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Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population

  • Authors:
    • Ying‑Yu Ma
    • Xiao‑Jun Wang
    • Yong Han
    • Gang Li
    • Hui‑Ju Wang
    • Shi‑Bing Wang
    • Xiao‑Yi Chen
    • Fan‑Long Liu
    • Xiang‑Lei He
    • Xiang‑Min Tong
    • Xiao‑Zhou Mou
  • View Affiliations / Copyright

    Affiliations: Clinical Research Institute, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China, Department of Anus, Rectum and Colon Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310014, P.R. China, Colorectal Department of Shaoxing People's Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, Zhejiang 312000, P.R. China, Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2541-2547
    |
    Published online on: July 21, 2016
       https://doi.org/10.3892/mmr.2016.5536
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Abstract

The coxsackie and adenovirus receptor (CAR) is considered a tumor suppressor and critical factor for the efficacy of therapeutic strategies that employ the adenovirus. However, data on CAR expression levels in colorectal cancer are conflicting and its clinical relevance remains to be elucidated. Immunohistochemistry was performed on tissue microarrays containing 251 pairs of colon cancer and adjacent normal tissue samples from Chinese Han patients to assess the expression levels of CAR. Compared with healthy mucosa, decreased CAR expression (40.6% vs. 95.6%; P<0.001) was observed in colorectal cancer samples. The CAR immunopositivity in tumor tissues was not significantly associated with gender, age, tumor size, differentiation, TNM stage, lymph node metastasis or distant metastasis in patients with colon cancer. However, expression of CAR is present in 83.3% of the tumor tissues from patient with colorectal liver metastasis, which was significantly higher than those without liver metastasis (39.6%; P=0.042). At the plasma membrane, CAR was observed in 29.5% normal mucosa samples, which was significantly higher than in colorectal cancer samples (4.0%; P<0.001). In addition, the survival analysis demonstrated that the expression level of CAR has no association with the prognosis of colorectal cancer. CAR expression was observed to be downregulated in colorectal cancer, and it exerts complex effects during colorectal carcinogenesis, potentially depending on the stage of the cancer development and progression. High CAR expression may promote liver metastasis. With regard to oncolytic therapy, CAR expression analysis should be performed prior to adenoviral oncolytic treatment to stratify Chinese Han patients for treatment.
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View References

1 

Siegel R, Naishadham D and Jemal A: Cancer statistics, 2013. CA Cancer J Clin. 63:11–30. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Chen W, Zheng R, Zhang S, Zhao P, Li G, Wu L and He J: Report of incidence and mortality in China cancer registries, 2009. Chin J Cancer Res. 25:10–21. 2013.PubMed/NCBI

3 

Chang GJ, Kaiser AM, Mills S, Rafferty JF and Buie WD; Standards Practice Task Force of the American Society of Colon and Rectal Surgeons: Practice parameters for the management of colon cancer. Dis Colon Rectum. 55:831–843. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Rayburn ER, Wang W, Zhang R and Wang H: Experimental therapy for colon cancer: Anti-cancer effects of TLR9 agonism, combination with other therapeutic modalities, and dependence upon p53. Int J Oncol. 30:1511–1519. 2007.PubMed/NCBI

5 

Zuckerman DS and Clark JW: Systemic therapy for metastatic colorectal cancer: Current questions. Cancer. 112:1879–1891. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Bergelson JM, Cunningham JA, Droguett G, Kurt-Jones EA, Krithivas A, Hong JS, Horwitz MS, Crowell RL and Finberg RW: Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2–5. Science. 275:1320–1333. 1997. View Article : Google Scholar : PubMed/NCBI

7 

Cohen CJ, Shieh JT, Pickles RJ, Okegawa T, Hsieh JT and Bergelson JM: The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. Proc Natl Acad Sci USA. 98:15191–15196. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Walters RW, Freimuth P, Moninger TO, Ganske I, Zabner J and Welsh MJ: Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape. Cell. 110:789–799. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Pandha HS, Stockwin LH, Eaton J, Clarke IA, Dalgleish AG, Todryk SM and Blair GE: Coxsackie B and adenovirus receptor, integrin and major histocompatibility complex class I expression in human prostate cancer cell lines: Implications for gene therapy strategies. Prostate Cancer Prostatic Dis. 6:6–11. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Kasuya H, Takeda S, Shimoyama S, Shikano T, Nomura N, Kanazumi N, Nomoto S, Sugimoto H and Nakao A: Oncolytic virus therapy-foreword. Curr Cancer Drug Targets. 7:123–125. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Abdolazimi Y, Mojarrad M, Pedram M and Modarressi MH: Analysis of the expression of coxsackievirus and adenovirus receptor in five colon cancer cell lines. World J Gastroenterol. 13:6365–6369. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Anders M, Vieth M, Röcken C, Ebert M, Pross M, Gretschel S, Schlag PM, Wiedenmann B, Kemmner W and Höcker M: Loss of the coxsackie and adenovirus receptor contributes to gastric cancer progression. Br J Cancer. 100:352–359. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Wang Y, Thorne S, Hannock J, Francis J, Au T, Reid T, Lemoine N, Kirn D and Halldén G: A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses. Clin Cancer Res. 11:351–360. 2005.PubMed/NCBI

14 

Yamashita M, Ino A, Kawabata K, Sakurai F and Mizuguchi H: Expression of coxsackie and adenovirus receptor reduces the lung metastatic potential of murine tumor cells. Int J Cancer. 121:1690–1696. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Wunder T, Schmid K, Wicklein D, Groitl P, Dobner T, Lange T, Anders M and Schumacher U: Expression of the coxsackie adenovirus receptor in neuroendocrine lung cancers and its implications for oncolytic adenoviral infection. Cancer Gene Ther. 20:25–32. 2013. View Article : Google Scholar

16 

Wunder T, Schumacher U and Friedrich RE: Coxsackie adenovirus receptor expression in carcinomas of the head and neck. Anticancer Res. 32:1057–1062. 2012.PubMed/NCBI

17 

Matsumoto K, Shariat SF, Ayala GE, Rauen KA and Lerner SP: Loss of coxsackie and adenovirus receptor expression is associated with features of aggressive bladder cancer. Urology. 66:441–446. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Dietel M, Häfner N, Jansen L, Durst M and Runnebaum IB: Novel splice variant CAR 4/6 of the coxsackie adenovirus receptor is differentially expressed in cervical carcinogenesis. J Mol Med (Berl). 89:621–630. 2011. View Article : Google Scholar

19 

Giaginis CT, Zarros AC, Papaefthymiou MA, Papadopouli AE, Sfiniadakis IK and Theocharis SE: Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: Possible clinical implications. World J Surg Oncol. 6:592008. View Article : Google Scholar : PubMed/NCBI

20 

Martin TA, Watkins G and Jiang WG: The Coxsackie-adenovirus receptor has elevated expression in human breast cancer. Clin Exp Med. 5:122–128. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Martino TA, Petric M, Weingartl H, Bergelson JM, Opavsky MA, Richardson CD, Modlin JF, Finberg RW, Kain KC, Willis N, et al: The coxsackie-adenovirus receptor (CAR) is used by reference strains and clinical isolates representing all six serotypes of coxsackievirus group B and by swine vesicular disease virus. Virology. 271:99–108. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Persson A, Fan X, Widegren B and Englund E: Cell type- and region-dependent coxsackie adenovirus receptor expression in the central nervous system. J Neurooncol. 78:1–6. 2006. View Article : Google Scholar

23 

Reimer D, Steppan I, Wiedemair A, Concin N, Hofstetter G, Marth C, Müller-Holzner E and Zeimet AG: Soluble isoforms but not the transmembrane form of coxsackie-adenovirus receptor are of clinical relevance in epithelial ovarian cancer. Int J Cancer. 120:2568–2575. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Wang Y, Wang S, Bao Y, Ni C, Guan N, Zhao J, Salford LG, Widegren B and Fan X: Coxsackievirus and adenovirus receptor expression in non-malignant lung tissues and clinical lung cancers. J Mol Histol. 37:153–160. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Zhang NH, Song LB, Wu XJ, Li RP, Zeng MS, Zhu XF, Wan DS, Liu Q, Zeng YX and Zhang XS: Proteasome inhibitor MG-132 modifies coxsackie and adenovirus receptor expression in colon cancer cell line lovo. Cell Cycle. 7:925–933. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Reeh M, Bockhorn M, Görgens D, Vieth M, Hoffmann T, Simon R, Izbicki JR, Sauter G, Schumacher U and Anders M: Presence of the coxsackievirus and adenovirus receptor (CAR) in human neoplasms: A multitumour array analysis. Br J Cancer. 109:1848–1858. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Stecker K, Vieth M, Koschel A, Wiedenmann B, Röcken C and Anders M: Impact of the coxsackievirus and adenovirus receptor on the adenoma-carcinoma sequence of colon cancer. Br J Cancer. 104:1426–1433. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Zhou X, Xie G, Wang S, Wang Y, Zhang K, Zheng S, Chu L, Xiao L, Yu Y, Zhang Y and Liu X: Potent and specific antitumor effect for colorectal cancer by CEA and Rb double regulated oncolytic adenovirus harboring ST13 gene. PLoS One. 7:e475662012. View Article : Google Scholar : PubMed/NCBI

29 

Korn WM, Macal M, Christian C, Lacher MD, McMillan A, Rauen KA, Warren RS and Ferrell L: Expression of the coxsackievirus- and adenovirus receptor in gastrointestinal cancer correlates with tumor differentiation. Cancer Gene Ther. 13:792–797. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Rauen KA, Sudilovsky D, Le JL, Chew KL, Hann B, Weinberg V, Schmitt LD and McCormick F: Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma: Potential relevance to gene therapy. Cancer Res. 62:3812–3818. 2002.PubMed/NCBI

31 

van Gijn W, Krijnen P, Lemmens VE, den Dulk M, Putter H and van de Velde CJ: Quality assurance in rectal cancer treatment in the Netherlands: A catch up compared to colon cancer treatment. Eur J Surg Oncol. 36:340–344. 2010. View Article : Google Scholar

32 

Cady B and Stone MD: The role of surgical resection of liver metastases in colorectal carcinoma. Semin Oncol. 18:399–406. 1991.PubMed/NCBI

33 

Tomlinson JS, Jarnagin WR, DeMatteo RP, Fong Y, Kornprat P, Gonen M, Kemeny N, Brennan MF, Blumgart LH and D'Angelica M: Actual 10-year survival after resection of colorectal liver metastases defines cure. J Clin Oncol. 25:4575–4580. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Fisher KD, Stallwood Y, Green NK, Ulbrich K, Mautner V and Seymour LW: Polymer-coated adenovirus permits efficient retargeting and evades neutralising antibodies. Gene Ther. 8:341–348. 2001. View Article : Google Scholar : PubMed/NCBI

35 

Lanciotti J, Song A, Doukas J, Sosnowski B, Pierce G, Gregory R, Wadsworth S and O'Riordan C: Targeting adenoviral vectors using heterofunctional polyethylene glycol FGF2 conjugates. Mol Ther. 8:99–107. 2003. View Article : Google Scholar : PubMed/NCBI

36 

Menezes KM, Mok HS and Barry MA: Increased transduction of skeletal muscle cells by fibroblast growth factor-modified adenoviral vectors. Hum Gene Ther. 17:314–320. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Segerman A, Atkinson JP, Marttila M, Dennerquist V, Wadell G and Arnberg N: Adenovirus type 11 uses CD46 as a cellular receptor. J Virol. 77:9183–9191. 2003. View Article : Google Scholar : PubMed/NCBI

38 

Short JJ, Pereboev AV, Kawakami Y, Vasu C, Holterman MJ and Curiel DT: Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors. Virology. 322:349–359. 2004. View Article : Google Scholar : PubMed/NCBI

39 

Tuve S, Wang H, Ware C, Liu Y, Gaggar A, Bernt K, Shay-akhmetov D, Li Z, Strauss R, Stone D and Lieber A: A new group B adenovirus receptor is expressed at high levels on human stem and tumor cells. J Virol. 80:12109–12120. 2006. View Article : Google Scholar : PubMed/NCBI

40 

Krasnykh V, Belousova N, Korokhov N, Mikheeva G and Curiel DT: Genetic targeting of an adenovirus vector via replacement of the fiber protein with the phage T4 fibritin. J Virol. 75:4176–4183. 2001. View Article : Google Scholar : PubMed/NCBI

41 

van Beusechem VW, van Rijswijk AL, van Es HH, Haisma HJ, Pinedo HM and Gerritsen WR: Recombinant adenovirus vectors with knobless fibers for targeted gene transfer. Gene Ther. 7:1940–641. 2000. View Article : Google Scholar : PubMed/NCBI

42 

Ma J, Zhao J, Lu J, Jiang Y, Yang H, Li P, Zhao M, Liu K and Dong Z: Coxsackievirus and adenovirus receptor promotes antitumor activity of oncolytic adenovirus H101 in esophageal cancer. Int J Mol Med. 30:1403–1409. 2012.PubMed/NCBI

43 

Kitazono M, Goldsmith ME, Aikou T, Bates S and Fojo T: Enhanced adenovirus transgene expression in malignant cells treated with the histone deacetylase inhibitor FR901228. Cancer Res. 61:6328–6330. 2001.PubMed/NCBI

44 

Yoo GH, Piechocki MP, Oliver J, Lonardo F, Zumstein L, Lin HS, Kim H, Shibuya TY, Shehadeh N and Ensley JF: Enhancement of Ad-p53 therapy with docetaxel in head and neck cancer. Laryngoscope. 114:1871–1879. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma YY, Wang XJ, Han Y, Li G, Wang HJ, Wang SB, Chen XY, Liu FL, He XL, Tong XM, Tong XM, et al: Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population. Mol Med Rep 14: 2541-2547, 2016.
APA
Ma, Y., Wang, X., Han, Y., Li, G., Wang, H., Wang, S. ... Mou, X. (2016). Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population. Molecular Medicine Reports, 14, 2541-2547. https://doi.org/10.3892/mmr.2016.5536
MLA
Ma, Y., Wang, X., Han, Y., Li, G., Wang, H., Wang, S., Chen, X., Liu, F., He, X., Tong, X., Mou, X."Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population". Molecular Medicine Reports 14.3 (2016): 2541-2547.
Chicago
Ma, Y., Wang, X., Han, Y., Li, G., Wang, H., Wang, S., Chen, X., Liu, F., He, X., Tong, X., Mou, X."Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population". Molecular Medicine Reports 14, no. 3 (2016): 2541-2547. https://doi.org/10.3892/mmr.2016.5536
Copy and paste a formatted citation
x
Spandidos Publications style
Ma YY, Wang XJ, Han Y, Li G, Wang HJ, Wang SB, Chen XY, Liu FL, He XL, Tong XM, Tong XM, et al: Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population. Mol Med Rep 14: 2541-2547, 2016.
APA
Ma, Y., Wang, X., Han, Y., Li, G., Wang, H., Wang, S. ... Mou, X. (2016). Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population. Molecular Medicine Reports, 14, 2541-2547. https://doi.org/10.3892/mmr.2016.5536
MLA
Ma, Y., Wang, X., Han, Y., Li, G., Wang, H., Wang, S., Chen, X., Liu, F., He, X., Tong, X., Mou, X."Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population". Molecular Medicine Reports 14.3 (2016): 2541-2547.
Chicago
Ma, Y., Wang, X., Han, Y., Li, G., Wang, H., Wang, S., Chen, X., Liu, F., He, X., Tong, X., Mou, X."Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population". Molecular Medicine Reports 14, no. 3 (2016): 2541-2547. https://doi.org/10.3892/mmr.2016.5536
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