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Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma

  • Authors:
    • Min Ye
    • Qundan Wu
    • Min Zhang
    • Jinbei Huang
  • View Affiliations / Copyright

    Affiliations: Department of Biopharmacy, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China, Department of Urology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350004, P.R. China
    Copyright: © Ye et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2953-2958
    |
    Published online on: August 8, 2016
       https://doi.org/10.3892/mmr.2016.5597
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Abstract

Lycopene has been shown to be associated with anticancer effects in numerous tumor types. However, the underlying mechanisms of lycopene in human head and neck squamous cell carcinoma (HNSCC) remain to be determined. The present study aimed to investigate the involvement of lycopene overload and the cytotoxic effects of lycopene on HNSCC cells, and to determine the possible mechanisms involved. Treatment with lycopene at a dose of >10 µM for >24 h inhibited the growth of FaDu and Cal27 cells in a time‑ and dose‑dependent manner. The clearest increase in growth inhibition was due to the apoptotic population being significantly increased. The invasion abilities decreased with 25 µM lycopene exerting significant inhibitory effects (P<0.01). Mechanistic studies revealed that lycopene induced the upregulation of the pro‑apoptotic protein, B‑cell lymphoma‑associated X protein, and therefore, resulted in the inhibition of the protein kinase B and mitogen‑activated protein kinase signaling pathway. These data provided insights into the antitumor activity of lycopene in HNSCC cells.
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Copy and paste a formatted citation
Spandidos Publications style
Ye M, Wu Q, Zhang M and Huang J: Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma. Mol Med Rep 14: 2953-2958, 2016.
APA
Ye, M., Wu, Q., Zhang, M., & Huang, J. (2016). Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma. Molecular Medicine Reports, 14, 2953-2958. https://doi.org/10.3892/mmr.2016.5597
MLA
Ye, M., Wu, Q., Zhang, M., Huang, J."Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma". Molecular Medicine Reports 14.4 (2016): 2953-2958.
Chicago
Ye, M., Wu, Q., Zhang, M., Huang, J."Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma". Molecular Medicine Reports 14, no. 4 (2016): 2953-2958. https://doi.org/10.3892/mmr.2016.5597
Copy and paste a formatted citation
x
Spandidos Publications style
Ye M, Wu Q, Zhang M and Huang J: Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma. Mol Med Rep 14: 2953-2958, 2016.
APA
Ye, M., Wu, Q., Zhang, M., & Huang, J. (2016). Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma. Molecular Medicine Reports, 14, 2953-2958. https://doi.org/10.3892/mmr.2016.5597
MLA
Ye, M., Wu, Q., Zhang, M., Huang, J."Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma". Molecular Medicine Reports 14.4 (2016): 2953-2958.
Chicago
Ye, M., Wu, Q., Zhang, M., Huang, J."Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma". Molecular Medicine Reports 14, no. 4 (2016): 2953-2958. https://doi.org/10.3892/mmr.2016.5597
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