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Expression and clinical significance of Apollon in esophageal squamous cell carcinoma

  • Authors:
    • Rong Li
    • Bo‑Lin Chen
    • Yan‑Wu Zhou
    • Ren‑Wei Guo
    • Meng‑Ting Shuai
    • Jun‑Xian Zeng
    • Ai‑Min Leng
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Xiangya Hospital, Changsha, Hunan 410008, P.R. China, Thoracic Medicine Department II, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South Univerisity, Changsha, Hunan 410013, P.R. China, Department of Thoracic Surgery, Xiangya Hospital, Central South Univerisity, Changsha, Hunan 410008, P.R. China, Department of Clinical Medicine, Hunan Xiangnan College, Chenzhou, Hunan 423043, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1933-1940
    |
    Published online on: July 6, 2016
       https://doi.org/10.3892/mmr.2016.5473
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Abstract

Apollon, an unusually large member of the inhibitors of apoptosis protein family, may be important for oncogenesis development. The aim of the present study was to assess the association between esophageal squamous cell carcinoma (ESCC) and Apollon expression levels, and to highlight the association between Apollon and the occurrence, development and prognosis of ESCC. Apollon expression was detected by immunohistochemical staining and reverse transcription-quantitative polymerase chain reaction in ESCC tissues, adjacent non‑cancerous tissues and paired normal tissues respectively, in order to analyze the association between Apollon expression and the clinicopathological features of ESCC. Survival analysis was used to assess the prognostic significance of Apollon expression. It was determined that the mRNA and protein expression levels of Apollon were significantly higher in the carcinoma tissues compared with the adjacent non‑cancerous tissues and normal control tissues (P<0.001). There was a significant difference in lymph node involvement and the tumor, nodes, and metastases stage in patients categorized according to different Apollon expression levels. The prognostic significance of Apollon was also determined using the log‑rank method. The overexpression of Apollon was associated with shorter overall survival and disease-free survival rates. The present study indicates that Apollon expression is associated with the biological characteristics of ESCC, and may be a valuable prognostic factor and a novel chemotherapeutic target for ESCC treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Li R, Chen BL, Zhou YW, Guo RW, Shuai MT, Zeng JX and Leng AM: Expression and clinical significance of Apollon in esophageal squamous cell carcinoma. Mol Med Rep 14: 1933-1940, 2016.
APA
Li, R., Chen, B., Zhou, Y., Guo, R., Shuai, M., Zeng, J., & Leng, A. (2016). Expression and clinical significance of Apollon in esophageal squamous cell carcinoma. Molecular Medicine Reports, 14, 1933-1940. https://doi.org/10.3892/mmr.2016.5473
MLA
Li, R., Chen, B., Zhou, Y., Guo, R., Shuai, M., Zeng, J., Leng, A."Expression and clinical significance of Apollon in esophageal squamous cell carcinoma". Molecular Medicine Reports 14.3 (2016): 1933-1940.
Chicago
Li, R., Chen, B., Zhou, Y., Guo, R., Shuai, M., Zeng, J., Leng, A."Expression and clinical significance of Apollon in esophageal squamous cell carcinoma". Molecular Medicine Reports 14, no. 3 (2016): 1933-1940. https://doi.org/10.3892/mmr.2016.5473
Copy and paste a formatted citation
x
Spandidos Publications style
Li R, Chen BL, Zhou YW, Guo RW, Shuai MT, Zeng JX and Leng AM: Expression and clinical significance of Apollon in esophageal squamous cell carcinoma. Mol Med Rep 14: 1933-1940, 2016.
APA
Li, R., Chen, B., Zhou, Y., Guo, R., Shuai, M., Zeng, J., & Leng, A. (2016). Expression and clinical significance of Apollon in esophageal squamous cell carcinoma. Molecular Medicine Reports, 14, 1933-1940. https://doi.org/10.3892/mmr.2016.5473
MLA
Li, R., Chen, B., Zhou, Y., Guo, R., Shuai, M., Zeng, J., Leng, A."Expression and clinical significance of Apollon in esophageal squamous cell carcinoma". Molecular Medicine Reports 14.3 (2016): 1933-1940.
Chicago
Li, R., Chen, B., Zhou, Y., Guo, R., Shuai, M., Zeng, J., Leng, A."Expression and clinical significance of Apollon in esophageal squamous cell carcinoma". Molecular Medicine Reports 14, no. 3 (2016): 1933-1940. https://doi.org/10.3892/mmr.2016.5473
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