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Prevention of ultraviolet radiation‑induced immunosuppression by sunscreen in Candida albicans‑induced delayed‑type hypersensitivity

  • Authors:
    • Quan Chen
    • Runxiang Li
    • Xiaoxia Zhao
    • Bihua Liang
    • Shaoyin Ma
    • Zhenjie Li
    • Huilan Zhu
  • View Affiliations / Copyright

    Affiliations: Guangzhou Institute of Dermatology, Guangzhou, Guangdong 510095, P.R. China, Department of Dermatology, Haikou City People's Hospital, Haikou, Hainan 570208, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 202-208
    |
    Published online on: May 13, 2016
       https://doi.org/10.3892/mmr.2016.5284
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Abstract

Ultraviolet (UV) radiation-induced immunosuppression leading to skin cancer has received increased attention in previous years. The present study aimed to investigate the immunoprotection offered by Anthelios sunscreen in a mouse model of Candida albicans‑induced delayed‑type hypersensitivity. Anthelios sunscreen was applied to the skin on the dorsal skin of BALB/c mice treated with a sub‑erythema dose of solar‑simulated radiation. Delayed‑type hypersensitivity was induced by immunization with Candida albicans. Changes in the skin thickness of the foot pads were measured, and immunosuppression rates were also evaluated. The expression levels of CD207, CD80 and CD86 in the Langerhans cells were semi‑quantitatively detected using Western blotting and immunohistochemical assays. The delayed‑type hypersensitivity mouse model was successfully established. The minimal erythema doses of UVA and UVB exposure to the mice were 2,000 and 145 mJ/cm2, respectively. The immunosuppression rates in the sunscreen group and non‑sunscreen group were 24.39 and 65.85%, respectively (P<0.01). The results of the Western blotting and immunohistochemistry showed that the expression levels of CD207 (P<0.01), CD80 (P<0.05) and CD86 (P<0.01) were higher in the sunscreen group, compared with those in the non‑sunscreen group. UV exposure reduced Candida albicans antigen‑induced delayed‑type hypersensitivity. Anthelios sunscreen was found to protect the skin from immunosuppression through the activation of epidermal Langerhans cells.
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Copy and paste a formatted citation
Spandidos Publications style
Chen Q, Li R, Zhao X, Liang B, Ma S, Li Z and Zhu H: Prevention of ultraviolet radiation‑induced immunosuppression by sunscreen in Candida albicans‑induced delayed‑type hypersensitivity. Mol Med Rep 14: 202-208, 2016.
APA
Chen, Q., Li, R., Zhao, X., Liang, B., Ma, S., Li, Z., & Zhu, H. (2016). Prevention of ultraviolet radiation‑induced immunosuppression by sunscreen in Candida albicans‑induced delayed‑type hypersensitivity. Molecular Medicine Reports, 14, 202-208. https://doi.org/10.3892/mmr.2016.5284
MLA
Chen, Q., Li, R., Zhao, X., Liang, B., Ma, S., Li, Z., Zhu, H."Prevention of ultraviolet radiation‑induced immunosuppression by sunscreen in Candida albicans‑induced delayed‑type hypersensitivity". Molecular Medicine Reports 14.1 (2016): 202-208.
Chicago
Chen, Q., Li, R., Zhao, X., Liang, B., Ma, S., Li, Z., Zhu, H."Prevention of ultraviolet radiation‑induced immunosuppression by sunscreen in Candida albicans‑induced delayed‑type hypersensitivity". Molecular Medicine Reports 14, no. 1 (2016): 202-208. https://doi.org/10.3892/mmr.2016.5284
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Q, Li R, Zhao X, Liang B, Ma S, Li Z and Zhu H: Prevention of ultraviolet radiation‑induced immunosuppression by sunscreen in Candida albicans‑induced delayed‑type hypersensitivity. Mol Med Rep 14: 202-208, 2016.
APA
Chen, Q., Li, R., Zhao, X., Liang, B., Ma, S., Li, Z., & Zhu, H. (2016). Prevention of ultraviolet radiation‑induced immunosuppression by sunscreen in Candida albicans‑induced delayed‑type hypersensitivity. Molecular Medicine Reports, 14, 202-208. https://doi.org/10.3892/mmr.2016.5284
MLA
Chen, Q., Li, R., Zhao, X., Liang, B., Ma, S., Li, Z., Zhu, H."Prevention of ultraviolet radiation‑induced immunosuppression by sunscreen in Candida albicans‑induced delayed‑type hypersensitivity". Molecular Medicine Reports 14.1 (2016): 202-208.
Chicago
Chen, Q., Li, R., Zhao, X., Liang, B., Ma, S., Li, Z., Zhu, H."Prevention of ultraviolet radiation‑induced immunosuppression by sunscreen in Candida albicans‑induced delayed‑type hypersensitivity". Molecular Medicine Reports 14, no. 1 (2016): 202-208. https://doi.org/10.3892/mmr.2016.5284
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