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Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinoma

  • Authors:
    • Zhi‑Yuan Deng
    • Yue‑Hong Wang
    • Hong‑Zhi Quan
    • Ou‑Sheng Liu
    • Yi‑Ping Li
    • Yuan Li
    • Wu Zhu
    • Krishna Munnee
    • Zhan‑Gui Tang
  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Xiangya School and Hospital of Stomatology, Central South University, Changsha, Hunan 410078, P.R. China, Department of Prosthodontics, Xiangya School and Hospital of Stomatology, Central South University, Changsha, Hunan 410078, P.R. China, Department of Oral and Maxillofacial Surgery, Changsha Stomatological Hospital, Changsha, Hunan 410005, P.R. China, Department of Oral and Maxillofacial Surgery, Yiyang Central Hospital, Yiyang, Hunan 413000, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2991-2996
    |
    Published online on: August 9, 2016
       https://doi.org/10.3892/mmr.2016.5608
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Abstract

Abnormal expression of microRNAs (miRNAs) is involved in the development of and anti‑apoptotic effects in various types of human cancer. However, miRNA‑mediated regulation of oral verrucous carcinoma (OVC) remains to be elucidated. The present study aimed to investigate the expression of miR‑181b in OVC and oral squamous cell carcinoma (OSCC). The expression levels of miR‑181b were determined using reverse transcription‑quantitative polymerase chain reaction. The expression levels of B‑cell lymphoma 2 (Bcl‑2) and leucine rich repeats and immunoglobulin like domains 1 (LRIG1), were evaluated using immunohistochemical staining. The correlation between Bcl‑2 and LRIG1 expression was determined using a Pearson correlation analysis. The expression levels of miR‑181b and Bcl‑2 in OVC were significantly higher compared with normal mucosal tissue (NM); however, lower compared with the OSCC. The key target of miR‑181b was LRIG1 and it was significantly lower in OVC tissues compared with NM tissue; however this was higher when compared with OSCC tissue. The expression levels of Bcl‑2 were correlated with expression levels of LRIG1 in OVC tissues. Therefore, LRIG1 may be associated with anti‑apoptotic function in OVC tissues.
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Copy and paste a formatted citation
Spandidos Publications style
Deng ZY, Wang YH, Quan HZ, Liu OS, Li YP, Li Y, Zhu W, Munnee K and Tang ZG: Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinoma. Mol Med Rep 14: 2991-2996, 2016.
APA
Deng, Z., Wang, Y., Quan, H., Liu, O., Li, Y., Li, Y. ... Tang, Z. (2016). Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinoma. Molecular Medicine Reports, 14, 2991-2996. https://doi.org/10.3892/mmr.2016.5608
MLA
Deng, Z., Wang, Y., Quan, H., Liu, O., Li, Y., Li, Y., Zhu, W., Munnee, K., Tang, Z."Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinoma". Molecular Medicine Reports 14.4 (2016): 2991-2996.
Chicago
Deng, Z., Wang, Y., Quan, H., Liu, O., Li, Y., Li, Y., Zhu, W., Munnee, K., Tang, Z."Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinoma". Molecular Medicine Reports 14, no. 4 (2016): 2991-2996. https://doi.org/10.3892/mmr.2016.5608
Copy and paste a formatted citation
x
Spandidos Publications style
Deng ZY, Wang YH, Quan HZ, Liu OS, Li YP, Li Y, Zhu W, Munnee K and Tang ZG: Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinoma. Mol Med Rep 14: 2991-2996, 2016.
APA
Deng, Z., Wang, Y., Quan, H., Liu, O., Li, Y., Li, Y. ... Tang, Z. (2016). Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinoma. Molecular Medicine Reports, 14, 2991-2996. https://doi.org/10.3892/mmr.2016.5608
MLA
Deng, Z., Wang, Y., Quan, H., Liu, O., Li, Y., Li, Y., Zhu, W., Munnee, K., Tang, Z."Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinoma". Molecular Medicine Reports 14.4 (2016): 2991-2996.
Chicago
Deng, Z., Wang, Y., Quan, H., Liu, O., Li, Y., Li, Y., Zhu, W., Munnee, K., Tang, Z."Investigation of the association between miR‑181b, Bcl‑2 and LRIG1 in oral verrucous carcinoma". Molecular Medicine Reports 14, no. 4 (2016): 2991-2996. https://doi.org/10.3892/mmr.2016.5608
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