Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2016 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2016 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis

  • Authors:
    • Hua Qian
    • Xiaoyue Guan
    • Zhuan Bian
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory Breeding Base of Basic Science of Stomatology and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, Hubei 430079, P.R. China
    Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2997-3006
    |
    Published online on: August 9, 2016
       https://doi.org/10.3892/mmr.2016.5613
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Periapical bone loss is one of the prominent pathological and clinical features of periapical periodontitis. Previous studies have demonstrated that follicle‑stimulating hormone (FSH) could directly affect skeletal remodelling by stimulating the formation and the function of osteoclasts in vitro and in vivo. However, the effect of FSH on periapical bone loss remained to be fully elucidated. In the current study, a rat model was established in order to verify the effect of FSH in experimental periapical lesions. It was identified that FSH aggravated the bone loss of periapical lesions. In addition, RANKL‑, TRAP‑, TNF‑α‑ and IL‑1β‑positive cells were increased significantly in FSH‑treated groups, which indicated that the function of FSH in bone loss may be mediated through the increasing activity of osteoclasts and the increased secretion of inflammatory cytokines. The results of the current study suggested that FSH, independent of oestrogen, may aggravate periapical bone loss by FSH receptors, which may serve an important role in the immune and inflammatory response of the host to root canal and periradicular infection during menopause.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Han NR, Kim HY, Yang WM, Jeong HJ and Kim HM: Glutamic acid ameliorates estrogen deficiency-induced menopausal-like symptoms in ovariectomized mice. Nutr Res. 35:774–783. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Wei S, Gong Z, An L, Zhang T, Dai H and Chen S: Cloprostenol and pregnant mare serum gonadotropin promote estrus synchronization, uterine development, and follicle-stimulating hormone receptor expression in mice. Genet Mol Res. 14:7184–7195. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Santi D, Granata AR and Simoni M: FSH treatment of male idiopathic infertility improves pregnancy rate: A meta-analysis. Endocr Connect. 4:R46–R58. 2015.PubMed/NCBI

4 

Herrera-Luna CV, Scarlet D, Walter I and Aurich C: Effect of stallion age on the expression of LH and FSH receptors and aromatase P450 in equine male reproductive tissues. Reprod Fertil Dev. 6–Jul;2015.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

5 

Cannon JG, Kraj B and Sloan G: Follicle-stimulating hormone promotes RANK expression on human monocytes. Cytokine. 53:141–144. 2011. View Article : Google Scholar :

6 

Robinson LJ, Tourkova I, Wang Y, Sharrow AC, Landau MS, Yaroslavskiy BB, Sun L, Zaidi M and Blair HC: FSH-receptor isoforms and FSH-dependent gene transcription in human monocytes and osteoclasts. Biochem Biophys Res Commun. 394:12–17. 2010. View Article : Google Scholar : PubMed/NCBI

7 

Petrova NL, Petrov PK, Edmonds ME and Shanahan CM: Inhibition of TNF-α Reverses the pathological resorption pit profile of osteoclasts from patients with acute Charcot osteoarthropathy. J Diabetes Res. 2015:9179452015. View Article : Google Scholar

8 

Tolias D, Koletsi K, Mamai-Homata E, Margaritis V and Kontakiotis E: Apical periodontitis in association with the quality of root fillings and coronal restorations: A 14-year investigation in young Greek adults. Oral Health Prev Dent. 10:297–303. 2012.PubMed/NCBI

9 

Zhang X and Peng B: Immunolocalization of receptor activator of NF kappa B ligand in rat periapical lesions. J Endod. 31:574–577. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Xiong H, Peng B, Wei L, Zhang X and Wang L: Effect of an estrogen-deficient state and alendronate therapy on bone loss resulting from experimental periapical lesions in rats. J Endod. 33:1304–1308. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Zhang X, Peng B, Fan M, Bian Z and Chen Z: The effect of estrogen deficiency on receptor activator of nuclear factor kappa B ligand and osteoprotegerin synthesis in periapical lesions induced in rats. J Endod. 33:1053–1056. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Liu S, Cheng Y, Fan M, Chen D and Bian Z: FSH aggravates periodontitis-related bone loss in ovariectomized rats. J Dent Res. 89:366–371. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Suzuki N, Takimoto K and Kawashima N: Cathepsin K inhibitor regulates inflammation and bone destruction in experimentally induced rat periapical lesions. J Endod. 41:1474–1479. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Velickovic M, Pejnovic N, Mitrovic S, Radosavljevic G, Jovanovic I, Kanjevac T, Jovicic N and Lukic A: ST2 deletion increases inflammatory bone destruction in experimentally induced periapical lesions in mice. J Endod. 41:369–375. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Lin SK, Hong CY, Chang HH, Chiang CP, Chen CS, Jeng JH and Kuo MYP: Immunolocalization of macrophages and transforming growth factor-β1 in induced rat periapical lesions. J Endod. 26:335–340. 2000. View Article : Google Scholar

16 

Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, Zaidi S, Zhu LL, Yaroslavskiy BB, Zhou H, et al: FSH directly regulates bone mass. Cell. 125:247–260. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Rawlinson SC, Boyde A, Davis GR, Howell PG, Hughes FJ and Kingsmill VJ: Ovariectomy vs. hypofunction: Their effects on rat mandibular bone. J Dent Res. 88:615–620. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Gomes-Filho JE, Wayama MT, Dornelles RC, Ervolino E, Yamanari GH, Lodi CS, Sivieri-Araújo G, Dezan-Júnior E and Cintra LT: Raloxifene modulates regulators of osteoclastogenesis and angiogenesis in an oestrogen deficiency periapical lesion model. Int Endod J. 48:1059–1068. 2015. View Article : Google Scholar

19 

Pitari MR, Rossi M, Amodio N, Botta C, Morelli E, Federico C, Gullà A, Caracciolo D, Di Martino MT, Arbitrio M, et al: Inhibition of miR-21 restores RANKL/OPG ratio in multiple myeloma-derived bone marrow stromal cells and impairs the resorbing activity of mature osteoclasts. Oncotarget. 6:27343–27358. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Sağlam M, Köseoğlu S, Hatipoğlu M, Esen HH and Köksal E: Effect of sumac extract on serum oxidative status, RANKL/OPG system and alveolar bone loss in experimental periodontitis in rats. J Appl Oral Sci. 23:33–41. 2015.

21 

Duan P, Wang ZM, Liu J, Wang LN, Yang Z and Tu P: Gene polymorphisms in RANKL/RANK/OPG pathway are associated with ages at menarche and natural menopause in Chinese women. BMC Womens Health. 15:322015. View Article : Google Scholar : PubMed/NCBI

22 

Duan P, Wang ZM, Liu J, Wang LN, Yang Z and Tu P: Association of gene polymorphisms in RANKL/RANK/OPG system with hypertension and blood pressure in Chinese women. J Hum Hypertens. 29:749–753. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Tu P, Duan P, Zhang RS, Xu DB, Wang Y, Wu HP, Liu YH and Si L: Polymorphisms in genes in the RANKL/RANK/OPG pathway are associated with bone mineral density at different skeletal sites in post-menopausal women. Osteoporos Int. 26:179–185. 2015. View Article : Google Scholar

24 

Xu XJ, Shen L, Yang YP, Zhu R, Shuai B, Li CG and Wu MX: Serum β-Catenin levels associated with the ratio of RANKL/OPG in patients with postmenopausal osteoporosis. Int J Endocrinol. 2013:5343522013. View Article : Google Scholar

25 

Marazzi J, Kleyer J, Paredes JM and Gertsch J: Endocannabinoid content in fetal bovine sera-unexpected effects on mononuclear cells and osteoclastogenesis. J Immunol Methods. 373:219–228. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Cenci S, Toraldo G, Weitzmann MN, Roggia C, Gao Y, Qian WP, Sierra O and Pacifici R: Estrogen deficiency induces bone loss by increasing T cell proliferation and lifespan through IFN-gamma-induced class II transactivator. Proc Natl Acad Sci USA. 100:10405–10410. 2003. View Article : Google Scholar : PubMed/NCBI

27 

Karadag F, Ozcan H, Karul AB, Yilmaz M and Cildag O: Sex hormone alterations and systemic inflammation in chronic obstructive pulmonary disease. Int J Clin Pract. 63:275–281. 2009. View Article : Google Scholar

28 

Kobayashi K, Takahashi N, Jimi E, Udagawa N, Takami M, Kotake S, Nakagawa N, Kinosaki M, Yamaguchi K, Shima N, et al: Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med. 191:275–286. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Lam J, Takeshita S, Barker JE, Kanagawa O, Ross FP and Teitelbaum SL: TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest. 106:1481–1488. 2000. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Qian H, Guan X and Bian Z: FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis. Mol Med Rep 14: 2997-3006, 2016.
APA
Qian, H., Guan, X., & Bian, Z. (2016). FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis. Molecular Medicine Reports, 14, 2997-3006. https://doi.org/10.3892/mmr.2016.5613
MLA
Qian, H., Guan, X., Bian, Z."FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis". Molecular Medicine Reports 14.4 (2016): 2997-3006.
Chicago
Qian, H., Guan, X., Bian, Z."FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis". Molecular Medicine Reports 14, no. 4 (2016): 2997-3006. https://doi.org/10.3892/mmr.2016.5613
Copy and paste a formatted citation
x
Spandidos Publications style
Qian H, Guan X and Bian Z: FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis. Mol Med Rep 14: 2997-3006, 2016.
APA
Qian, H., Guan, X., & Bian, Z. (2016). FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis. Molecular Medicine Reports, 14, 2997-3006. https://doi.org/10.3892/mmr.2016.5613
MLA
Qian, H., Guan, X., Bian, Z."FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis". Molecular Medicine Reports 14.4 (2016): 2997-3006.
Chicago
Qian, H., Guan, X., Bian, Z."FSH aggravates bone loss in ovariectomised rats with experimental periapical periodontitis". Molecular Medicine Reports 14, no. 4 (2016): 2997-3006. https://doi.org/10.3892/mmr.2016.5613
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team