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Article

Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model

  • Authors:
    • Weiwei Yang
    • Liping She
    • Kun Yu
    • Shan Yan
    • Xuefeng Zhang
    • Xiaoyi Tian
    • Shuren Ma
    • Xiwen Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Nephrology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China, Department of Intensive Care Unit, Jiangsu Province Geriatric Hospital, Nanjing, Jiangsu 210000, P.R. China, Department of Cardiology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, Jiangsu 223300, P.R. China
  • Pages: 3277-3284
    |
    Published online on: August 18, 2016
       https://doi.org/10.3892/mmr.2016.5634
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Abstract

Jatrorrhizine hydrochloride (JH) is an active component of the traditional Chinese herb Coptis chinensis, which has been used to prevent and treat metabolic disorders. Hyperlipidemia is one of the principal factors underlying numerous metabolic diseases, including diabetes and obesity. Therefore, the aim of the present study was to investigate the lipid lowering effects of JH treatment in vivo in an obesity mouse model. JH-treated hyperlipidemic mice exhibited a reduction in body weight, as well as improved glucose tolerance and insulin sensitivity. In addition, JH‑treated hyperlipidemic mice exhibited reduced serum triglyceride, total cholesterol and low‑density lipoprotein cholesterol levels, as well as increased high‑density lipoprotein cholesterol levels compared with untreated mice fed a high‑fat diet. Notably, JH treatment ameliorated the pathophysiological changes observed in the livers of hyperlipidemic mice. At the molecular level, JH downregulated the hepatic mRNA expression levels of SREBP‑1c and FAS, and induced PPAR‑α and CPT1A mRNA expression in hyperlipidemic mice. These findings suggest that JH ameliorates hyperlipidemia via the suppression of lipogenesis and the enhancement of lipid oxidation in the liver.
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Copy and paste a formatted citation
Spandidos Publications style
Yang W, She L, Yu K, Yan S, Zhang X, Tian X, Ma S and Zhang X: Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model. Mol Med Rep 14: 3277-3284, 2016.
APA
Yang, W., She, L., Yu, K., Yan, S., Zhang, X., Tian, X. ... Zhang, X. (2016). Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model. Molecular Medicine Reports, 14, 3277-3284. https://doi.org/10.3892/mmr.2016.5634
MLA
Yang, W., She, L., Yu, K., Yan, S., Zhang, X., Tian, X., Ma, S., Zhang, X."Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model". Molecular Medicine Reports 14.4 (2016): 3277-3284.
Chicago
Yang, W., She, L., Yu, K., Yan, S., Zhang, X., Tian, X., Ma, S., Zhang, X."Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model". Molecular Medicine Reports 14, no. 4 (2016): 3277-3284. https://doi.org/10.3892/mmr.2016.5634
Copy and paste a formatted citation
x
Spandidos Publications style
Yang W, She L, Yu K, Yan S, Zhang X, Tian X, Ma S and Zhang X: Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model. Mol Med Rep 14: 3277-3284, 2016.
APA
Yang, W., She, L., Yu, K., Yan, S., Zhang, X., Tian, X. ... Zhang, X. (2016). Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model. Molecular Medicine Reports, 14, 3277-3284. https://doi.org/10.3892/mmr.2016.5634
MLA
Yang, W., She, L., Yu, K., Yan, S., Zhang, X., Tian, X., Ma, S., Zhang, X."Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model". Molecular Medicine Reports 14.4 (2016): 3277-3284.
Chicago
Yang, W., She, L., Yu, K., Yan, S., Zhang, X., Tian, X., Ma, S., Zhang, X."Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model". Molecular Medicine Reports 14, no. 4 (2016): 3277-3284. https://doi.org/10.3892/mmr.2016.5634
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