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Article

Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway

Corrigendum in: /10.3892/mmr.2022.12621
  • Authors:
    • Xue‑Jing Yue
    • Yan Guo
    • Hai‑Jie Yang
    • Zhi‑Wei Feng
    • Tong Li
    • Yu‑Ming Xu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450003, P.R. China, Department of Neurology, First Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan 453100, P.R. China, College of Life Science and Technology, Xinxiang Medical University, Xinxiang, Henan 453003, P.R. China
  • Pages: 1709-1713
    |
    Published online on: June 17, 2016
       https://doi.org/10.3892/mmr.2016.5411
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Abstract

Leptomeningeal fibrosis is important in the pathogenesis of communicating hydrocephalus following subarachnoid hemorrhage; however, the underlying mechanisms of leptomeningeal fibrosis remain largely unclear. In the present study, primary meningeal mesothelial cells (MMCs) were used as a cell model to investigate the effect of transforming growth factor‑β1 (TGF‑β1) on leptomeningeal fibrosis. Firstly, primary MMCs were isolated from rat brains and characterized by immunofluorescene, staining positive for keratin and vimentin, but negative for factor VIII. Upon TGF‑β1 treatment, MMCs were induced to express connective tissue growth factor (CTGF), an indicator of fibrosis, in a dose‑dependent manner. Furthermore, p38 mitogen‑activated protein kinase (MAPK) signaling was significantly activated by TGF‑β1. However, in the presence of a p38 MAPK inhibitor, TGF‑β1‑induced CTGF expression was markedly suppressed. Together, these data suggest that TGF‑β1 could induce fibrosis of MMCs via the p38 MAPK signaling pathway, providing a novel potential target for intervention in TGF‑β1‑induced leptomeningeal fibrosis.
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Copy and paste a formatted citation
Spandidos Publications style
Yue XJ, Guo Y, Yang HJ, Feng ZW, Li T and Xu YM: Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway Corrigendum in /10.3892/mmr.2022.12621. Mol Med Rep 14: 1709-1713, 2016.
APA
Yue, X., Guo, Y., Yang, H., Feng, Z., Li, T., & Xu, Y. (2016). Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway Corrigendum in /10.3892/mmr.2022.12621. Molecular Medicine Reports, 14, 1709-1713. https://doi.org/10.3892/mmr.2016.5411
MLA
Yue, X., Guo, Y., Yang, H., Feng, Z., Li, T., Xu, Y."Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway Corrigendum in /10.3892/mmr.2022.12621". Molecular Medicine Reports 14.2 (2016): 1709-1713.
Chicago
Yue, X., Guo, Y., Yang, H., Feng, Z., Li, T., Xu, Y."Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway Corrigendum in /10.3892/mmr.2022.12621". Molecular Medicine Reports 14, no. 2 (2016): 1709-1713. https://doi.org/10.3892/mmr.2016.5411
Copy and paste a formatted citation
x
Spandidos Publications style
Yue XJ, Guo Y, Yang HJ, Feng ZW, Li T and Xu YM: Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway Corrigendum in /10.3892/mmr.2022.12621. Mol Med Rep 14: 1709-1713, 2016.
APA
Yue, X., Guo, Y., Yang, H., Feng, Z., Li, T., & Xu, Y. (2016). Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway Corrigendum in /10.3892/mmr.2022.12621. Molecular Medicine Reports, 14, 1709-1713. https://doi.org/10.3892/mmr.2016.5411
MLA
Yue, X., Guo, Y., Yang, H., Feng, Z., Li, T., Xu, Y."Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway Corrigendum in /10.3892/mmr.2022.12621". Molecular Medicine Reports 14.2 (2016): 1709-1713.
Chicago
Yue, X., Guo, Y., Yang, H., Feng, Z., Li, T., Xu, Y."Transforming growth factor-β1 induces fibrosis in rat meningeal mesothelial cells via the p38 signaling pathway Corrigendum in /10.3892/mmr.2022.12621". Molecular Medicine Reports 14, no. 2 (2016): 1709-1713. https://doi.org/10.3892/mmr.2016.5411
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