Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2016 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2016 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia

  • Authors:
    • Wen-Jun Liu
    • Jing Bai
    • Qu-Lian Guo
    • Zhe Huang
    • Hong Yang
    • Yong-Qi Bai
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2052-2060
    |
    Published online on: July 11, 2016
       https://doi.org/10.3892/mmr.2016.5504
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to examine and understand changes in platelet functions prior to and after the treatment of primary immune thrombocytopenia (ITP) in children. An automatic hematology analyzer and whole blood flow cytometry were used to detect immature platelet fraction (IPF), IPC and membrane glycoproteins (CD62p, PAC-1 and CD42b) in ITP children (ITP group), children with complete response after ITP treatment (ITP-CR group) and children with elective surgery (normal control group). The results showed that, levels of platelet count (PLT) and plateletcrit in the ITP group were lower alhtough the levels of mean platelet volume, platelet distribution width and platelet-large cell ratio (P-LCR) were higher than those in the normal control and ITP-CR groups. PLT in the ITP-CR group was lower than that in the normal controls. Additionally, IPF% was higher in the normal control and ITP-CR groups, IPC was lower in the ITP group compared to the normal control and ITP-CR groups. Furthermore, prior to ADP activation, the expression levels of CD62p, PAC-1 and CD42b in the ITP group were lower in ITP group than those in the normal control and ITP-CR groups. The expression level of PAC-1 was lower in the ITP-CR and normal control groups. No differences were identified in CD62p and CD42b expression levels. Following ATP activation, CD62p, PAC-1 and CD42b expression in the ITP group was lower than that in the normal control and ITP-CR groups. PAC-1 expression was lower while CD62p expression was higher in the ITP-CR group compared to the normal control group. In conclusion, the activation of platelets in ITP children was low. Decreased platelet function, platelet parameters and platelet glycoproteins may be used as markers for monitoring the treatment efficacy in ITP children.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Min Z and Lin X: The advancement in the treatment of the children with refractory idiopathic thrombocytopenic purpura. J Clin Pediatr. 26:727–730. 2008.

2 

Terrell DR, Beebe LA, Vesely SK, Neas BR, Segal JB and George JN: The incidence of immune thrombocytopenic purpura in children and adults: a critical review of published reports. Am J Hematol. 85:174–180. 2010.PubMed/NCBI

3 

Hu Q: Diagnosis of idiopathic thrombocytopenic purpura in children. Journal of Applied Clinical Pediatrics. 25:159–161. 2010.In Chinese.

4 

Li P, Shi T, Gao J, Zhao D and Xiao A: The immunization in the children with acute immune thrombocytopenia. Chinese Journal of Practical Pediatrics. 29:548–550. 2014.In Chinese.

5 

Provan D and Newland AC: Newl and current management of primary immune thrombocytopenia. Adv Ther. 32:875–887. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Liu W and Qian X: Interpretation of the recommendations for the diagnosis and treatment of pediatric primary immune thrombocytopenia. Chin J Obstet Gynecol Pediatr. 21:245–248. 2015.

7 

Winkler J, Kroiss S, Rand ML, Azzouzi I, Annie Bang KW, Speer O and Schmugge M: Platelet apoptosis in paediatric immune thrombocytopenia is ameliorated by intravenous immunoglobulin. Br J Haematol. 156:508–515. 2012. View Article : Google Scholar

8 

Yin J, Wang J, Chen XQ, Yu WJ, Liao JY and Wang DX: Investigation on platelet apoptosis in patients with chronic idiopathic thrombocytopenic purpura. J Diagn Concepts & Pract. 9:236–241. 2010.In Chinese.

9 

Korkmaz S, Uslu AU, Aydin B, Dogan O and Sencan M: Pre-treatment and post-treatment changes in platelet indices in patients with immune thrombocytopenia. Saudi Med J. 34:591–596. 2013.PubMed/NCBI

10 

Ntaios G, Papadopoulos A, Chatzinikolaou A, Saouli Z, Karalazou P, Kaiafa G, Girtovitis F, Kontoninas Z, Savopoulos C, Hatzitolios A, et al: Increased values of mean platelet volume and platelet size deviation width may provide a safe positive diagnosis of idiopathic thrombocytopenic purpura. Acta Haematol. 119:173–177. 2008. View Article : Google Scholar : PubMed/NCBI

11 

Chen JF, Yang LH, Chang LX, Feng JJ and Liu JQ: The clinical significance of circulating B cells secreting anti-glycoprotein IIb/IIIa antibody and platelet glycoprotein IIb/IIIa in patients with primary immune thrombocytopenia. Hematology. 17:283–290. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Thomas MR, Wijeyeratne YD, May JA, Johnson A, Heptinstall S and Fox SC: A platelet P-selectin test predicts adverse cardiovascular events in patients with acute coronary syndromes treated with aspirin and clopidogrel. Platelets. 25:612–618. 2014. View Article : Google Scholar : PubMed/NCBI

13 

He Y, Zhao YX, Zhu MQ, Wu Q and Ruan CG: Detection of auto-antibodies against platelet glycoproteins in patients with immune thrombocytopenic purpura by flow cytometric immunobead array. Clin Chim Acta. 415:176–180. 2013. View Article : Google Scholar

14 

Xun L, Zhu WB, Wu JS, Cai XY, Liu X, Han YS, Yang HZ, Zheng CC and Li Q: Diagnosing ITP by Measuring the CD 61 and PAIg with FCM. Chin J Thromb Hemost. 17:8–12. 2011.In Chinese.

15 

Wang T, Zhang C and Lu J: Platelet parameter and platelet membrane glycoprotein in childhood acute lymphoblastic leukemia. J Chin Pediatr Blood Cancer. 11:12–16. 2006.In Chinese.

16 

Psaila B, Bussel JB, Frelinger AL, Babula B, Linden MD, Li Y, Barnard MR, Tate C, Feldman EJ and Michelson AD: Differences in platelet function in patients with acute myeloid leukemia and myelodysplasia compared to equally thrombocytopenic patients with immune thrombocytopenia. J Thromb Haemost. 9:2302–2310. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Subspecialty Group of Hematology, The Society of Pediatrics Chinese Medical Association; Editorial Board, Chinese Journal of Pediatrics: Recommendations for diagnosis and treatment of primary immune thrombocytopenia in children. Zhonghua Er Ke Za Zhi. 51:382–384. 2013.In Chinese.

18 

Xu Q and Liu WJ: Advances in the diagnosis and treatment of primary immune thrombocytopenia in children. Chin J Pract Pediatr. 28:646–652. 2013.In Chinese.

19 

Huang Z, Liu WJ, Guo QL and Liu CY: Platelet parameters and expression of platelet membrane glycoprotein in childhood acute lymphoblastic leukemia. Genet Mol Res. 14:16074–16089. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Sarratt KL, Chen H, Zutter MM, Santoro SA, Hammer DA and Kahn ML: GPVI and alpha2beta1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow. Blood. 106:1268–1277. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Huang Z and Liu W: Progress in research on platelet glycoproteins of thrombocytopenia in children. J Appl Clin Pediatr. 29:227–230. 2014.In Chinese.

22 

Mutlu A, Gyulkhandanyan AV, Freedman J and Leytin V: Concurrent and separate inside-out transition of platelet apoptosis and activation markers to the platelet surface. Br J Haematol. 163:377–384. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Serebruany V, Malinin A, Aradi D, Kuliczkowski W, Norgard NB and Boden WE: The in vitro effects of niacin on platelet biomarkers in human volunteers. Thromb Haemost. 104:311–317. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Cines DB and Blanchette VS: Immune thrombocytopenic purpura. N Engl J Med. 346:995–1008. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Dong NZ, Cui RJ and Ruan CG: Generation of human Fab antibody against platelet membrane glycoprotein iib/iia and its effect on platelet aggregation. Chin J Cell Mol Immunol. 25:65–67. 2009.In Chinese.

26 

Yang G: research and application of platelet glycoprotein iib/iiia acceptor antagonist. Clin Med Eng. 17:149–151. 2010.

27 

Kashiwagi H and Tomiyama Y: Pathophysiology and management of primary immune thrombocytopenia. Int J Hematol. 98:24–33. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Bhoria P, Sharma S, Varma N, Malhotra P, Varma S and Luthra-Guptasarma M: Effect of steroids on the activation status of platelets in patients with Immune thrombocytopenia (ITP). Platelets. 26:119–126. 2015. View Article : Google Scholar

29 

Wang C, Niu A, Lu Z, Yang X, Wang L and Zou X: The clinical significances of PAIgG, PAC-1 and CD62P in patients with idiopathic thrombocytopenic purpura. Zhejiang J Lab Med. 3:7–10. 2005.In Chinese.

30 

Psaila B, Bussel JB, Linden MD, Babula B, Li Y, Barnard MR, Tate C, Mathur K, Frelinger AL and Michelson AD: In vivo effects of eltrombopag on platelet function in immune thrombocytopenia: no evidence of platelet activation. Blood. 119:4066–4072. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Vinholt PJ, Hvas AM and Nybo M: An overview of platelet indices and methods for evaluating platelet function in thrombocytopenic patients. Eur J Haematol. 92:367–376. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Zhang Y and Gang W: Study on clinical significance of platelet relevant parameters in diagnosis of thrombocytopenia. J Clin Exp Med. 12:1533–1535. 2013.

33 

Bai J and Liu W: Changes of platelet parameters and platelet function in primary immune thrombocytopenia. Chin J Pract Pediatr. 30:150–153. 2015.In Chinese.

34 

Adly AA, Ragab IA, Ismail EA and Farahat MM: Evaluation of the immature platelet fraction in the diagnosis and prognosis of childhood immune thrombocytopenia. Platelets. 26:645–650. 2015. View Article : Google Scholar

35 

Balduini CL and Noris P: Mean platelet volume for distinguishing between inherited thrombocytopenias and immune thrombocytopenia - response to Beyan. Br J Haematol. 163:413–414. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Fan L and Wei W: Platelet parameters in children with idiopathic thrombocytopenic purpura clinical application analysis. J Clin Exp Med. 13:124–126. 2014.

37 

Strauss G, Vollert C, von Stackelberg A, Weimann A, Gaedicke G and Schulze H: Immature platelet count: A simple parameter for distinguishing thrombocytopenia in pediatric acute lymphocytic leukemia from immune thrombocytopenia. Pediatr Blood Cancer. 57:641–647. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Pons I, Monteagudo M, Lucchetti G, Muñoz L, Perea G, Colomina I, Guiu J and Obiols J: Correlation between immature platelet fraction and reticulated platelets. Usefulness in the etiology diagnosis of thrombocytopenia. Eur J Haematol. 85:158–163. 2010.PubMed/NCBI

39 

Jiang W, Jiang H, Wu Y, Zhang Z and Chen X: The variation of immature platelet fraction in patients with thrombocytopenic diseases. Lab Med. 28:47–50. 2013.

40 

Yang J, Zhao Y, Wu W, Hua B, Zhu Z, Yang R and Wang S: Value of Reticulated Platelet Countsin Identifying Thrombocytopenia Aetiology. J Exp Hematol. 18:482–485. 2010.In Chinese.

41 

Michur H, Maślanka K, Szczepiński A and Mariańska B: Reticulated platelets as a marker of platelet recovery after allogeneic stem cell transplantation. Int J Lab Hematol. 30:519–525. 2008.PubMed/NCBI

42 

Liu Y, Wang Z, Yuan B, Wang X, Wu Q and Yuan H: Role of reticulated platelets and platelet-associated antibody in differential diagnosis of idiopathic thrombocytopenic purpura. J Exp Hematol. 19:979–982. 2011.In Chinese.

43 

Xiao M, Liu J, Wu P and Yuan Q: Significance of platelet parameters measurement in thrombocytopenia disease. Int J Lab Med. 34:418–420. 2013.In Chinese.

44 

Adly AA, Ragab IA, Ismail EA and Farahat MM: Evaluation of the immature platelet fraction in the diagnosis and prognosis of childhood immune thrombocytopenia. Platelets. 26:645–650. 2015. View Article : Google Scholar

45 

Barsam SJ, Psaila B, Forestier M, Page LK, Sloane PA, Geyer JT, Villarica GO, Ruisi MM, Gernsheimer TB, Beer JH, et al: Platelet production and platelet destruction: assessing mechanisms of treatment effect in immune thrombocytopenia. Blood. 117:5723–5732. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Greene LA, Chen S, Seery C, Imahiyerobo AM and Bussel JB: Beyond the platelet count: Immature platelet fraction and thromboelastometry correlate with bleeding in patients with immune thrombocytopenia. Br J Haematol. 166:592–600. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Banfi G and Germagnoli L: Preanalytical phase in haematology. J Med Biochem. 27:348–353. 2008. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu W, Bai J, Guo Q, Huang Z, Yang H and Bai Y: Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia. Mol Med Rep 14: 2052-2060, 2016.
APA
Liu, W., Bai, J., Guo, Q., Huang, Z., Yang, H., & Bai, Y. (2016). Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia. Molecular Medicine Reports, 14, 2052-2060. https://doi.org/10.3892/mmr.2016.5504
MLA
Liu, W., Bai, J., Guo, Q., Huang, Z., Yang, H., Bai, Y."Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia". Molecular Medicine Reports 14.3 (2016): 2052-2060.
Chicago
Liu, W., Bai, J., Guo, Q., Huang, Z., Yang, H., Bai, Y."Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia". Molecular Medicine Reports 14, no. 3 (2016): 2052-2060. https://doi.org/10.3892/mmr.2016.5504
Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Bai J, Guo Q, Huang Z, Yang H and Bai Y: Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia. Mol Med Rep 14: 2052-2060, 2016.
APA
Liu, W., Bai, J., Guo, Q., Huang, Z., Yang, H., & Bai, Y. (2016). Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia. Molecular Medicine Reports, 14, 2052-2060. https://doi.org/10.3892/mmr.2016.5504
MLA
Liu, W., Bai, J., Guo, Q., Huang, Z., Yang, H., Bai, Y."Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia". Molecular Medicine Reports 14.3 (2016): 2052-2060.
Chicago
Liu, W., Bai, J., Guo, Q., Huang, Z., Yang, H., Bai, Y."Role of platelet function and platelet membrane glycoproteins in children with primary immune thrombocytopenia". Molecular Medicine Reports 14, no. 3 (2016): 2052-2060. https://doi.org/10.3892/mmr.2016.5504
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team