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Article

In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound

  • Authors:
    • Byung Cheol Lee
    • Arim Lee
    • Jee Hyung Jung
    • Sang Ho Choi
    • Tae Sung Kim
  • View Affiliations / Copyright

    Affiliations: Department of Life Sciences, College of Life Sciences and Biotechnology, Korea University, Seoul 136‑701, Republic of Korea, Department of Pharmacy, Pusan National University, Geumjeong‑gu, Busan 609‑735, Republic of Korea, National Research Laboratory of Molecular Microbiology and Toxicology, Department of Agricultural Biotechnology, Seoul National University, Seoul 151‑921, Republic of Korea
  • Pages: 2691-2696
    |
    Published online on: July 18, 2016
       https://doi.org/10.3892/mmr.2016.5522
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Abstract

Vibrio vulnificus is known to induce severely fulminant and fatal septicemia in susceptible hosts. In the present study, the antimicrobial activity of natural marine product-derived compounds against V. vulnificus, were investigated in vitro and in vivo. Twelve pure compounds were isolated from natural marine products and their inhibitory effects on V. vulnificus-induced cytotoxicity were determined in INT‑407 cells. Among the 12 pure compounds tested, treatment with psammaplin A significantly suppressed V. vulnificus‑induced cytotoxicity in INT‑407 cells. Notably, treatment with psammaplin A (5-50 µg) had improved survival rates compared with that in the untreated mice, when the mice were infected with V. vulnificus intraperitoneally. In addition, the bacterial load of V. vulnificus in several tissues (spleen, liver and small intestine) was significantly lower in psammaplin A‑treated mice than in untreated mice. Furthermore, psammaplin A treatment significantly suppressed the growth of V. vulnificus. Taken together, these results indicate that psammaplin A may be a potential agent for the prevention and treatment of V. vulnificus infections.
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Copy and paste a formatted citation
Spandidos Publications style
Lee BC, Lee A, Jung JH, Choi SH and Kim TS: In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound. Mol Med Rep 14: 2691-2696, 2016.
APA
Lee, B.C., Lee, A., Jung, J.H., Choi, S.H., & Kim, T.S. (2016). In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound. Molecular Medicine Reports, 14, 2691-2696. https://doi.org/10.3892/mmr.2016.5522
MLA
Lee, B. C., Lee, A., Jung, J. H., Choi, S. H., Kim, T. S."In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound". Molecular Medicine Reports 14.3 (2016): 2691-2696.
Chicago
Lee, B. C., Lee, A., Jung, J. H., Choi, S. H., Kim, T. S."In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound". Molecular Medicine Reports 14, no. 3 (2016): 2691-2696. https://doi.org/10.3892/mmr.2016.5522
Copy and paste a formatted citation
x
Spandidos Publications style
Lee BC, Lee A, Jung JH, Choi SH and Kim TS: In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound. Mol Med Rep 14: 2691-2696, 2016.
APA
Lee, B.C., Lee, A., Jung, J.H., Choi, S.H., & Kim, T.S. (2016). In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound. Molecular Medicine Reports, 14, 2691-2696. https://doi.org/10.3892/mmr.2016.5522
MLA
Lee, B. C., Lee, A., Jung, J. H., Choi, S. H., Kim, T. S."In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound". Molecular Medicine Reports 14.3 (2016): 2691-2696.
Chicago
Lee, B. C., Lee, A., Jung, J. H., Choi, S. H., Kim, T. S."In vitro and in vivo anti-Vibrio vulnificus activity of psammaplin A, a natural marine compound". Molecular Medicine Reports 14, no. 3 (2016): 2691-2696. https://doi.org/10.3892/mmr.2016.5522
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