Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
August-2016 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
August-2016 Volume 14 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity

  • Authors:
    • Na‑Rae Kim
    • Sun‑Young Nam
    • Ka-Jung Ryu
    • Hyung‑Min Kim
    • Hyun‑Ja Jeong
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 130‑701, Republic of Korea, Department of Food Technology and Biochip Research Center, Hoseo University, Asan, Chungnam 336‑795, Republic of Korea
  • Pages: 1673-1680
    |
    Published online on: June 17, 2016
       https://doi.org/10.3892/mmr.2016.5407
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Korean bamboo salt (BS) is known to have therapeutic effects in the treatment of diseases, including viral disease, dental plaque, diabetes, circulatory organ disorders, cancer and inflammatory disorders. However, the effect of BS on immune functions remains to be elucidated. The present study was designed to determine the immune‑enhancing effect of BS and its component, hydrogen sulfide, using RAW264.7 macrophages and a forced swimming test (FST) animal model. BS and sodium hydrosulfide (NaSH), a hydrogen sulfide donor, significantly increased the levels of tumor necrosis factor (TNF)‑α through the activation of nuclear factor‑κB in the RAW 264.7 cells. In an in vivo experiment, BS and NaSH were administered orally once a day for 28 days. After the 28 days, the immobility times in the FST were significantly decreased in the BS and NaSH‑fed groups, compared with the control group. In addition, BS and NaSH induced significant increases in the levels of interferon‑γ, interleukin‑2 and TNF‑α, compared with the control group. Taken together, these results indicated that BS and NaSH may improve immune function.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Aderem A and Ulevitch RJ: Toll-like receptors in the induction of the innate immune response. Nature. 406:782–787. 2000. View Article : Google Scholar : PubMed/NCBI

2 

Hoffmann JA, Kafatos FC, Janeway CA and Ezekowitz RA: Phylogenetic perspectives in innate immunity. Science. 284:1313–1318. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Bonilla FA, Bernstein IL, Khan DA, Ballas ZK, Chinen J, Frank MM, Kobrynski LJ, Levinson AI, Mazer B, Nelson RP Jr, et al: Practice parameter for the diagnosis and management of primary immunodeficiency. Ann Allergy Asthma Immunol. 94(5 Suppl 1): S1–S63. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Younger EM, Epland K, Zampelli A and Hintermeyer MK: Primary immunodeficiency diseases: A primer for PCPs. Nurse Pract. 40:1–7. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Kaminogawa S and Nanno M: Modulation of immune functions by foods. Evid Based Complement Alternat Med. 1:241–250. 2004. View Article : Google Scholar

6 

Park HJ, Yang HJ, Kim KH and Kim SH: Aqueous extract of Orostachys japonicus A. Berger exerts immunostimulatory activity in RAW 264.7 macrophages. J Ethnopharmacol. 170:210–217. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Adams OD and Hamilton TA: Molecular basis of macrophage activation and its origins. Oxford University Press; New York: pp. 75–114. 1992

8 

Nathan C: Nitric oxide as a secretory product of mammalian cells. FASEB J. 6:3051–3064. 1992.PubMed/NCBI

9 

Jeong HJ, Han NR, Kim KY, Choi IS and Kim HM: Gomisin A decreases the LPS-induced expression of iNOS and COX-2 and activation of RIP2/NF-κB in mouse peritoneal macrophages. Immunopharmacol Immunotoxicol. 36:195–201. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Del Prete GF, De Carli M, Mastromauro C, Biagiotti R, Macchia D, Falagiani P, Ricci M and Romagnani S: Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production. J Clin Invest. 88:346–350. 1991. View Article : Google Scholar : PubMed/NCBI

11 

Carter LL and Dutton RW: Type 1 and type 2: A fundamental dichotomy for all T-cell subsets. Curr Opin Immunol. 8:336–342. 1996. View Article : Google Scholar : PubMed/NCBI

12 

Linder J: The thymus gland in secondary immunodeficiency. Arch Pathol Lab Med. 111:1118–1122. 1987.PubMed/NCBI

13 

Kim KY, Nam SY, Shin TY, Park KY, Jeong HJ and Kim HM: Bamboo salt reduces allergic responses by modulating the caspase-1 activation in an OVA-induced allergic rhinitis mouse model. Food Chem Toxicol. 50:3480–3488. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Kim YS, Lee EH and Kim HM: Surprisingly, traditional purple bamboo salt, unlike other salts does not induce hypertension in rats. TANG. 3:e162013.

15 

Nam SY, Oh HA, Choi Y, Park KY, Kim HM and Jeong HJ: Inhibition of IL-32 signaling by bamboo salt decreases pro-inflammatory responses in cellular models of allergic rhinitis. J Med Food. 17:939–948. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Shin HY, Na HJ, Moon PD, Shin T, Shin TY, Kim SH, Hong SH and Kim HM: Inhibition of mast cell dependent immediate-type hypersensitivity reactions by purple bamboo salt. J Ethnopharmacol. 91:153–157. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Zhao X, Kim SY and Park KY: Bamboo salt has in vitro anticancer activity in HCT-116 cells and exerts anti-metastatic effects in vivo. J Med Food. 16:9–19. 2013. View Article : Google Scholar

18 

Han J, Xuan JL, Hu HR and Chen ZW: Effects and mechanisms of hyperoside on vascular endothelium function in middle cerebral arteries of rats ex vivo. Zhongguo Zhong Yao Za Zhi. 39:4849–4855. 2014.In Chinese.

19 

Zhang Y, Li H, Zhao G, Sun A, Zong NC, Li Z, Zhu H, Zou Y, Yang X and Ge J: Hydrogen sulfide attenuates the recruitment of CD11b+Gr−1+myeloid cells and regulates Bax/Bcl−2 signaling in myocardial ischemia injury. Sci Rep. 4:47742014.

20 

Jeong HJ, Koo HN, Na HJ, Kim MS, Hong SH, Eom JW, Kim KS, Shin TY and Kim HM: Inhibition of TNF-alpha and IL-6 production by Aucubin through blockade of NF-kappaB activation RBL-2H3 mast cells. Cytokine. 18:252–259. 2002. View Article : Google Scholar : PubMed/NCBI

21 

Porsolt RD, Bertin A and Jalfre M: Behavioral despair in mice: A primary screening test for antidepressants. Arch Int Pharmacodyn Ther. 229:327–336. 1977.PubMed/NCBI

22 

An HJ, Choi HM, Park HS, Han JG, Lee EH, Park YS, Um JY, Hong SH and Kim HM: Oral administration of hot water extracts of Chlorella vulgaris increases physical stamina in mice. Ann Nutr Metab. 50:380–386. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Paul WE and Seder RA: Lymphocyte responses and cytokines. Cell. 76:241–251. 1994. View Article : Google Scholar : PubMed/NCBI

24 

Abbas AK, Murphy KM and Sher A: Functional diversity of helper T lymphocytes. Nature. 383:787–793. 1996. View Article : Google Scholar : PubMed/NCBI

25 

Cho CW, Han CJ, Rhee YK, Lee YC, Shin KS, Shin JS, Lee KT and Hong HD: Cheonggukjang polysaccharides enhance immune activities and prevent cyclophosphamide-induced immunosuppression. Int J Biol Macromol. 72:519–525. 2015. View Article : Google Scholar

26 

Baker RG, Hayden MS and Ghosh S: NF-κB, inflammation, and metabolic disease. Cell Metab. 13:11–22. 2011. View Article : Google Scholar : PubMed/NCBI

27 

Park SY, Kim HB, Kim JH, Lee JM, Kim SR, Shin HS and Yi TH: Immunostimulatory effect of fermented red ginseng in the mouse model. Prev Nutr Food Sci. 19:10–18. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Connor TJ, Kelliher P, Shen Y, Harkin A, Kelly JP and Leonard BE: Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test. Pharmacol Biochem Behav. 65:591–597. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Jeong HJ, Kim JH, Kim NR, Yoou MS, Nam SY, Kim KY, Choi Y, Jang JB, Kang IC, Baek NI and Kim HM: Antidepressant effect of Stillen. Arch Pharm Res. 38:1223–1231. 2015. View Article : Google Scholar

30 

Irwin M, Smith TL and Gillin JC: Low natural killer cytotoxicity in major depression. Life Sci. 41:2127–2133. 1987. View Article : Google Scholar : PubMed/NCBI

31 

Shu J, Stevenson JR and Zhou X: Modulation of cellular immune responses by cold water swim stress in the rat. Dev Comp Immunol. 17:357–371. 1993. View Article : Google Scholar : PubMed/NCBI

32 

Shin HY, Jeong HJ, Hyo-Jin-An, Hong SH, Um JY, Shin TY, Kwon SJ, Jee SY, Seo BI, Shin SS, et al: The effect of Panax ginseng on forced immobility time & immune function in mice. Indian J Med Res. 124:199–206. 2006.PubMed/NCBI

33 

Yamaguchi R, Kawata J, Yamamoto T, Ishimaru Y, Sakamoto A, Ono T, Narahara S, Sugiuchi H, Hirose E and Yamaguchi Y: Mechanism of interferon-gamma production by monocytes stimulated with myeloperoxidase and neutrophil extracellular traps. Blood Cells Mol Dis. 55:127–133. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Shaker MA and Younes HM: Interleukin-2: Evaluation of routes of administration and current delivery systems in cancer therapy. J Pharm Sci. 98:2268–2298. 2009. View Article : Google Scholar

35 

Lee JA, Kim YM, Hyun PM, Jeon JW, Park JK, Suh GH, Jung BG and Lee BJ: Honeybee (Apis mellifera) venom reinforces viral clearance during the early stage of infection with porcine reproductive and respiratory syndrome virus through the up-regulation of Th1-specific immune responses. Toxins (Basel). 7:1837–1853. 2015. View Article : Google Scholar

36 

Dalgleish AG: Cancer vaccines. Br J Cancer. 82:1619–1624. 2000.PubMed/NCBI

37 

An HJ, Rim HK, Jeong HJ, Hong SH, Um JY and Kim HM: Hot water extracts of Chlorella vulgaris improve immune function in protein-deficient weanling mice and immune cells. Immunopharmacol Immunotoxicol. 32:585–592. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Schafer AS, Leal MLR, Molento MB, et al: Immune response of lambs experimentally infected with Haemonchus contortus and parenterally treated with a combination of zinc and copper. Small Ruminant Res. 123:183–188. 2015. View Article : Google Scholar

39 

Jansen J, Karges W and Rink L: Zinc and diabetes-clinical links and molecular mechanisms. J Nutr Biochem. 20:399–417. 2009. View Article : Google Scholar : PubMed/NCBI

40 

Percival SS: Copper and immunity. Am J Clin Nutr. 67(5 Suppl): 1064S–1068S. 1998.PubMed/NCBI

41 

Tam M, Gómez S, González-Gross M and Marcos A: Possible roles of magnesium on the immune system. Eur J Clin Nutr. 57:1193–1197. 2003. View Article : Google Scholar : PubMed/NCBI

42 

Speich M, Pineau A and Ballereau F: Minerals, trace elements and related biological variables in athletes and during physical activity. Clin Chim Acta. 312:1–11. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Azizi F, Seifi B, Kadkhodaee M and Ahghari P: Administration of hydrogen sulfide protects ischemia reperfusion-induced acute kidney injury by reducing the oxidative stress. Ir J Med Sci. 2015.Epub ahead of print. PubMed/NCBI

44 

Hunter JP, Hosgood SA, Patel M, Furness P, Sayers RD and Nicholson ML: Hydrogen sulfide reduces inflammation following abdominal aortic occlusion in rats. Ann Vasc Surg. 29:353–360. 2015. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kim NR, Nam SY, Ryu K, Kim HM and Jeong HJ: Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity. Mol Med Rep 14: 1673-1680, 2016.
APA
Kim, N., Nam, S., Ryu, K., Kim, H., & Jeong, H. (2016). Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity. Molecular Medicine Reports, 14, 1673-1680. https://doi.org/10.3892/mmr.2016.5407
MLA
Kim, N., Nam, S., Ryu, K., Kim, H., Jeong, H."Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity". Molecular Medicine Reports 14.2 (2016): 1673-1680.
Chicago
Kim, N., Nam, S., Ryu, K., Kim, H., Jeong, H."Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity". Molecular Medicine Reports 14, no. 2 (2016): 1673-1680. https://doi.org/10.3892/mmr.2016.5407
Copy and paste a formatted citation
x
Spandidos Publications style
Kim NR, Nam SY, Ryu K, Kim HM and Jeong HJ: Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity. Mol Med Rep 14: 1673-1680, 2016.
APA
Kim, N., Nam, S., Ryu, K., Kim, H., & Jeong, H. (2016). Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity. Molecular Medicine Reports, 14, 1673-1680. https://doi.org/10.3892/mmr.2016.5407
MLA
Kim, N., Nam, S., Ryu, K., Kim, H., Jeong, H."Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity". Molecular Medicine Reports 14.2 (2016): 1673-1680.
Chicago
Kim, N., Nam, S., Ryu, K., Kim, H., Jeong, H."Effects of bamboo salt and its component, hydrogen sulfide, on enhancing immunity". Molecular Medicine Reports 14, no. 2 (2016): 1673-1680. https://doi.org/10.3892/mmr.2016.5407
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team