|
1
|
Van Gaal LF, Mertens IL and De Block CE:
Mechanisms linking obesity with cardiovascular disease. Nature.
444:875–880. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Dorresteijn JA, Visseren FL and Spiering
W: Mechanisms linking obesity to hypertension. Obes Rev. 13:17–26.
2012. View Article : Google Scholar
|
|
3
|
Bell JA, Kivimaki M and Hamer M:
Metabolically healthy obesity and risk of incident type 2 diabetes:
A meta-analysis of prospective cohort studies. Obes Rev.
15:504–515. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Cummings DE and Schwartz MW: Genetics and
pathophysiology of human obesity. Annu Rev Med. 54:453–471. 2003.
View Article : Google Scholar
|
|
5
|
Morigny P, Houssier M, Mouisel E and
Langin D: Adipocyte lipolysis and insulin resistance. Biochimie.
2015.Epub ahead of print. PubMed/NCBI
|
|
6
|
Fasshauer M and Blüher M: Adipokines in
health and disease. Trends Pharmacol Sci. 36:461–470. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Bluher M: Adipose tissue dysfunction
contributes to obesity related metabolic diseases. Best Pract Res
Clin Endocrinol Metab. 27:163–177. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Guilherme A, Virbasius JV, Puri V and
Czech MP: Adipocyte dysfunctions linking obesity to insulin
resistance and type 2 diabetes. Nat Rev Mol Cell Biol. 9:367–377.
2008. View
Article : Google Scholar : PubMed/NCBI
|
|
9
|
Bartel DP: MicroRNAs: Genomics,
biogenesis, mechanism and function. Cell. 116:281–297. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Kusakabe R and Inoue K: Developmental
regulation and evolution of muscle-specific microRNAs. Semin Cell
Dev Biol. 47–48:9–16. 2015. View Article : Google Scholar
|
|
11
|
Alvarez-Garcia I and Miska EA: MicroRNA
functions in animal development and human disease. Development.
132:4653–4662. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Sun M, Liu XH, Li JH, Yang JS, Zhang EB,
Yin DD, Liu ZL, Zhou J, Ding Y, Li SQ, et al: MiR-196a is
upregulated in gastric cancer and promotes cell proliferation by
downregulating p27(kip1). Mol Cancer Ther. 11:842–852. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Jung KH, Zhang J, Zhou C, Shen H, Gagea M,
Rodriguez-Aguayo C, Lopez-Berestein G, Sood AK and Beretta L:
Differentiation therapy for hepatocellular carcinoma: Multifaceted
effects of miR-148a on tumor growth and phenotype and liver
fibrosis. Hepatology. 63:864–879. 2016. View Article : Google Scholar :
|
|
14
|
Thomas H: Diabetes: Enterovirus
dysregulates islet miRNAs. Nat Rev Endocrinol. 12:22016.
|
|
15
|
Esau C, Kang X, Peralta E, Hanson E,
Marcusson EG, Ravichandran LV, Sun Y, Koo S, Perera RJ, Jain R, et
al: MicroRNA-143 regulates adipocyte differentiation. J Biol Chem.
279:52361–52365. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Chen L, Dai YM, Ji CB, Yang L, Shi CM, Xu
GF, Pang LX, Huang FY, Zhang CM and Guo XR: MiR-146b is a regulator
of human visceral preadipocyte proliferation and differentiation
and its expression is altered in human obesity. Mol Cell
Endocrinol. 393:65–74. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Gerin I, Bommer GT, McCoin CS, Sousa KM,
Krishnan V and MacDougald OA: Roles for miRNA-378/378* in adipocyte
gene expression and lipogenesis. Am J Physiol Endocrinol Metab.
299:E198–E206. 2010.PubMed/NCBI
|
|
18
|
Martinelli R, Nardelli C, Pilone V,
Buonomo T, Liguori R, Castanò I, Buono P, Masone S, Persico G,
Forestieri P, et al: miR-519d overexpression is associated with
human obesity. Obesity (Silver Spring). 18:2170–2176. 2010.
View Article : Google Scholar
|
|
19
|
Williams MD and Mitchell GM: MicroRNAs in
insulin resistance and obesity. Exp Diabetes Res. 2012:4846962012.
View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Zhu H and Leung SW: Identification of
microRNA biomarkers in type 2 diabetes: A meta-analysis of
controlled profiling studies. Diabetologia. 58:900–911. 2015.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Nesca V, Guay C, Jacovetti C, Menoud V,
Peyot ML, Laybutt DR, Prentki M and Regazzi R: Identification of
particular groups of microRNAs that positively or negatively impact
on beta cell function in obese models of type 2 diabetes.
Diabetologia. 56:2203–2012. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Shi C, Zhang M, Tong M, Yang L, Pang L,
Chen L, Xu, Chi X, Hong Q, Ni Y, et al: miR-148a is associated with
obesity and modulates adipocyte differentiation of mesenchymal stem
cells through Wnt signaling. Sci Rep. 5:99302015. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Yang L, Shi CM, Chen L, Pang LX, Xu GF, Gu
N, Zhu LJ, Guo XR, Ni YH and Ji CB: The biological effects of
hsa-miR-1908 in human adipocytes. Mol Biol Rep. 42:927–935. 2015.
View Article : Google Scholar
|
|
24
|
Wellen KE, Fucho R, Gregor MF, Furuhashi
M, Morgan C, Lindstad T, Vaillancourt E, Gorgun CZ, Saatcioglu F
and Hotamisligil GS: Coordinated regulation of nutrient and
inflammatory responses by STAMP2 is essential for metabolic
homeostasis. Cel. 129:537–548. 2007. View Article : Google Scholar
|
|
25
|
Kralisch S, Klein J, Lossner U, Bluher M,
Paschke R, Stumvoll M and Fasshauer M: Interleukin-6 is a negative
regulator of visfatin gene expression in 3T3-L1 adipocytes. Am J
Physiol Endocrinol Metab. 289:E586–E590. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Shi C, Zhu L, Chen X, Gu N, Chen L, Zhu L,
Yang L, Pang L, Guo X, Ji C and Zhang C: IL-6 and TNF-α induced
obesity-related inflammatory response through transcriptional
regulation of miR-146b. J Interferon Cytokine Res. 34:342–348.
2014. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Neville MJ, Collins JM, Gloyn AL, McCarthy
MI and Karpe F: Comprehensive human adipose tissue mRNA and
microRNA endogenous control selection for quantitative
real-time-PCR normalization. Obesity (Silver Spring). 19:888–892.
2011. View Article : Google Scholar
|
|
28
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
29
|
Leal VO and Mafra D: Adipokines in
obesity. Clin Chim Acta. 419:87–94. 2013. View Article : Google Scholar
|
|
30
|
Fornari F, Milazzo M, Chieco P, Negrini M,
Calin GA, Grazi GL, Pollutri D, Croce CM, Bolondi L and Gramantieri
L: MiR-199a-3p regulates mTOR and c-Met to influence the
doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res.
70:5184–5193. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Gao Y, Milazzo M, Chieco P, Negrini M,
Calin GA, Grazi GL, Pollutri D, Croce CM, Bolondi L and Gramantieri
L: CD44 is a direct target of miR-199a-3p and contributes to
aggressive progression in osteosarcoma. Sci Rep. 5:113652015.
View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Kinose Y, Sawada K, Nakamura K, Sawada I,
Toda A, Nakatsuka E, Hashimoto K, Mabuchi S, Takahashi K, Kurachi
H, et al: The hypoxia-related microRNA miR-199a-3p displays tumor
suppressor functions in ovarian carcinoma. Oncotarget.
6:11342–11856. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Minna E, Sawada K, Nakamura K, Sawada I,
Toda A, Nakatsuka E, Hashimoto K, Mabuchi S, Takahashi K, Kurachi
H, et al: miR-199a-3p displays tumor suppressor functions in
papillary thyroid carcinoma. Oncotarget. 5:2513–2528. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Zuk PA, Zhu M, Ashjian P, De Ugarte DA,
Huang JI, Mizuno H, Alfonso ZC, Fraser JK, Benhaim P and Hedrick
MH: Human adipose tissue is a source of multipotent stem cells. Mol
Biol Cell. 13:4279–4295. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Gesta S, Tseng YH and Kahn CR:
Developmental origin of fat: Tracking obesity to its source. Cell.
131:242–256. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Boeuf S, Klingenspor M, Van Hal NL,
Schneider T, Keijer J and Klaus S: Differential gene expression in
white and brown preadipocytes. Physiol Genomics. 7:15–25. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Bluher M and Mantzoros CS: From leptin to
other adipokines in health and disease: Facts and expectations at
the beginning of the 21st century. Metabolism. 64:131–145. 2015.
View Article : Google Scholar
|
|
38
|
Jéquier E: Leptin signaling, adiposity,
and energy balance. Ann N Y Acad Sci. 967:379–388. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Ahima RS, Prabakaran D, Mantzoros C, Qu D,
Lowell B, Maratos-Flier E and Flier JS: Role of leptin in the
neuroendocrine response to fasting. Nature. 382:250–252. 1996.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Considine RV, Sinha MK, Heiman ML,
Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee
LJ, Bauer TL, et al: Serum immunoreactive-leptin concentrations in
normal-weight and obese humans. N Engl J Med. 334:292–295. 1996.
View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Müller G, Ertl J, Gerl M and Preibisch G:
Leptin impairs metabolic actions of insulin in isolated rat
adipocytes. J Biol Chem. 272:10585–10593. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Steppan CM, Bailey ST, Bhat S, Brown EJ,
Banerjee RR, Wright CM, Patel HR, Ahima RS and Lazar MA: The
hormone resistin links obesity to diabetes. Nature. 409:307–312.
2001. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Chen BH, Song Y, Ding EL, Roberts CK,
Manson JE, Rifai N, Buring JE, Gaziano JM and Liu S: Circulating
levels of resistin and risk of type 2 diabetes in men and women:
Results from two prospective cohorts. Diabetes Care. 32:329–334.
2009. View Article : Google Scholar :
|
|
44
|
Sheng CH, Di J, Jin Y, Zhang YC, Wu M, Sun
Y and Zhang GZ: Resistin is expressed in human hepatocytes and
induces insulin resistance. Endocrine. 33:135–143. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Akira S, Taga T and Kishimoto T:
Interleukin-6 in biology and medicine. Adv Immunol. 54:1–78. 1993.
View Article : Google Scholar : PubMed/NCBI
|
|
46
|
Lai Y and Dong C: Therapeutic antibodies
that target inflammatory cytokines in autoimmune diseases. Int
Immunol. 28:181–188. 2016. View Article : Google Scholar
|
|
47
|
Hotamisligil GS, Shargill NS and
Spiegelman BM: Adipose expression of tumor necrosis factor-alpha:
Direct role in obesity-linked insulin resistance. Science.
259:87–91. 1993. View Article : Google Scholar : PubMed/NCBI
|
|
48
|
Roytblat L, Rachinsky M, Fisher A,
Greemberg L, Shapira Y, Douvdevani A and Gelman S: Raised
interleukin-6 levels in obese patients. Obes Res. 8:673–675. 2000.
View Article : Google Scholar
|
|
49
|
Eder K, Baffy N, Falus A and Fulop AK: The
major inflammatory mediator interleukin-6 and obesity. Inflamm Res.
58:727–736. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
50
|
Boden G: Role of fatty acids in the
pathogenesis of insulin resistance and NIDDM. Diabetes. 46:3–10.
1997. View Article : Google Scholar : PubMed/NCBI
|
|
51
|
Gustafson B, Gogg S, Hedjazifar S,
Jenndahl L, Hammarstedt A and Smith U: Inflammation and impaired
adipogenesis in hypertrophic obesity in man. Am J Physiol
Endocrinol Metab. 297:E999–E1003. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
52
|
Boden G: Obesity, insulin resistance and
free fatty acids. Curr Opin Endocrinol Diabetes Obes. 18:139–143.
2011. View Article : Google Scholar : PubMed/NCBI
|
|
53
|
Pei YF, Zhang L, Liu Y, Li J, Shen H, Liu
YZ, Tian Q, He H, Wu S, Ran S, et al: Meta-analysis of genome-wide
association data identifies novel susceptibility loci for obesity.
Hum Mol Genet. 23:820–830. 2014. View Article : Google Scholar :
|
|
54
|
Maier VH, Melvin DR, Lister CA, Chapman H,
Gould GW and Murphy GJ: v- and t-SNARE protein expression in models
of insulin resistance: Normalization of glycemia by rosiglitazone
treatment corrects overexpression of cellubrevin,
vesicle-associated membrane protein-2 and syntaxin 4 in skeletal
muscle of Zucker diabetic fatty rats. Diabetes. 49:618–625. 2000.
View Article : Google Scholar : PubMed/NCBI
|
|
55
|
Helenius K, Yang Y, Alasaari J and Mäkelä
TP: Mat1 inhibits peroxisome proliferator-activated receptor
gamma-mediated adipocyte differentiation. Mol Cell Biol.
29:315–323. 2009. View Article : Google Scholar
|
