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Dynamic co-expression network analysis of lncRNAs and mRNAs associated with venous congestion

  • Authors:
    • Jinshun Li
    • Yuqin Xu
    • Jia Xu
    • Jinhua Wang
    • Liying Wu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Heilongjiang Provincial Hospital, Harbin, Heilongjiang 150001, P.R. China, Infectious Disease Department, Harbin Binghua Hospital, Harbin, Heilongjiang 150086, P.R. China, Department of Nephrology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Pharmacy Intravenous Admixture Services, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2045-2051
    |
    Published online on: July 7, 2016
       https://doi.org/10.3892/mmr.2016.5480
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Abstract

Venous congestion and volume overload are important in cardiorenal syndromes, in which multiple regulated factors are involved, including long non‑coding RNAs (lncRNAs). To investigate the underlying role of lncRNAs in regulating the development of venous congestion, an Affymetrix microarray associated with peripheral venous congestion was annotated, then a bipartite dynamic lncRNA-mRNA co-expression network was constructed in which nodes indicated lncRNAs or mRNAs. The nodes were connected when the lncRNAs or mRNAs were dynamically co‑expressed. Following functional analysis of this network, several dynamic alternative pathways were identified, including the calcium signaling pathway during venous congestion development. Additionally, certain lncRNAs (LINC00523, LINC01210 and RP11-435O5.5) were identified that may potentially dynamically regulate certain proteins, including plasma membrane calcium ATPase (PMCA) and G protein‑coupled receptor (GPCR), in the calcium signaling pathway. Particularly, the dynamically regulated switch of LINC00523 from co‑expression with PMCA to GPCR may be involved in damage to steady state intracellular calcium. In brief, the current study demonstrated a potential novel mechanism of lncRNA function during venous congestion.
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Copy and paste a formatted citation
Spandidos Publications style
Li J, Xu Y, Xu J, Wang J and Wu L: Dynamic co-expression network analysis of lncRNAs and mRNAs associated with venous congestion. Mol Med Rep 14: 2045-2051, 2016.
APA
Li, J., Xu, Y., Xu, J., Wang, J., & Wu, L. (2016). Dynamic co-expression network analysis of lncRNAs and mRNAs associated with venous congestion. Molecular Medicine Reports, 14, 2045-2051. https://doi.org/10.3892/mmr.2016.5480
MLA
Li, J., Xu, Y., Xu, J., Wang, J., Wu, L."Dynamic co-expression network analysis of lncRNAs and mRNAs associated with venous congestion". Molecular Medicine Reports 14.3 (2016): 2045-2051.
Chicago
Li, J., Xu, Y., Xu, J., Wang, J., Wu, L."Dynamic co-expression network analysis of lncRNAs and mRNAs associated with venous congestion". Molecular Medicine Reports 14, no. 3 (2016): 2045-2051. https://doi.org/10.3892/mmr.2016.5480
Copy and paste a formatted citation
x
Spandidos Publications style
Li J, Xu Y, Xu J, Wang J and Wu L: Dynamic co-expression network analysis of lncRNAs and mRNAs associated with venous congestion. Mol Med Rep 14: 2045-2051, 2016.
APA
Li, J., Xu, Y., Xu, J., Wang, J., & Wu, L. (2016). Dynamic co-expression network analysis of lncRNAs and mRNAs associated with venous congestion. Molecular Medicine Reports, 14, 2045-2051. https://doi.org/10.3892/mmr.2016.5480
MLA
Li, J., Xu, Y., Xu, J., Wang, J., Wu, L."Dynamic co-expression network analysis of lncRNAs and mRNAs associated with venous congestion". Molecular Medicine Reports 14.3 (2016): 2045-2051.
Chicago
Li, J., Xu, Y., Xu, J., Wang, J., Wu, L."Dynamic co-expression network analysis of lncRNAs and mRNAs associated with venous congestion". Molecular Medicine Reports 14, no. 3 (2016): 2045-2051. https://doi.org/10.3892/mmr.2016.5480
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