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Article

Expression of ATP binding cassette E1 enhances viability and invasiveness of lung adenocarcinoma cells in vitro

  • Authors:
    • Ye Tian
    • Xin Tian
    • Xu Han
    • Yong Chen
    • Cheng‑Yang Song
    • Yan‑Bin Zhang
    • Da‑Li Tian
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China, Department of Molecular Oncology, Cancer Research Institute, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China
  • Pages: 1345-1350
    |
    Published online on: June 10, 2016
       https://doi.org/10.3892/mmr.2016.5388
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Abstract

ATP binding cassette E1 (ABCE1), a member of the family of ATP binding cassette transporters, has initially emerged as an RNase L inhibitor. As a highly conserved protein, it is involved in capsid assembly and translation processes of the human immunodeficiency virus as well as in tumor development and progression. Studies have shown that ABCE1 protein was overexpressed in lung carcinoma tissues and metastatic lymph nodes compared to normal lung tissues. However, little is known about the roles of ABCE1 in lung cancer. The present study investigated the biological effects of vector-mediated ABCE1 overexpression in lung cancer cells in vitro and examined the underlying molecular mechanisms. Overexpression of ABCE1 in the LTEP‑a-2 lung adenocarcinoma cell line was achieved by transfection with a plasmid containing full‑length ABCE1 cDNA. The ectopic expression of ABCE1 was shown to promote the viability and invasive capacity of lung cancer cells, and to in reduce p27 expression. However, overexpression of ABCE1 did not significantly affect the cell cycle distribution. In conclusion, the present study suggested that ABCE1 promotes the growth, invasion and metastasis of lung adenocarcinoma cells and may represent a potential biomarker and therapeutic target for lung cancer.
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1 

Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127:2893–2917. 2010. View Article : Google Scholar

2 

Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials. Non-small cell lung cancer collaborative group. BMJ. 311:899–909. 1995. View Article : Google Scholar : PubMed/NCBI

3 

Filipits M, Pirker R, Dunant A, Lantuejoul S, Schmid K, Huynh A, Haddad V, André F, Stahel R, Pignon JP, et al: Cell cycle regulators and outcome of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer: The international adjuvant lung cancer trial biologic program. J Clin Oncol. 25:2735–2740. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Mamdani H, Induru R and Jalal SI: Novel therapies in small cell-lung cancer. Transl Lung Cancer Res. 4:533–544. 2015.PubMed/NCBI

5 

Dean M, Hamon Y and Chimini G: The human ATP-binding cassette (ABC) transporter superfamily. J Lipid Res. 42:1007–1017. 2001.PubMed/NCBI

6 

Mendoza JL, Urcelay E, Lana R, Martín MC, López N, Guijarro LG, Mayol JA, Taxonera C, de la Concha EG, Peña AS and Díaz-Rubio M: MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn's disease. Inflamm Bowel Dis. 13:585–590. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Bisbal C, Martinand C, Silhol M, Lebleu B and Salehzada T: Cloning and characterization of a RNase L inhibitor. A new component of the interferon-regulated 2–5 A pathway. J Biol Chem. 270:13308–13317. 1995. View Article : Google Scholar : PubMed/NCBI

8 

Hassel BA, Zhou A, Sotomayor C, Maran A and Silverman RH: A dominant negative mutant of 2–5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon. EMBO J. 12:3297–3304. 1993.PubMed/NCBI

9 

Le Roy F, Bisbal C, Silhol M, Martinand C, Lebleu B and Salehzada T: The 2–5A/RNase L/RNase L inhibitor (RLI) [correction of (RNI)] pathway regulates mitochondrial mRNAs stability in interferon alpha-treated H9 cells. J Biol Chem. 276:48473–48482. 2001.PubMed/NCBI

10 

Chen ZQ, Dong J, Ishimura A, Daar I, Hinnebusch AG and Dean M: The essential vertebrate ABCE1 protein interacts with eukaryotic initiation factors. J Biol Chem. 281:7452–7457. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Pisareva VP, Skabkin MA, Hellen CU, Pestova TV and Pisarev AV: Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes. EMBO J. 30:1804–1817. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Huang B, Gao Y, Tian D and Zheng M: A small interfering ABCE1-targeting RNA inhibits the proliferation and inva-siveness of small cell lung cancer. Int J Mol Med. 25:687–693. 2010.PubMed/NCBI

13 

Ren Y, Li Y and Tian D: Role of the ABCE1 gene in human lung adenocarcinoma. Oncol Rep. 27:965–970. 2012.PubMed/NCBI

14 

Hlavata I, Mohelnikova-Duchonova B, Vaclavikova R, Liska V, Pitule P, Novak P, Bruha J, Vycital O, Holubec L, Treska V, et al: The role of ABC transporters in progression and clinical outcome of colorectal cancer. Mutagenesis. 27:187–196. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Furuta M, Kozaki KI, Tanaka S, Arii S, Imoto I and Inazawa J: MiR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis. 31:766–776. 2010. View Article : Google Scholar

16 

Tian Y, Han X and Tian DL: The biological regulation of ABCE1. IUBMB Life. 64:795–800. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Huang B, Zhou H, Lang X and Liu Z: SiRNA-induced ABCE1 silencing inhibits proliferation and invasion of breast cancer cells. Mol Med Rep. 10:1685–1690. 2014.PubMed/NCBI

18 

Wang L, Zhang M and Liu DX: Knock-down of ABCE1 gene induces G1/S arrest in human oral cancer cells. Int J Clin Exp Pathol. 7:5495–5504. 2014.PubMed/NCBI

19 

Tian Y, Tian X, Han X, Chen Y, Song CY, Jiang WJ and Tian DL: ABCE1 plays an essential role in lung cancer progression and metastasis. Tumor Biol. Jan 5–2016.Epub ahead of print. View Article : Google Scholar

20 

Nürenberg E and Tampé R: Tying up loose ends: Ribosome recycling in eukaryotes and archaea. Trends Biochem Sci. 38:64–74. 2013. View Article : Google Scholar

21 

Franckenberg S, Becker T and Beckmann R: Structural view on recycling of archaeal and eukaryotic ribosomes after canonical termination and ribosome rescue. Curr Opin Struct Biol. 22:786–796. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Khoshnevis S, Gross T, Rotte C, Baierlein C, Ficner R and Krebber H: The iron-sulphur protein RNase L inhibitor functions in translation termination. EMBO Rep. 11:214–219. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Yasui K, Mihara S, Zhao C, Okamoto H, Saito-Ohara F, Tomida A, Funato T, Yokomizo A, Naito S, Imoto I, et al: Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res. 64:1403–1410. 2004. View Article : Google Scholar : PubMed/NCBI

24 

Slingerland J and Pagano M: Regulation of the cdk inhibitor p27 and its deregulation in cancer. J Cell Physiol. 183:10–17. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Chu IM, Hengst L and Slingerland JM: The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy. Nat Rev Cancer. 8:253–267. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Esposito V, Baldi A, De Luca A, Groger AM, Loda M, Giordano GG, Caputi M, Baldi F, Pagano M and Giordano A: Prognostic role of the cyclin-dependent kinase Inhibitor p27 in non-small cell lung cancer. Cancer Res. 57:3381–3385. 1997.PubMed/NCBI

27 

Chen J, Willingham T, Shuford M and Nisen PD: Tumor suppression and inhibition of aneuploid cell accumulation in human brain tumor cells by ectopic overexpression of the cyclin-dependent kinase inhibitor p27KIP1. J Clin Invest. 97:1983–1988. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Díez-Juan A and Andrés V: Coordinate control of proliferation and migration by the p27kip1/cyclin-dependent kinase/retinoblastoma pathway in vascular smooth muscle cells and fibroblasts. Circ Res. 92:402–410. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Supriatno, Harada K, Kawaguchi S, Yoshida H and Sato M: Effect of p27Kip1 on the ability of invasion and metastasis of an oral cancer cell line. Oncol Rep. 10:527–532. 2003.PubMed/NCBI

30 

Alhebshi A, Sideri TC, Holland SL and Avery SV: The essential iron-sulfur protein Rli1 is an important target accounting for inhibition of cell growth by reactive oxygen species. Mol Biol Cell. 23:3582–3590. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Zhai C, Li Y, Mascarenhas C, et al: The function of ORAOV1/LTO1, a gene that is overexpressed frequently in cancer: Essential roles in the function and biogenesis of the ribosome. Oncogene. 33:484–494. 2014. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Tian Y, Tian X, Han X, Chen Y, Song CY, Zhang YB and Tian DL: Expression of ATP binding cassette E1 enhances viability and invasiveness of lung adenocarcinoma cells in vitro. Mol Med Rep 14: 1345-1350, 2016.
APA
Tian, Y., Tian, X., Han, X., Chen, Y., Song, C., Zhang, Y., & Tian, D. (2016). Expression of ATP binding cassette E1 enhances viability and invasiveness of lung adenocarcinoma cells in vitro. Molecular Medicine Reports, 14, 1345-1350. https://doi.org/10.3892/mmr.2016.5388
MLA
Tian, Y., Tian, X., Han, X., Chen, Y., Song, C., Zhang, Y., Tian, D."Expression of ATP binding cassette E1 enhances viability and invasiveness of lung adenocarcinoma cells in vitro". Molecular Medicine Reports 14.2 (2016): 1345-1350.
Chicago
Tian, Y., Tian, X., Han, X., Chen, Y., Song, C., Zhang, Y., Tian, D."Expression of ATP binding cassette E1 enhances viability and invasiveness of lung adenocarcinoma cells in vitro". Molecular Medicine Reports 14, no. 2 (2016): 1345-1350. https://doi.org/10.3892/mmr.2016.5388
Copy and paste a formatted citation
x
Spandidos Publications style
Tian Y, Tian X, Han X, Chen Y, Song CY, Zhang YB and Tian DL: Expression of ATP binding cassette E1 enhances viability and invasiveness of lung adenocarcinoma cells in vitro. Mol Med Rep 14: 1345-1350, 2016.
APA
Tian, Y., Tian, X., Han, X., Chen, Y., Song, C., Zhang, Y., & Tian, D. (2016). Expression of ATP binding cassette E1 enhances viability and invasiveness of lung adenocarcinoma cells in vitro. Molecular Medicine Reports, 14, 1345-1350. https://doi.org/10.3892/mmr.2016.5388
MLA
Tian, Y., Tian, X., Han, X., Chen, Y., Song, C., Zhang, Y., Tian, D."Expression of ATP binding cassette E1 enhances viability and invasiveness of lung adenocarcinoma cells in vitro". Molecular Medicine Reports 14.2 (2016): 1345-1350.
Chicago
Tian, Y., Tian, X., Han, X., Chen, Y., Song, C., Zhang, Y., Tian, D."Expression of ATP binding cassette E1 enhances viability and invasiveness of lung adenocarcinoma cells in vitro". Molecular Medicine Reports 14, no. 2 (2016): 1345-1350. https://doi.org/10.3892/mmr.2016.5388
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