Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2016 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2016 Volume 14 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males

  • Authors:
    • Huihui Ji
    • Yunliang Wang
    • Danjie Jiang
    • Guili Liu
    • Xuting Xu
    • Dongjun Dai
    • Xiaohui Zhou
    • Wei Cui
    • Jinfeng Li
    • Zhongming Chen
    • Ying Li
    • Dongsheng Zhou
    • Qin Zha
    • Renjie Zhuo
    • Liting Jiang
    • Yu Liu
    • Lili Shen
    • Beibei Zhang
    • Lei Xu
    • Haochang Hu
    • Yuzheng Zhang
    • Honglei Yin
    • Shiwei Duan
    • Qinwen Wang
  • View Affiliations / Copyright

    Affiliations: Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, P.R. China, Department of Neurology, The 148 Central Hospital of PLA, Zibo, Shandong 255000, P.R. China, Department of Internal Medicine for Cadres, The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang 830000, P.R. China, Geriatric Department, Ningbo Kangning Hospital, Ningbo, Zhejiang 315201, P.R. China, Geriatric Department, Ningbo No. 1 Hospital, Ningbo, Zhejiang 315010, P.R. China, Geriatric Department, The Affiliated Hospital of School of Medicine of Ningbo University, Ningbo, Zhejiang 315200, P.R. China
  • Pages: 2732-2738
    |
    Published online on: July 27, 2016
       https://doi.org/10.3892/mmr.2016.5560
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Aberrant promoter methylation of multiple genes is associated with various diseases, including Alzheimer's disease (AD). The goal of the present study was to determine whether dopamine receptor D4 (DRD4) promoter methylation is associated with AD. In the current study, the methylation levels of the DRD4 promoter were measured in 46 AD patients and 61 controls using bisulfite pyrosequencing technology. The results of the present study demonstrated that DRD4 promoter methylation was significantly higher in AD patients than in controls. A further breakdown analysis by gender revealed that there was a significant association of DRD4 promoter methylation with AD in males (23 patients and 45 controls). In conclusion, the results of the present study demonstrated that elevated DRD4 promoter methylation was associated with AD risk in males.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Wilson RS, Barnes LL, Mendes de Leon CF, Aggarwal NT, Schneider JS, Bach J, Pilat J, Beckett LA, Arnold SE, Evans DA and Bennett DA: Depressive symptoms, cognitive decline, and risk of AD in older persons. Neurology. 59:364–370. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Querfurth HW and LaFerla FM: Alzheimer's disease. N Engl J Med. 362:329–344. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Kubota T: Epigenome: What we learned from Rett syndrome, a neurological disease caused by mutation of a methyl-CpG binding protein. Rinsho Shinkeigaku. 53:1339–1341. 2013.In Japanese. View Article : Google Scholar

4 

Alonso Vilatela ME, Lopez-Lopez M and Yescas-Gomez P: Genetics of Alzheimer's disease. Genetics of Alzheimer's disease. 43:622–631. 2012.

5 

Tang LL, Liu Q, Bu SZ, Xu LT, Wang QW, Mai YF and Duan SW: The effect of environmental factors and DNA methylation on type 2 diabetes mellitus. Yi Chuan. 35:1143–1152. 2013.In Chinese. View Article : Google Scholar

6 

Zhang W, Zheng Y and Hou L: Pharmacogenomic discovery delineating the genetic basis of drug response. Curr Genet Med Rep. 1:143–149. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Wang T, Garcia JG and Zhang W: Epigenetic regulation in particulate matter-mediated cardiopulmonary toxicities: A systems biology perspective. Curr Pharmacogenomics Person Med. 10:314–321. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Jiang D, Hong Q, Shen Y, Xu Y, Zhu H, Li Y, Xu C, Ouyang G and Duan S: The diagnostic value of DNA methylation in leukemia: A systematic review and meta-analysis. PloS One. 9:e968222014. View Article : Google Scholar : PubMed/NCBI

9 

Cheng J, Wang L, Xu L, Wang H, Liu P, Bu S, Ye M, Zhang L, Wang Q and Duan S: Gender-dependent miR-375 promoter methylation and the risk of type 2 diabetes. Exp Ther Med. 5:1687–1692. 2013.PubMed/NCBI

10 

Tang LL, Liu Q, Bu SZ, Xu LT, Wang QW, Mai YF and Duan SW: The effect of environmental factors and DNA methylation on type 2 diabetes mellitus. Yi Chuan. 35:1143–1152. 2013.In Chinese. View Article : Google Scholar

11 

Xu L, Zheng D, Wang L, Jiang D, Liu H, Xu L, Liao Q, Zhang L, Liu P, Shi X, et al: GCK gene-body hypomethylation is associated with the risk of coronary heart disease. Biomed Res Int. 2014:1517232014. View Article : Google Scholar : PubMed/NCBI

12 

Jiang D, Zheng D, Wang L, Huang Y, Liu H, Xu L, Liao Q, Liu P, Shi X, Wang Z, et al: Elevated PLA2G7 gene promoter methylation as a gender-specific marker of aging increases the risk of coronary heart disease in females. PloS One. 8:e597522013. View Article : Google Scholar : PubMed/NCBI

13 

Cheng J, Wang Y, Zhou K, Wang L, Li J, Zhuang Q, Xu X, Xu L, Zhang K, Dai D, et al: Male-specific association between dopamine receptor D4 gene methylation and schizophrenia. PloS One. 9:e891282014. View Article : Google Scholar : PubMed/NCBI

14 

Hodgson N, Trivedi M, Muratore C, Li S and Deth R: Soluble oligomers of amyloid-b cause changes in redox state, DNA methylation and gene transcription by inhibiting EAAT3 mediated cysteine uptake. J Alzheimers Dis. 36:197–209. 2013.

15 

Ji Huihui, Zhou Xiaohui, Chen Zhongming, Li Ying, Zhou Dongsheng, Zhuo Renjie, Duan Shiwei and Wang Qinwen: Research progress of DNA methylation in Alzheimer's disease. Chi J Cell Biol. 36:1551–1559. 2014.

16 

Al Akeel R: Role of epigenetic reprogramming of host genes in bacterial pathogenesis. Saudi J Biol Sci. 20:305–309. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Fatemi M, Pao MM, Jeong S, Gal-Yam EN, Egger G, Weisenberger DJ and Jones PA: Footprinting of mammalian promoters: Use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level. Nucleic Acids Res. 33:e1762005. View Article : Google Scholar : PubMed/NCBI

18 

Yu Z, Kong Q and Kone BC: Aldosterone reprograms promoter methylation to regulate αENaC transcription in the collecting duct. Am J Physiol Renal Physiol. 305:F1006–F1013. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Moen EL, Zhang X, Mu W, Delaney SM, Wing C, McQuade J, Myers J, Godley LA, Dolan ME and Zhang W: Genome-wide variation of cytosine modifications between European and African populations and the implications for complex traits. Genetics. 194:987–996. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Moen EL, Stark AL, Zhang W, Dolan ME and Godley LA: The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide. Mol Cancer Ther. 13:1334–1344. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Kirley A, Hawi Z, Daly G, McCarron M, Mullins C, Millar N, Waldman I, Fitzgerald M and Gill M: Dopaminergic system genes in ADHD: Toward a biological hypothesis. Neuropsychopharmacology. 27:607–619. 2002.PubMed/NCBI

22 

Lin WY, Wu BT, Lee CC, Sheu JJ, Liu SH, Wang WF, Tsai CH, Liu HP and Tsai FJ: Association analysis of dopaminergic gene variants (Comt, Drd4 And Dat1) with Alzheimer s disease. J Biol Regul Homeost Agents. 26:401–410. 2012.PubMed/NCBI

23 

Docherty SJ, Davis OS, Haworth CM, Plomin R, D'Souza U and Mill J: A genetic association study of DNA methylation levels in the DRD4 gene region finds associations with nearby SNPs. Behav Brain Funct. 8:312012. View Article : Google Scholar : PubMed/NCBI

24 

Zhang H, Herman AI, Kranzler HR, Anton RF, Zhao H, Zheng W and Gelernter J: Array-based profiling of DNA methylation changes associated with alcohol dependence. Alcohol Clin Exp Res. 37(Suppl 1): E108–E115. 2013. View Article : Google Scholar

25 

Mill J and Heijmans BT: From promises to practical strategies in epigenetic epidemiology. Nat Rev Genet. 14:585–594. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, Pace TW, Mercer KB, Mayberg HS, Bradley B, et al: Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nature Neurosci. 16:33–41. 2013. View Article : Google Scholar

27 

Provencal N, Suderman MJ, Guillemin C, Massart R, Ruggiero A, Wang D, Bennett AJ, Pierre PJ, Friedman DP, Côté SM, et al: The signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells. J Neurosci. 32:15626–15642. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Liu X, Zheng Y, Zhang W, Zhang X, Lioyd-Jones DM, Baccarelli AA, Ning H, Fornage M, He K, Liu K and Hou L: Blood methylomics in response to arsenic exposure in a low-exposed US population. J Expo Sci Environ Epidemiol. 24:145–149. 2014. View Article : Google Scholar

29 

Fiedler U, Wiltfang J, Peters N and Benninghoff J: Advances in the diagnostics of Alzheimer's disease. Nervenarzt. 83:661–673. 2012.In German. View Article : Google Scholar : PubMed/NCBI

30 

Doumas BT: Standards for total serum protein assays-a collaborative study. Clin Chem. 21:1159–1166. 1975.PubMed/NCBI

31 

McPherson IG and Everard DW: Serum albumin estimation: Modification of the bromcresol green method. Clinic Chim Acta. 37:117–121. 1972. View Article : Google Scholar

32 

Yang X, Liu B, Sang Y, Yuan Y, Pu J, Liu Y, Li Z, Feng J, Xie Y, Tang R, et al: Kinetic analysis of the lactate-dehydrogenase-coupled reaction process and measurement of alanine transaminase by an integration strategy. Anal Sci. 26:1193–1198. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Nath RL and Ghosh NK: A preliminary report on the determination of the normal values of serum alkaline phosphatase activity by velocity constant method. Bull Calcutta Sch Trop Med. 10:71–72. 1962.PubMed/NCBI

34 

Zhang GH, Cong AR, Xu GB, Li CB, Yang RF and Xia TA: An enzymatic cycling method for the determination of serum total bile acids with recombinant 3alpha-hydroxysteroid dehydrogenase. Biochem Biophys Res Commun. 326:87–92. 2005. View Article : Google Scholar

35 

Roberts RF and Roberts WL: Performance characteristics of a recombinant enzymatic cycling assay for quantification of total homocysteine in serum or plasma. Clin Chim Acta. 344:95–99. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Jaynes PK, Feld RD and Johnson GF: An enzymic, reaction-rate assay for serum creatinine with a centrifugal analyzer. Clin Chem. 28:114–117. 1982.PubMed/NCBI

37 

Tabacco A, Meiattini F, Moda E and Tarli P: Simplified enzymic/colorimetric serum urea nitrogen determination. Clin Chem. 25:336–337. 1979.PubMed/NCBI

38 

Whitlow K and Gochman N: Continuous-flow enzymic method evaluated for measurement of serum triglycerides with use of an improved lipase reagent. Clin Chem. 24:2018–2019. 1978.PubMed/NCBI

39 

Knob M and Rosenmund H: Enzymic determination of total serum cholesterol with centrifugal analyzers (author's transl). Z Klin Chem Klin Biochem. 13:493–498. 1975.In German. PubMed/NCBI

40 

Hunziker P and Keller H: A mechanized enzymic method for the determination of uric acid (author's transl). Z Klin Chem Klin Biochem. 13:89–96. 1975.In German. PubMed/NCBI

41 

Asrow G: Semiautomated enzymic micro methods for blood glucose and lactic acid on a single filtrate. Anal Biochem. 28:130–138. 1969. View Article : Google Scholar : PubMed/NCBI

42 

Egloff M, Léglise D, Duvillard L, Steinmetz J, Boyer MJ, Ruelland A, Agher R and Beucler I: Multicenter evaluation on different analyzers of three methods for direct HDL-cholesterol assay. Ann Biol Clin (Paris). 57:561–572. 1999.

43 

DaCol P and Kostner GM: Immunoquantification of total apolipoprotein B in serum by nephelometry: Influence of lipase treatment and detergents. Clin Chem. 29:1045–1050. 1983.PubMed/NCBI

44 

Girault A, Loiseau D and Girault M: Quantitative determination of apolipoprotein A in human serum by laser nephelometry. Ric Clin Lab. 11(Suppl 2): S19–S29. 1981.

45 

Cazzolato G, Prakasch G, Green S and Kostner GM: The determination of lipoprotein Lp(a) by rate and endpoint nephelometry. Clin Chim Acta. 135:203–208. 1983. View Article : Google Scholar : PubMed/NCBI

46 

Deyo RA, Pope RM and Persellin RH: Interference by rheumatoid factor with the detection of C-reactive protein by the latex agglutination method. J Rheumatol. 7:279–287. 1980.PubMed/NCBI

47 

Rifai N and Silverman LM: A simple immunotechnique for the determination of serum concentration of apolipoprotein E. Clin Chim Acta. 163:207–213. 1987. View Article : Google Scholar : PubMed/NCBI

48 

Ma J, Cheng J, Wang L, Wang H, Xu L, Liu P, Bu S, Zhang L, Le Y, Ye M, et al: No association between IRS-1 promoter methylation and type 2 diabetes. Mol Med Rep. 8:949–953. 2013.PubMed/NCBI

49 

Zhang LN, Liu PP, Wang L, Yuan F, Xu L, Xin Y, Fei LJ, Zhong QL, Huang Y, Xu L, et al: Lower ADD1 gene promoter DNA methylation increases the risk of essential hypertension. PloS One. 8:e634552013. View Article : Google Scholar : PubMed/NCBI

50 

Zemek F, Drtinova L, Nepovimova E, Sepsova V, Korabecny J, Klimes J and Kuca K: Outcomes of Alzheimer's disease therapy with acetylcholinesterase inhibitors and memantine. Expert Opin Drug Saf. 13:759–774. 2014.PubMed/NCBI

51 

Pritchard AL, Ratcliffe L, Sorour E, Haque S, Holder R, Bentham P and Lendon CL: Investigation of dopamine receptors in susceptibility to behavioural and psychological symptoms in Alzheimer's disease. Int J Geriatr Psychiatry. 24:1020–1025. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Fratiglioni L, Viitanen M, von Strauss E, Tontodonati V, Herlitz A and Winblad B: Very old women at highest risk of dementia and Alzheimer's disease: Incidence data from the Kungsholmen Project, Stockholm. Neurology. 48:132–138. 1997. View Article : Google Scholar : PubMed/NCBI

53 

Penaloza CG, Estevez B, Han DM, Norouzi M, Lockshin RA and Zakeri Z: Sex-dependent regulation of cytochrome P450 family members Cyp1a1, Cyp2e1, and Cyp7b1 by methylation of DNA. FASEB J. 28:966–977. 2014. View Article : Google Scholar :

54 

Piferrer F: Epigenetics of sex determination and gonadogenesis. Dev Dyn. 242:360–370. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Siegmund KD, Connor CM, Campan M, Long TI, Weisenberger DJ, Biniszkiewicz D, Jaenisch R, Laird PW and Akbarian S: DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PloS One. 2:e8952007. View Article : Google Scholar : PubMed/NCBI

56 

Paula-Lima AC, Tricerri MA, Brito-Moreira J, Bomfim TR, Oliveira FF, Magdesian MH, Grinberg LT, Panizzutti R and Ferreira ST: Human apolipoprotein A-I binds amyloid-beta and prevents Abeta-induced neurotoxicity. Int J Biochem Cell Biol. 41:1361–1370. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Fagan AM, Younkin LH, Morris JC, Fryer JD, Cole TG, Younkin SG and Holtzman DM: Differences in the Abeta40/Abeta42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype. Ann Neurol. 48:201–210. 2000. View Article : Google Scholar : PubMed/NCBI

58 

Emanuele E, Peros E, Tomaino C, Feudatari E, Bernardi L, Binetti G, Maletta R, Micieli G, Bruni AC and Geroldi D: Relation of apolipoprotein(a) size to alzheimer's disease and vascular dementia. Dement Geriatr Cogn Disord. 18:189–196. 2004. View Article : Google Scholar : PubMed/NCBI

59 

Solfrizzi V, Panza F, D'Introno A, Colacicco AM, Capurso C, Basile AM and Capurso A: Lipoprotein(a), apolipoprotein E genotype, and risk of Alzheimer's disease. J Neurol Neurosurg Psychiatry. 72:732–736. 2002. View Article : Google Scholar : PubMed/NCBI

60 

Suszynska-Zajczyk J, Luczak M, Marczak L and Jakubowski H: Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration. J Alzheimers Dis. 42:247–260. 2014.PubMed/NCBI

61 

Nazef K, Khelil M, Chelouti H, Kacimi G, Bendini M, Tazir M, Belarbi S, El Hadi Cherifi M and Djerdjouri B: Hyperhomocysteinemia is a risk factor for Alzheimer's disease in an Algerian population. Arch Med Res. 45:247–250. 2014. View Article : Google Scholar : PubMed/NCBI

62 

Hosseinzadeh S, Dabidi Roshan V and Pourasghar M: Effects of intermittent aerobic training on passive avoidance test (shuttle box) and stress markers in the dorsal hippocampus of wistar rats exposed to administration of homocysteine. Iran J Psychiatry Behav Sci. 7:37–44. 2013.

63 

Lu YQ, Luo Y, He ZF, Chen J, Yan BL, Wang Y and Yu Q: Hydroxysafflor yellow A ameliorates homocysteine-induced Alzheimer-like pathologic dysfunction and memory/synaptic disorder. Rejuvenation Res. 16:446–452. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Yarchoan M, Louneva N, Xie SX, Swenson FJ, Hu W, Soares H, Trojanowski JQ, Lee VM, Kling MA, Shaw LM, et al: Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease. J Neurol Sci. 333:9–12. 2013. View Article : Google Scholar : PubMed/NCBI

65 

Duong T, Nikolaeva M and Acton PJ: C-reactive protein-like immunoreactivity in the neurofibrillary tangles of Alzheimer's disease. Brain Res. 749:152–156. 1997. View Article : Google Scholar : PubMed/NCBI

66 

Iwamoto N, Nishiyama E, Ohwada J and Arai H: Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: Immunohistochemical study using formic acid pretreatment of tissue sections. Neurosci Lett. 177:23–26. 1994. View Article : Google Scholar : PubMed/NCBI

67 

Ponnayyan Sulochana S, Sharma K, Mullangi R and Sukumaran SK: Review of the validated HPLC and LC-MS/MS methods for determination of drugs used in clinical practice for Alzheimer's disease. Biomed Chromatogr. 28:1431–1490. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Ji H, Wang Y, Jiang D, Liu G, Xu X, Dai D, Zhou X, Cui W, Li J, Chen Z, Chen Z, et al: Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males. Mol Med Rep 14: 2732-2738, 2016.
APA
Ji, H., Wang, Y., Jiang, D., Liu, G., Xu, X., Dai, D. ... Wang, Q. (2016). Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males. Molecular Medicine Reports, 14, 2732-2738. https://doi.org/10.3892/mmr.2016.5560
MLA
Ji, H., Wang, Y., Jiang, D., Liu, G., Xu, X., Dai, D., Zhou, X., Cui, W., Li, J., Chen, Z., Li, Y., Zhou, D., Zha, Q., Zhuo, R., Jiang, L., Liu, Y., Shen, L., Zhang, B., Xu, L., Hu, H., Zhang, Y., Yin, H., Duan, S., Wang, Q."Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males". Molecular Medicine Reports 14.3 (2016): 2732-2738.
Chicago
Ji, H., Wang, Y., Jiang, D., Liu, G., Xu, X., Dai, D., Zhou, X., Cui, W., Li, J., Chen, Z., Li, Y., Zhou, D., Zha, Q., Zhuo, R., Jiang, L., Liu, Y., Shen, L., Zhang, B., Xu, L., Hu, H., Zhang, Y., Yin, H., Duan, S., Wang, Q."Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males". Molecular Medicine Reports 14, no. 3 (2016): 2732-2738. https://doi.org/10.3892/mmr.2016.5560
Copy and paste a formatted citation
x
Spandidos Publications style
Ji H, Wang Y, Jiang D, Liu G, Xu X, Dai D, Zhou X, Cui W, Li J, Chen Z, Chen Z, et al: Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males. Mol Med Rep 14: 2732-2738, 2016.
APA
Ji, H., Wang, Y., Jiang, D., Liu, G., Xu, X., Dai, D. ... Wang, Q. (2016). Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males. Molecular Medicine Reports, 14, 2732-2738. https://doi.org/10.3892/mmr.2016.5560
MLA
Ji, H., Wang, Y., Jiang, D., Liu, G., Xu, X., Dai, D., Zhou, X., Cui, W., Li, J., Chen, Z., Li, Y., Zhou, D., Zha, Q., Zhuo, R., Jiang, L., Liu, Y., Shen, L., Zhang, B., Xu, L., Hu, H., Zhang, Y., Yin, H., Duan, S., Wang, Q."Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males". Molecular Medicine Reports 14.3 (2016): 2732-2738.
Chicago
Ji, H., Wang, Y., Jiang, D., Liu, G., Xu, X., Dai, D., Zhou, X., Cui, W., Li, J., Chen, Z., Li, Y., Zhou, D., Zha, Q., Zhuo, R., Jiang, L., Liu, Y., Shen, L., Zhang, B., Xu, L., Hu, H., Zhang, Y., Yin, H., Duan, S., Wang, Q."Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males". Molecular Medicine Reports 14, no. 3 (2016): 2732-2738. https://doi.org/10.3892/mmr.2016.5560
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team