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Article Open Access

Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats

  • Authors:
    • Jun Yan
    • Xue Yang
    • Dong Han
    • Juan Feng
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, The Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
    Copyright: © Yan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1601-1609
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    Published online on: June 23, 2016
       https://doi.org/10.3892/mmr.2016.5431
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Abstract

Multiple sclerosis (MS) is an inflammatory autoimmune neurodegenerative disease, which features focal demyelination and inflammatory cell infiltration of the brain and the spinal cord. Tanshinone IIA (TSIIA), one of the major fat‑soluble components of Salvia miltiorrhiza (Danshen), has anti‑inflammatory, immunoregulatory and neuroprotective activity; however, its efficacy in MS remains unknown. The current study was designed to investigate the potential therapeutic function of TSIIA on MS in the experimental autoimmune encephalomyelitis (EAE) rat model. In comparison to the vehicle control group, the TSIIA‑treated groups showed notably improved clinical symptoms and pathological changes, including central nervous system inflammatory cell infiltration and demyelination. Following administration of TSIIA, the quantity of CD4+ T cells, CD8+ T cells and macrophages/microglia in the spinal cord were reduced to different extents. Furthermore, TSIIA was also shown to downregulate interleukin (IL)‑17 and IL‑23 levels in the brain and serum of EAE rats. The results collectively provide evidence that TSIIA alleviates EAE and support its utility as a novel therapy for MS.
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1 

Rangachari M and Kuchroo VK: Using EAE to better understand principles of immune function and autoimmune pathology. J Autoimmun. 45:31–39. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Leuenberger T, Paterka M, Reuter E, Herz J, Niesner RA, Radbruch H, Bopp T, Zipp F and Siffrin V: The role of CD8 (+) T cells and their local interaction with CD4 (+) T cells in myelin oligodendrocyte glycoprotein 35–55-induced experimental autoimmune encephalomyelitis. J Immunol. 191:4960–4968. 2013. View Article : Google Scholar : PubMed/NCBI

3 

Cabarrocas J, Bauer J, Piaggio E, Liblau R and Lassmann H: Effective and selective immune surveillance of the brain by MHC class I-restricted cytotoxic T lymphocytes. Eur J Immunol. 33:1174–1182. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Fischer HG and Reichmann G: Brain dendritic cells and macrophages/microglia in central nervous system inflammation. J Immunol. 166:2717–2726. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Li Y, Chu N, Hu A, Gran B, Rostami A and Zhang GX: Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia. Brain. 130:490–501. 2007. View Article : Google Scholar

6 

Langrish CL, Chen Y, Blumenschein WM, Mattson J, Basham B, Sedgwick JD, McClanahan T, Kastelein RA and Cua DJ: IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J Exp Med. 201:233–240. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Luchtman DW, Ellwardt E, Larochelle C and Zipp F: IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: Current and future developments. Cytokine Growth Factor Rev. 25:403–413. 2014. View Article : Google Scholar : PubMed/NCBI

8 

McFarland HF and Martin R: Multiple sclerosis: A complicated picture of autoimmunity. Nat Immunol. 8:913–919. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Castro-Borrero W, Graves D, Frohman TC, Flores AB, Hardeman P, Logan D, Orchard M, Greenberg B and Frohman EM: Current and emerging therapies in multiple sclerosis: A systematic review. Ther Adv Neurol Disord. 5:205–220. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Wu B, Liu M and Zhang S: Cochrane systematic review: danshen agents for acute ischaemic stroke. Chinese Journal of Evidence-Based Medicine. 2:101–105. 2005.

11 

Cheng TO: Cardiovascular effects of Danshen. Int J Cardiol. 121:9–22. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Xu S and Liu P: Tanshinone II-A: New perspectives for old remedies. Expert Opin Ther Pat. 23:149–153. 2013. View Article : Google Scholar

13 

Ren B, Zhang YX, Zhou HX, Sun FW, Zhang ZF, Wei Z, Zhang CY and Si DW: Tanshinone IIA prevents the loss of nigrostriatal dopaminergic neurons by inhibiting NADPH oxidase and iNOS in the MPTP model of Parkinson's disease. J Neurol Sci. 348:142–152. 2015. View Article : Google Scholar

14 

Jiang P, Li C, Xiang Z and Jiao B: Tanshinone IIA reduces the risk of Alzheimer's disease by inhibiting iNOS, MMP-2 and NF-κBp65 transcription and translation in the temporal lobes of rat models of Alzheimer's disease. Mol Med Rep. 10:689–694. 2014.PubMed/NCBI

15 

Zhang K, Wang J, Jiang H, Xu X, Wang S, Zhang C, Li Z, Gong X and Lu W: Tanshinone IIA inhibits lipopolysaccharide-induced MUC1 overexpression in alveolar epithelial cells. Am J Physiol Cell Physiol. 306:C59–C65. 2014. View Article : Google Scholar

16 

Zhu W, Lu Q, Chen HW, Feng J, Wan L and Zhou DX: Protective effect of sodium tanshinone II A sulfonate on injury of small intestine in rats with sepsis and its mechanism. Chin J Integr Med. 18:496–501. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Liu M, Yang J and Li M: Tanshinone IIA attenuates interleukin-17A-induced systemic sclerosis patient-derived dermal vascular smooth muscle cell activation via inhibition of the extracellular signal-regulated kinase signaling pathway. Clinics (Sao Paulo). 70:250–256. 2015. View Article : Google Scholar

18 

Mao YS, Lu CZ, Wang X and Xiao BG: Induction of experimental autoimmune encephalomyelitis in Lewis rats by a viral peptide with limited homology to myelin basic protein. Exp Neurol. 206:231–239. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Jokubaitis VG, Gresle MM, Kemper DA, Doherty W, Perreau VM, Cipriani TL, Jonas A, Shaw G, Kuhlmann T, Kilpatrick TJ and Butzkueven H: Endogenously regulated Dab2 worsens inflammatory injury in experimental autoimmune encephalomyelitis. Acta Neuropathol Commun. 1:322013. View Article : Google Scholar : PubMed/NCBI

20 

Nitsch R, Pohl EE, Smorodchenko A, Infante-Duarte C, Aktas O and Zipp F: Direct impact of T cells on neurons revealed by two-photon microscopy in living brain tissue. J Neurosci. 24:2458–2464. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Aktas O, Smorodchenko A, Brocke S, Infante-Duarte C, Schulze Topphoff U, Vogt J, Prozorovski T, Meier S, Osmanova V, Pohl E, et al: Neuronal damage in autoimmune neuroinflammation mediated by the death ligand TRAIL. Neuron. 46:421–432. 2005. View Article : Google Scholar : PubMed/NCBI

22 

del Pilar Martin M, Cravens PD, Winger R, Frohman EM, Racke MK, Eagar TN, Zamvil SS, Weber MS, Hemmer B, Karandikar NJ, et al: Decrease in the numbers of dendritic cells and CD4+ T cells in cerebral perivascular spaces due to natalizumab. Arch Neurol. 65:1596–1603. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Babbe H, Roers A, Waisman A, Lassmann H, Goebels N, Hohlfeld R, Friese M, Schröder R, Deckert M, Schmidt S, et al: Clonal expansions of CD8 (+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micro-manipulation and single cell polymerase chain reaction. J Exp Med. 192:393–404. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Kuhlmann T, Lingfeld G, Bitsch A, Schuchardt J and Brück W: Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. Brain. 125:2202–2212. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Meuth SG, Herrmann AM, Simon OJ, Siffrin V, Melzer N, Bittner S, Meuth P, Langer HF, Hallermann S, Boldakowa N, et al: Cytotoxic CD8+ T cell-neuron interactions: Perforin-dependent electrical silencing precedes but is not causally linked to neuronal cell death. J Neurosci. 29:15397–15409. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Zang YC, Li S, Rivera VM, Hong J, Robinson RR, Breitbach WT, Killian J and Zhang JZ: Increased CD8+ cytotoxic T cell responses to myelin basic protein in multiple sclerosis. J Immunol. 172:5120–5127. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Yu Q, Chen H, Sheng L, Liang Y and Li Q: Sodium tanshinone IIA sulfonate prolongs the survival of skin allografts by inhibiting inflammatory cell infiltration and T cell proliferation. Int Immunopharmacol. 22:277–284. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Li HZ, Lu YH, Huang GS, Chen Q, Fu Q and Li ZL: Tanshinone II A inhibits dendritic cell-mediated adaptive immunity: Potential role in anti-atherosclerotic activity. Chin J Integr Med. 20:764–769. 2014. View Article : Google Scholar

29 

Nikić I, Merkler D, Sorbara C, Brinkoetter M, Kreutzfeldt M, Bareyre FM, Brück W, Bishop D, Misgeld T and Kerschensteiner M: A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis. Nat Med. 17:495–499. 2011. View Article : Google Scholar

30 

Pitt D, Werner P and Raine CS: Glutamate excitotoxicity in a model of multiple sclerosis. Nat Med. 6:67–70. 2000. View Article : Google Scholar

31 

Jack C, Ruffini F, Bar-Or A and Antel JP: Microglia and multiple sclerosis. J Neurosci Res. 81:363–373. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Chen TH, Hsu YT, Chen CH, Kao SH and Lee HM: Tanshinone IIA from Salvia miltiorrhiza induces heme oxygenase-1 expression and inhibits lipopolysaccharide-induced nitric oxide expression in RAW 264.7 cells. Mitochondrion. 7:101–105. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Choi HS, Cho DI, Choi HK, Im SY, Ryu SY and Kim KM: Molecular mechanisms of inhibitory activities of tanshinones on lipopolysaccharide-induced nitric oxide generation in RAW 264.7 cells. Arch Pharm Res. 27:1233–1237. 2004. View Article : Google Scholar

34 

Fan GW, Gao XM, Wang H, Zhu Y, Zhang J, Hu LM, Su YF, Kang LY and Zhang BL: The anti-inflammatory activities of Tanshinone IIA, an active component of TCM, are mediated by estrogen receptor activation and inhibition of iNOS. J Steroid Biochem Mol Biol. 113:275–280. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Cao FL, Xu M, Wang Y, Gong KR and Zhang JT: Tanshinone IIA attenuates neuropathic pain via inhibiting glial activation and immune response. Pharmacol Biochem Behav. 128:1–7. 2015. View Article : Google Scholar

36 

Huitinga I, van Rooijen N, de Groot CJ, Uitdehaag BM and Dijkstra CD: Suppression of experimental allergic encephalo-myelitis in Lewis rats after elimination of macrophages. J Exp Med. 172:1025–1033. 1990. View Article : Google Scholar : PubMed/NCBI

37 

Heppner FL, Greter M, Marino D, Falsig J, Raivich G, Hövelmeyer N, Waisman A, Rülicke T, Prinz M, Priller J, et al: Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat Med. 11:146–152. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Bullard DC, Hu X, Schoeb TR, Axtell RC, Raman C and Barnum SR: Critical requirement of CD11b (Mac-1) on T cells and accessory cells for development of experimental autoimmune encephalomyelitis. J Immunol. 175:6327–6333. 2005. View Article : Google Scholar : PubMed/NCBI

39 

Qin S, Wen J, Bai XC, Chen TY, Zheng RC, Zhou GB, Ma J, Feng JY, Zhong BL and Li YM: Endogenous n-3 polyunsaturated fatty acids protect against imiquimod-induced psoriasis-like inflammation via the IL-17/IL-23 axis. Mol Med Rep. 9:2097–2104. 2014.PubMed/NCBI

40 

Ghadimi D, Helwig U, Schrezenmeir J, Heller KJ and de Vrese M: Epigenetic imprinting by commensal probiotics inhibits the IL-23/IL-17 axis in an in vitro model of the intestinal mucosal immune system. J Leukoc Biol. 92:895–911. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Gaffen SL, Jain R, Garg AV and Cua DJ: The IL-23-IL-17 immune axis: From mechanisms to therapeutic testing. Nat Rev Immunol. 14:585–600. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Cua DJ, Sherlock J, Chen Y, Murphy CA, Joyce B, Seymour B, Lucian L, To W, Kwan S, Churakova T, et al: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature. 421:744–748. 2003. View Article : Google Scholar : PubMed/NCBI

43 

McGeachy MJ, Chen Y, Tato CM, Laurence A, Joyce-Shaikh B, Blumenschein WM, McClanahan TK, O'Shea JJ and Cua DJ: The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol. 10:314–324. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Gyuelveszi G, Haak S and Becher B: IL-23-driven encephalo-tropism and Th17 pola rization during CNS-inflammation in vivo. Eur J Immunol. 39:1864–1869. 2009. View Article : Google Scholar

45 

Ghoreschi K, Laurence A, Yang XP, Tato CM, McGeachy MJ, Konkel JE, Ramos HL, Wei L, Davidson TS, Bouladoux N, et al: Generation of pathogenic T (H) 17 cells in the absence of TGF-β signalling. Nature. 467:967–971. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Goverman J: Autoimmune T cell responses in the central nervous system. Nat Rev Immunol. 9:393–407. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Kebir H, Kreymborg K, Ifergan I, Dodelet-Devillers A, Cayrol R, Bernard M, Giuliani F, Arbour N, Becher B and Prat A: Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nat Med. 13:1173–1175. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Chen Y, Langrish CL, McKenzie B, Joyce-Shaikh B, Stumhofer JS, McClanahan T, Blumenschein W, Churakovsa T, Low J, Presta L, et al: Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encepha-lomyelitis. J Clin Invest. 116:1317–1326. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Tzartos JS, Friese MA, Craner MJ, Palace J, Newcombe J, Esiri MM and Fugger L: Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am J Pathol. 172:146–155. 2008. View Article : Google Scholar :

50 

Komiyama Y, Nakae S, Matsuki T, Nambu A, Ishigame H, Kakuta S, Sudo K and Iwakura Y: IL-17 plays an important role in the development of experimental autoimmune encephalomy-elitis. J Immunol. 177:566–573. 2006. View Article : Google Scholar : PubMed/NCBI

51 

Kawanokuchi J, Shimizu K, Nitta A, Yamada K, Mizuno T, Takeuchi H and Suzumura A: Production and functions of IL-17 in microglia. J Neuroimmunol. 194:54–61. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Trajkovic V, Stosic-Grujicic S, Samardzic T, Markovic M, Miljkovic D, Ramic Z and Mostarica Stojkovic M: Interleukin-17 stimulates inducible nitric oxide synthase activation in rodent astrocytes. J Neuroimmunol. 119:183–191. 2001. View Article : Google Scholar : PubMed/NCBI

53 

Wojkowska DW, Szpakowski P, Ksiazek-Winiarek D, Leszczynski M and Glabinski A: Interactions between neutrophils, Th17 cells and chemokines during the initiation of experimental model of multiple sclerosis. Mediators Inflamm. 2014:5904092014. View Article : Google Scholar

54 

Paintlia MK, Paintlia AS, Singh AK and Singh I: Synergistic activity of interleukin-17 and tumor necrosis factor-α enhances oxidative stress-mediated oligodendrocyte apoptosis. J Neurochem. 116:508–521. 2011. View Article : Google Scholar :

55 

Prineas JW, Barnard RO, Kwon EE, Sharer LR and Cho ES: Multiple sclerosis: Remyelination of nascent lesions. Ann Neurol. 33:137–151. 1993. View Article : Google Scholar : PubMed/NCBI

56 

Miossec P and Kolls JK: Targeting IL-17and TH17 cells in chronic inflammation. Nat Rev Drug Disco. 11:763–776. 2012. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Yan J, Yang X, Han D and Feng J: Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats. Mol Med Rep 14: 1601-1609, 2016.
APA
Yan, J., Yang, X., Han, D., & Feng, J. (2016). Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats. Molecular Medicine Reports, 14, 1601-1609. https://doi.org/10.3892/mmr.2016.5431
MLA
Yan, J., Yang, X., Han, D., Feng, J."Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats". Molecular Medicine Reports 14.2 (2016): 1601-1609.
Chicago
Yan, J., Yang, X., Han, D., Feng, J."Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats". Molecular Medicine Reports 14, no. 2 (2016): 1601-1609. https://doi.org/10.3892/mmr.2016.5431
Copy and paste a formatted citation
x
Spandidos Publications style
Yan J, Yang X, Han D and Feng J: Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats. Mol Med Rep 14: 1601-1609, 2016.
APA
Yan, J., Yang, X., Han, D., & Feng, J. (2016). Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats. Molecular Medicine Reports, 14, 1601-1609. https://doi.org/10.3892/mmr.2016.5431
MLA
Yan, J., Yang, X., Han, D., Feng, J."Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats". Molecular Medicine Reports 14.2 (2016): 1601-1609.
Chicago
Yan, J., Yang, X., Han, D., Feng, J."Tanshinone IIA attenuates experimental autoimmune encephalomyelitis in rats". Molecular Medicine Reports 14, no. 2 (2016): 1601-1609. https://doi.org/10.3892/mmr.2016.5431
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