Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
October-2016 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2016 Volume 14 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women

  • Authors:
    • Ayesha Mazhar
    • Farrukh Jamil
    • Qamar Bashir
    • Munawar Saleem Ahmad
    • Misbah Masood
    • Imrana Tanvir
    • Naeem Rashid
    • Abdul Waheed
    • Muhammad Naveed Afzal
    • Muhammad Akram Tariq
  • View Affiliations / Copyright

    Affiliations: Department of Biosciences, COMSATS Institute of Information Technology (CIIT), Sahiwal, Punjab 57000, Pakistan, School of Biological Sciences, University of The Punjab (New Campus), Lahore, Punjab 54590, Pakistan, Department of Zoology, University of Swabi, Swabi, Khyber Pakhtunkhwa 20201, Pakistan, The Oncology Department, Institute of Nuclear Medicine and Oncology (INMOL), Lahore, Punjab 54770, Pakistan, Department of Pathology, Fatima Memorial College of Medicine and Dentistry, Lahore, Punjab 21243, Pakistan, School of Health Sciences, University of Management and Technology, Lahore, Punjab 53720, Pakistan
  • Pages: 3443-3451
    |
    Published online on: August 18, 2016
       https://doi.org/10.3892/mmr.2016.5633
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Single nucleotide polymorphisms (SNPs) lead to genetic differences in breast cancer (BC) susceptibility among women from different ethnicities. The present study aimed at investigating the involvement of SNPs of three genes, including fibroblast growth factor receptor 2 (FGFR2), trinucleotide-repeat-containing 9 (TNRC9) and mitogen-activated protein kinase kinase kinase 1 (MAP3K1), as risk factors for the development of BC. A case‑control study (90‑100 cases; 90‑100 controls) was performed to evaluate five genetic variants of three genes, including FGFR2 (SNPs: rs1219648, rs2981582), TNRC9 (SNPs: rs8051542, rs3803662) and MAP3K1 (SNP: rs889312) as BC risk factors in Pakistani women. Significant associations were observed between BC risk and two SNPs of FGFR2 [rs2981582 (P=0.005), rs1219648 (P=9.08e‑006)] and one SNP of TNRC9 [rs3803662) (P=0.012)] in Pakistani women. On examining the different interactions of these SNPs with various clinicopathological characteristics, all three associated genetic variants, rs2981582 rs1219648 and rs3803662, exhibited a greater predisposition to sporadic, in comparison to familial, BC. Furthermore, there was an increased effect of BC risk between haplotype combinations of the two SNPs of FGFR2 (rs2981582 and rs1219648) in Pakistani women. The results of the present study suggest that variants of FGFR2 and TNRC9 may contribute to the genetic susceptibility of BC in Pakistani women.
View Figures

Figure 1

Figure 2

View References

1 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Hortobagyi GN, de la Garza Salazar J, Pritchard K, Amadori D, Haidinger R, Hudis CA, Khaled H, Liu MC, Martin M, Namer M, et al: The global breast cancer burden: Variations in epidemiology and survival. Clin Breast Cancer. 6:391–401. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Shaukat U, Toor M, Ahmad B, Fazal S and Mehmood N: Genetic and computational analysis of Tgfb1 & Fgfr2 polymorphism in correlation to breast cancer susceptibility in Pakistani women. J Cancer Sci Ther. 6:433–439. 2014.

4 

Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A and Hemminki K: Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark and Finland. N Engl J Med. 343:78–85. 2000. View Article : Google Scholar : PubMed/NCBI

5 

Thompson D and Easton D: The genetic epidemiology of breast cancer genes. J Mammary Gland Biol Neoplasia. 9:221–236. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Antoniou AC and Easton DF: Models of genetic susceptibility to breast cancer. Oncogene. 25:5898–5905. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Pharoah PD, Antoniou A, Bobrow M, Zimmern RL, Easton DF and Ponder BA: Polygenic susceptibility to breast cancer and implications for prevention. Nat Genet. 31:33–36. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Han W, Woo JH, Yu JH, Lee MJ, Moon HG, Kang D and Noh DY: Common genetic variants associated with breast cancer in Korean women and differential susceptibility according to intrinsic subtype. Cancer Epidemiol Biomarkers Prev. 20:793–798. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS and Manolio TA: Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci USA. 106:9362–9367. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Fanale D, Amodeo V, Corsini LR, Rizzo S, Bazan V and Russo A: Breast cancer genome-wide association studies: There is strength in numbers. Oncogene. 31:2121–2128. 2012. View Article : Google Scholar

11 

Nordgard SH, Johansen FE, Alnaes GI, Naume B, Børresen-Dale AL and Kristensen VN: Genes harbouring susceptibility SNPs are differentially expressed in the breast cancer subtypes. Breast Cancer Res. 9:1132007. View Article : Google Scholar : PubMed/NCBI

12 

Easton DF and Eeles RA: Genome-wide association studies in cancer. Hum Mol Genet. 17:R109–R115. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Grose R and Dickson C: Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev. 16:179–186. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Moffa AB and Ethier SP: Differential signal transduction of alternatively spliced FGFR2 variants expressed in human mammary epithelial cells. J Cell Physiol. 210:720–731. 2007. View Article : Google Scholar

15 

Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, Struewing JP, Morrison J, Field H, Luben R, et al: Genome-wide association study identifies novel breast cancer susceptibility loci. Nature. 447:1087–1093. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Liu CL, Hu XP, Guo WD, Yang L, Dang J and Jiao HY: Case-control study on the fibroblast growth factor receptor 2 gene polymorphisms associated with breast cancer in Chinese han women. J Breast Cancer. 16:366–371. 2013. View Article : Google Scholar

17 

Saadatian Z, Gharesouran J, Ghojazadeh M, Ghohari-Lasaki S, Tarkesh-Esfahani N and Mohaddes Ardebili SM: Association of rs1219648 in FGFR2 and rs1042522 in TP53 with premenopausal breast cancer in an Iranian Azeri population. Asian Pac J Cancer Prev. 15:7955–7958. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Siddiqui S, Chattopadhyay S, Akhtar MS, Najm MZ, Deo SV, Shukla NK and Husain SA: A study on genetic variants of fibroblast growth factor receptor 2 (FGFR2) and the risk of breast cancer from North India. PLoS One. 9:e1104262014. View Article : Google Scholar : PubMed/NCBI

19 

Shan J, Dsouza SP, Bakhru S, Al-Azwani EK, Ascierto ML, Sastry KS, Bedri S, Kizhakayil D, Aigha II, Malek J, et al: TNRC9 downregulates BRCA1 expression and promotes breast cancer aggressiveness. Cancer Res. 73:2840–2849. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Mcinerney N, Colleran G, Rowan A, Walther A, Barclay E, Spain S, Jones AM, Tuohy S, Curran C, Miller N, et al: Low penetrance breast cancer predisposition SNPs are site specific. Breast Cancer Res Treat. 117:151–159. 2009. View Article : Google Scholar

21 

Chalabi N, Bernard-Gallon DJ, Bignon YJ; Breast Med Consortium; Kwiatkowski F, Agier M, Vidal V, Laplace-Chabaud V, Sylvain-Vidal V, Bertholet V, et al: Comparative clinical and transcriptomal profiles of breast cancer between French and South Mediterranean patients show minor but significative biological differences. Cancer Genomics Proteomics. 5:253–261. 2008.

22 

Huijts PE, Vreeswijk MP, Kroeze-Jansema KH, Jacobi CE, Seynaeve C, Krol-Warmerdam EM, Wijers-Koster PM, Blom JC, Pooley KA, Klijn JG, et al: Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases. Breast Cancer Res. 9:R782007. View Article : Google Scholar : PubMed/NCBI

23 

Sueta A, Ito H, Kawase T, Hirose K, Hosono S, Yatabe Y, Tajima K, Tanaka H, Iwata H, Iwase H and Matsuo K: A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population. Breast Cancer Res Treat. 132:711–721. 2012. View Article : Google Scholar

24 

Ruiz-Narváez EA, Rosenberg L, Cozier YC, Cupples LA, Adams-Campbell LL and Palmer JR: Polymorphisms in the TOX3/LOC643714 locus and risk of breast cancer in African-American women. Cancer Epidemiol Biomarkers Prev. 19:1320–1327. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Long J, Shu XO, Cai Q, Gao YT, Zheng Y, Li G, Li C, Gu K, Wen W, Xiang YB, et al: Evaluation of breast cancer susceptibility loci in Chinese women. Cancer Epidemiol Biomarkers Prev. 19:2357–2365. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Pham TT, Angus SP and Johnson GL: MAP3K1: Genomic alterations in cancer and function in promoting cell survival or apoptosis. Genes Cancer. 4:419–426. 2013. View Article : Google Scholar

27 

Hirschhorn JN, Lohmueller K, Byrne E and Hirschhorn K: A comprehensive review of genetic association studies. Genet Med. 4:45–61. 2002. View Article : Google Scholar : PubMed/NCBI

28 

Kim HC, Lee JY, Sung H, Choi JY, Park SK, Lee KM, Kim YJ, Go MJ, Li L, Cho YS, et al: A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: Results from the Seoul breast cancer study. Breast Cancer Res. 14:R562012. View Article : Google Scholar : PubMed/NCBI

29 

Barnholtz-Sloan JS, Shetty PB, Guan X, Nyante SJ, Luo J, Brennan DJ and Millikan RC: FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women. Carcinogenesis. 31:1417–1423. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Zheng Y, Ogundiran TO, Falusi AG, Nathanson KL, John EM, Hennis AJ, Ambs S, Domchek SM, Rebbeck TR, Simon MS, et al: Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers. Carcinogenesis. 34:1520–1528. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Chen F, Chen GK, Millikan RC, John EM, Ambrosone CB, Bernstein L, Zheng W, Hu JJ, Ziegler RG, Deming SL, et al: Fine-mapping of breast cancer susceptibility loci characterizes genetic risk in African Americans. Hum Mol Genet. 20:4491–4503. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Fu F, Wang C, Huang M, Song C, Lin S and Huang H: Polymorphisms in second intron of the FGFR2 gene are associated with the risk of early-onset breast cancer in Chinese Han women. Tohoku J Exp Med. 226:221–229. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Maniatis T, Fritsch EF and Sambrook J: 1982 Molecular cloning: A laboratory manual. Cold Spring Harbor Laboratory; Cold Spring Harbor, New York:

34 

Hirotsu N, Murakami N, Kashiwagi T, Ujiie K and Ishimaru K: Protocol: A simple gel-free method for SNP genotyping using allele-specific primers in rice and other plant species. Plant Methods. 6:122010. View Article : Google Scholar : PubMed/NCBI

35 

Li Z, Zhang Z, He Z, Tang W, Li T, Zeng Z, He L and Shi Y: A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: Update of the SHEsis (http://analysis.bio-x.cn). Cell Res. 19:519–523. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Haffty BG, Buchholz TA and Perez CA: Early stage breast cancer. Principles and Practice of Radiation Oncology. Halperin EC, Perez CA and Brady LW: 5th ed. J. B. Lippincott & Co.; Philadelphia: pp. 1175–1291. 2008

37 

Liang J, Chen P, Hu Z, Zhou X, Chen L, Li M, Wang Y, Tang J, Wang H and Shen H: Genetic variants in fibroblast growth factor receptor 2 (FGFR2) contribute to susceptibility of breast cancer in Chinese women. Carcinogenesis. 29:2341–2346. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Kawase T, Matsuo K, Suzuki T, Hiraki A, Watanabe M, Iwata H, Tanaka H and Tajima K: FGFR2 intronic polymorphisms interact with reproductive risk factors of breast cancer: Results of a case control study in Japan. Int J Cancer. 125:1946–1952. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Stacey SN, Manolescu A, Sulem P, Thorlacius S, Gudjonsson SA, Jonsson GF, Jakobsdottir M, Bergthorsson JT, Gudmundsson J, Aben KK, et al: Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer. Nat Genet. 40:703–706. 2008. View Article : Google Scholar : PubMed/NCBI

40 

Slattery ML, Baumgartner KB, Giuliano AR, Byers T, Herrick JS and Wolff RK: Replication of five GWAS-identified loci and breast cancer risk among Hispanic and non-Hispanic white women living in the Southwestern United States. Breast Cancer Res Treat. 129:531–539. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Zheng W, Cai Q, Signorello LB, Long J, Hargreaves MK, Deming SL, Li G, Li C, Cui Y and Blot WJ: Evaluation of 11 breast cancer susceptibility loci in African-American women. Cancer Epidemiol Biomarkers Prev. 18:2761–2764. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Shan J, Mahfoudh W, Dsouza SP, Hassen E, Bouaouina N, Abdelhak S, Benhadjayed A, Memmi H, Mathew RA, Aigha II, et al: Genome-wide association studies (GWAS) breast cancer susceptibility loci in Arabs: Susceptibility and prognostic implications in Tunisians. Breast Cancer Res Treat. 135:715–724. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Huijts PE, van Dongen M, de Goeij MC, van Moolenbroek AJ, Blanken F, Vreeswijk MP, de Kruijf EM, Mesker WE, van Zwet EW, Tollenaar RA, et al: Allele-specific regulation of FGFR2 expression is cell type-dependent and may increase breast cancer risk through a paracrine stimulus involving FGF10. Breast Cancer Res. 13:R722011. View Article : Google Scholar : PubMed/NCBI

44 

Raskin L, Pinchev M, Arad C, Lejbkowicz F, Tamir A, Rennert HS, Rennert G and Gruber SB: FGFR2 is a breast cancer susceptibility gene in Jewish and Arab Israeli population. Cancer Epidemiol Biomarkers Prev. 17:1060–1065. 2008. View Article : Google Scholar : PubMed/NCBI

45 

Broeks A, Schmidt MK, Sherman ME, Couch FJ, Hopper JL, Dite GS, Apicella C, Smith LD, Hammet F, Southey MC, et al: Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: Findings from the breast cancer association consortium. Hum Mol Genet. 20:3289–3303. 2011. View Article : Google Scholar : PubMed/NCBI

46 

Chen MB, Wu XY, Shen W, Wei MX, Li C, Cai B, Tao GQ and Lu PH: Association between polymorphisms of trinucleotide repeat containing 9 gene and breast cancer risk: Evidence from 62,005 subjects. Breast Cancer Res Treat. 126:177–183. 2011. View Article : Google Scholar

47 

He X, Yao G, Li F, Li M and Yang X: Risk-association of five SNPs in TOX3/LOC643714 with breast cancer in southern China. Int J Mol Sci. 15:2130–2141. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Garcia-Closas M, Hall P, Nevanlinna H, Pooley K, Morrison J, Richesson DA, Bojesen SE, Nordestgaard BG, Axelsson CK, Arias JI, et al: Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet. 4:e10000542008. View Article : Google Scholar : PubMed/NCBI

49 

Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, Hankinson SE, Wacholder S, Wang Z, Welch R, Hutchinson A, et al: A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet. 39:870–874. 2007. View Article : Google Scholar : PubMed/NCBI

50 

Shan J, Dsouza SP, Bakhru S, Al-Azwani EK, Ascierto ML, Sastry KS, Bedri S, Kizhakayil D, Aigha II, Malek J, et al: TNRC9 downregulates BRCA1 expression and promotes breast cancer aggressiveness. Cancer Res. 73:2840–2849. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Chalabi N, Bernard-Gallon DJ, Bignon YJ, Kwiatkowski F, Agier M, Vidal V, Laplace-Chabaud V, Sylvain-Vidal V, Bertholet V, De Longueville F, et al: Comparative clinical and transcriptomal profiles of breast cancer between French and South Mediterranean patients show minor but significative biological differences. Cancer Genomics Proteomics. 5:253–261. 2008.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mazhar A, Jamil F, Bashir Q, Ahmad MS, Masood M, Tanvir I, Rashid N, Waheed A, Afzal MN, Tariq MA, Tariq MA, et al: Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women. Mol Med Rep 14: 3443-3451, 2016.
APA
Mazhar, A., Jamil, F., Bashir, Q., Ahmad, M.S., Masood, M., Tanvir, I. ... Tariq, M.A. (2016). Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women. Molecular Medicine Reports, 14, 3443-3451. https://doi.org/10.3892/mmr.2016.5633
MLA
Mazhar, A., Jamil, F., Bashir, Q., Ahmad, M. S., Masood, M., Tanvir, I., Rashid, N., Waheed, A., Afzal, M. N., Tariq, M. A."Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women". Molecular Medicine Reports 14.4 (2016): 3443-3451.
Chicago
Mazhar, A., Jamil, F., Bashir, Q., Ahmad, M. S., Masood, M., Tanvir, I., Rashid, N., Waheed, A., Afzal, M. N., Tariq, M. A."Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women". Molecular Medicine Reports 14, no. 4 (2016): 3443-3451. https://doi.org/10.3892/mmr.2016.5633
Copy and paste a formatted citation
x
Spandidos Publications style
Mazhar A, Jamil F, Bashir Q, Ahmad MS, Masood M, Tanvir I, Rashid N, Waheed A, Afzal MN, Tariq MA, Tariq MA, et al: Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women. Mol Med Rep 14: 3443-3451, 2016.
APA
Mazhar, A., Jamil, F., Bashir, Q., Ahmad, M.S., Masood, M., Tanvir, I. ... Tariq, M.A. (2016). Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women. Molecular Medicine Reports, 14, 3443-3451. https://doi.org/10.3892/mmr.2016.5633
MLA
Mazhar, A., Jamil, F., Bashir, Q., Ahmad, M. S., Masood, M., Tanvir, I., Rashid, N., Waheed, A., Afzal, M. N., Tariq, M. A."Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women". Molecular Medicine Reports 14.4 (2016): 3443-3451.
Chicago
Mazhar, A., Jamil, F., Bashir, Q., Ahmad, M. S., Masood, M., Tanvir, I., Rashid, N., Waheed, A., Afzal, M. N., Tariq, M. A."Genetic variants in FGFR2 and TNRC9 genes are associated with breast cancer risk in Pakistani women". Molecular Medicine Reports 14, no. 4 (2016): 3443-3451. https://doi.org/10.3892/mmr.2016.5633
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team