Open Access

Electroacupuncture ameliorates post-stroke learning and memory through minimizing ultrastructural brain damage and inhibiting the expression of MMP-2 and MMP-9 in cerebral ischemia-reperfusion injured rats

  • Authors:
    • Ruhui Lin
    • Kunqiang Yu
    • Xiaojie Li
    • Jing Tao
    • Yukun Lin
    • Congkuai Zhao
    • Chunyan Li
    • Li‑Dian Chen
  • View Affiliations

  • Published online on: May 9, 2016     https://doi.org/10.3892/mmr.2016.5227
  • Pages: 225-233
  • Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The aim of the present study was to investigate the potential neuroprotective effects of electroacupuncture (EA) in the treatment of cerebral ischemia/reperfusion (I/R) injury, and to elucidate the association between this neuroprotective effect and brain ultrastructure and expression of matrix metalloproteinase (MMP)‑2 and 9. Rats underwent focal cerebral I/R injury by arterial ligation and received in vivo therapeutic EA at the Baihui (DU20) and Shenting (DU24) acupoints. The therapeutic efficacy was then evaluated following the surgery. The results of the current study demonstrated that EA treatment significantly ameliorated neurological deficits and reduced cerebral infarct volume compared with I/R injured rats. Furthermore, EA improved the learning and memory ability of rats following I/R injury, inhibited blood brain barrier breakdown and reduced neuronal damage in the ischemic penumbra. Furthermore, EA attenuated ultrastructural changes in the brain tissue following ischemia and inhibited MMP‑2/MMP‑9 expression in cerebral I/R injured rats. The results suggest that EA ameliorates anatomical deterioration, and learning and memory deficits in rats with cerebral I/R injury.
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July-2016
Volume 14 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Lin R, Yu K, Li X, Tao J, Lin Y, Zhao C, Li C and Chen LD: Electroacupuncture ameliorates post-stroke learning and memory through minimizing ultrastructural brain damage and inhibiting the expression of MMP-2 and MMP-9 in cerebral ischemia-reperfusion injured rats. Mol Med Rep 14: 225-233, 2016
APA
Lin, R., Yu, K., Li, X., Tao, J., Lin, Y., Zhao, C. ... Chen, L. (2016). Electroacupuncture ameliorates post-stroke learning and memory through minimizing ultrastructural brain damage and inhibiting the expression of MMP-2 and MMP-9 in cerebral ischemia-reperfusion injured rats. Molecular Medicine Reports, 14, 225-233. https://doi.org/10.3892/mmr.2016.5227
MLA
Lin, R., Yu, K., Li, X., Tao, J., Lin, Y., Zhao, C., Li, C., Chen, L."Electroacupuncture ameliorates post-stroke learning and memory through minimizing ultrastructural brain damage and inhibiting the expression of MMP-2 and MMP-9 in cerebral ischemia-reperfusion injured rats". Molecular Medicine Reports 14.1 (2016): 225-233.
Chicago
Lin, R., Yu, K., Li, X., Tao, J., Lin, Y., Zhao, C., Li, C., Chen, L."Electroacupuncture ameliorates post-stroke learning and memory through minimizing ultrastructural brain damage and inhibiting the expression of MMP-2 and MMP-9 in cerebral ischemia-reperfusion injured rats". Molecular Medicine Reports 14, no. 1 (2016): 225-233. https://doi.org/10.3892/mmr.2016.5227