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Antioxidant effect of angiotensin (1‑7) in the protection of pancreatic β cell function

  • Authors:
    • Fen Zhang
    • Chang Liu
    • Lei Wang
    • Xi Cao
    • Ying Ying Wang
    • Jin Kui Yang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1963-1969
    |
    Published online on: July 13, 2016
       https://doi.org/10.3892/mmr.2016.5514
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Abstract

It is well known that the local renin-angiotensin system (RAS) is activated in the diabetic state, which results in an increase in the level of oxidative stress injury to pancreatic β cells. The angiotensin‑converting enzyme 2 (ACE2)/angiotensin (1‑7) [Ang (1‑7)]/Mas axis is a negative regulator of the classical renin‑angiotensin system. In order to investigate the antioxidant effect of Ang (1‑7) on pancreatic β cells, INS‑1 cells were cultured and oxidative stress was induced by treatment with H2O2. Glucose‑stimulated insulin secretion (GSIS), the generation of reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and glucose-stimulated calcium (GSCa) responses in β cells were determined following treatment with Ang (1-7). It was observed that H2O2 significantly impaired the insulin secreting function, increased the production of ROS, and also decreased the levels of GSCa and MMP. Pre‑treatment with Ang (1‑7) alleviated these effects and treatment with A779 [antagonist of Ang (1‑7)] prevented the effects of Ang (1-7). Based on these findings, it was concluded that Ang (1‑7) can protect pancreatic β cells from oxidative injury and such protection can be blocked by its antagonist A779.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang F, Liu C, Wang L, Cao X, Wang YY and Yang JK: Antioxidant effect of angiotensin (1‑7) in the protection of pancreatic β cell function. Mol Med Rep 14: 1963-1969, 2016.
APA
Zhang, F., Liu, C., Wang, L., Cao, X., Wang, Y.Y., & Yang, J.K. (2016). Antioxidant effect of angiotensin (1‑7) in the protection of pancreatic β cell function. Molecular Medicine Reports, 14, 1963-1969. https://doi.org/10.3892/mmr.2016.5514
MLA
Zhang, F., Liu, C., Wang, L., Cao, X., Wang, Y. Y., Yang, J. K."Antioxidant effect of angiotensin (1‑7) in the protection of pancreatic β cell function". Molecular Medicine Reports 14.3 (2016): 1963-1969.
Chicago
Zhang, F., Liu, C., Wang, L., Cao, X., Wang, Y. Y., Yang, J. K."Antioxidant effect of angiotensin (1‑7) in the protection of pancreatic β cell function". Molecular Medicine Reports 14, no. 3 (2016): 1963-1969. https://doi.org/10.3892/mmr.2016.5514
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang F, Liu C, Wang L, Cao X, Wang YY and Yang JK: Antioxidant effect of angiotensin (1‑7) in the protection of pancreatic β cell function. Mol Med Rep 14: 1963-1969, 2016.
APA
Zhang, F., Liu, C., Wang, L., Cao, X., Wang, Y.Y., & Yang, J.K. (2016). Antioxidant effect of angiotensin (1‑7) in the protection of pancreatic β cell function. Molecular Medicine Reports, 14, 1963-1969. https://doi.org/10.3892/mmr.2016.5514
MLA
Zhang, F., Liu, C., Wang, L., Cao, X., Wang, Y. Y., Yang, J. K."Antioxidant effect of angiotensin (1‑7) in the protection of pancreatic β cell function". Molecular Medicine Reports 14.3 (2016): 1963-1969.
Chicago
Zhang, F., Liu, C., Wang, L., Cao, X., Wang, Y. Y., Yang, J. K."Antioxidant effect of angiotensin (1‑7) in the protection of pancreatic β cell function". Molecular Medicine Reports 14, no. 3 (2016): 1963-1969. https://doi.org/10.3892/mmr.2016.5514
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