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Screening targeted testis‑specific genes for molecular assessment of aberrant sperm quality

  • Authors:
    • Xue Xia Liu
    • Xiao Fang Shen
    • Fu‑Jun Liu
  • View Affiliations / Copyright

    Affiliations: Central Laboratory, Yantai Yu Huang Ding Hospital, Qingdao University, Yantai, Shandong 264000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1594-1600
    |
    Published online on: June 23, 2016
       https://doi.org/10.3892/mmr.2016.5434
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Abstract

Teratospermia is a heterogeneous and complex disorder, which is closely associated with male fertility. Genes and gene products associated with teratospermia may serve as targeted biomarkers that help understand the underlying mechanisms of male infertility; however, systematic information on the subject remains to be elucidated. The present study performed a comparative bioinformatics analysis to identify biomarkers associated with sperm quality, particular focusing on testis‑specific biomarkers. A stepwise screening approach identified 1,085 testis/epididymis‑specific genes and 3,406 teratospermia‑associated genes, resulting in 348 testis‑specific genes associated with aberrant sperm quality. These genes were functionally associated with the reproduction process. Gene products corresponding to heat shock protein family A (Hsp70) member 4 like (HSPA4L) and phosphoglycerate kinase 2 were characterized at the cellular level in human testes and ejaculated spermatozoa. HSPA4L expression in sperm was revealed to be associated with sperm quality. The present study provided a novel insight into the understanding of sperm quality, and a potential method for the diagnosis and assessment of sperm quality in the event of male infertility.
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1 

Olea N and Fernandez MF: Chemicals in the environment and human male fertility. Occup Environ Med. 64:430–431. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Rockliff HE, Lightman SL, Rhidian E, Buchanan H, Gordon U and Vedhara K: A systematic review of psychosocial factors associated with emotional adjustment in in vitro fertilization patients. Hum Reprod Update. 20:594–613. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Manfo FP, Nantia EA and Mathur PP: Effect of environmental contaminants on mammalian testis. Curr Mol Pharmacol. 7:119–135. 2014. View Article : Google Scholar

4 

Coutton C, Escoffier J, Martinez G, Arnoult C and Ray PF: Teratozoospermia: Spotlight on the main genetic actors in the human. Hum Reprod Update. 21:455–485. 2015. View Article : Google Scholar : PubMed/NCBI

5 

De Braekeleer M, Nguyen MH, Morel F and Perrin A: Genetic aspects of monomorphic teratozoospermia: A review. J Assist Reprod Genet. 32:615–623. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Brahem S, Elghezal H, Ghédir H, Landolsi H, Amara A, Ibala S, Gribaa M, Saad A and Mehdi M: Cytogenetic and molecular aspects of absolute teratozoospermia: Comparison between polymorphic and monomorphic forms. Urology. 78:1313–1319. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Hamatani T: Human spermatozoal RNAs. Fertil Steril. 97:275–281. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Dadoune JP: Spermatozoal RNAs: What about their functions? Microsc Res Tech. 72:536–551. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Zhao C, Huo R, Wang FQ, Lin M, Zhou ZM and Sha JH: Identification of several proteins involved in regulation of sperm motility by proteomic analysis. Fertil Steril. 87:436–438. 2007. View Article : Google Scholar

10 

Martinez-Heredia J, de Mateo S, Vidal-Taboada JM, Ballescà JL and Oliva R: Identification of proteomic differences in asthenozoospermic sperm samples. Hum Reprod. 23:783–791. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Chan CC, Shui HA, Wu CH, Wang CY, Sun GH, Chen HM and Wu GJ: Motility and protein phosphorylation in healthy and asthenozoospermic sperm. J Proteome Res. 8:5382–5386. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Siva AB, Kameshwari DB, Singh V, Pavani K, Sundaram CS, Rangaraj N, Deenadayal M and Shivaji S: Proteomics-based study on asthenozoospermia: Differential expression of proteasome alpha complex. Mol Hum Reprod. 16:452–462. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Shen S, Wang J, Liang J and He D: Comparative proteomic study between human normal motility sperm and idiopathic asthenozoospermia. World J Urol. 31:1395–1401. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Parte PP, Rao P, Redij S, Lobo V, D'Souza SJ, Gajbhiye R and Kulkarni V: Sperm phosphoproteome profiling by ultra performance liquid chromatography followed by data independent analysis (LC-MS (E)) reveals altered proteomic signatures in asthenozoospermia. J Proteomics. 75:5861–5871. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Amaral A, Paiva C, Attardo Parrinello C, Estanyol JM, Ballescà JL, Ramalho-Santos J and Oliva R: Identification of proteins involved in human sperm motility using high-throughput differential proteomics. J Proteome Res. 13:5670–5684. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Garrido N, García-Herrero S and Meseguer M: Assessment of sperm using mRNA microarray technology. Fertil Steril. 99:1008–1022. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Feugang JM, Rodriguez-Osorio N, Kaya A, Wang H, Page G, Ostermeier GC, Topper EK and Memili E: Transcriptome analysis of bull spermatozoa: Implications for male fertility. Reprod Biomed Online. 21:312–324. 2010. View Article : Google Scholar : PubMed/NCBI

18 

She X, Rohl CA, Castle JC, Kulkarni AV, Johnson JM and Chen R: Definition, conservation and epigenetics of housekeeping and tissue-enriched genes. BMC Genomics. 10:2692009. View Article : Google Scholar : PubMed/NCBI

19 

Platts AE, Dix DJ, Chemes HE, Thompson KE, Goodrich R, Rockett JC, Rawe VY, Quintana S, Diamond MP, Strader LF and Krawetz SA: Success and failure in human spermatogenesis as revealed by teratozoospermic RNAs. Hum Mol Genet. 16:763–773. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Hinton BT and Cooper TG: The epididymis as a target for male contraceptive development. Handb Exp Pharmacol. 198:117–137. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Gupta GS: LDH-C4: A target with therapeutic potential for cancer and contraception. Mol Cell Biochem. 371:115–127. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Dacheux JL and Dacheux F: New insights into epididymal function in relation to sperm maturation. Reproduction. 147:R27–R42. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Kogo H, Kowa Sugiyama H, Yamada K, Bolor H, Tsutsumi M, Ohye T, Inagaki H, Taniguchi M, Toda T and Kurahashi H: Screening of genes involved in chromosome segregation during meiosis I: Toward the identification of genes responsible for infertility in humans. J Hum Genet. 55:293–299. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Grimes SR: Testis-specific transcriptional control. Gene. 343:11–22. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Ounis L, Zoghmar A, Coutton C, Rouabah L, Hachemi M, Martinez D, Martinez G, Bellil I, Khelifi D, Arnoult C, et al: Mutations of the aurora kinase C gene causing macrozoospermia are the most frequent genetic cause of male infertility in Algerian men. Asian J Androl. 17:68–73. 2015. View Article : Google Scholar :

26 

Karaca N, Yilmaz R, Kanten GE, Kervancioglu E, Solakoglu S and Kervancioglu ME: First successful pregnancy in a globozoospermic patient having homozygous mutation in SPATA16. Fertil Steril. 102:103–107. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Koscinski I, Elinati E, Fossard C, Redin C, Muller J, Velez de la Calle J, Schmitt F, Ben Khelifa M, Ray PF, Kilani Z, et al: DPY19L2 deletion as a major cause of globozoospermia. Am J Hum Genet. 88:344–350. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Li X, Mao Z, Wu M and Xia J: Rescuing infertility of Pick1 knockout mice by generating testis-specific transgenic mice via testicular infection. Sci Rep. 3:28422013.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu XX, Shen XF and Liu FJ: Screening targeted testis‑specific genes for molecular assessment of aberrant sperm quality. Mol Med Rep 14: 1594-1600, 2016.
APA
Liu, X.X., Shen, X.F., & Liu, F. (2016). Screening targeted testis‑specific genes for molecular assessment of aberrant sperm quality. Molecular Medicine Reports, 14, 1594-1600. https://doi.org/10.3892/mmr.2016.5434
MLA
Liu, X. X., Shen, X. F., Liu, F."Screening targeted testis‑specific genes for molecular assessment of aberrant sperm quality". Molecular Medicine Reports 14.2 (2016): 1594-1600.
Chicago
Liu, X. X., Shen, X. F., Liu, F."Screening targeted testis‑specific genes for molecular assessment of aberrant sperm quality". Molecular Medicine Reports 14, no. 2 (2016): 1594-1600. https://doi.org/10.3892/mmr.2016.5434
Copy and paste a formatted citation
x
Spandidos Publications style
Liu XX, Shen XF and Liu FJ: Screening targeted testis‑specific genes for molecular assessment of aberrant sperm quality. Mol Med Rep 14: 1594-1600, 2016.
APA
Liu, X.X., Shen, X.F., & Liu, F. (2016). Screening targeted testis‑specific genes for molecular assessment of aberrant sperm quality. Molecular Medicine Reports, 14, 1594-1600. https://doi.org/10.3892/mmr.2016.5434
MLA
Liu, X. X., Shen, X. F., Liu, F."Screening targeted testis‑specific genes for molecular assessment of aberrant sperm quality". Molecular Medicine Reports 14.2 (2016): 1594-1600.
Chicago
Liu, X. X., Shen, X. F., Liu, F."Screening targeted testis‑specific genes for molecular assessment of aberrant sperm quality". Molecular Medicine Reports 14, no. 2 (2016): 1594-1600. https://doi.org/10.3892/mmr.2016.5434
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