Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2016 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2016 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga mice

  • Authors:
    • Myung Ah Kang
    • Se‑Young Choung
  • View Affiliations / Copyright

    Affiliations: Department of Life and Nanopharmaceutical Science of Pharmacy, College of Pharmacy, Kyung Hee University, Seoul 130‑701, Republic of Korea
    Copyright: © Kang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3093-3103
    |
    Published online on: August 8, 2016
       https://doi.org/10.3892/mmr.2016.5595
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Solanum tuberosum L. cv Hongyoung (SH) is a widely consumed anthocyanin-rich food and medicinal plant, which possesses anti‑inflammatory and anti‑allergic activities. The present study aimed to examine the inhibitory effects of SH extract on atopic dermatitis (AD)‑like skin lesions induced by the topical application of 2,4‑dinitrochlorobenzene (DNCB) in NC/Nga mice. SH extract was orally administered to the DNCB‑treated NC/Nga mice. The anti‑AD effects of SH extract were examined by measuring symptom severity; ear thickness; scratching behavior; serum levels of immunoglobulin (Ig)E; T‑helper (Th)1, Th2 and Th17 cytokine levels in the spleen; mRNA expression levels of inflammatory cytokines and chemokines; and tissue infiltration of inflammatory cells. The results demonstrated that SH extract inhibited the development of AD‑like lesions, and reduced IgE levels and the production of cytokines. Furthermore, SH extract significantly suppressed the expression of AD‑associated mRNAs in lesional skin. Histological alterations in the AD‑like lesions were visualized using hematoxylin and eosin, and toluidine blue staining in the DNCB‑treated group; the alterations were attenuated following SH treatment. In addition, thickening of the epidermis and accumulation of inflammatory cells in the DNCB‑treated mice were suppressed by SH treatment. These results suggested that SH extract may suppress the development of AD symptoms through modulation of the Th1 and Th2 responses.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Udompataikul M and Limpa-o-vart D: Comparative trial of 5% dexpanthenol in water-in-oil formulation with 1% hydrocortisone ointment in the treatment of childhood atopic dermatitis: A pilot study. J Drugs Dermatol. 11:366–374. 2012.PubMed/NCBI

2 

Amin K: The role of mast cells in allergic inflammation. Respir Med. 106:9–14. 2012. View Article : Google Scholar

3 

Sampson HA: Atopic dermatitis. Ann Allergy. 69:469–479. 1992.PubMed/NCBI

4 

Schneider L, Tilles S, Lio P, Boguniewicz M, Beck L, Lebovidge J, et al: Atopic dermatitis: A practice parameter update 2012. J Allergy Clin Immunol. 131:295–299. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Hashimoto Y, Takaoka A, Sugimoto M, Honma Y, Sakurai T, Futaki N and Arai I: Itch-associated scratching contributes to the development of dermatitis and hyperimmunoglobulinaemia E in NC/Nga mice. Exp Dermatol. 20:820–825. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Leung DY and Soter NA: Cellular and immunologic mechanisms in atopic dermatitis. J Am Acad Dermatol. 44(Suppl 1): S1–S12. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Miraglia del Giudice M, Decimo F, Leonardi S, Maioello N, Amelio R, Capasso A, Capristo C and Capristo AF: Immune dysregulation in atopic dermatitis. Allergy Asthma Proc. 27:451–455. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Wierenga EA, Snoek M, Jansen HM, Bos JD, van Lier RA and Kapsenberg ML: Human atopen-specific types 1 and 2 T helper cell clones. J Immunol. 147:2942–2949. 1991.PubMed/NCBI

9 

Szegedi A, Baráth S, Nagy G, Szodoray P, Gál M, Sipka S, Bagdi E, Banham AH and Krenács L: Regulatory T cells in atopic dermatitis: epidermal dendritic cell clusters may contribute to their local expansion. Br J Dermatol. 160:984–993. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Oyoshi MK, He R, Kumar L, Yoon J and Geha RS: Cellular and molecular mechanisms in atopic dermatitis. Adv Immunol. 102:135–226. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C and Cavani A: IL-17 in atopic eczema: Linking allergen-specific adaptive and microbial-triggered innate immune response. J Allergy Clin Immunol. 123:59–66.e4. 2009. View Article : Google Scholar

12 

Nakae S, Komiyama Y, Nambu A, Sudo K, Iwase M, Homma I, Sekikawa K, Asano M and Iwakura Y: Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity. 17:375–387. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Hengge UR, Ruzicka T, Schwartz RA and Cork MJ: Adverse effects of topical glucocorticosteroids. J Am Acad Dermatol. 54:1–15; quiz 16–18. 2006. View Article : Google Scholar

14 

Yang G, Choi CH, Lee K, Lee M, Ham I and Choi HY: Effects of Catalpa ovata stem bark on atopic dermatitis-like skin lesions in NC/Nga mice. J Ethnopharmacol. 145:416–423. 2013. View Article : Google Scholar

15 

Ieri F, Innocenti M, Andrenelli L, Vecchio V and Mulinacci N: Rapid HPLC/DAD/MS method to determine phenolic acids, glycoalkaloids and anthocyanins in pigmented potatoes (Solanum tuberosum L.) and correlations with variety and geographical origin. Food Chemistry. 125:750–759. 2011. View Article : Google Scholar

16 

Mulinacci N, Ieri F, Giaccherini C, Innocenti M, Andrenelli L, Canova G, Saracchi M and Casiraghi MC: Effect of cooking on the anthocyanins, phenolic acids, glycoalkaloids, and resistant starch content in two pigmented cultivars of Solanum tuberosum L. J Agric Food Chem. 56:11830–11837. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Afaq F, Malik A, Syed D, Maes D, Matsui MS and Mukhtar H: Pomegranate fruit extract modulates UV-B-mediated phosphorylation of mitogen-activated protein kinases and activation of nuclear factor kappa B in normal human epidermal keratinocytes paragraph sign. Photochem Photobiol. 81:38–45. 2005. View Article : Google Scholar

18 

Suto H, Matsuda H, Mitsuishi K, Hira K, Uchida T, Unno T, Ogawa H and Ra C: NC/Nga mice: A mouse model for atopic dermatitis. Int Arch Allergy Immunol. 120(Suppl 1): S70–S75. 1999. View Article : Google Scholar

19 

Takano N, Arai I and Kurachi M: Analysis of the spontaneous scratching behavior by NC/Nga mice: A possible approach to evaluate antipruritics for subjects with atopic dermatitis. Eur J Pharmacol. 471:223–228. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Mihara K, Kuratani K, Matsui T, Nakamura M and Yokota K: Vital role of the itch-scratch response in development of spontaneous dermatitis in NC/Nga mice. Br J Dermatol. 151:335–345. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

22 

Wesolowski J and Paumet F: The impact of bacterial infection on mast cell degranulation. Immunol Res. 51:215–226. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Lee TY, Kim DJ, Won JN, Lee IH, Sung MH and Poo H: Oral administration of poly-gamma-glutamate ameliorates atopic dermatitis in Nc/Nga mice by suppressing Th2-biased immune response and production of IL-17A. J Invest Dermatol. 134:704–711. 2014. View Article : Google Scholar

24 

Koga C, Kabashima K, Shiraishi N, Kobayashi M and Tokura Y: Possible pathogenic role of Th17 cells for atopic dermatitis. J Invest Dermatol. 128:2625–2630. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Bieber T: Atopic dermatitis. N Engl J Med. 358:1483–1494. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Akdis M, Simon HU, Weigl L, Kreyden O, Blaser K and Akdis CA: Skin homing (cutaneous lymphocyte-associated antigen-positive) CD8+ T cells respond to superantigen and contribute to eosinophilia and IgE production in atopic dermatitis. J Immunol. 163:466–475. 1999.PubMed/NCBI

27 

Akdis CA, Akdis M, Simon D, Dibbert B, Weber M, Gratzl S, Kreyden O, Disch R, Wüthrich B, Blaser K and Simon HU: T cells and T cell-derived cytokines as pathogenic factors in the nonallergic form of atopic dermatitis. J Invest Dermatol. 113:628–634. 1999. View Article : Google Scholar : PubMed/NCBI

28 

Kim GD, Kim TH, Park YS, Ahn HJ, Cho JJ and Park CS: Immune response against 2,4-dinitrofluorobenzene-induced atopic dermatitis-like clinical manifestation is suppressed by spermidine in NCNga mice. Scand J Immunol. 81:221–228. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Lin YT, Wang CT, Chao PS, Lee JH, Wang LC, Yu HH, Yang YH and Chiang BL: Skin-homing CD4+ Foxp3+ T cells exert Th2-like function after staphylococcal superantigen stimulation in atopic dermatitis patients. Clin Exp Allergy. 41:516–525. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Werfel T: The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis. J Invest Dermatol. 129:1878–1891. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Hinz D, Bauer M, Röder S, Olek S, Huehn J, Sack U, Borte M, Simon JC and Lehmann I: Cord blood Tregs with stable FOXP3 expression are influenced by prenatal environment and associated with atopic dermatitis at the age of one year. Allergy. 67:380–389. 2012. View Article : Google Scholar

32 

Mountford AP, Fisher A and Wilson RA: The profile of IgG1 and IgG2a antibody responses in mice exposed to Schistosoma mansoni. Parasite Immunol. 16:521–527. 1994. View Article : Google Scholar : PubMed/NCBI

33 

N'Dri D, Mazzeo T, Zaupa M, Ferracane R, Fogliano V and Pellegrini N: Effect of cooking on the total antioxidant capacity and phenolic profile of some whole-meal African cereals. J Sci Food Agric. 93:29–36. 2013. View Article : Google Scholar

34 

Eichhorn S and Winterhalter P: Anthocyanins from pigmented potato (Solanum tuberosum L.) varieties. Food Research International. 38:943–948. 2005. View Article : Google Scholar

35 

Han KH, Sekikawa M, Shimada K, Hashimoto M, Hashimoto N, Noda T, Tanaka H and Fukushima M: Anthocyanin-rich purple potato flake extract has antioxidant capacity and improves antioxidant potential in rats. Br J Nutr. 96:1125–1133. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Afaq F, Saleem M, Krueger CG, Reed JD and Mukhtar H: Anthocyanin- and hydrolyzable tannin-rich pomegranate fruit extract modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in CD-1 mice. Int J Cancer. 113:423–433. 2005. View Article : Google Scholar

37 

Zhang EY, Chen AY and Zhu BT: Mechanism of dinitrochlorobenzene-induced dermatitis in mice: Role of specific antibodies in pathogenesis. PLoS One. 4:e77032009. View Article : Google Scholar : PubMed/NCBI

38 

Vestergaard C, Yoneyama H, Murai M, Nakamura K, Tamaki K, Terashima Y, Imai T, Yoshie O, Irimura T, Mizutani H and Matsushima K: Overproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions. J Clin Invest. 104:1097–1105. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Kishimoto T and Hirano T: Molecular regulation of B lymphocyte response. Annu Rev Immunol. 6:485–512. 1988. View Article : Google Scholar : PubMed/NCBI

40 

Hussain Z, Katas H, Mohd Amin MC and Kumolosasi E: Efficient immuno-modulation of TH1/TH2 biomarkers in 2,4-dinitroflu-orobenzene-induced atopic dermatitis: Nanocarrier-mediated transcutaneous co-delivery of anti-inflammatory and antioxidant drugs. PLoS One. 9:e1131432014. View Article : Google Scholar

41 

Niebuhr M and Werfel T: Innate immunity, allergy and atopic dermatitis. Curr Opin Allergy Clin Immunol. 10:463–468. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Wollenberg A, Kraft S, Hanau D and Bieber T: Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema. J Invest Dermatol. 106:446–453. 1996. View Article : Google Scholar : PubMed/NCBI

43 

Bieber T: The pro- and anti-inflammatory properties of human antigen-presenting cells expressing the high affinity receptor for IgE (Fc epsilon RI). Immunobiology. 212:499–503. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Novak N, Valenta R, Bohle B, Laffer S, Haberstok J, Kraft S and Bieber T: FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro. J Allergy Clin Immunol. 113:949–957. 2004. View Article : Google Scholar : PubMed/NCBI

45 

Kasraie S, Niebuhr M, Baumert K and Werfel T: Functional effects of interleukin 31 in human primary keratinocytes. Allergy. 66:845–852. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Meyer N, Zimmermann M, Bürgler S, Bassin C, Woehrl S, Moritz K, Rhyner C, Indermitte P, Schmid-Grendelmeier P, Akdis M, et al: IL-32 is expressed by human primary keratinocytes and modulates keratinocyte apoptosis in atopic dermatitis. J Allergy Clin Immunol. 125:858–865.e810. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Klunker S, Trautmann A, Akdis M, Verhagen J, Schmid-Grendelmeier P, Blaser K and Akdis CA: A second step of chemotaxis after transendothelial migration: Keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha-chemoattractant for T cell chemotaxis toward epidermis in atopic dermatitis. J Immunol. 171:1078–1084. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Homey B, Steinhoff M, Ruzicka T and Leung DY: Cytokines and chemokines orchestrate atopic skin inflammation. J Allergy Clin Immunol. 118:178–189. 2006. View Article : Google Scholar : PubMed/NCBI

49 

Sokol CL and Luster AD: The chemokine system in innate immunity. Cold Spring Harb Perspect Biol. 7:pii: a016303. 2015. View Article : Google Scholar : PubMed/NCBI

50 

Nakatani T, Kaburagi Y, Shimada Y, Inaoki M, Takehara K, Mukaida N and Sato S: CCR4 memory CD4+ T lymphocytes are increased in peripheral blood and lesional skin from patients with atopic dermatitis. J Allergy Clin Immunol. 107:353–358. 2001. View Article : Google Scholar : PubMed/NCBI

51 

Amerio P, Frezzolini A, Feliciani C, Verdolini R, Teofoli P, De Pità O and Puddu P: Eotaxins and CCR3 receptor in inflammatory and allergic skin diseases: Therapeutical implications. Curr Drug Targets Inflamm Allergy. 2:81–94. 2003. View Article : Google Scholar : PubMed/NCBI

52 

Esnault S, Benbernou N, Lavaud F, Shin HC, Potron G and Guenounou M: Differential spontaneous expression of mRNA for IL-4, IL-10, IL-13, IL-2 and interferon-gamma (IFN-gamma) in peripheral blood mononuclear cells (PBMC) from atopic patients. Clin Exp Immunol. 103:111–118. 1996. View Article : Google Scholar : PubMed/NCBI

53 

Conti P, Pang X, Boucher W, Letourneau R, Reale M, Barbacane RC, Thibault J and Theoharides TC: Impact of Rantes and MCP-1 chemokines on in vivo basophilic cell recruitment in rat skin injection model and their role in modifying the protein and mRNA levels for histidine decarboxylase. Blood. 89:4120–4127. 1997.PubMed/NCBI

54 

Imai T, Baba M, Nishimura M, Kakizaki M, Takagi S and Yoshie O: The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J Biol Chem. 272:15036–15042. 1997. View Article : Google Scholar : PubMed/NCBI

55 

Schröder JM and Mochizuki M: The role of chemokines in cutaneous allergic inflammation. Biol Chem. 380:889–896. 1999. View Article : Google Scholar : PubMed/NCBI

56 

Galli SJ, Nakae S and Tsai M: Mast cells in the development of adaptive immune responses. Nat Immunol. 6:135–142. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kang MA and Choung SY: Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga mice. Mol Med Rep 14: 3093-3103, 2016.
APA
Kang, M.A., & Choung, S. (2016). Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga mice. Molecular Medicine Reports, 14, 3093-3103. https://doi.org/10.3892/mmr.2016.5595
MLA
Kang, M. A., Choung, S."Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga mice". Molecular Medicine Reports 14.4 (2016): 3093-3103.
Chicago
Kang, M. A., Choung, S."Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga mice". Molecular Medicine Reports 14, no. 4 (2016): 3093-3103. https://doi.org/10.3892/mmr.2016.5595
Copy and paste a formatted citation
x
Spandidos Publications style
Kang MA and Choung SY: Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga mice. Mol Med Rep 14: 3093-3103, 2016.
APA
Kang, M.A., & Choung, S. (2016). Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga mice. Molecular Medicine Reports, 14, 3093-3103. https://doi.org/10.3892/mmr.2016.5595
MLA
Kang, M. A., Choung, S."Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga mice". Molecular Medicine Reports 14.4 (2016): 3093-3103.
Chicago
Kang, M. A., Choung, S."Solanum tuberosum L. cv Hongyoung extract inhibits 2,4‑dinitrochlorobenzene‑induced atopic dermatitis in NC/Nga mice". Molecular Medicine Reports 14, no. 4 (2016): 3093-3103. https://doi.org/10.3892/mmr.2016.5595
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team