Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2016 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2016 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts

  • Authors:
    • Gyöngyi Kirschner
    • Bernadett Balla
    • Péter Horváth
    • Andrea Kövesdi
    • Gergely Lakatos
    • István Takács
    • Zsolt Nagy
    • Bálint Tóbiás
    • Kristóf Árvai
    • János Pál Kósa
    • Péter Lakatos
  • View Affiliations / Copyright

    Affiliations: First Department of Internal Medicine, Semmelweis University, 1083 Budapest, Hungary, Second Department of Internal Medicine, Semmelweis University, 1083 Budapest, Hungary
    Copyright: © Kirschner et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2025-2037
    |
    Published online on: June 30, 2016
       https://doi.org/10.3892/mmr.2016.5459
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Numerous clinical observations have confirmed that breakpoint cluster region-abelson fusion oncoprotein tyrosine kinase inhibitors used in leukemia treatment alter bone physiology in a complex manner. The aim of the present study was to analyze the whole transcriptome of cultured murine osteoblasts and determine the changes following treatment with imatinib and nilotinib using Sequencing by Oligonucleotide Ligation and Detection next generation RNA sequencing. This study also aimed to identify candidate signaling pathways and network regulators by multivariate Ingenuity Pathway Analysis. Based on the right-tailed Fisher's exact test, significantly altered pathways including upstream regulators were defined for each drug. The correlation between these pathways and bone metabolism was also examined. The preliminary results suggest the two drugs have different mechanisms of action on osteoblasts, and imatinib was shown to have a greater effect on gene expression. Data also indicated the potential role of a number of genes and signaling cascades that may contribute to identifying novel targets for the treatment of metabolic bone diseases.
View Figures

Figure 1

View References

1 

Cohen MH, Moses ML and Pazdur R: Gleeve™ for the treatment of chronic myelogenous leukemia: U.S. food and drug administration regulatory mechanisms, accelerated approval, and orphan drug status. Oncologist. 7:390–392. 2002. View Article : Google Scholar

2 

Tibullo D, Barbagallo I, Giallongo C, La Cava P, Branca A, Conticello C, Stagno F, Chiarenza A, Palumbo GA and Di Raimondo F: Effects of second-generation tyrosine kinase inhibitors towards osteogenic differentiation of human mesenchymal cells of healthy donors. Hematol Oncol. 30:27–33. 2012. View Article : Google Scholar

3 

O'Sullivan S, Lin JM, Watson M, Callon K, Tong PC, Naot D, Horne A, Aati O, Porteous F, Gamble G, et al: The skeletal effects of the tyrosine kinase inhibitor nilotinib. Bone. 49:281–289. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Wihlidal P, Karlic H, Pfeilstöcker M, Klaushofer K and Varga F: Imatinib mesylate (IM)-induced growth inhibition is associated with production of spliced osteocalcin-mRNA in cell lines. Leuk Res. 32:437–443. 2008. View Article : Google Scholar

5 

Tibullo D, Giallongo C, La Cava P, Berretta S, Stagno F, Chiarenza A, Conticello C, Palumbo GA and Di Raimondo F: Effects of imatinib mesylate in osteoblastogenesis. Exp Hematol. 37:461–468. 2009. View Article : Google Scholar : PubMed/NCBI

6 

O'Sullivan S, Naot D, Callon K, Porteous F, Horne A, Wattie D, Watson M, Cornish J, Browett P and Grey A: Imatinib promotes osteoblast differentiation by inhibiting PDGFR signaling and inhibits osteoclastogenesis by both direct and stromal cell-dependent mechanisms. J Bone Miner Res. 22:1679–1689. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Fitter S, Dewar AL, Kostakis P, To LB, Hughes TP, Roberts MM, Lynch K, Vernon-Roberts B and Zannettino AC: Long-term imatinib therapy promotes bone formation in CML patients. Blood. 111:2538–2547. 2008. View Article : Google Scholar

8 

Jönsson S, Hjorth-Hansen H, Olsson B, Wadenvik H, Sundan A and Standal T: Imatinib inhibits proliferation of human mesenchymal stem cells and promotes early but not late osteoblast differentiation in vitro. J Bone Miner Metab. 30:119–123. 2012. View Article : Google Scholar

9 

Fierro F, Illmer T, Jing D, Schleyer E, Ehninger G, Boxberger S and Bornhauser M: Inhibition of platelet-derived growth factor receptorbeta by imatinib mesylate suppresses proliferation and alters differentiation of human mesenchymal stem cells in vitro. Cell Prolif. 40:355–366. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Vandyke K, Fitter S, Dewar AL, Hughes TP and Zannettino AC: Dysregulation of bone remodeling by imatinib mesylate. Blood. 115:766–774. 2010. View Article : Google Scholar

11 

Benito R, Lumbreras E, Abáigar M, Gutiérrez NC, Delgado M, Robledo C, García JL, Rodríguez-Vicente AE, Cañizo MC and Rivas JM: Imatinib therapy of chronic myeloid leukemia restores the expression levels of key genes for DNA damage and cell-cycle progression. Pharmacogenet Genomics. 22:381–388. 2012.PubMed/NCBI

12 

Vandyke K, Fitter S, Drew J, Fukumoto S, Schultz CG, Sims NA, Yeung DT, Hughes TP and Zannettino AC: Prospective histomorphometric and DXA evaluation of bone remodeling in imatinib-treated CML patients: Evidence for site-specific skeletal effects. J Clin Endocrinol Metab. 98:67–76. 2013. View Article : Google Scholar

13 

Berman E, Nicolaides M, Maki RG, Fleisher M, Chanel S, Scheu K, Wilson BA, Heller G and Sauter NP: Altered bone and mineral metabolism in patients receiving imatinib mesylate. N Engl J Med. 354:2006–2013. 2006. View Article : Google Scholar : PubMed/NCBI

14 

Berman E, Girotra M, Cheng C, Chanel S, Maki R, Shelat M, Strauss HW, Fleisher M, Heller G and Farooki A: Effect of long term imatinib on bone in adults with chronic myelogenous leukemia and gastrointestinal stromal tumors. Leuk Res. 37:790–794. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Jonsson S, Olsson B, Ohlsson C, Lorentzon M, Mellström D and Wadenvik H: Increased cortical bone mineralization in imatinib treated patients with chronic myelogenous leukemia. Haematologica. 93:1101–1103. 2008. View Article : Google Scholar : PubMed/NCBI

16 

O'Sullivan S, Horne A, Wattie D, Porteous F, Callon K, Gamble G, Ebeling P, Browett P and Grey A: Decreased bone turnover despite persistent secondary hyperparathyroidism during prolonged treatment with imatinib. J Clin Endocrinol Metab. 94:1131–1136. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Hoehn D, Medeiros LJ, Kantarjian HM, Cortes JE, Wang XM and Bueso-Ramos CE: Digital image analysis as a tool to assess the effects of imatinib on trabecular bone in patients with chronic myelogenous leukemia. Hum Pathol. 43:2354–2359. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Lawrence L: Long-term treatment with imatinib affected bone mineral density. Cancer Network; 2013

19 

Reiner A, Yekutieli D and Benjamini Y: Identifying differentially expressed genes using false discovery rate controlling procedures. Bioinformatics. 19:368–375. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Yoav Benjamini YH: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol. 57:289–300. 1995.

21 

Onishi M, Fujita Y, Yoshikawa H and Yamashita T: Inhibition of Rac1 promotes BMP-2-induced osteoblastic differentiation. Cell Death Dis. 4:e6982013. View Article : Google Scholar : PubMed/NCBI

22 

Ma Z, Thomas KS, Webb DJ, Moravec R, Salicioni AM, Mars WM and Gonias SL: Regulation of Rac1 activation by the low density lipoprotein receptor-related protein. J Cell Biol. 159:1061–1070. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Li S, Guo HB, Liu YS, Wu F, Zhang H, Zhang Z, Xie Z, Sheng Z and Liao E: Relationships of serum lipid profiles and bone mineral density in postmenopausal Chinese women. Clin Endocrinol (Oxf). 82:53–58. 2015. View Article : Google Scholar

24 

Lotinun S, Scott Pearsall R, Horne WC and Baron R: Activin receptor signaling: A potential therapeutic target for osteoporosis. Curr Mol Pharmacol. 5:S195–S204. 2012. View Article : Google Scholar

25 

Chanprasertyothin S, Saetung S, Rajatanavin R and Ongphiphadhanakul B: Genetic variant in the aquaporin 9 gene is associated with bone mineral density in postmenopausal women. Endocrine. 38:83–86. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Aharon R and Bar-Shavit Z: Involvement of aquaporin 9 in osteoclast differentiation. J Biol Chem. 281:19305–19309. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Liu Y, Song L, Wang Y, Rojek A, Nielsen S, Agre P and Carbrey JM: Osteoclast differentiation and function in aquaglyceroporin AQP9-null mice. Biol Cell. 101:133–140. 2009. View Article : Google Scholar

28 

Kraus DM, Elliott GS, Chute H, Horan T, Pfenninger KH, Sanford SD, Foster S, Scully S, Welcher AA and Holers VM: CSMD1 is a novel multiple domain complement-regulatory protein highly expressed in the central nervous system and epithelial tissues. J Immunol. 176:4419–4430. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Hiramitsu S, Terauchi M and Kubota T: The effects of Dickkopf-4 on the proliferation, differentiation, and apoptosis of osteoblasts. Endocrinology. 154:4618–4626. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Bais M, McLean J, Sebastiani P, Young M, Wigner N, Smith T, Kotton DN, Einhorn TA and Gerstenfeld LC: Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes. PLoS One. 4:e53932009. View Article : Google Scholar : PubMed/NCBI

31 

Aleman JO, Farooki A and Girotra M: Effects of tyrosine kinase inhibition on bone metabolism: Untargeted consequences of targeted therapies. Endocr Relat Cancer. 21:R247–R259. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Rix U, Hantschel O, Düernberger G, Remsing Rix LL, Planyavsky M, Fernbach NV, Kaupe I, Bennett KL, Valent P, Colinge J, et al: Chemical proteomic profiles of the BCR-ABL inhibitors imatinib, nilotinib and dasatinib, reveal novel kinase and nonkinase targets. Blood. 110:4055–4063. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Yang JY, Jung JY, Cho SW, Choi HJ, Kim SW, Kim SY, Kim HJ, Jang CH, Lee MG, Han J and Shin CS: Chloride intracellular channel 1 regulates osteoblast differentiation. Bone. 45:1175–1185. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Fujimori S, Hinoi E and Yoneda Y: Functional GABA (B) receptors expressed in cultured calvarial osteoblasts. Biochem Biophys Res Commun. 293:1445–1452. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Mentink A, Hulsman M, Groen N, Licht R, Dechering KJ, van der Stok J, Alves HA, Dhert WJ, van Someren EP, Reinders MJ, et al: Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1. Biomaterials. 34:4592–4601. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Muhammad SI, Maznah I, Mahmud R, Zuki AB and Imam MU: Upregulation of genes related to bone formation by γ-amino butyric acid and gamma-oryzanol in germinated brown rice is via the activation of GABA (B)-receptors and reduction of serum IL-6 in rats. Clin Interv Aging. 8:1259–1271. 2013. View Article : Google Scholar :

37 

Takahata Y, Takarada T, Hinoi E, Nakamura Y, Fujita H and Yoneda Y: Osteoblastic γ-aminobutyric acid, type B receptors negatively regulate osteoblastogenesis toward disturbance of osteoclastogenesis mediated by receptor activator of nuclear factor κB ligand in mouse bone. J Biol Chem. 286:32906–32917. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Schrauwen I, Ealy M, Huentelman MJ, Thys M, Homer N, Vanderstraeten K, Fransen E, Corneveaux JJ, Craig DW, Claustres M, et al: A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis. Am J Hum Genet. 84:328–338. 2009. View Article : Google Scholar : PubMed/NCBI

39 

May P, Herz J and Bock HH: Molecular mechanisms of lipo-protein receptor signalling. Cell Mol Life Sci. 62:2325–2338. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Westbroek I, van der Plas A, de Rooij KE, Klein-Nulend J and Nijweide PJ: Expression of serotonin receptors in bone. J Biol Chem. 276:28961–28968. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Bliziotes MM, Eshleman AJ, Zhang XW and Wiren KM: Neurotransmitter action in osteoblasts: Expression of a functional system for serotonin receptor activation and reuptake. Bone. 29:477–486. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Dai SQ, Yu LP, Shi X, Wu H, Shao P, Yin GY and Wei YZ: Serotonin regulates osteoblast proliferation and function in vitro. Braz J Med Biol Res. 47:759–765. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Yadav VK and Karsenty G: Serotonin: A new player in the regulation of bone remodeling. Medicographia. 32:357–363. 2010.

44 

Bliziotes M: Update in serotonin and bone. J Clin Endocrinol Metab. 95:4124–4132. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Ducy P and Karsenty G: The two faces of serotonin in bone biology. J Cell Biol. 191:7–13. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Battaglino R, Fu J, Späte U, Ersoy U, Joe M, Sedaghat L and Stashenko P: Serotonin regulates osteoclast differentiation through its transporter. J Bone Miner Res. 19:1420–1431. 2004. View Article : Google Scholar : PubMed/NCBI

47 

Saito A, Ochiai K, Kondo S, Tsumagari K, Murakami T, Cavener DR and Imaizumi K: Endoplasmic reticulum stress response mediated by the PERK-eIF2 alpha-ATF4 pathway is involved in osteoblast differentiation induced by BMP2. J Biol Chem. 286:4809–4818. 2011. View Article : Google Scholar

48 

Hamamura K and Yokota H: Stress to endoplasmic reticulum of mouse osteoblasts induces apoptosis and transcriptional activation for bone remodeling. FEBS Lett. 581:1769–1774. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Hirasawa H, Jiang C, Zhang P, Yang FC and Yokota H: Mechanical stimulation suppresses phosphorylation of eIF2alpha and PERK-mediated responses to stress to the endoplasmic reticulum. FEBS Lett. 584:745–752. 2010. View Article : Google Scholar

50 

Bais MV, Shabin ZM, Young M, Einhorn TA, Kotton DN and Gerstnefeld LC: Role of Nanog in the maintenance of marrow stromal stem cells during post natal bone regeneration. Biochem Biophys Res Commun. 417:211–216. 2012. View Article : Google Scholar :

51 

Suzuki A, Raya A, Kawakami Y, Morita M, Matsui T, Nakashima K, Gaget FH, Rodríguez-Esteban C and Izpisúa Belmonte JC: Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci USA. 103:10294–10299. 2006. View Article : Google Scholar : PubMed/NCBI

52 

Daluiski A, Engstrand T, Bahamonde ME, Gamer LW, Agius E, Stevenson SL, Cox K, Rosen V and Lyons KM: Bone morphogenetic protein-3 is a negative regulator of bone density. Nat Genet. 27:84–88. 2001. View Article : Google Scholar : PubMed/NCBI

53 

Bahamonde ME and Lyons KM: BMP3: To be or not to be a BMP. J Bone Joint Surg. 83-A(Suppl 1): S56–S62. 2001.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kirschner G, Balla B, Horváth P, Kövesdi A, Lakatos G, Takács I, Nagy Z, Tóbiás B, Árvai K, Kósa JP, Kósa JP, et al: Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts. Mol Med Rep 14: 2025-2037, 2016.
APA
Kirschner, G., Balla, B., Horváth, P., Kövesdi, A., Lakatos, G., Takács, I. ... Lakatos, P. (2016). Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts. Molecular Medicine Reports, 14, 2025-2037. https://doi.org/10.3892/mmr.2016.5459
MLA
Kirschner, G., Balla, B., Horváth, P., Kövesdi, A., Lakatos, G., Takács, I., Nagy, Z., Tóbiás, B., Árvai, K., Kósa, J. P., Lakatos, P."Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts". Molecular Medicine Reports 14.3 (2016): 2025-2037.
Chicago
Kirschner, G., Balla, B., Horváth, P., Kövesdi, A., Lakatos, G., Takács, I., Nagy, Z., Tóbiás, B., Árvai, K., Kósa, J. P., Lakatos, P."Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts". Molecular Medicine Reports 14, no. 3 (2016): 2025-2037. https://doi.org/10.3892/mmr.2016.5459
Copy and paste a formatted citation
x
Spandidos Publications style
Kirschner G, Balla B, Horváth P, Kövesdi A, Lakatos G, Takács I, Nagy Z, Tóbiás B, Árvai K, Kósa JP, Kósa JP, et al: Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts. Mol Med Rep 14: 2025-2037, 2016.
APA
Kirschner, G., Balla, B., Horváth, P., Kövesdi, A., Lakatos, G., Takács, I. ... Lakatos, P. (2016). Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts. Molecular Medicine Reports, 14, 2025-2037. https://doi.org/10.3892/mmr.2016.5459
MLA
Kirschner, G., Balla, B., Horváth, P., Kövesdi, A., Lakatos, G., Takács, I., Nagy, Z., Tóbiás, B., Árvai, K., Kósa, J. P., Lakatos, P."Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts". Molecular Medicine Reports 14.3 (2016): 2025-2037.
Chicago
Kirschner, G., Balla, B., Horváth, P., Kövesdi, A., Lakatos, G., Takács, I., Nagy, Z., Tóbiás, B., Árvai, K., Kósa, J. P., Lakatos, P."Effects of imatinib and nilotinib on the whole transcriptome of cultured murine osteoblasts". Molecular Medicine Reports 14, no. 3 (2016): 2025-2037. https://doi.org/10.3892/mmr.2016.5459
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team