhang, Shan Chen, Ying Zhou, Dehua Yang, Kang Li, Yuan Liu, Shuiqing Chi, Yong Wang, Lizhi Li, Shao-Tao Tang
Article Number: 28
Published online on: 03 November 2025

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Involvement of the thioredoxin system in multiple diseases: A focus on mechanisms of action in autophagy and ferroptosis (Review)

Weihua Wang, Yingdong Mou, Dunlin Lu, Shanshan Xu
Article Number: 27
Published online on: 03 November 2025

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MicroRNA‑199a‑3p suppresses non‑small cell lung cancer progression by targeting FTO to enhance m6A‑mediated downregulation of MZF1 and its transcriptional activation of CLDND1

Yuzhen Cui, Xiaoqian Li, Hongkui Zhang, Weiqiang Yuan, Enbo Zhu
Article Number: 26
Published online on: 03 November 2025

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Role of ubiquitin‑proteasome system in preeclampsia (Review)

Chang-Zhu Pei, Xiao-Xing Song, Hao Xu, Kwang-Hyun Baek
Article Number: 25
Published online on: 03 November 2025

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Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai
Article Number: 24
Published online on: 03 November 2025

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The gut‑bone‑cartilage triad: Microbial regulation of the Wnt/β‑catenin signaling pathway in osteoarthritis joint remodeling (Review)

Ruipu Zhang, Liang Zhang, Bin Tian, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 23
Published online on: 31 October 2025

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Protective impact of landiolol against acute lung injury following hemorrhagic shock and resuscitation in rats

Risa Sakamoto, Hiroko Shimizu, Ryu Nakamura, Yifu Lu, Yaqiang Li, Emiko Omori, Toru Takahashi, Hiroshi Morimatsu
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Published online on: 31 October 2025

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Hidden connection: Impact of the gut microbiota on respiratory diseases in children (Review)

Yanhua Han, Yuchao Jia, Lili Chen, Mingyao Zhang
Article Number: 21
Published online on: 29 October 2025

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From renal development to pathology: An analysis of the multilevel role of insulin‑like growth factor 2 (Review)

Yuping Sun, Wenke Hao, Wei Liu, Wenxue Hu
Article Number: 20
Published online on: 29 October 2025

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[Corrigendum] Early anticoagulation therapy for severe burns complicated by inhalation injury in a rabbit model

Zhong-Hua Fu, Guang-Hua Guo, Zhen-Fang Xiong, Xincheng Liao, Ming-Zhuo Liu, Jinhua Luo
Article Number: 19
Published online on: 29 October 2025

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Mucin 2 and unfolded protein response reshape the mucus barrier in inflammatory bowel disease (Review)

Zhiwei Yuan, Zheng Xia, Liyun Ling, Jingzhe Xie, Feng Zhang
Article Number: 18
Published online on: 29 October 2025

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RING finger protein family in leukemia (Review)

Ye Wang, Yue Zhao, Jihong Zhang
Article Number: 17
Published online on: 29 October 2025

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Retinal light perception and biological rhythms: The role of light in sleep and mood from an ophthalmic perspective (Review)

Man Yuan, Hanxiang Liu, Ranjie Zhu, Yuzhen Li, Siyuan Song, Anhuai Yang
Article Number: 16
Published online on: 29 October 2025

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[Retracted] Oxymatrine‑mediated maturation of dendritic cells leads to activation of FOXP3+/CD4+ Treg cells and reversal of cisplatin‑resistance in lung cancer cells

Hui Liu, Manman Zou, Pei Li, Haifeng Wang, Xijun Lin, Jin Ye
Article Number: 15
Published online on: 27 October 2025

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Zinc finger protein 514 promotes esophageal cancer progression by enhancing cell proliferation, migration and invasion

Lin Lv, Xiaoming Sun, Houlu Zhang, Guangxu Wang, Chao Zhang, Haibo Liu, Liangming Zhu
Article Number: 14
Published online on: 24 October 2025

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Effects of zinc carnosine on bone loss in mice with diabetic osteoporosis 

Jingyuan Gao, Hao Yang, Qiangqiang Lian, Yunpeng Hu, Zhou Yang, Lei Xing, Ying Xue, Xiaoli Hou, Faming Tian, Dong Hu
Article Number: 13
Published online on: 24 October 2025

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Rapamycin improves endometriosis‑related infertility involving ovarian senescence via the PPARα/IGFBP2 pathway

Qiongwei Wu, Jiao Fan, Qingjing Sheng, Xiaoying He
Article Number: 12
Published online on: 24 October 2025

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Combining tadalafil and hyperbaric oxygen therapy protects against ovarian ischemia‑reperfusion damage in rats

Mehmet Akif Baktir, Mustafa Ermis, Esra Balcioglu, Betul Yalcin, Enes Karaman, Ahmet Cumaoglu
Article Number: 11
Published online on: 23 October 2025

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Liquid‑liquid phase separation of PHLDB2 promotes oral squamous cell carcinoma metastasis through regulating epithelial mesenchymal transition and PIK3CA expression

Kunyi Chen, Yuhong Wang, Jianing Cui, Qianrui Liu, Xiaoyong Liu, Wenjin Wang, Jinsong Hou
Article Number: 10
Published online on: 22 October 2025

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Mitochondrial gatekeeper in hepatocellular carcinoma: Unraveling the multifaceted roles of VDAC in metabolic reprogramming, apoptosis evasion and therapeutic innovation (Review)

Jie Wang, Yu Liang, Xiaotao Jia, Xinmao Yang, Danning Shi, Yuanchun Wang, Yanfang Pan
Article Number: 9
Published online on: 21 October 2025

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[Retracted] Knockdown of ubiquitin‑specific protease 51 attenuates cisplatin resistance in lung cancer through ubiquitination of zinc‑finger E‑box binding homeobox 1

Feng Zhou, Chunling Du, Donghui Xu, Jinchang Lu, Lei Zhou, Chaomin Wu, Bo Wu, Jianan Huang
Article Number: 8
Published online on: 20 October 2025

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Exploring the role of cytochrome P450 family 1 subfamily B member 1 and quercetin in modulating neuropathic pain after spinal cord injury

Pengyu Zhou, Lu Li, Yu Cao, Jiahao Chen, Chuyin Chen, Xiangsheng Zhang, Jiurong Chen, Yingdong Deng, Ziqiang Lin, Yupei Lai, Suo Wang, Simin Tang, Wenqi Zhang, Peng Sun, Jun Zhou
Article Number: 7
Published online on: 15 October 2025

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R‑loops in hepatocellular carcinoma: Bridging genomic instability and therapeutic opportunity (Review)

Ching-Hua Hsieh, Yueh-Wei Liu, Pei-Chin Chuang
Article Number: 6
Published online on: 15 October 2025

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Role and relevance of exosome-mediated epigenetic regulation in the pathogenesis, diagnosis and treatment of 
cardiovascular diseases (Review)

Yishuo Zhang, Shanshan Zhang, Yijing Li, Wenqi Jin, Liya Zhou, Jing Lu
Article Number: 5
Published online on: 15 October 2025

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PLIN5 deficiency ameliorates metabolic dysfunction‑associated fatty liver disease by inhibiting ferroptosis

Ya Li, Xiaohan Wang, Xuecui Yin, Xiaohui Zhu, Weiqi Cui, Lin Dong, Yu Xia, Ying Wang, Liu Liu, Pengyuan Zheng, Youcai Tang
Article Number: 4
Published online on: 14 October 2025

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Circadian clock genes: Their influence on liver metabolism, disease development and treatment (Review)

Junmin Wang, Mengxing Cao, Shen Li, Wen Pei, Jing Li, Zhen Wang
Article Number: 3
Published online on: 14 October 2025

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MALT1 inhibition by MI‑2 suppresses epithelial‑to‑mesenchymal transition and fibrosis by inactivating the NF‑κB pathway in high glucose‑treated HK‑2 cells

Yating Lan, Jian Ma, Huijun Chen, Chaohong Lan, Na Zhao
Article Number: 2
Published online on: 14 October 2025

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[Retracted] Protective effect of erythropoietin against myocardial injury in rats with sepsis and its underlying mechanisms

Xinliang Zhang, Shimin Dong, Yanjun Qin, Xiaohua Bian
Article Number: 1
Published online on: 14 October 2025

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February-2026 Volume 33 Issue 2

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Impact Factor: 3.5

CiteScore: 8.5

CiteScore Rank: Q1: #78/441 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 0.772

SCImago Journal Rank (SJR): 0.841

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Mitophagy and oxidative stress in chronic kidney disease (Review)

Quwu Mushuo, Yihuai Tian, Jianchun Li, Yanqin Qiu, Hui Fan, Qiongdan Hu, Qiong Zhang
Article Number: 61
Published online on: 04 December 2025

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ABCC9 knockdown attenuates isoproterenol‑induced myocardial hypertrophy by inhibiting the PI3K/AKT signaling pathway

Qian Peng, Rui Chang, Linlin Ma, Yanfei Li
Article Number: 60
Published online on: 04 December 2025

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MeCP2 suppresses ferroptosis to drive EMT in retinal pigment epithelial cells: Implications for PVR pathogenesis

Sibei Guo, Yongya Zhang, Xue Li, Xueru Zhao, Yingjuan Liang, Xiaohua Li
Article Number: 59
Published online on: 04 December 2025

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[Corrigendum] Screening for implicated genes in colorectal cancer using whole‑genome gene expression profiling

Long-Ci Sun, Hai-Xin Qian
Article Number: 58
Published online on: 04 December 2025

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Hyperoside prevents osteoporosis by activating the PI3K/AKT signaling pathway to inhibit oxidative stress and promote osteogenesis

Lirong Li, Huaidong Deng, Shabin Zhuan, Boyu Wu, Dawei Xiao
Article Number: 57
Published online on: 03 December 2025

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[Retracted] Interference with Tim‑3 protein expression attenuates the invasion of clear cell renal cell carcinoma and aggravates anoikis

Muming Yu, Bin Lu, Yancun Liu, Ying Me, Lijun Wang, Hui Li
Article Number: 56
Published online on: 01 December 2025

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Acetylshikonin induces ferroptosis via the lipid peroxidation pathway in osteosarcoma cells

Ji-Ying Chen, Guo-Shou Wang, Tsung-Ming Chang, Ju-Fang Liu
Article Number: 55
Published online on: 27 November 2025

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Liver X receptor: A potential target for inflammatory bowel disease and colorectal cancer (Review)

Yingjie Li, Xiaoyan Fu, Meiwen Bai, Jiaqi Zhou, Jiatai Qiu, Hongxia Zhang, Shujuan Liang, Meifang Liu
Article Number: 54
Published online on: 27 November 2025

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lncRNA NEAT1 promotes the proliferation of hemangioma cells by transcriptionally activating β‑catenin via enhancing H3K18 lactylation

Li Yu, Nian Zhou, Xiao-Liang Zhang, Xue-Jing Pang, Lu Xing, Yun-Jing Pu, Li Zhang, Jing-Nan Wu, Hong Shu
Article Number: 53
Published online on: 25 November 2025

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[Retracted] MicroRNA‑206 exerts anti‑oncogenic functions in esophageal squamous cell carcinoma by suppressing the c‑Met/AKT/mTOR pathway

Jin Zhang, Xianen Fa, Qingyong Zhang
Article Number: 52
Published online on: 25 November 2025

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