Open Access

Proteomic and bioinformatic analyses of spinal cord injury‑induced skeletal muscle atrophy in rats

  • Authors:
    • Zhi‑Jian Wei
    • Xian‑Hu Zhou
    • Bao‑You Fan
    • Wei Lin
    • Yi‑Ming Ren
    • Shi‑Qing Feng
  • View Affiliations

  • Published online on: May 13, 2016     https://doi.org/10.3892/mmr.2016.5272
  • Pages: 165-174
  • Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Spinal cord injury (SCI) may result in skeletal muscle atrophy. Identifying diagnostic biomarkers and effective targets for treatment is an important challenge in clinical work. The aim of the present study is to elucidate potential biomarkers and therapeutic targets for SCI‑induced muscle atrophy (SIMA) using proteomic and bioinformatic analyses. The protein samples from rat soleus muscle were collected at different time points following SCI injury and separated by two‑dimensional gel electrophoresis and compared with the sham group. The identities of these protein spots were analyzed by mass spectrometry (MS). MS demonstrated that 20 proteins associated with muscle atrophy were differentially expressed. Bioinformatic analyses indicated that SIMA changed the expression of proteins associated with cellular, developmental, immune system and metabolic processes, biological adhesion and localization. The results of the present study may be beneficial in understanding the molecular mechanisms of SIMA and elucidating potential biomarkers and targets for the treatment of muscle atrophy.
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July-2016
Volume 14 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wei ZJ, Zhou XH, Fan BY, Lin W, Ren YM and Feng SQ: Proteomic and bioinformatic analyses of spinal cord injury‑induced skeletal muscle atrophy in rats. Mol Med Rep 14: 165-174, 2016
APA
Wei, Z., Zhou, X., Fan, B., Lin, W., Ren, Y., & Feng, S. (2016). Proteomic and bioinformatic analyses of spinal cord injury‑induced skeletal muscle atrophy in rats. Molecular Medicine Reports, 14, 165-174. https://doi.org/10.3892/mmr.2016.5272
MLA
Wei, Z., Zhou, X., Fan, B., Lin, W., Ren, Y., Feng, S."Proteomic and bioinformatic analyses of spinal cord injury‑induced skeletal muscle atrophy in rats". Molecular Medicine Reports 14.1 (2016): 165-174.
Chicago
Wei, Z., Zhou, X., Fan, B., Lin, W., Ren, Y., Feng, S."Proteomic and bioinformatic analyses of spinal cord injury‑induced skeletal muscle atrophy in rats". Molecular Medicine Reports 14, no. 1 (2016): 165-174. https://doi.org/10.3892/mmr.2016.5272