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Neuroprotection induced by post-conditioning following ischemia/reperfusion in mice is associated with altered microRNA expression

  • Authors:
    • Wei Miao
    • Tian‑Hao Bao
    • Jian‑Hong Han
    • Mei Yin
    • Jie Zhang
    • Yong Yan
    • Yu‑Hong Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Neurology, Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650031, P.R. China, Department of Geratology, Psychiatric Hospital of Yunnan Kunming, Yunnan 650224, P.R. China
    Copyright: © Miao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2582-2588
    |
    Published online on: July 29, 2016
       https://doi.org/10.3892/mmr.2016.5576
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Abstract

Ischemic preconditioning and ischemic postconditioning (IPostC) represent promising strategies to reduce ischemia-reperfusion (I/R) injury and attenuate the lethal ischemic damage following stroke. However, the mechanism underlying this attenuation remains to be elucidated. It was hypothesized that alterations in microRNA (miRNA) expression in the cerebral cortex and hippocampus of mice following I/R is associated with the functional improvement induced by IPostC. Behavioral changes were assessed in a mouse model of I/R in the absence or presence of IPostC, followed by microarray analyses to investigate the expressional alterations of miRNAs in the cerebral cortex and hippocampus of mice. The results of the present study revealed that IPostC abrogated the neurological impairment and hippocampus‑associated cognitive deficits induced by I/R, and upregulated or downregulated the expression levels of numerous miRNAs. Furthermore, the upregulation of miR‑19a, and the downregulation of miR‑1, let‑7f and miR‑124 expression levels following IPostC was confirmed utilizing reverse transcription‑quantitative polymerase chain reaction. The results of the present study demonstrated that alterations in miRNA expression in the cerebral cortex and hippocampus of mice following I/R was associated with the neuroprotection induced by IPostC.
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Copy and paste a formatted citation
Spandidos Publications style
Miao W, Bao TH, Han JH, Yin M, Zhang J, Yan Y and Zhu YH: Neuroprotection induced by post-conditioning following ischemia/reperfusion in mice is associated with altered microRNA expression. Mol Med Rep 14: 2582-2588, 2016.
APA
Miao, W., Bao, T., Han, J., Yin, M., Zhang, J., Yan, Y., & Zhu, Y. (2016). Neuroprotection induced by post-conditioning following ischemia/reperfusion in mice is associated with altered microRNA expression. Molecular Medicine Reports, 14, 2582-2588. https://doi.org/10.3892/mmr.2016.5576
MLA
Miao, W., Bao, T., Han, J., Yin, M., Zhang, J., Yan, Y., Zhu, Y."Neuroprotection induced by post-conditioning following ischemia/reperfusion in mice is associated with altered microRNA expression". Molecular Medicine Reports 14.3 (2016): 2582-2588.
Chicago
Miao, W., Bao, T., Han, J., Yin, M., Zhang, J., Yan, Y., Zhu, Y."Neuroprotection induced by post-conditioning following ischemia/reperfusion in mice is associated with altered microRNA expression". Molecular Medicine Reports 14, no. 3 (2016): 2582-2588. https://doi.org/10.3892/mmr.2016.5576
Copy and paste a formatted citation
x
Spandidos Publications style
Miao W, Bao TH, Han JH, Yin M, Zhang J, Yan Y and Zhu YH: Neuroprotection induced by post-conditioning following ischemia/reperfusion in mice is associated with altered microRNA expression. Mol Med Rep 14: 2582-2588, 2016.
APA
Miao, W., Bao, T., Han, J., Yin, M., Zhang, J., Yan, Y., & Zhu, Y. (2016). Neuroprotection induced by post-conditioning following ischemia/reperfusion in mice is associated with altered microRNA expression. Molecular Medicine Reports, 14, 2582-2588. https://doi.org/10.3892/mmr.2016.5576
MLA
Miao, W., Bao, T., Han, J., Yin, M., Zhang, J., Yan, Y., Zhu, Y."Neuroprotection induced by post-conditioning following ischemia/reperfusion in mice is associated with altered microRNA expression". Molecular Medicine Reports 14.3 (2016): 2582-2588.
Chicago
Miao, W., Bao, T., Han, J., Yin, M., Zhang, J., Yan, Y., Zhu, Y."Neuroprotection induced by post-conditioning following ischemia/reperfusion in mice is associated with altered microRNA expression". Molecular Medicine Reports 14, no. 3 (2016): 2582-2588. https://doi.org/10.3892/mmr.2016.5576
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