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Article

Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model

  • Authors:
    • Fang Li
    • Jian Luo
    • Zhixiong Wu
    • Ting Xiao
    • Ou Zeng
    • Lin Li
    • Yan Li
    • Jun Yang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China
  • Pages: 865-873
    |
    Published online on: May 17, 2016
       https://doi.org/10.3892/mmr.2016.5289
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Abstract

Endoplasmic reticulum (ER) stress is critical in the occurrence and development of diabetic cardiomyopathy (DC). Hydrogen sulfide (H2S) has been found to be the third gaseous signaling molecule with anti‑ER stress effects. Previous studies have shown that H2S acts as a potent inhibitor of fibrosis in the heart of diabetic rats. This study aimed to demonstrate whether H2S exhibits protective effects on the myocardium of streptozotocin (STZ)‑induced diabetic rats by suppressing ER stress. In this study, diabetic models were established by intraperitoneal (i.p.) injection of 40 mg/kg STZ. The STZ‑treated mice were divided into three groups, and subsequently treated with normal saline, 30 µmol/kg or 100 µmol/kg NaHS, i.p., respectively, for 8 weeks. The extent of myocyte hypertrophy was measured using hematoxylin and eosin‑stained sections and collagen components were investigated using immunostaining. The expression of glucose-regulated protein (Grp78), C/EBP‑homologous protein (CHOP) and caspase‑12 in the heart tissue of each group was detected by western blot analysis. It was demonstrated that H2S could improve myocardial hypertrophy and myocardial collagen deposition in diabetic rats. In addition, it could reduce the expression of Grp78, caspase-12 and CHOP. In conclusion, these findings demonstrate that H2S suppresses STZ‑induced ER stress in the hearts of rats, and it may serve as a novel cardioprotective agent for DC.
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Copy and paste a formatted citation
Spandidos Publications style
Li F, Luo J, Wu Z, Xiao T, Zeng O, Li L, Li Y and Yang J: Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model. Mol Med Rep 14: 865-873, 2016.
APA
Li, F., Luo, J., Wu, Z., Xiao, T., Zeng, O., Li, L. ... Yang, J. (2016). Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model. Molecular Medicine Reports, 14, 865-873. https://doi.org/10.3892/mmr.2016.5289
MLA
Li, F., Luo, J., Wu, Z., Xiao, T., Zeng, O., Li, L., Li, Y., Yang, J."Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model". Molecular Medicine Reports 14.1 (2016): 865-873.
Chicago
Li, F., Luo, J., Wu, Z., Xiao, T., Zeng, O., Li, L., Li, Y., Yang, J."Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model". Molecular Medicine Reports 14, no. 1 (2016): 865-873. https://doi.org/10.3892/mmr.2016.5289
Copy and paste a formatted citation
x
Spandidos Publications style
Li F, Luo J, Wu Z, Xiao T, Zeng O, Li L, Li Y and Yang J: Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model. Mol Med Rep 14: 865-873, 2016.
APA
Li, F., Luo, J., Wu, Z., Xiao, T., Zeng, O., Li, L. ... Yang, J. (2016). Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model. Molecular Medicine Reports, 14, 865-873. https://doi.org/10.3892/mmr.2016.5289
MLA
Li, F., Luo, J., Wu, Z., Xiao, T., Zeng, O., Li, L., Li, Y., Yang, J."Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model". Molecular Medicine Reports 14.1 (2016): 865-873.
Chicago
Li, F., Luo, J., Wu, Z., Xiao, T., Zeng, O., Li, L., Li, Y., Yang, J."Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model". Molecular Medicine Reports 14, no. 1 (2016): 865-873. https://doi.org/10.3892/mmr.2016.5289
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