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Article

Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells

  • Authors:
    • Min Ju Ryu
    • Ha Sook Chung
  • View Affiliations / Copyright

    Affiliations: Department of Food and Nutrition, College of Natural Sciences, Duksung Women's University, Seoul 01369, Republic of Korea
  • Pages: 3255-3260
    |
    Published online on: August 11, 2016
       https://doi.org/10.3892/mmr.2016.5623
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Abstract

Fucoidan, a sulfated polysaccharide, is found in edible brown algae. In the present study, the molecular mechanisms of fucoidan against mild oxidative stress in human keratinocytes were investigated. The current study indicated that fucoidan significantly augmented the antioxidants heme oxygenase‑1 (HO‑1) and superoxide dismutase‑1 (SOD‑1) via the upregulation of nuclear factor erythroid 2‑related factor 2 (Nrf2) and markedly reduced the cytoplasmic stability of kelch‑like ECH‑associated protein 1. The upregulation of HO‑1 and SOD‑1 detected in the fucoidan‑treated cells may be responsible for the increased resistance to mild oxidative stress, indicating that fucoidan may augment the activities of antioxidant enzymes via stimulating Nrf2. This is the first report, to the best of our knowledge, to demonstrate that fucoidan attenuates oxidative stress by regulating the gene expression of SOD‑1 and HO‑1 via the Nrf2/extracellular signal‑regulated kinase signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Ryu MJ and Chung HS: Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells. Mol Med Rep 14: 3255-3260, 2016.
APA
Ryu, M.J., & Chung, H.S. (2016). Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells. Molecular Medicine Reports, 14, 3255-3260. https://doi.org/10.3892/mmr.2016.5623
MLA
Ryu, M. J., Chung, H. S."Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells". Molecular Medicine Reports 14.4 (2016): 3255-3260.
Chicago
Ryu, M. J., Chung, H. S."Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells". Molecular Medicine Reports 14, no. 4 (2016): 3255-3260. https://doi.org/10.3892/mmr.2016.5623
Copy and paste a formatted citation
x
Spandidos Publications style
Ryu MJ and Chung HS: Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells. Mol Med Rep 14: 3255-3260, 2016.
APA
Ryu, M.J., & Chung, H.S. (2016). Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells. Molecular Medicine Reports, 14, 3255-3260. https://doi.org/10.3892/mmr.2016.5623
MLA
Ryu, M. J., Chung, H. S."Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells". Molecular Medicine Reports 14.4 (2016): 3255-3260.
Chicago
Ryu, M. J., Chung, H. S."Fucoidan reduces oxidative stress by regulating the gene expression of HO‑1 and SOD‑1 through the Nrf2/ERK signaling pathway in HaCaT cells". Molecular Medicine Reports 14, no. 4 (2016): 3255-3260. https://doi.org/10.3892/mmr.2016.5623
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