|
1
|
Musso G, Gambino R, Cassader M and Pagano
G: Meta-analysis: Natural history of non-alcoholic fatty liver
disease (NAFLD) and diagnostic accuracy of non-invasive tests for
liver disease severity. Ann Med. 43:617–649. 2011. View Article : Google Scholar
|
|
2
|
Preiss D and Sattar N: Non-alcoholic fatty
liver disease: An overview of prevalence, diagnosis, pathogenesis
and treatment considerations. Clin Sci (Lond). 115:141–150. 2008.
View Article : Google Scholar
|
|
3
|
Day CP and James OF: Steatohepatitis: A
tale of two 'hits'? Gastroenterology. 114:842–845. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Musso G, Gambino R and Cassader M: Recent
insights into hepatic lipid metabolism in non-alcoholic fatty liver
disease (NAFLD). Prog Lipid Res. 48:1–26. 2009. View Article : Google Scholar
|
|
5
|
Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S,
Befroy D, Romanelli AJ and Shulman GI: Mechanism of hepatic insulin
resistance in non-alcoholic fatty liver disease. J Biol Chem.
279:32345–32353. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Bugianesi E, Mccullough AJ and Marchesini
G: Insulin resistance: A metabolic pathway to chronic liver
disease. Hepatology. 42:987–1000. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Wellen KE and Hotamisligil GS:
Inflammation, stress, and diabetes. J Clin Invest. 115:1111–1119.
2005. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Paz K, Hemi R, LeRoith D, Karasik A,
Elhanany E, Kanety H and Zick Y: A molecular basis for insulin
resistance. Elevated serine/threonine phosphorylation of IRS-1 and
IRS-2 inhibits their binding to the juxtamembrane region of the
insulin receptor and impairs their ability to undergo
insulin-induced tyrosine phosphorylation. J Biol Chem.
272:29911–29918. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Houstis N, Rosen ED and Lander ES:
Reactive oxygen species have a causal role in multiple forms of
insulin resistance. Nature. 440:944–948. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Videla LA, Rodrigo R, Araya J and
Poniachik J: Insulin resistance and oxidative stress
interdependency in non-alcoholic fatty liver disease. Trends Mol
Med. 12:555–558. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Evans JL, Maddux BA and Goldfine ID: The
molecular basis for oxidative stress-induced insulin resistance.
Antioxid Redox Signal. 7:1040–1052. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Zhang DD and Hannink M: Distinct cysteine
in Keap1 are required for Keap1-dependent ubiquitination on Nrf2
and for stabilization of Nrf2 by chemopreventive agents and
oxidative stress. Mol Cell Biol. 23:8137–8151. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Bataille AM and Manautou JE: Nrf2: A
potential target for new therapeutics in liver disease. Clin
Pharmacol Ther. 92:340–348. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Itoh K, Chiba T, Takahashi S, Ishii T,
Igarashi K, Katoh Y, Oyake T, Hayashi N, Satoh K, Hatayama I, et
al: An Nrf2/small Maf heterodimer mediates the induction of phase
II detoxifying enzyme genes through antioxidant response elements.
Biochem Biophys Res Commun. 236:313–322. 1997. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Chowdhry S, Nazmy MH, Meakin PJ,
Dinkova-Kostova AT, Walsh SV, Tsujita T, Dillon JF, Ashford ML and
Hayes JD: Loss of Nrf2 markedly exacerbates nonalcoholic
steatohepatitis. Free Radic Biol Med. 48:357–371. 2010. View Article : Google Scholar
|
|
16
|
Luley C, Ronquist G, Reuter W, Paal V,
Gottschling HD, Westphal S, King GL, Bakker SJ, Heine RJ and
Hattemer A: Point-of-care testing of triglycerides: Evaluation of
the Accutrend triglycerides system. Clin Chem. 46:287–291.
2000.PubMed/NCBI
|
|
17
|
Amaral ME, Oliveira HC, Carneiro EM,
Delghingaro-Augusto V, Vieira EC, Berti JA and Boschero AC: Plasma
glucose regulation and insulin secretion in hypertriglyceridemic
mice. Horm Metab Res. 34:21–26. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Angel MF, Ramasastry SS, Swartz WM,
Narayanan K, Kuhns DB, Basford RE and Futrell JW: The critical
relationship between free radicals and degrees of ischemia:
Evidence for tissue intolerance of marginal perfusion. Plast
Reconstr Surg. 81:233–239. 1988. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Zhong D, Zhang Y, Zeng YJ, Gao M, Wu GZ,
Hu CJ, Huang G and He FT: MicroRNA-613 represses lipogenesis in
HepG2 cells by downregulating LXRα. Lipids Health Dis. 12:322013.
View Article : Google Scholar
|
|
20
|
He L, Wang H, Jin H, Guo C, Xie H, Yan K,
Li X, Shen Q, Qiao T, Chen G, et al: CIAPIN1 inhibits the growth
and proliferation of clear cell renal cell carcinoma. Cancer Lett.
276:88–94. 2009. View Article : Google Scholar
|
|
21
|
Arkan MC, Hevener AL, Greten FR, Maeda S,
Li ZW, Long JM, Wynshaw-Boris A, Poli G, Olefsky J and Karin M:
IKK-beta links inflammation to obesity-induced insulin resistance.
Nat Med. 11:191–198. 2005. View
Article : Google Scholar : PubMed/NCBI
|
|
22
|
Nakamuta M, Kohjima M, Morizono S, Kotoh
K, Yoshimoto T, Miyagi I and Enjoji M: Evaluation of fatty acid
metabolism-related gene expression in nonalcoholic fatty liver
disease. Int J Mol Med. 16:631–635. 2005.PubMed/NCBI
|
|
23
|
Mantena SK, King AL, Andringa KK,
Eccleston HB and Bailey SM: Mitochondrial dysfunction and oxidative
stress in the pathogenesis of alcohol- and obesity-induced fatty
liver diseases. Free Radic Biol Med. 44:1259–1272. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
24
|
Kobayashi M and Yamamoto M: Nrf2-Keap1
regulation of cellular defense mechanisms against electrophiles and
reactive oxygen species. Adv Enzyme Regul. 46:113–140. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Liu M, Grigoryev DN, Crow MT, Haas M,
Yamamoto M, Reddy SP and Rabb H: Transcription factor Nrf2 is
protective during ischemic and nephrotoxic acute kidney injury in
mice. Kidney Int. 76:277–285. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Chan K, Lu R, Chang JC and Kan YW: NRF2, a
member of the NFE2 family of transcription factors, is not
essential for murine erythropoiesis, growth, and development. Proc
Natl Acad Sci USA. 93:13943–13948. 1996. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Okada K, Warabi E, Sugimoto H, Horie M,
Gotoh N, Tokushige K, Hashimoto E, Utsunomiya H, Takahashi H, Ishii
T, et al: Deletion of Nrf2 leads to rapid progression of
steatohepatitis in mice fed atherogenic plus high-fat diet. J
Gastroenterol. 48:620–632. 2013. View Article : Google Scholar
|
|
28
|
Sugimoto H, Okada K, Shoda J, Warabi E,
Ishige K, Ueda T, Taguchi K, Yanagawa T, Nakahara A, Hyodo I, et
al: Deletion of nuclear factor-E2-related factor-2 leads to rapid
onset and progression of nutritional steatohepatitis in mice. Am J
Physiol Gastrointest Liver Physiol. 298:G283–G294. 2010. View Article : Google Scholar
|
|
29
|
Marchesini G and Forlani G: NASH: From
liver diseases to metabolic disorders and back to clinical
hepatology. Hepatology. 35:497–499. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Hebbard L and George J: Animal models of
nonalcoholic fatty liver disease. Nat Rev Gastroenterol Hepatol.
8:35–44. 2011. View Article : Google Scholar
|
|
31
|
Biddinger SB and Kahn CR: From mice to
men: Insights into the insulin resistance syndromes. Annu Rev
Physiol. 68:123–158. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Tilg H and Moschen AR: Insulin resistance,
inflammation, and non-alcoholic fatty liver disease. Trends
Endocrinol Metab. 19:371–379. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Leclercq IA, Da Silva Morais A, Schroyen
B, Van Hul N and Geerts A: Insulin resistance in hepatocytes and
sinusoidal liver cells: Mechanisms and consequences. J Hepatol.
47:142–156. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Barnes PJ and Karin M: Nuclear
factor-kappaB: A pivotal transcription factor in chronic
inflammatory diseases. N Engl J Med. 336:1066–1071. 1997.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Baker RG, Hayden MS and Ghosh S: NF-κB,
inflammation, and metabolic disease. Cell Metab. 13:11–22. 2011.
View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Cai D, Yuan M, Frantz DF, Melendez PA,
Hansen L, Lee J and Shoelson SE: Local and systemic insulin
resistance resulting from hepatic activation of IKK-beta and
NF-kappaB. Nat Med. 11:183–190. 2005. View
Article : Google Scholar : PubMed/NCBI
|
|
37
|
Hayden MS and Ghosh S: Shared principles
in NF-kappaB signaling. Cell. 132:344–362. 2008. View Article : Google Scholar : PubMed/NCBI
|
