MicroRNA‑126 is downregulated in thyroid cancer cells, and regulates proliferation, migration and invasion by targeting CXCR4

  • Authors:
    • Yan Qian
    • Xiaoli Wang
    • Zhanlu Lv
    • Chen Guo
    • Yongjian Yang
    • Jinliang Zhang
    • Xianliang Wang
  • View Affiliations

  • Published online on: May 13, 2016     https://doi.org/10.3892/mmr.2016.5276
  • Pages: 453-459
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MicroRNA-126 (miR-126) has previously been reported to be downregulated in various types of cancer; however, at present, there are no studies of miR‑126 in human thyroid cancer. The present study aimed to determine the expression and effects of miR‑126 on thyroid cancer. The expression levels of miR‑126 were detected in human thyroid cancer tissues, matched normal adjacent tissues and human thyroid cancer cell lines using quantitative polymerase chain reaction. In addition, post‑transfection of human thyroid cancer cells with miR‑126 mimics, cell proliferation, migration and invasion assays, western blot analysis and luciferase assays were conducted. The results demonstrated that miR‑126 was downregulated in thyroid cancer tissues and cells. Furthermore, upregulation of miR‑126 inhibited cell proliferation, migration and invasion in thyroid cancer cells. The present study also provided evidence suggesting that miR‑126 may directly target C‑X‑C chemokine receptor type 4 (CXCR4) in thyroid cancer. These results indicated that miR‑126 may be investigated as a target for the treatment of thyroid cancer.
View Figures
View References

Related Articles

Journal Cover

July-2016
Volume 14 Issue 1

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Qian Y, Wang X, Lv Z, Guo C, Yang Y, Zhang J and Wang X: MicroRNA‑126 is downregulated in thyroid cancer cells, and regulates proliferation, migration and invasion by targeting CXCR4. Mol Med Rep 14: 453-459, 2016
APA
Qian, Y., Wang, X., Lv, Z., Guo, C., Yang, Y., Zhang, J., & Wang, X. (2016). MicroRNA‑126 is downregulated in thyroid cancer cells, and regulates proliferation, migration and invasion by targeting CXCR4. Molecular Medicine Reports, 14, 453-459. https://doi.org/10.3892/mmr.2016.5276
MLA
Qian, Y., Wang, X., Lv, Z., Guo, C., Yang, Y., Zhang, J., Wang, X."MicroRNA‑126 is downregulated in thyroid cancer cells, and regulates proliferation, migration and invasion by targeting CXCR4". Molecular Medicine Reports 14.1 (2016): 453-459.
Chicago
Qian, Y., Wang, X., Lv, Z., Guo, C., Yang, Y., Zhang, J., Wang, X."MicroRNA‑126 is downregulated in thyroid cancer cells, and regulates proliferation, migration and invasion by targeting CXCR4". Molecular Medicine Reports 14, no. 1 (2016): 453-459. https://doi.org/10.3892/mmr.2016.5276