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Article Open Access

Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice

  • Authors:
    • Hui Han
    • Yanjia Chen
    • Jinzhou Zhu
    • Jingwei Ni
    • Jiateng Sun
    • Ruiyan Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3122-3128
    |
    Published online on: August 12, 2016
       https://doi.org/10.3892/mmr.2016.5626
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Abstract

p-cresyl sulfate (PCS) is a protein-bound uremic toxin retained in the blood of patients with chronic kidney disease (CKD) As atherosclerosis is a primary cardiovascular complication for patients with CKD, the aim of the present study was to investigate the mechanisms underlying the aggravation of atherosclerosis by PCS. In addition, the effect of atorvastatin was assessed in reversing the effects of PCS. PCS was revealed to promote the initiation and progression of atherosclerosis. Following treatment with atorvastatin, apolipoprotein E knockout mice demonstrated a reduction in PCS‑induced atherogenesis and plaque vulnerability. In addition, atorvastatin decreased the protein expression levels of vascular cell adhesion molecule‑1 and intercellular cell adhesion molecule‑1, and the interaction between leukocytes and endothelia. The plasma lipid profiles of mice were not significantly affected by gavage of low‑dose atorvastatin. The results of the present study indicate that PCS promotes plaque growth and instability by enhancing leukocyte‑endothelium interaction, and that these effects may be attenuated by atorvastatin treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Han H, Chen Y, Zhu J, Ni J, Sun J and Zhang R: Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice. Mol Med Rep 14: 3122-3128, 2016.
APA
Han, H., Chen, Y., Zhu, J., Ni, J., Sun, J., & Zhang, R. (2016). Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice. Molecular Medicine Reports, 14, 3122-3128. https://doi.org/10.3892/mmr.2016.5626
MLA
Han, H., Chen, Y., Zhu, J., Ni, J., Sun, J., Zhang, R."Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice". Molecular Medicine Reports 14.4 (2016): 3122-3128.
Chicago
Han, H., Chen, Y., Zhu, J., Ni, J., Sun, J., Zhang, R."Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice". Molecular Medicine Reports 14, no. 4 (2016): 3122-3128. https://doi.org/10.3892/mmr.2016.5626
Copy and paste a formatted citation
x
Spandidos Publications style
Han H, Chen Y, Zhu J, Ni J, Sun J and Zhang R: Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice. Mol Med Rep 14: 3122-3128, 2016.
APA
Han, H., Chen, Y., Zhu, J., Ni, J., Sun, J., & Zhang, R. (2016). Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice. Molecular Medicine Reports, 14, 3122-3128. https://doi.org/10.3892/mmr.2016.5626
MLA
Han, H., Chen, Y., Zhu, J., Ni, J., Sun, J., Zhang, R."Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice". Molecular Medicine Reports 14.4 (2016): 3122-3128.
Chicago
Han, H., Chen, Y., Zhu, J., Ni, J., Sun, J., Zhang, R."Atorvastatin attenuates p‑cresyl sulfate‑induced atherogenesis and plaque instability in ApoE knockout mice". Molecular Medicine Reports 14, no. 4 (2016): 3122-3128. https://doi.org/10.3892/mmr.2016.5626
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