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Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells

  • Authors:
    • Bin Liu
    • Yufeng Shi
    • Wending Peng
    • Qingyu Zhang
    • Jie Liu
    • Nianping Chen
    • Runzhi Zhu
  • View Affiliations / Copyright

    Affiliations: Laboratory of Hepatobiliary Surgery, Guangdong Medical University; Zhanjiang Key Laboratory of Hepatobiliary Diseases, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 159-164
    |
    Published online on: May 12, 2016
       https://doi.org/10.3892/mmr.2016.5258
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Abstract

Diosmetin (Dio) is a major active component of flavonoid compounds. A previous study demonstrated that Dio exhibited anticancer activity and induced apoptosis in HepG2 human hepatoma cells via cytochrome P450, family 1-catalyzed metabolism. The present study observed that cell proliferation of HepG2 cells was inhibited by Dio treatment and tumor protein p53 was significantly increased following Dio treatment. Following addition of recombinant transforming growth factor‑β (TGF‑β) protein to Dio‑treated HepG2 cells, cell growth inhibition and cell apoptosis was partially reversed. These findings suggest a novel function for the TGF‑β/TGF‑β receptor signaling pathway and that it may be a key target of Dio‑induced cell apoptosis in HepG2 cells.
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Copy and paste a formatted citation
Spandidos Publications style
Liu B, Shi Y, Peng W, Zhang Q, Liu J, Chen N and Zhu R: Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells. Mol Med Rep 14: 159-164, 2016.
APA
Liu, B., Shi, Y., Peng, W., Zhang, Q., Liu, J., Chen, N., & Zhu, R. (2016). Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells. Molecular Medicine Reports, 14, 159-164. https://doi.org/10.3892/mmr.2016.5258
MLA
Liu, B., Shi, Y., Peng, W., Zhang, Q., Liu, J., Chen, N., Zhu, R."Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells". Molecular Medicine Reports 14.1 (2016): 159-164.
Chicago
Liu, B., Shi, Y., Peng, W., Zhang, Q., Liu, J., Chen, N., Zhu, R."Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells". Molecular Medicine Reports 14, no. 1 (2016): 159-164. https://doi.org/10.3892/mmr.2016.5258
Copy and paste a formatted citation
x
Spandidos Publications style
Liu B, Shi Y, Peng W, Zhang Q, Liu J, Chen N and Zhu R: Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells. Mol Med Rep 14: 159-164, 2016.
APA
Liu, B., Shi, Y., Peng, W., Zhang, Q., Liu, J., Chen, N., & Zhu, R. (2016). Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells. Molecular Medicine Reports, 14, 159-164. https://doi.org/10.3892/mmr.2016.5258
MLA
Liu, B., Shi, Y., Peng, W., Zhang, Q., Liu, J., Chen, N., Zhu, R."Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells". Molecular Medicine Reports 14.1 (2016): 159-164.
Chicago
Liu, B., Shi, Y., Peng, W., Zhang, Q., Liu, J., Chen, N., Zhu, R."Diosmetin induces apoptosis by upregulating p53 via the TGF-β signal pathway in HepG2 hepatoma cells". Molecular Medicine Reports 14, no. 1 (2016): 159-164. https://doi.org/10.3892/mmr.2016.5258
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