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MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia

  • Authors:
    • Youbang Xie
    • Wenqian Li
    • Jianming Feng
    • Tianyi Wu
    • Jianping Li
  • View Affiliations / Copyright

    Affiliations: Qinghai University, Qinghai Provincial People's Hospital, Xining, Qinghai 810000, P.R. China, Qinghai Provincial People's Hospital, Xining, Qinghai 810007, P.R. China, Qinghai High Altitude Medical Research Institute, Xining, Qinghai 810000, P.R. China
    Copyright: © Xie et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2503-2510
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    Published online on: July 29, 2016
       https://doi.org/10.3892/mmr.2016.5578
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Abstract

The aim of the present study was to investigate regulatory relationships among hypoxia-inducible factor-1α (HIF-1α), microRNA and erythroid transcription factors. K562 cells were transfected with HIF-1α knockout or with overexpression lentivirus of plasmid (MOI 10). The cells were divided into 3 groups: the negative control, overexpressing and interference groups. The cells were cultured under normoxia and hypoxia. Expression of miR-17*, miR-363 and miR-574-5p in the three groups was determined by quantitative PCR. Expression levels of erythroid transcription factor mRNAs such as GATA-1/GATA-2 and nuclear factor‑erythroid 2 (NF-E2) were measured using RT-qPCR while the protein expression was studied using western blot analysis. Under normoxia or hypoxia, the levels of miR-17*, miR-363 and miR‑574-5p in the overexpression group were higher than those in the other groups. Differences were statistically significant (P<0.05). Under hypoxia, the level of miR-363 in the interference group was less than that in the negative control group and difference was statistically significant (P<0.05). The level of GATA-1 mRNA in the overexpression group was higher than that in the negative control group, however, in the interference group the level was lower than that in the overexpression group under both normoxic and hypoxic conditions. The level of GATA-2 mRNA in the interference group was higher than that in other two groups under normoxic or hypoxic conditions. The NF-E2 mRNA was reversely related to GATA-2. The levels of HIF-1α, GATA-1 and NF-E2 mRNAs in the negative control under hypoxia were higher than those of normoxia. The level of HIF-1α mRNA in the overexpression group in hypoxia was lower than that in normoxia, while the GATA-1 and GATA-2 mRNA showed a reverse association. The levels of HIF-1α and GATA-2 mRNA in the interference group under hypoxia were higher compared to those of normoxia. Differences were statistically significant (P<0.05). Western blot results suggested that GATA-1, GATA-2 and NF-E2 protein expression correlated with changes in their respective mRNA transcription levels. The results therefore suggested that GATA-l and miR-363 were involved in the regulation of hematopoiesis via the HIF-1α pathway in K562 cells under hypoxic condition. The hsa-miR-17* and hsa-miR‑574-5p were not entirely dependent on HIF-1α, suggesting possible complex regulatory mechanisms involved in hypoxia.
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1 

Hattangadi SM, Wong P, Zhang L, et al: From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood. 118:6258–6268. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Undi RB, Kandi R and Gutti RK: MicroRNAs as haematopoiesis regulators. Adv Hematol. 2013:695–754. 2013. View Article : Google Scholar

3 

Ha M and Kim VN: Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 15:509–524. 2014. View Article : Google Scholar : PubMed/NCBI

4 

Zhao S and Liu M: The progress of microRNA mechanism and research. China Science C Series. 39:109–113. 2009.

5 

Hashimoto K, Otero M, Imagawa K, de Andrés MC, Coico JM, Roach HI, Oreffo RO, Marcu KB and Goldring MB: Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. J Biol Chem. 288:10061–10072. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Cai L: Epigenetic frontier (M) Beijing. Tsinghua University Press. 2012. 133–142. 2012.

7 

Tsai FY, Keller G, Kuo FC, Weiss M, Chen J, Rosenblatt M, Alt FW and Orkin SH: An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature. 371:221–226. 1994. View Article : Google Scholar : PubMed/NCBI

8 

Tsai FY and Orkin SH: Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood. 89:3636–3643. 1997.PubMed/NCBI

9 

Vicente C, Conchillo A, García-Sánchez MA and Odero MD: The role of the GATA2 transcription factor in normal and malignant hematopoiesis. Crit Rev Oncol Hematol. 82:1–17. 2012. View Article : Google Scholar

10 

Ferreira R, Ohneda K, Yamamoto M and Philipsen S: GATA1 function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol. 25:1215–1227. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Pevny L, Simon MC, Robertson E, Klein WH, Tsai SF, D'Agati V, Orkin SH and Costantini F: Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature. 349:257–260. 1991. View Article : Google Scholar : PubMed/NCBI

12 

Pevny L, Lin CS, D'Agati V, Simon MC, Orkin SH and Costantini F: Development of hematopoietic cells lacking transcription factor GATA-1. Development. 121:163–172. 1995.PubMed/NCBI

13 

Zon LI, Youssoufian H, Mather C, Lodish HF and Orkin SH: Activation of the erythropoietin receptor promoter by transcription factor GATA-1. Proc Natl Acad Sci USA. 88:10638–10641. 1991. View Article : Google Scholar : PubMed/NCBI

14 

Lacombe C and Mayeux P: The molecular biology of erythropoietin. Nephrol Dial Transplant. 14(Suppl 2): 22–28. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Zhou Z, Li X, Deng C, Ney PA, Huang S and Bungert J: USF and NF-E2 cooperate to regulate the recruitment and activity of RNA polymerase II in the beta-globin gene locus. J Biol Chem. 285:15894–15905. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Kapralova K, Lanikova L, Lorenzo F, Song J, Horvathova M, Divoky V and Prchal JT: RUNX1 and NF-E2 upregulation is not specific for MPNs, but is seen in polycythemic disorders with augmented HIF signaling. Blood. 123:391–394. 2014. View Article : Google Scholar :

17 

Li Y, Bai H, Zhang Z, Li W, Dong L, Wei X, Ma Y, Zhang J, Yu J, Sun G, et al: The up-regulation of miR-199b-5p in erythroid differentiation is associated with GATA-1 and NF-E2. Mol Cells. 37:213–219. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Wang F, Zhu Y, Guo L, Dong L, Liu H, Yin H, Zhang Z, Li Y, Liu C, Ma Y, et al: A regulatory circuit comprising GATA1/2 switch and microRNA-27a/24 promotes erythropoiesis. Nucleic Acids Res. 42:442–457. 2014. View Article : Google Scholar

19 

Xu H, Iyer N, Huettner JE and Sakiyama-Elbert SE: A puromycin selectable cell line for the enrichment of mouse embryonic stem cell-derived V3 interneurons. Stem Cell Res Ther. 6:2202015. View Article : Google Scholar : PubMed/NCBI

20 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

21 

Hattangadi SM, Wong P, Zhang L, Flygare J and Lodish HF: From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications. Blood. 118:6258–6268. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Doré LC, Chlon TM, Brown CD, White KP and Crispino JD: Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood. 119:3724–3733. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Bresnick EH, Lee HY, Fujiwara T, Johnson KD and Keles S: GATA switches as developmental drivers. J Biol Chem. 285:31087–31093. 2010. View Article : Google Scholar : PubMed/NCBI

24 

Grass JA, Boyer ME, Pal S, Wu J, Weiss MJ and Bresnick EH: GATA-1-dependent transcriptional repression of GATA-2 via disruption of positive autoregulation and domain-wide chromatin remodeling. Proc Natl Acad Sci USA. 100:8811–8816. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Martowicz ML, Grass JA, Boyer ME, Guend H and Bresnick EH: Dynamic GATA factor interplay at a multicomponent regulatory region of the GATA-2 locus. J Biol Chem. 280:1724–1732. 2005. View Article : Google Scholar

26 

Grass JA, Jing H, Kim SI, Martowicz ML, Pal S, Blobel GA and Bresnick EH: Distinct functions of dispersed GATA factor complexes at an endogenous gene locus. Mol Cell Biol. 26:7056–7067. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Wightman B, Ha I and Ruvkun G: Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 75:855–862. 1993. View Article : Google Scholar : PubMed/NCBI

28 

Lee RC, Feinbaum RL and Ambros V: The C. elegans hetero chronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 75:843–854. 1993. View Article : Google Scholar : PubMed/NCBI

29 

Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD and Chen YG: MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood. 111:588–595. 2008. View Article : Google Scholar

30 

Fu YF, Du TT, Dong M, Zhu KY, Jing CB, Zhang Y, Wang L, Fan HB, Chen Y, Jin Y, et al: Mir-144 selectively regulates embryonic alpha-hemoglobin synthesis during primitive erythropoiesis. Blood. 113:1340–1349. 2009. View Article : Google Scholar

31 

Patrick DM, Zhang CC, Tao Y, Yao H, Qi X, Schwartz RJ, Jun-Shen Huang L and Olson EN: Defective erythroid differentiation in miR-451 mutant mice mediated by 14-3-3zeta. Genes Dev. 24:1614–1619. 2010. View Article : Google Scholar : PubMed/NCBI

32 

Rasmussen KD, Simmini S, Abreu-Goodger C, Bartonicek N, Di Giacomo M, Bilbao-Cortes D, Horos R, Von Lindern M, Enright AJ and O'Carroll D: The miR-144/451 locus is required for erythroid homeostasis. J Exp Med. 207:1351–1358. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Yu D, dos Santos CO, Zhao G, Jiang J, Amigo JD, Khandros E, Dore LC, Yao Y, D'Souza J, Zhang Z, et al: miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev. 24:1620–1633. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Sankaran VG, Menne TF, Šćepanović D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES and Lodish HF: MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proc Natl Acad Sci USA. 108:1519–1524. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Zhang L, Flygare J, Wong P, Lim B and Lodish HF: miR-191 regulates mouse erythroblast enucleation by down-regulating Riok3 and Mxi1. Genes Dev. 25:119–124. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Georgantas RW III, Hildreth R, Morisot S, Alder J, Liu CG, Heimfeld S, Calin GA, Croce CM and Civin CI: CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci USA. 104:2750–2755. 2007. View Article : Google Scholar

37 

Norfo R, Zini R, Pennucci V, Bianchi E, Salati S, Guglielmelli P, Bogani C, Fanelli T, Mannarelli C, Rosti V, et al: Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative Investigators: miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis. Blood. 124:e21–e32. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Crispino JD, Lodish MB, MacKay JP and Orkin SH: Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex. Mol Cell. 3:219–228. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Jelkmann W: Molecular biology of erythropoietin. Intern Med. 43:649–659. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Fried W: Erythropoietin and erythropoiesis. Exp Hematol. 37:1007–1015. 2009. View Article : Google Scholar : PubMed/NCBI

41 

Zhang FL, Shen GM, Liu XL, Wang F, Zhao YZ and Zhang JW: Hypoxia-inducible factor 1-mediated human GATA1 induction promotes erythroid differentiation under hypoxic conditions. J Cell Mol Med. 16:1889–1899. 2012. View Article : Google Scholar

42 

Weiss MJ and Orkin SH: GATA transcription factors: key regulators of hematopoiesis. Exp Hematol. 23:99–107. 1995.PubMed/NCBI

43 

Orkin SH: GATA-binding transcription factors in hematopoietic cells. Blood. 80:575–581. 1992.PubMed/NCBI

44 

Moriguchi T and Yamamoto M: Network regulation of Gata1 and Gata2 gene-dynamics underlies erythroid differentiation. Rinsho Ketsueki. 55:633–642. 2014.In Japanese. PubMed/NCBI

45 

Yang Y, Ma W, Wu D, Huang Y, Li H, Zou J, Zhang Y, Feng M and Luo J: MiR-17 partly promotes hematopoietic cell expansion through augmenting HIF-1α in osteoblasts. PLoS One. 8:e702322013. View Article : Google Scholar

46 

Bianchi N, Zuccato C, Lampronti I, Borgatti M and Gambari R: Expression of miR-210 during erythroid differentiation and induction of gamma-globin gene expression. BMB Rep. 42:493–499. 2009. View Article : Google Scholar : PubMed/NCBI

47 

Fabbri E, Manicardi A, Tedeschi T, Sforza S, Bianchi N, Brognara E, Finotti A, Breveglieri G, Borgatti M, Corradini R, et al: Modulation of the biological activity of microRNA-210 with peptide nucleic acids (PNAs). Chem Med Chem. 6:2192–2202. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xie Y, Li W, Feng J, Wu T and Li J: MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia. Mol Med Rep 14: 2503-2510, 2016.
APA
Xie, Y., Li, W., Feng, J., Wu, T., & Li, J. (2016). MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia. Molecular Medicine Reports, 14, 2503-2510. https://doi.org/10.3892/mmr.2016.5578
MLA
Xie, Y., Li, W., Feng, J., Wu, T., Li, J."MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia". Molecular Medicine Reports 14.3 (2016): 2503-2510.
Chicago
Xie, Y., Li, W., Feng, J., Wu, T., Li, J."MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia". Molecular Medicine Reports 14, no. 3 (2016): 2503-2510. https://doi.org/10.3892/mmr.2016.5578
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Y, Li W, Feng J, Wu T and Li J: MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia. Mol Med Rep 14: 2503-2510, 2016.
APA
Xie, Y., Li, W., Feng, J., Wu, T., & Li, J. (2016). MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia. Molecular Medicine Reports, 14, 2503-2510. https://doi.org/10.3892/mmr.2016.5578
MLA
Xie, Y., Li, W., Feng, J., Wu, T., Li, J."MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia". Molecular Medicine Reports 14.3 (2016): 2503-2510.
Chicago
Xie, Y., Li, W., Feng, J., Wu, T., Li, J."MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia". Molecular Medicine Reports 14, no. 3 (2016): 2503-2510. https://doi.org/10.3892/mmr.2016.5578
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