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Article Open Access

Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis

Corrigendum in: /10.3892/mmr.2016.5882
  • Authors:
    • Chao Huang
    • Hong Liu
    • Xiuli Gong
    • Bin Wen
    • Dan Chen
    • Jinyuan Liu
    • Fengliang Hu
  • View Affiliations / Copyright

    Affiliations: Spleen‑Stomach Institute, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510000, P.R. China, Pathology Department, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510000, P.R. China, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510000, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2555-2565
    |
    Published online on: August 1, 2016
       https://doi.org/10.3892/mmr.2016.5584
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Abstract

The present study aimed to observe the varying expression of biomarkers in the microenvironment adjacent to colorectal cancer lesions to provide additional insight into the functions of microenvironment components in carcinogenesis and present a novel or improved indicator for early diagnosis of cancer. A total of 144 human samples from three different locations in 48 patients were collected, these locations were 10, 5 and 2 cm from the colorectal cancer lesion, respectively. The biomarkers analyzed included E‑cadherin, cytokeratin 18 (CK18), hyaluronidase‑1 (Hyal‑1), collagen type I (Col‑I), Crumbs3 (CRB3), vimentin, proteinase activated receptor 3 (PAR‑3), α‑smooth muscle actin (α‑SMA), cyclin D1 (CD1) and cluster of differentiation (CD)133. In addition, crypt architecture was observed. Related functional analysis of proteins was performed using hierarchical index cluster analysis. More severe destroyed crypt architecture closer to the cancer lesions was observed compared with the 10 cm sites, with certain crypts degraded entirely. Expression levels of E‑cadherin, CK18, CRB3 and PAR‑3 were lower in 2 cm sites compared with the 10 cm sites (all P<0.001), while the expression levels of the other biomarkers in the 2 cm sites were increased compared with 10 cm sites (all P<0.0001). Notably, the expression of CK18 in 2 cm sites was higher than in the 5 cm site (P<0.0001), which was different from the expression of E‑cadherin, CRB3 and PAR‑3. The expression levels of Hyal‑1 and Col‑I at the 2 cm sites were lower than that of the 5 cm sites (P>0.05 and P=0.0001, respectively), while the expression of vimentin, α‑SMA, CD1 and CD133 were not. Hyal‑1 and Col‑I may be independently important in cancer initiation in the tumor microenvironment. The results of the present study suggest that the biomarkers in the tissue microenvironment are associated with early tumorigenesis and may contribute to the development of carcinomas. These observations may be useful for early diagnosis of colorectal cancer.
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View References

1 

Brücher BL and Jamall IS: Epistemology of the origin of cancer: A new paradigm. BMC Cancer. 14:3312014. View Article : Google Scholar : PubMed/NCBI

2 

Paget S: The distribution of secondary growths in cancer of the breast 1889. Cancer Metastasis Rev. 8:98–101. 1989.PubMed/NCBI

3 

Korkaya H, Liu S and Wicha MS: Breast cancer stem cells, cytokine networks, and the tumor microenvironment. J Clin Invest. 121:3804–3809. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Felsher DW: Cancer revoked: Oncogenes as therapeutic targets. Nat Rev Cancer. 3:375–380. 2003. View Article : Google Scholar : PubMed/NCBI

5 

Li R and Pendergast AM: Arg kinase regulates epithelial cell polarity by targeting β1-integrin and small GTPase pathways. Curr Biol. 21:1534–1542. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Hammoudi A, Song F, Reed KR, Jenkins RE, Meniel VS, Watson AJ, Pritchard DM, Clarke AR and Jenkins JR: Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectalcancer (CRC). Biochem Biophys Res Commun. 440:364–370. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Elsum IA, Martin C and Humbert PO: Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation. J Cell Sci. 126:3990–3999. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Sfakianos J, Togawa A, Maday S, Hull M, Pypaert M, Cantley L, Toomre D and Mellman I: Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells. J Cell Biol. 179:1133–1140. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Reed MJ, Damodarasamy M, Chan CK, Johnson MN, Wight TN and Vernon RB: Cleavage of hyaluronan is impaired in aged dermal wounds. Matrix Biol. 32:45–51. 2013. View Article : Google Scholar :

10 

Tlsty TD and Hein PW: Know thy neighbor: Stromal cells can contribute oncogenic signals. Curr Opin Genet Dev. 11:54–59. 2001. View Article : Google Scholar : PubMed/NCBI

11 

Weinberg R and Mihich E: Eighteenth annual pezcoller symposium: Tumor microenvironment and heterotypic interactions. Cancer Res. 66:11550–11553. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Roncucci L, Pedroni M, Vaccina F, Benatti P, Marzona L and De Pol A: Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics. Cell Prolif. 33:1–18. 2000. View Article : Google Scholar : PubMed/NCBI

13 

Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Guo F, Wang Q, Zhou Y, Wu L, Ma X, Liu F, Huang F and Qin G: Lentiviral vector-mediated FoxO1 overexpression inhibits extracellular matrix protein secretion under high glucose conditions in mesangial cells. J Cell Biochem. 117:74–83. 2016. View Article : Google Scholar

15 

Kolliopoulos C, Bounias D, Bouga H, Kyriakopoulou D, Stavropoulos M and Vynios DH: Hyaluronidases and their inhibitors in the serum of colorectal carcinoma patients. J Pharm Biomed Anal. 83:299–304. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Barreto SC, Hopkins CA, Bhowmick M and Ray A: Extracellular matrix in obesity-cancer interactions. Horm Mol Biol Clin Investig. 22:63–77. 2015.PubMed/NCBI

17 

Abu El-Asrar AM, De Hertogh G, van den Eynde K, Alam K, Van Raemdonck K, Opdenakker G, Van Damme J, Geboes K and Struyf S: Myofibroblasts in proliferative diabetic retinopathy can originate from infiltrating fibrocytes and through endothelial-to-mesenchymal transition (EndoMT). Exp Eye Res. 132:179–189. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Noah TK, Lo YH, Price A, Chen G, King E, Washington MK, Aronow BJ and Shroyer NF: SPDEF functions as a colorectal tumor suppressor by inhibiting β-catenin activity. Gastroenterology. 144:1012–1023.e6. 2013. View Article : Google Scholar

19 

Grosse-Gehling P, Fargeas CA, Dittfeld C, Garbe Y, Alison MR, Corbeil D and Kunz-Schughart LA: CD133 as a biomarker for putative cancer stem cells in solid tumours: Limitations, problems and challenges. J Pathol. 229:355–378. 2013. View Article : Google Scholar

20 

Wang P: Suppression of DACH1 promotes migration and invasion of colorectal cancer via activating TGF-β-mediated epithelial-mesenchymal transition. Biochem Biophys Res Commun. 460:314–319. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Lai DW, Liu SH, Karlsson AI, Lee WJ, Wang KB, Chen YC, Shen CC, Wu SM, Liu CY, Tien HR, et al: The novel Aryl hydrocarbon receptor inhibitor biseugenol inhibits gastric tumor growth and peritoneal dissemination. Oncotarget. 5:7788–7804. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Knösel T, Emde V, Schlüns K, Schlag PM, Dietel M and Petersen I: Cytokeratin profiles identify diagnostic signatures in colorectal cancer using multiplex analysis of tissue microarrays. Cell Oncol. 28:167–175. 2006.PubMed/NCBI

23 

Cernat L, Blaj C, Jackstadt R, Brandl L, Engel J, Hermeking H, Jung A, Kirchner T and Horst D: Colorectal cancers mimic structural organization of normal colonic crypts. PLoS One. 9:e1042842014. View Article : Google Scholar : PubMed/NCBI

24 

Milicic A, Harrison LA, Goodlad RA, Hardy RG, Nicholson AM, Presz M, Sieber O, Santander S, Pringle JH, Mandir N, et al: Ectopic expression of P-cadherin correlates with promoter hypomethylation early in colorectal carcinogenesis and enhanced intestinal crypt fission in vivo. Cancer Res. 68:7760–7768. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Whiteman EL, Liu CJ, Fearon ER and Margolis B: The transcription factor snail represses Crumbs3 expression and disrupts apicobasal polarity complexes. Oncogene. 27:3875–3879. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Ribeiro AL and Okamoto OK: Combined effects of pericytes in the tumor microenvironment. Stem Cells Int. 2015:8684752015. View Article : Google Scholar : PubMed/NCBI

27 

Kim MJ, Lee YS, Han GY, Lee HN, Ahn C and Kim CW: Profilin 2 promotes migration, invasion, and stemness of HT29 human colorectal cancer stem cells. Biosci Biotechnol Biochem. 79:1438–1446. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Chen CC, Sureshbabul M, Chen HW, Lin YS, Lee JY, Hong QS, Yang YC and Yu SL: Curcumin suppresses metastasis via Sp-1, FAK inhibition and E-Cadherin upregulation in colorectal cancer. Evid Based Complement Alternat Med. 2013:5416952013. View Article : Google Scholar

29 

Ng L, Wan TM, Lam CS, Chow AK, Wong SK, Man JH, Li HS, Cheng NS, Pak RC, Cheung AH, et al: Post-operative plasma osteopontin predicts distant metastasis in human colorectal cancer. PLoS One. 10:e01262192015. View Article : Google Scholar : PubMed/NCBI

30 

Kim YJ, Kang HB, Yim HS, Kim JH and Kim JW: NDRG2 positively regulates E-cadherin expression and prolongs overall survival in colon cancer patients. Oncol Rep. 30:1890–1898. 2013.PubMed/NCBI

31 

Elsum IA, Martin C and Humbert PO: Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation. J Cell Sci. 126:3990–3999. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Karp CM, Tan TT, Mathew R, Nelson D, Mukherjee C, Degenhardt K, Karantza-Wadsworth V and White E: Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression. Cancer Res. 68:4105–4115. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Sfakianos J, Togawa A, Maday S, Hull M, Pypaert M, Cantley L, Toomre D and Mellman I: Par3 functions in the biogenesis of the primary cilium in polarized epithelial cells. J Cell Biol. 179:1133–1140. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Liu J, Zhang W, Liu J, Lu X, Long Y, Zhou Y and Liu S: Expressions of connexin and par-3 in the distal margin of rectal cancer after ultra-low anterior resection. J Huazhong Univ Sci Technolog Med Sci. 29:330–334. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Mack NA, Porter AP, Whalley HJ, Schwarz JP, Jones RC, Khaja AS, Bjartell A, Anderson KI and Malliri A: β2-syntrophin and Par-3 promote an apicobasal Rac activity gradient at cell-cell junctions by differentially regulating Tiam1 activity. Nat Cell Biol. 14:1169–1180. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Wong CS, Wong VW, Chan CM, Ma BB, Hui EP, Wong MC, Lam MY, Au TC, Chan WH, Cheuk W and Chan AT: Identification of 5-fluorouracil response proteins in colorectal carcinoma cell line SW480 by two-dimensional electrophoresis and MALDI-TOF mass spectrometry. Oncol Rep. 20:89–98. 2008.PubMed/NCBI

37 

Wang P: Suppression of DACH1 promotes migration and invasion of colorectal cancer via activating TGF-β-mediated epithelial-mesenchymal transition. Biochem Biophys Res Commun. 460:314–319. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Chen Y, Cha Z, Fang W, Qian B, Yu W, Li W, Yu G and Gao Y: The prognostic potential and oncogenic effects of PRR11 expression in hilar cholangiocarcinoma. Oncotarget. 6:20419–20433. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Ji Q, Liu X, Han Z, Zhou L, Sui H, Yan L, Jiang H, Ren J, Cai J and Li Q: Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression. BMC Cancer. 15:972015. View Article : Google Scholar

40 

Lee WS, Woo EY, Kwon J, Park MJ, Lee JS, Han YH and Bae IH: Bcl-w enhances mesenchymal changes and invasiveness of glioblastoma cells by inducing nuclear accumulation of β-catenin. PLoS One. 8:e680302013. View Article : Google Scholar

41 

Matsumoto K, Arao T, Tanaka K, Kaneda H, Kudo K, Fujita Y, Tamura D, Aomatsu K, Tamura T, Yamada Y, et al: mTOR signal and hypoxia-inducible factor-1 alpha regulate CD133 expression in cancer cells. Cancer Res. 69:7160–7164. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Pistollato F, Abbadi S, Rampazzo E, Persano L, Della Puppa A, Frasson C, Sarto E, Scienza R, D'avella D and Basso G: Intratumoral hypoxic gradient drives stem cells distribution and MGMT expression in glioblastoma. Stem Cells. 28:851–862. 2010.PubMed/NCBI

43 

Ding Q, Yoshimitsu M, Kuwahata T, Maeda K, Hayashi T, Obara T, Miyazaki Y, Matsubara S, Natsugoe S and Takao S: Establishment of a highly migratory subclone reveals that CD133 contributes to migration and invasion through epithelial-mesenchymal transition in pancreatic cancer. Hum Cell. 25:1–8. 2012. View Article : Google Scholar

44 

Tlsty TD and Coussens LM: Tumor stroma and regulation of cancer development. Annu Rev Pathol. 1:119–150. 2006. View Article : Google Scholar

45 

Herrera A, Herrera M, Alba-Castellón L, Silva J, García V, Loubat-Casanovas J, Alvarez-Cienfuegos A, Miguel García J, Rodriguez R, Gil B, et al: Protumorigenic effects of Snail-expression fibroblasts on colon cancer cells. Int J Cancer. 134:2984–2990. 2014. View Article : Google Scholar

46 

Yang MC, Wang CJ, Liao PC, Yen CJ and Shan YS: Hepatic stellate cells secretes type I collagen to trigger epithelial mesenchymal transition of hepatoma cells. Am J Cancer Res. 4:751–763. 2014.PubMed/NCBI

47 

Feng Y, Xu X, Zhang Y, Ding J, Wang Y, Zhang X, Wu Z, Kang L, Liang Y, Zhou L, et al: HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion. Sci Rep. 5:94292015. View Article : Google Scholar : PubMed/NCBI

48 

Zhang HS, Yan B, Li XB, Fan L, Zhang YF, Wu GH, Li M and Fang J: PAX2 protein induces expression of cyclin D1 through activating AP-1 protein and promotes proliferation of colon cancer cells. J Biol Chem. 287:44164–44172. 2012. View Article : Google Scholar : PubMed/NCBI

49 

Park EJ, Chung HJ, Park HJ, Kim GD, Ahn YH and Lee SK: Suppression of Src/ERK and GSK-3/β-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells. Food Chem Toxicol. 55:424–433. 2013. View Article : Google Scholar : PubMed/NCBI

50 

Hayashido Y, Kitano H, Sakaue T, Fujii T, Suematsu M, Sakurai S and Okamoto T: Overexpression of integrin αv facilitates proliferation and invasion of oral squamous cell carcinoma cells via MEK/ERK signaling pathway that is activated by interaction of integrin αvβ8 with type I collagen. Int J Oncol. 45:1875–1882. 2014.PubMed/NCBI

51 

Nykopp TK, Pasonen-Seppänen S, Tammi MI, Tammi RH, Kosma VM, Anttila M and Sironen R: Decreased hyaluronidase 1 expression is associated with early disease recurrence in human endometrial cancer. Gynecol Oncol. 137:152–159. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Song L, Liu D, Wang B, He J, Zhang S, Dai Z, Ma X and Wang X: miR-494 suppresses the progression of breast cancer in vitro by targeting CXCR4 through the Wnt/β-catenin signaling pathway. Oncol Rep. 34:525–531. 2015.PubMed/NCBI

53 

Cao F, Miao Y, Xu K and Liu P: Lethal (2) giant larvae: An indispensable regulator of cell polarity and cancer development. Int J Biol Sci. 11:380–389. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Mayne R, Vail MS and Miller EJ: Characterization of the collagen chains synthesized by cultured smooth muscle cells derived from rhesus monkey thoracic aorta. Biochemistry. 17:446–452. 1978. View Article : Google Scholar : PubMed/NCBI

55 

Brücher BL and Jamall IS: Cell-cell communication in the tumor microenvironment, carcinogenesis and anticancer treatment. Cell Physiol Biochem. 34:213–243. 2014. View Article : Google Scholar

56 

Yamanaka T, Horikoshi Y, Suzuki A, Sugiyama Y, Kitamura K, Maniwa R, Nagai Y, Yamashita A, Hirose T, Ishikawa H and Ohno S: Par-6 regulates aPKC activity in a novel way and mediates cell-cell contact-induced formation of the epithelial junctional complex. Genes Cells. 6:721–731. 2001. View Article : Google Scholar : PubMed/NCBI

57 

Guo J, Niu R, Huang W, Zhou M, Shi J, Zhang L and Liao H: Growth factors from tumor microenvironment possibly promote the proliferation of glioblastoma-derived stem-like cells in vitro. Pathol Oncol Res. 18:1047–1057. 2012. View Article : Google Scholar : PubMed/NCBI

58 

Itoh M, Sasaki H, Furuse M, Ozaki H, Kita T and Tsukita S: Junctional adhesion molecule (JAM) binds to PAR-3: A possible mechanism for the recruitment of PAR-3 to tight junctions. J Cell Biol. 154:491–497. 2001. View Article : Google Scholar : PubMed/NCBI

59 

Ebnet K, Suzuki A, Horikoshi Y, Hirose T, Meyer Zu, Brickwedde MK, Ohno S and Vestweber D: The cell polarity protein ASIP/PAR-3 directly associates with junctional adhesion molecule (JAM). EMBO J. 20:3738–3748. 2001. View Article : Google Scholar : PubMed/NCBI

60 

Lokeshwar VB, Rubinowicz D, Schroeder GL, Forgacs E, Minna JD, Block NL, Nadji M and Lokeshwar BL: Stromal and epithelial expression of tumor markers hyaluronic acid and HYAL1 hyaluronidase in prostate cancer. J Biol Chem. 276:11922–11932. 2001. View Article : Google Scholar : PubMed/NCBI

61 

Lokeshwar VB, Young MJ, Goudarzi G, Iida N, Yudin AI, Cherr GN and Selzer MG: Identification of bladder tumor-derived hyaluronidase: Its similarity to HYAL1. Cancer Res. 59:4464–44670. 1999.PubMed/NCBI

62 

McCrea PD, Gu D and Balda MS: Junctional music that the nucleus hears: Cell-cell contact signaling and the modulation of gene activity. Cold Spring Harb Perspect Biol. 1:a0029232009. View Article : Google Scholar

63 

Menzel EJ and Farr C: Hyaluronidase and its substrate hyaluronan: Biochemistry, biological activities and therapeutic uses. Cancer Lett. 131:3–11. 1998. View Article : Google Scholar : PubMed/NCBI

64 

Turley EA, Noble PW and Bourguignon LY: Signaling properties of hyaluronan receptors. J Biol Chem. 277:4589–4592. 2002. View Article : Google Scholar

65 

Paiva P, Van Damme MP, Tellbach M, Jones RL, Jobling T and Salamonsen LA: Expression patterns of hyaluronan, hyaluronan synthases and hyaluronidases indicate a role for hyaluronan in the progression of endometrial cancer. Gynecol Oncol. 98:193–202. 2005. View Article : Google Scholar : PubMed/NCBI

66 

Wang F, Grigorieva EV, Li J, Senchenko VN, Pavlova TV, Anedchenko EA, Kudryavtseva AV, Tsimanis A, Angeloni D, Lerman MI, et al: HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro. PLoS One. 3:e30312008. View Article : Google Scholar : PubMed/NCBI

67 

Lokeshwar VB, Cerwinka WH and Lokeshwar BL: HYAL1 hyaluronidase: A molecular determinant of bladder tumor growth and invasion. Cancer Res. 65:2243–2250. 2005. View Article : Google Scholar : PubMed/NCBI

68 

Kramer MW, Golshani R, Merseburger AS, Knapp J, Garcia A, Hennenlotter J, Duncan RC, Soloway MS, Jorda M, Kuczyk MA, et al: HYAL-1 hyaluronidase: A potential prognostic indicator for progression to muscle invasion and recurrence in bladder cancer. Eur Urol. 57:86–93. 2010. View Article : Google Scholar :

69 

Wakitani S, Kimura T, Hirooka A, Ochi T, Yoneda M, Yasui N, Owaki H and Ono K: Repair of rabbit articular surfaces with allograft chodnrocytes embedded in collagen gel. J Bone Joint Surg Br. 71:74–80. 1989.PubMed/NCBI

70 

Frenkel SR, Toolan B, Menche D, Pitman MI and Pachence JM: Chondrocyte transplantation using a collagen bilayer matrix for cartilage repair. J Bone Joint Surg Br. 79:831–836. 1997. View Article : Google Scholar : PubMed/NCBI

71 

Schuppan D, Schmid M, Somasundaram R, Ackermann R, Ruehl M, Nakamura T and Riecken EO: Collagens in the liver extracellular matrix bind hepatocyte growth factor. Gastroenterology. 114:139–152. 1998. View Article : Google Scholar : PubMed/NCBI

72 

Kauppila S, Stenbäck F, Risteli J, Jukkola A and Risteli L: Aberrant type I and III collagen gene expression in human breast cancer in vivo. J Pathol. 186:262–268. 1998. View Article : Google Scholar

73 

Minamoto T, Ooi A, Okada Y, Mai M, Nagai Y and Nakanishi I: Desmoplastic reaction of gastric carcinoma: A light- and electron microscopic immunohistochemical analysis using collagen type-specific antibodies. Hum Pathol. 19:815–821. 1988. View Article : Google Scholar : PubMed/NCBI

74 

Bosman FT, de Bruïne A, Flohil C, van der Wurff A, ten Kate J and Dinjens WW: Epithelial-stromal interactions in colon cancer. Int J Dev Biol. 37:203–211. 1993.PubMed/NCBI

75 

Dahlman T, Lammerts E, Wik M, Bergström D, Grimelius L, Westermark K, Rubin K and Heldin NE: Fibrosis in undifferentiated (anaplastic) thyroid carcinomas: Evidence for a dual action of tumour cells in collagen type I synthesis. J Pathol. 191:376–386. 2000. View Article : Google Scholar : PubMed/NCBI

76 

Pietras K and Ostman A: Hallmarks of cancer: Interactions with the tumor stroma. Exp Cell Res. 316:1324–1331. 2010. View Article : Google Scholar : PubMed/NCBI

77 

Niehans GA, Kratzke RA, Froberg MK, Aeppli DM, Nguyen PL and Geradts J: G1 checkpoint protein and p53 abnormalities occur in most invasive transitional cell carcinomas of the urinary bladder. Br J Cancer. 80:1175–1184. 1999. View Article : Google Scholar : PubMed/NCBI

78 

Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, et al: The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 133:704–715. 2008. View Article : Google Scholar : PubMed/NCBI

79 

Huang R, Wang G, Song Y, Tang Q, You Q, Liu Z, Chen Y, Zhang Q, Li J, Muhammand S, et al: Colorectal cancer stem cell and chemo-resistant colorectal cancer cell phenotypes and increased sensitivity to Notch pathway inhibitor. Mol Med Rep. 12:2417–2424. 2015.PubMed/NCBI

80 

Alao JP: The regulation of cyclin D1 degradation: Roles in cancer development and the potential for therapeutic invention. Mol Cancer. 6:242007. View Article : Google Scholar : PubMed/NCBI

81 

Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C and De Maria R: Identification and expansion of human colon-cancer-initiating cells. Nature. 445:111–115. 2007. View Article : Google Scholar

82 

O'Brien CA, Pollett A, Gallinger S and Dick JE: A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 445:106–110. 2007. View Article : Google Scholar

83 

Gilcrease MZ: Integrin signaling in epithelial cells. Cancer Lett. 247:1–25. 2007. View Article : Google Scholar

84 

Takada Y, Ye X and Simon S: The integrins. Genome Biol. 8:2152007. View Article : Google Scholar : PubMed/NCBI

85 

Iwatsuki H, Sasaki K, Suda M and Itano C: Vimentin intermediate filament protein as differentiation marker of optic vesicle epithelium in the chick embryo. Acta Histochem. 101:369–382. 1999. View Article : Google Scholar : PubMed/NCBI

86 

Gilles C, Polette M, Zahm JM, Tournier JM, Volders L, Foidart JM and Birembaut P: Vimentin contributes to human mammary epithelial cell migration. J Cell Sci. 112:4615–4625. 1999.PubMed/NCBI

87 

Shattil SJ, Kim C and Ginsberg MH: The final steps of integrin activation: The end game. Nat Rev Mol Cell Biol. 11:288–300. 2010. View Article : Google Scholar : PubMed/NCBI

88 

Box C, Rogers SJ, Mendiola M and Eccles SA: Tumour-microenvironmental interactions: Paths to progression and targets for treatment. Semin Cancer Biol. 20:128–138. 2010. View Article : Google Scholar : PubMed/NCBI

89 

Hammoudi A, Song F, Reed KR, Jenkins RE, Meniel VS, Watson AJ, Pritchard DM, Clarke AR and Jenkins JR: Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC). Biochem Biophys Res Commun. 440:364–370. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang C, Liu H, Gong X, Wen B, Chen D, Liu J and Hu F: Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis Corrigendum in /10.3892/mmr.2016.5882. Mol Med Rep 14: 2555-2565, 2016.
APA
Huang, C., Liu, H., Gong, X., Wen, B., Chen, D., Liu, J., & Hu, F. (2016). Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis Corrigendum in /10.3892/mmr.2016.5882. Molecular Medicine Reports, 14, 2555-2565. https://doi.org/10.3892/mmr.2016.5584
MLA
Huang, C., Liu, H., Gong, X., Wen, B., Chen, D., Liu, J., Hu, F."Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis Corrigendum in /10.3892/mmr.2016.5882". Molecular Medicine Reports 14.3 (2016): 2555-2565.
Chicago
Huang, C., Liu, H., Gong, X., Wen, B., Chen, D., Liu, J., Hu, F."Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis Corrigendum in /10.3892/mmr.2016.5882". Molecular Medicine Reports 14, no. 3 (2016): 2555-2565. https://doi.org/10.3892/mmr.2016.5584
Copy and paste a formatted citation
x
Spandidos Publications style
Huang C, Liu H, Gong X, Wen B, Chen D, Liu J and Hu F: Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis Corrigendum in /10.3892/mmr.2016.5882. Mol Med Rep 14: 2555-2565, 2016.
APA
Huang, C., Liu, H., Gong, X., Wen, B., Chen, D., Liu, J., & Hu, F. (2016). Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis Corrigendum in /10.3892/mmr.2016.5882. Molecular Medicine Reports, 14, 2555-2565. https://doi.org/10.3892/mmr.2016.5584
MLA
Huang, C., Liu, H., Gong, X., Wen, B., Chen, D., Liu, J., Hu, F."Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis Corrigendum in /10.3892/mmr.2016.5882". Molecular Medicine Reports 14.3 (2016): 2555-2565.
Chicago
Huang, C., Liu, H., Gong, X., Wen, B., Chen, D., Liu, J., Hu, F."Analysis of different components in the peritumoral tissue microenvironment of colorectal cancer: A potential prospect in tumorigenesis Corrigendum in /10.3892/mmr.2016.5882". Molecular Medicine Reports 14, no. 3 (2016): 2555-2565. https://doi.org/10.3892/mmr.2016.5584
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