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Article

Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes

  • Authors:
    • Sun‑Joo Oh
    • Kyunghoon Kim
    • Chang‑Jin Lim
  • View Affiliations / Copyright

    Affiliations: Department of Biological Sciences, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon 200‑701, Republic of Korea, Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon, Gangwon 200‑701, Republic of Korea
  • Pages: 2839-2845
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    Published online on: August 1, 2016
       https://doi.org/10.3892/mmr.2016.5581
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Abstract

Ginsenosides are responsible for diverse pharmacological properties ascribed to ginseng, a plant used in traditional medicine. Ginsenosides are classified into three categories: Protopanaxadiol, protopanaxatriol (PPT) and oleanolic acid. As an aglycone of PPT-type ginsenosides, PPT exists in two stereoisomeric forms, 20(S)-PPT and 20(R)‑PPT. The 20(S)‑PPT stereoisomer is a major metabolic product of PPT‑type ginsenosides produced in the gastrointestinal tract. In the present study, 20(S)-PPT suppressed the elevation of reactive oxygen species in HaCaT cells following irradiation with ultraviolet (UV)‑B. In addition, 20(S)‑PPT inhibited UV‑B‑induced gelatinase activities of matrix metalloproteinase-2 and -9 in HaCaT cells, and suppressed UV‑B‑induced expression and secretion of these proteins. Accordingly, 20(S)‑PPT restored the total glutathione levels in UV‑B‑irradiated keratinocytes. Taken together, these data indicated that 20(S)‑PPT may possess photoprotective properties that combat the effects of UV‑B radiation.
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Spandidos Publications style
Oh SJ, Kim K and Lim CJ: Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes. Mol Med Rep 14: 2839-2845, 2016.
APA
Oh, S., Kim, K., & Lim, C. (2016). Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes. Molecular Medicine Reports, 14, 2839-2845. https://doi.org/10.3892/mmr.2016.5581
MLA
Oh, S., Kim, K., Lim, C."Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes". Molecular Medicine Reports 14.3 (2016): 2839-2845.
Chicago
Oh, S., Kim, K., Lim, C."Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes". Molecular Medicine Reports 14, no. 3 (2016): 2839-2845. https://doi.org/10.3892/mmr.2016.5581
Copy and paste a formatted citation
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Spandidos Publications style
Oh SJ, Kim K and Lim CJ: Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes. Mol Med Rep 14: 2839-2845, 2016.
APA
Oh, S., Kim, K., & Lim, C. (2016). Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes. Molecular Medicine Reports, 14, 2839-2845. https://doi.org/10.3892/mmr.2016.5581
MLA
Oh, S., Kim, K., Lim, C."Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes". Molecular Medicine Reports 14.3 (2016): 2839-2845.
Chicago
Oh, S., Kim, K., Lim, C."Photoprotective properties of 20(S)-protopanaxatriol, an aglycone of ginseng saponins: Protection from ultraviolet-B radiation-induced oxidative stress in human epidermal keratinocytes". Molecular Medicine Reports 14, no. 3 (2016): 2839-2845. https://doi.org/10.3892/mmr.2016.5581
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