Open Access

CLI-095 decreases atherosclerosis by modulating foam cell formation in apolipoprotein E-deficient mice

  • Authors:
    • Xiao‑Qing Wang
    • Hui‑Qing Wan
    • Xian‑Jing Wei
    • Ying Zhang
    • Peng Qu
  • View Affiliations

  • Published online on: May 10, 2016     https://doi.org/10.3892/mmr.2016.5233
  • Pages: 49-56
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Toll-like receptor 4 (TLR4) is considered to have a critical role in the occurrence and development of atherosclerosis in atherosclerosis-prone mice; however, it remains uncertain whether treatment with a TLR4 inhibitor may attenuate atherosclerosis. The present study aimed to determine the vascular protective effects of the TLR4 inhibitor CLI-095 on apolipoprotein E‑deficient (ApoE‑/‑) mice. ApoE‑/‑ mice were fed either chow or a high‑fat diet, and were treated with or without CLI‑095 for 10 weeks. The mean atherosclerotic plaque area in the aortic sections of CLI‑095‑treated mice was 54.3% smaller than in the vehicle‑treated mice (P=0.0051). In vitro, murine peritoneal macrophages were treated with or without CLI‑095, and were subsequently stimulated with oxidized low‑density lipoprotein. Treatment with CLI‑095 markedly reduced the expression levels of lectin‑like oxidized low‑density lipoprotein receptor‑1 and acyl-coenzyme A:cholesterol acyltransferase‑1, and significantly upregulated the expression levels of ATP‑binding cassette transporter A1, predominantly via suppressing activation of the TLR4/nuclear factor‑κB signaling pathway. The results of the present study indicated that the TLR4 inhibitor CLI‑095 has the ability to suppress the progression of atherosclerosis in an in vivo model by reducing macrophage foam cell formation.
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July-2016
Volume 14 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Wang XQ, Wan HQ, Wei XJ, Zhang Y and Qu P: CLI-095 decreases atherosclerosis by modulating foam cell formation in apolipoprotein E-deficient mice. Mol Med Rep 14: 49-56, 2016
APA
Wang, X., Wan, H., Wei, X., Zhang, Y., & Qu, P. (2016). CLI-095 decreases atherosclerosis by modulating foam cell formation in apolipoprotein E-deficient mice. Molecular Medicine Reports, 14, 49-56. https://doi.org/10.3892/mmr.2016.5233
MLA
Wang, X., Wan, H., Wei, X., Zhang, Y., Qu, P."CLI-095 decreases atherosclerosis by modulating foam cell formation in apolipoprotein E-deficient mice". Molecular Medicine Reports 14.1 (2016): 49-56.
Chicago
Wang, X., Wan, H., Wei, X., Zhang, Y., Qu, P."CLI-095 decreases atherosclerosis by modulating foam cell formation in apolipoprotein E-deficient mice". Molecular Medicine Reports 14, no. 1 (2016): 49-56. https://doi.org/10.3892/mmr.2016.5233