Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2016 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2016 Volume 14 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways

  • Authors:
    • Yan‑Feng Liu
    • Yun‑Qing Bai
    • Ming Qi
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116011, P.R. China
  • Pages: 955-962
    |
    Published online on: May 18, 2016
       https://doi.org/10.3892/mmr.2016.5304
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The current study focuses on the protection of daidzein on nerves, as daidzein was demonstrated to have a protective effect on neurons of the central nervous system in a glutamate excitotoxicity and oxygen/glucose deprivation model. However, the effect of daidzein on the abdominal aortic aneurysm (AAA) remains unclear. The angiotensin II-induced AAA mouse model was utilized in the present study to determine the effect of daidzein on AAA. The results demonstrated that daidzein significantly attenuated incidence of AAA, max aortic aneurysm and mortality in the angiotensin II‑induced AAA mice. Daidzein had an anti‑inflammatory effect by inhibiting tumor necrosis factor α (TNF-α), interleukin 1β (IL‑1β) and nuclear factor κB (NF‑κB) protein expression. In addition, daidzein strongly suppressed the gene expression of cyclooxygenase (COX)‑2, matrix metalloproteinase 2 (MMP‑2), tissue inhibitor of metalloproteinase 1 (TIMP-1), transforming growth factor β1 (TGF‑β1), and inhibited inducible nitric oxide synthase (iNOS) protein expression in angiotensin II‑induced AAA mice. It also inhibited phosphorylation of the p38 mitogen-activated protein kinase (MAPK) signaling pathway. These results demonstrate, to the best of our knowledge for the first time, that the anti‑inflammatory effects and inhibitory mechanism of daidzein attenuates AAA in angiotensin II‑induced mice. Daidzein contains strong anti‑inflammatory activity and affects various mechanism pathways including the NF‑κB, p38MAPK and TGF-β1 pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Gyoten T, Doi T, Yamashita A, Fukahara K, Kotoh K and Yoshimura N: Ruptured abdominal aortic aneurysm and aortoiliac vein fistula. Asian Cardiovasc Thorac Ann. 23:449–451. 2015. View Article : Google Scholar

2 

Knops AM, Goossens A, Ubbink DT, Balm R, Koelemay MJ, Vahl AC, de Nie AJ, van den Akker PJ, Willems MC, Koedam NA, et al: A decision aid regarding treatment options for patients with an asymptomatic abdominal aortic aneurysm: A randomised clinical trial. Eur J Vasc Endovasc Surg. 48:276–283. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Bonfreschi V, Giuliani E, Malagnino FC, Navi A, Coppi G, Silingardi R, D'Amico R and Barbieri A: Analgesia during abdominal aortic aneurysm endovascular repair: Remifentanil vs. fentanyl-midazolam - a randomized controlled trial. Eur J Anaesthesiol. 26:782–787. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Candell L, Tucker LY, Goodney P, Walker J, Okuhn S, Hill B and Chang R: Early and delayed rupture after endovascular abdominal aortic aneurysm repair in a 10-year multicenter registry. J Vasc Surg. 60:1146–1152. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Choke E, Cockerill GW, Laing K, Dawson J, Wilson WR, Loftus IM and Thompson MM: Whole genome-expression profiling reveals a role for immune and inflammatory response in abdominal aortic aneurysm rupture. Eur J Vasc Endovasc Surg. 37:305–310. 2009. View Article : Google Scholar

6 

Watanabe A, Ichiki T, Sankoda C, Takahara Y, Ikeda J, Inoue E, Tokunou T, Kitamoto S and Sunagawa K: Suppression of abdominal aortic aneurysm formation by inhibition of prolyl hydroxylase domain protein through attenuation of inflammation and extracellular matrix disruption. Clin Sci (Lond). 126:671–678. 2014. View Article : Google Scholar

7 

Duellman T, Warren CL, Peissig P, Wynn M and Yang J: Matrix metalloproteinase-9 genotype as a potential genetic marker for abdominal aortic aneurysm. Circ Cardiovasc Genet. 5:529–537. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Henriksen NA, Sorensen LT, Jorgensen LN and Lindholt JS: Lack of association between inguinal hernia and abdominal aortic aneurysm in a population-based male cohort. Br J Surg. 100:1478–1482. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Takahashi Y, Maki T, Liang AC, Itoh K, Lok J, Osumi N and Arai K: p38 MAP kinase mediates transforming-growth factor-β1-induced upregulation of matrix metalloproteinase-9 but not -2 in human brain pericytes. Brain Res. 1593:1–8. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, Kurosaka M and Nishida K: Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Arthritis Res Ther. 14:R512012. View Article : Google Scholar : PubMed/NCBI

11 

Brown LC, Thompson SG, Greenhalgh RM and Powell JT: Endovascular Aneurysm Repair trial participants: Incidence of cardiovascular events and death after open or endovascular repair of abdominal aortic aneurysm in the randomized EVAR trial 1. Br J Surg. 98:935–942. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Walsh SR, Sadat U, Boyle JR, Tang TY, Lapsley M, Norden AG and Gaunt ME: Remote ischemic preconditioning for renal protection during elective open infrarenal abdominal aortic aneurysm repair: Randomized controlled trial. Vasc Endovascular Surg. 44:334–340. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Morbelli S, Ghigliotti G, Spinella G, Marini C, Bossert I, Cimmino M, Pane B, Rousas N, Cittadini G, Massollo M, et al: Systemic vascular inflammation in abdominal aortic aneurysm patients: A contrast-enhanced PET/CT study. Q J Nucl Med Mol Imaging. 58:299–309. 2014.PubMed/NCBI

14 

Lim TG, Kim JE, Lee SY, Park JS, Yeom MH, Chen H, Bode AM, Dong Z and Lee KW: The daidzein metabolite, 6,7,4′-Trihydroxyisoflavone, is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1. Int J Mol Sci. 15:21419–21432. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Choi EY, Jin JY, Lee JY, Choi JI, Choi IS and Kim SJ: Anti-inflammatory effects and the underlying mechanisms of action of daidzein in murine macrophages stimulated with Prevotella intermedia lipopolysaccharide. J Periodontal Res. 47:204–211. 2012. View Article : Google Scholar

16 

Zheng YH, Li FD, Tian C, Ren HL, Du J and Li HH: Notch γ-secretase inhibitor dibenzazepine attenuates angiotensin II-induced abdominal aortic aneurysm in ApoE knockout mice by multiple mechanisms. PLoS One. 8:e833102013. View Article : Google Scholar

17 

Soumyakrishnan S, Divya T, Kalayarasan S, Sriram N and Sudhandiran G: Daidzein exhibits anti-fibrotic effect by reducing the expressions of Proteinase activated receptor 2 and TGFβ1/smad mediated inflammation and apoptosis in Bleomycin-induced experimental pulmonary fibrosis. Biochimie. 103:23–36. 2014. View Article : Google Scholar : PubMed/NCBI

18 

King VL, Trivedi DB, Gitlin JM and Loftin CD: Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. Arterioscler Thromb Vasc Biol. 26:1137–1143. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Iezzi R, Cotroneo AR, Filippone A, Di Fabio F, Santoro M and Storto ML: MDCT angiography in abdominal aortic aneurysm treated with endovascular repair: Diagnostic impact of slice thickness on detection of endoleaks. AJR Am J Roentgenol. 189:1414–1420. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Dawson JA, Choke E, Loftus IM, Cockerill GW and Thompson MM: A randomised placebo-controlled double-blind trial to evaluate lipid-lowering pharmacotherapy on proteolysis and inflammation in abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 41:28–35. 2011. View Article : Google Scholar

21 

Peshkova IO, Schaefer G and Koltsova EK: Atherosclerosis and Aortic Aneurysm: Is inflammation a common denominator? FEBS J. Dec 24–2015.ePub ahead of print.

22 

Fu XM, Yamawaki-Ogata A, Oshima H, Ueda Y, Usui A and Narita Y: Intravenous administration of mesenchymal stem cells prevents angiotensin II-induced aortic aneurysm formation in apolipoprotein E-deficient mouse. J Transl Med. 11:1752013. View Article : Google Scholar : PubMed/NCBI

23 

Arnaoutoglou E, Kouvelos G, Papa N, Koulouras V, Milionis H and Matsagkas M: Regarding 'the impact of endograft type on inflammatory response after endovascular treatment of abdominal aortic aneurysm'. J Vasc Surg. 58:5702013. View Article : Google Scholar

24 

Gao F, Chambon P, Offermanns S, Tellides G, Kong W, Zhang X and Li W: Disruption of TGF-β signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm. Biochem Biophys Res Commun. 454:137–143. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Ciavarella C, Alviano F, Gallitto E, Ricci F, Buzzi M, Velati C, Stella A, Freyrie A and Pasquinelli G: Human Vascular Wall Mesenchymal Stromal Cells Contribute to Abdominal Aortic Aneurysm Pathogenesis Through an Impaired Immunomodulatory Activity and Increased Levels of Matrix Metalloproteinase-9. Circ J. 79:1460–1469. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Dilmé JF, Bellmunt S, Camacho M, Solà-Villà D, Romero JM, Escudero JR and Vila L: Influence of cardiovascular risk factors on levels of matrix metalloproteinases 2 and 9 in human abdominal aortic aneurysms. Eur J Vasc Endovasc Surg. 48:374–381. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Pay S, Abbasov T, Erdem H, Musabak U, Simsek I, Pekel A, Akdogan A, Sengul A and Dinc A: Serum MMP-2 and MMP-9 in patients with Behçet's disease: Do their higher levels correlate to vasculo-Behçet's disease associated with aneurysm formation? Clin Exp Rheumatol. 25:S70–75. 2007.PubMed/NCBI

28 

Khan AQ, Khan R, Rehman MU, Lateef A, Tahir M, Ali F and Sultana S: Soy isoflavones (daidzein & genistein) inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cutaneous inflammation via modulation of COX-2 and NF-κB in Swiss albino mice. Toxicology. 302:266–274. 2012. View Article : Google Scholar : PubMed/NCBI

29 

Armstrong PJ, Franklin DP, Carey DJ and Elmore JR: Suppression of experimental aortic aneurysms: Comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors. Ann Vasc Surg. 19:248–257. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Luehmann HP, Detering L, Fors BP, Pressly ED, Woodard PK, Randolph GJ, Gropler RJ, Hawker C and Liu Y: PET/CT Imaging of Chemokine Receptors in Inflammatory Atherosclerosis Using Targeted Nanoparticles. J Nucl Med. Jan 21–2016.ePub ahead of print. View Article : Google Scholar : PubMed/NCBI

31 

Rohm I, Atiskova Y, Drobnik S, Fritzenwanger M, Kretzschmar D, Pistulli R, Zanow J, Krönert T, Mall G, Figulla HR and Yilmaz A: Decreased regulatory T cells in vulnerable atherosclerotic lesions: Imbalance between pro- and anti-inflammatory cells in atherosclerosis. Mediators Inflamm. 2015:3647102015. View Article : Google Scholar : PubMed/NCBI

32 

Eo HS, Lee KB, Kim AK, Kim MH, Kim DH and Kim DI: Association with inflammatory cells and apolipoproteins to the progression of atherosclerosis. J Korean Surg Soc. 80:289–296. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Khan JA, Abdul Rahman MN, Mazari FA, Shahin Y, Smith G, Madden L, Fagan MJ, Greenman J, McCollum PT and Chetter IC: Intraluminal thrombus has a selective influence on matrix metalloproteinases and their inhibitors (tissue inhibitors of matrix metalloproteinases) in the wall of abdominal aortic aneurysms. Ann Vasc Surg. 26

34 

Takawale A, Fan D, Basu R, Shen M, Parajuli N, Wang W, Wang X, Oudit GY and Kassiri Z: Myocardial recovery from ischemia-reperfusion is compromised in the absence of tissue inhibitor of metalloproteinase 4. Circ Heart Fail. 7:652–662. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Zhang W, Han Y, Meng G, Bai W, Xie L, Lu H, Shao Y, Wei L, Pan S, Zhou S, et al: Direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion injury by activating nitric oxide synthase signaling in spontaneously hypertensive rats. J Am Heart Assoc. 3:e0006062014. View Article : Google Scholar : PubMed/NCBI

36 

Tang W, Yang J, Zhang F, Guo H, Peng F and Wang X: Activation of extracellular signal-regulated kinase 1/2 and Sp1 may contribute to the expression of tissue inhibitor of metal-loproteinases-1 induced by transforming growth factor-β1 in human pulmonary arterial smooth muscle cells. Cytotherapy. 16:225–233. 2014. View Article : Google Scholar

37 

Gao YD, Zheng JW, Li P, Cheng M and Yang J: Store-operated Ca2+ entry is involved in transforming growth factor-β1 facilitated proliferation of rat airway smooth muscle cells. J Asthma. 50:439–448. 2013. View Article : Google Scholar : PubMed/NCBI

38 

Golledge J, Clancy P, Jones GT, Cooper M, Palmer LJ, van Rij AM and Norman PE: Possible association between genetic polymorphisms in transforming growth factor beta receptors, serum transforming growth factor beta1 concentration and abdominal aortic aneurysm. Br J Surg. 96:628–632. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Dai J, Losy F, Guinault AM, Pages C, Anegon I, Desgranges P, Becquemin JP and Allaire E: Overexpression of transforming growth factor-beta1 stabilizes already-formed aortic aneurysms: A first approach to induction of functional healing by endovascular gene therapy. Circulation. 112:1008–1015. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Huang CK, Luo J, Lai KP, Wang R, Pang H, Chang E, Yan C, Sparks J, Lee SO, Cho J and Chang C: Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1α and transforming growth factor-β1 expression. Hypertension. 66:881–891. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Thompson AR, Cooper JA, Jones GT, Drenos F, van Bockxmeer FM, Biros E, Walker PJ, van Rij AM, Golledge J, Norman PE, et al: Assessment of the association between genetic polymorphisms in transforming growth factor beta, and its binding protein (LTBP), and the presence, and expansion, of Abdominal Aortic Aneurysm. Atherosclerosis. 209:367–373. 2010. View Article : Google Scholar

42 

Yang CQ, Li W, Li SQ, Li J, Li YW, Kong SX, Liu RM, Wang SM and Lv WM: MCP-1 stimulates MMP-9 expression via ERK 1/2 and p38 MAPK signaling pathways in human aortic smooth muscle cells. Cell Physiol Biochem. 34:266–276. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu YF, Bai YQ and Qi M: Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways. Mol Med Rep 14: 955-962, 2016.
APA
Liu, Y., Bai, Y., & Qi, M. (2016). Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways. Molecular Medicine Reports, 14, 955-962. https://doi.org/10.3892/mmr.2016.5304
MLA
Liu, Y., Bai, Y., Qi, M."Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways". Molecular Medicine Reports 14.1 (2016): 955-962.
Chicago
Liu, Y., Bai, Y., Qi, M."Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways". Molecular Medicine Reports 14, no. 1 (2016): 955-962. https://doi.org/10.3892/mmr.2016.5304
Copy and paste a formatted citation
x
Spandidos Publications style
Liu YF, Bai YQ and Qi M: Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways. Mol Med Rep 14: 955-962, 2016.
APA
Liu, Y., Bai, Y., & Qi, M. (2016). Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways. Molecular Medicine Reports, 14, 955-962. https://doi.org/10.3892/mmr.2016.5304
MLA
Liu, Y., Bai, Y., Qi, M."Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways". Molecular Medicine Reports 14.1 (2016): 955-962.
Chicago
Liu, Y., Bai, Y., Qi, M."Daidzein attenuates abdominal aortic aneurysm through NF-κB, p38MAPK and TGF-β1 pathways". Molecular Medicine Reports 14, no. 1 (2016): 955-962. https://doi.org/10.3892/mmr.2016.5304
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team